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Expert Opinion on Investigational Drugs Volume 14, 2005 - Issue 12
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Review

The glutamatergic system outside the CNS and in cancer biology

Niki Kalariti Department of Experimental Physiology, Medical School, University of Athens, 75 Micras Asias, Goudi-Athens, Greece. [email protected]
,
Nikos Pissimissis Department of Experimental Physiology, Medical School, University of Athens, 75 Micras Asias, Goudi-Athens, Greece. [email protected]
&
Michael Koutsilieris Department of Experimental Physiology, Medical School, University of Athens, 75 Micras Asias, Goudi-Athens, Greece. [email protected]
Pages 1487-1496 | Published online: 25 Nov 2005

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Sherin Ramadan Hamad. (2022) Histopathological and immunohistochemical studies on the influence of orally administration monosodium glutamate, a food additive dependent on time in vivo. The Journal of Basic and Applied Zoology 83:1.
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Ankit Srivastava, Deeksha Rikhari, Biswajita Pradhan, Kaushik Kumar Bharadwaj, Antonio Gaballo, Alessandra Quarta, Mrutyunjay Jena, Sameer Srivastava & Andrea Ragusa. (2022) An Insight into Neuropeptides Inhibitors in the Biology of Colorectal Cancer: Opportunity and Translational Perspectives. Applied Sciences 12:18, pages 8990.
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Jing Ding, Liuqin He, Tiejun Li & Yulong Yin. (2022) Research progress on the function of the amino acid transporter SLC1A3 and its regulation mechanism of action in the nervous system and mitochondria. Chinese Science Bulletin 67:25, pages 3005-3013.
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Zaihua Yan, Peidong Li, Yuan Xue, Hongpeng Tian, Tong Zhou & Guangjun Zhang. (2021) Glutamate receptor, ionotropic, N‑methyl D‑aspartate‑associated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR‑296‑3p. Molecular Medicine Reports 24:4.
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Tao Li, Jie Yang, Ben Yang, Guoqing Zhao, Hai Lin, Qi Liu, Leiming Wang, Yingchun Wan & Hongyang Jiang. (2021) Ketamine Inhibits Ovarian Cancer Cell Growth by Regulating the lncRNA-PVT1/EZH2/p57 Axis. Frontiers in Genetics 11.
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Xiang-Rong Li, Xiaju Cheng, Jia Sun, Yan S. Xu, Nannan Chen, Yimei Hao, Chao Huang & Y. Eugene Chin. (2021) Acetylation-dependent glutamate receptor GluR signalosome formation for STAT3 activation in both transcriptional and metabolism regulation. Cell Death Discovery 7:1.
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Shree Goyal, Pallab Chakraborty & Balasubramaniam Shankar. (2021) Ionotropic glutamate receptors and their implications in cancer and cancer therapeutics. Biomedical and Biotechnology Research Journal (BBRJ) 5:4, pages 349.
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Tina Kazemi, Shuyan Huang, Naze G. Avci, Charlotte Mae K. Waits, Yasemin M. Akay & Metin Akay. (2020) Investigating the influence of perinatal nicotine and alcohol exposure on the genetic profiles of dopaminergic neurons in the VTA using miRNA–mRNA analysis. Scientific Reports 10:1.
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Mohanan Valiya Veettil, Gayathri Krishna, Arunava Roy, Anandita Ghosh, Dipanjan Dutta, Binod Kumar, Sayan Chakraborty, Thoppil Raveendran Anju, Neelam Sharma-Walia & Bala Chandran. (2020) Kaposi’s Sarcoma-Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells. Journal of Virology 94:8.
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Edna Suárez-Pozos, Elizabeth J. Thomason & Babette Fuss. (2019) Glutamate Transporters: Expression and Function in Oligodendrocytes. Neurochemical Research 45:3, pages 551-560.
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Russell L. Blaylock. (2019) Accelerated cancer aggressiveness by viral oncomodulation: New targets and newer natural treatments for cancer control and treatment. Surgical Neurology International 10, pages 199.
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Wenming Duan, Jianjun Hu & Yahua Liu. (2019) Ketamine inhibits colorectal cancer cells malignant potential via blockage of NMDA receptor. Experimental and Molecular Pathology 107, pages 171-178.
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Li Wei, Fei He, Wen Zhang, Wenhua Chen & Bo Yu. (2018) Bioinformatics analysis of microarray data to reveal the pathogenesis of diffuse intrinsic pontine glioma. Biological Research 51:1.
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Jeffrey C. Pelletier, Suzie Chen, Haiyan Bian, Raj Shah, Garry R. Smith, Jay E. Wrobel & Allen B. Reitz. (2018) Dipeptide Prodrugs of the Glutamate Modulator Riluzole. ACS Medicinal Chemistry Letters 9:7, pages 752-756.
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Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen & Patrik Danielson. (2017) Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells. BMC Musculoskeletal Disorders 18:1.
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Magdalena Gorska-Ponikowska, Ugo Perricone, Alicja Kuban-Jankowska, Giosuè Lo Bosco & Giampaolo Barone. (2017) 2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor. Journal of Cellular Physiology 232:11, pages 3030-3049.
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Mery Stefani Leivas Pereira, Fábio Klamt, Chairini Cássia Thomé, Paulo Valdeci Worm & Diogo Losch de Oliveira. (2017) Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas. Oncotarget 8:13, pages 22279-22298.
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Sally Liao, Yuleisy Ruiz, Hira Gulzar, Zarina Yelskaya, Lyes Ait Taouit, Murielle Houssou, Trisha Jaikaran, Yuriy Schvarts, Kristina Kozlitina, Upal Basu-Roy, Alka Mansukhani & Shahana S. Mahajan. (2017) Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLOS ONE 12:2, pages e0171256.
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Sonia Spitzer, Katrin Volbracht, Iben Lundgaard & Ragnhildur T. Káradóttir. (2016) Glutamate signalling: A multifaceted modulator of oligodendrocyte lineage cells in health and disease. Neuropharmacology 110, pages 574-585.
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WEI LU, LIN WANG, CHUNXIN WO & JING YAO. (2016) Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model. Molecular Medicine Reports 13:6, pages 5013-5020.
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S. Parenti, G. Casagrande, M. Montanari, M. Espahbodinia, R. Ettari, A. Grande & L. Corsi. (2016) A novel 2,3-benzodiazepine-4-one derivative AMPA antagonist inhibits G2/M transition and induces apoptosis in human leukemia Jurkat T cell line. Life Sciences 152, pages 117-125.
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Manuela Malsy, Kristina Gebhardt, Michael Gruber, Christoph Wiese, Bernhard Graf & Anika Bundscherer. (2015) Effects of ketamine, s-ketamine, and MK 801 on proliferation, apoptosis, and necrosis in pancreatic cancer cells. BMC Anesthesiology 15:1.
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RK Koiri. (2015) N-Methyl-D-Aspartate (NMDA) Receptors: Therapeutic Target against Cancer. International Journal of Immunotherapy and Cancer Research, pages 013-017.
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Vidyanand AnapartiRamses IlarrazaKanami OriharaGerald L. StelmackOluwaseun O. OjoThomas H. MahoodHelmut Unruh, Andrew J. HalaykoRedwan Moqbel. (2015) NMDA receptors mediate contractile responses in human airway smooth muscle cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 308:12, pages L1253-L1264.
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Andrzej Stepulak, Radoslaw Rola, Krzysztof Polberg & Chrysanthy Ikonomidou. (2014) Glutamate and its receptors in cancer. Journal of Neural Transmission 121:8, pages 933-944.
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Yonatan Ganor & Mia Levite. (2014) The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells. Journal of Neural Transmission 121:8, pages 983-1006.
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Fuminori Yamaguchi, Yuko Hirata, Hossain Akram, Kazuyo Kamitori, Youyi Dong, Li Sui & Masaaki Tokuda. (2013) FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801. BMC Cancer 13:1.
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SHA LI, YANLAI SUN & DONGWEI GAO. (2013) Role of the nervous system in cancer metastasis. Oncology Letters 5:4, pages 1101-1111.
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Mark E. McDonnell, Matthew D. Vera, Benjamin E. Blass, Jeffrey C. Pelletier, Richard C. King, Carmen Fernandez-Metzler, Garry R. Smith, Jay Wrobel, Suzie Chen, Brian A. Wall & Allen B. Reitz. (2012) Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling. Bioorganic & Medicinal Chemistry 20:18, pages 5642-5648.
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Yonatan Ganor & Mia Levite. 2012. Nerve-Driven Immunity. Nerve-Driven Immunity 121 161 .
Mario Mancino, Elisabet Ametller, Pedro Gascón & Vanessa Almendro. (2011) The neuronal influence on tumor progression. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1816:2, pages 105-118.
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Kyu Yeong Choi, Kai Chang, James M. Pickel, John D. BadgerIIII & Katherine W. Roche. (2011) Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. Proceedings of the National Academy of Sciences 108:37, pages 15219-15224.
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Patrik Danielson & Alexander Scott. 2011. Anterior Knee Pain and Patellar Instability. Anterior Knee Pain and Patellar Instability 229 236 .
Helga Susanne Haas, Alexander Linecker, Roswitha Pfragner & Anton Sadjak. (2010) Peripheral glutamate signaling in head and neck areas. Head & Neck 32:11, pages 1554-1572.
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Janet Wangari-Talbot, James Goydos & Suzie Chen. (2010) Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development. Pharmaceuticals 3:9, pages 2821-2837.
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Andrzej Stepulak, Hella Luksch, Christine Gebhardt, Ortrud Uckermann, Jenny Marzahn, Marco Sifringer, Wojciech Rzeski, Christian Staufner, Katja S. Brocke, Lechoslaw Turski & Chrysanthy Ikonomidou. (2009) Expression of glutamate receptor subunits in human cancers. Histochemistry and Cell Biology 132:4, pages 435-445.
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T. Piepoli, L. Mennuni, S. Zerbi, M. Lanza, L.C. Rovati & G. Caselli. (2009) Glutamate signaling in chondrocytes and the potential involvement of NMDA receptors in cell proliferation and inflammatory gene expression. Osteoarthritis and Cartilage 17:8, pages 1076-1083.
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Alexander Scott, Håkan Alfredson & Sture Forsgren. (2007) VGluT2 expression in painful Achilles and patellar tendinosis: Evidence of local glutamate release by tenocytes. Journal of Orthopaedic Research 26:5, pages 685-692.
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Santokh Gill, Michael Barker & Olga Pulido. (2008) Neuroexcitatory Targets in the Female Reproductive System of the Nonhuman Primate ( Macaca fascicularis ) . Toxicologic Pathology 36:3, pages 478-484.
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Colin G. Rousseaux. (2008) A Review of Glutamate Receptors II: Pathophysiology and Pathology. Journal of Toxicologic Pathology 21:3, pages 133-173.
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