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Expert Opinion on Investigational Drugs Volume 14, 2005 - Issue 3
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Review

Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists

Arthur A Hancock Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6125, USA. [email protected]
&
Michael E Brune Metabolic Diseases Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6126, USA
Pages 223-241 | Published online: 22 Apr 2005

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M. Zendehdel, A. Baghbanzadeh, P. Aghelkohan & S. Hassanpour. (2016) Central histaminergic system interplay with suppressive effects of immune challenge on food intake in chicken. British Poultry Science 57:2, pages 271-279.
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Maikel Wijtmans, Rob Leurs & Iwan de Esch. (2007) Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas. Expert Opinion on Investigational Drugs 16:7, pages 967-985.
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Michael Berlin & Christopher W Boyce. (2007) Recent advances in the development of histamine H3 antagonists. Expert Opinion on Therapeutic Patents 17:6, pages 675-687.
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Dr Peter Norman. (2007) A H3 antagonist for treating allergic rhinitis: a development candidate?. Expert Opinion on Therapeutic Patents 17:4, pages 449-452.
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Articles from other publishers (59)

Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron & Natalie Jane Michael. (2023) Histaminergic regulation of food intake. Frontiers in Endocrinology 14.
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Kamil Mika, Małgorzata Szafarz, Monika Zadrożna, Barbara Nowak, Marek Bednarski, Katarzyna Szczepańska, Krzysztof Pociecha, Monika Kubacka, Noemi Nicosia, Izabela Juda, Katarzyna Kieć-Kononowicz & Magdalena Kotańska. (2022) KSK-74: Dual Histamine H3 and Sigma-2 Receptor Ligand with Anti-Obesity Potential. International Journal of Molecular Sciences 23:13, pages 7011.
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Kamil Mika, Małgorzata Szafarz, Marek Bednarski, Gniewomir Latacz, Sylwia Sudoł, Jadwiga Handzlik, Krzysztof Pociecha, Joanna Knutelska, Noemi Nicosia, Katarzyna Szczepańska, Kamil J. Kuder, Katarzyna Kieć-Kononowicz & Magdalena Kotańska. (2021) Histamine H3 Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating. Pharmaceuticals 14:11, pages 1080.
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Katarzyna Szczepańska, Kamil J. Kuder & Katarzyna Kieć-Kononowicz. (2021) Dual-targeting Approach on Histamine H3 and Sigma-1 Receptor Ligands as Promising Pharmacological Tools in the Treatment of CNS-linked Disorders. Current Medicinal Chemistry 28:15, pages 2974-2995.
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Katarzyna Szczepańska, Steffen Pockes, Sabina Podlewska, Carina Höring, Kamil Mika, Gniewomir Latacz, Marek Bednarski, Agata Siwek, Tadeusz Karcz, Martin Nagl, Merlin Bresinsky, Denise Mönnich, Ulla Seibel, Kamil J. Kuder, Magdalena Kotańska, Holger Stark, Sigurd Elz & Katarzyna Kieć-Kononowicz. (2021) Structural modifications in the distal, regulatory region of histamine H3 receptor antagonists leading to the identification of a potent anti-obesity agent. European Journal of Medicinal Chemistry 213, pages 113041.
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Magdalena Kotańska, Kamil Mika, Karolina Reguła, Katarzyna Szczepańska, Małgorzata Szafarz, Marek Bednarski, Agnieszka Olejarz-Maciej, Katarzyna Nowak, Gniewomir Latacz, Szczepan Mogilski, Kamil J. Kuder, Katarzyna Kieć-Kononowicz & Jacek Sapa. (2019) KSK19 – Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice. Biochemical Pharmacology 168, pages 193-203.
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Ajeet Kumar, Venkata Reddy Pasam, Ravi Kumar Thakur, Maninder Singh, Kartikey Singh, Mahendra Shukla, Anubhav Yadav, Shalini Dogra, Chandan Sona, Deepmala Umrao, Swati Jaiswal, Hafsa Ahmad, Mamunur Rashid, Sandeep K. Singh, Muhammad Wahajuddin, Anil Kumar Dwivedi, Mohammad Imran Siddiqi, Jawahar Lal, Rama Pati Tripathi & Prem N. Yadav. (2019) Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity. Journal of Medicinal Chemistry 62:9, pages 4638-4655.
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M Jaefari-Anari, M Zendehdel, H Gilanpour, A Asghari & V Babapour. (2018) Central Opioidergic System Interplay with Histamine on Food Intake in Neonatal Chicks: Role of µ-Opioid and H1/H3 Receptors. Brazilian Journal of Poultry Science 20:3, pages 595-604.
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Magdalena Kotańska, Kamil J. Kuder, Katarzyna Szczepańska, Jacek Sapa & Katarzyna Kieć-Kononowicz. (2018) The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice. Naunyn-Schmiedeberg's Archives of Pharmacology 391:8, pages 875-881.
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Hooman Heidarzadeh, Morteza Zendehdel, Vahab Babapour & Hasan Gilanpour. (2017) The effect of Nesfatin-1 on food intake in neonatal chicks: role of CRF1 /CRF2 and H1/ H3 receptors. Veterinary Research Communications 42:1, pages 39-47.
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Jolene Zheng, Joseph R. Vasselli, Jason F. King, Michael L. King, Wenqian We, Zachary Fitzpatrick, William D. Johnson, John W. Finley, Roy J. Martin, Michael J. Keenan, Frederic M. Enright & Frank L. Greenway. (2016) Using Caenorhabditis elegans as a Model for Obesity Pharmacology Development. American Journal of Therapeutics 23:6, pages e1363-e1370.
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Magdalena Dudek, Kamil Kuder, Marcin Kołaczkowski, Adrian Olczyk, Elżbieta Żmudzka, Aleksandra Rak, Marek Bednarski, Karolina Pytka, Jacek Sapa & Katarzyna Kieć-Kononowicz. (2016) H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metabolic Brain Disease 31:5, pages 1023-1029.
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Alessandro Pini, Ilona Obara, Emma Battell, Paul L. Chazot & Arianna Carolina Rosa. (2016) Histamine in diabetes: Is it time to reconsider?. Pharmacological Research 111, pages 316-324.
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Gustavo Provensi, Patrizio Blandina & Maria Beatrice Passani. 2016. Histamine Receptors. Histamine Receptors 341 360 .
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Gregory Sliwoski, Sandeepkumar Kothiwale, Jens Meiler & Edward W. LoweJr.Jr.. (2013) Computational Methods in Drug Discovery. Pharmacological Reviews 66:1, pages 334-395.
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Dimitry N. Krementsov, Emma H. Wall, Rebecca A. Martin, Meenakumari Subramanian, Rajkumar Noubade, Roxana Del Rio, Gary M. Mawe, Jeffrey P. Bond, Matthew E. Poynter, Elizabeth P. Blankenhorn & Cory Teuscher. (2013) Histamine H3 Receptor Integrates Peripheral Inflammatory Signals in the Neurogenic Control of Immune Responses and Autoimmune Disease Susceptibility. PLoS ONE 8:7, pages e62743.
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