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Expert Opinion on Investigational Drugs Volume 15, 2006 - Issue 11
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Review

The histamine H4 receptor in autoimmune disease

Mai Zhang Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. [email protected]
,
Jennifer D Venable Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. [email protected]
&
Robin L Thurmond Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. [email protected]
Pages 1443-1452 | Published online: 16 Oct 2006

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Nir Barak. (2008) Betahistine: what's new on the agenda?. Expert Opinion on Investigational Drugs 17:5, pages 795-804.
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Crossref
Umesh Kumar, Pankti Mehta, Sandeep Kumar, Avinash Jain, Anupam Guleria, Venkatesh Kumar R, Ramnath Misra & Dinesh Kumar. (2021) Circulatory histidine levels as predictive indicators of disease activity in takayasu arteritis. Analytical Science Advances 2:11-12, pages 527-535.
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Alain Couvineau, Thierry Voisin, Pascal Nicole, Valerie Gratio & Anne Blais. (2021) Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions. World Journal of Gastroenterology 27:44, pages 7582-7596.
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Danxia Qin, Han Zhang, Jiehua Wang & Zhuquan Hong. (2019) Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease. BMC Medical Genomics 12:1.
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Alain Couvineau, Thierry Voisin, Pascal Nicole, Valérie Gratio, Catalina Abad & Yossan-Var Tan. (2019) Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases. Frontiers in Endocrinology 10.
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James Holmes, Lucy C. Fairclough & Ian Todd. (2019) Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity. Archives of Dermatological Research 311:3, pages 141-162.
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David L. Boyle, Samuel E. DePrimo, Cesar Calderon, Dion Chen, Paul J. Dunford, William Barchuk, Gary S. Firestein & Robin L. Thurmond. (2019) Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study. Inflammation Research 68:4, pages 261-274.
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N. Messal, N. Fernandez, S. Dayot, V. Gratio, P. Nicole, C. Prochasson, I. Chantret, G. LeGuilloux, A. Jarry, A. Couvelard, X. Tréton, T. Voisin, E. Ogier-Denis & A. Couvineau. (2018) Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:11, pages 3618-3628.
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Kyoung-Woon Kim, Bo-Mi Kim, Kyung-Ann Lee, Sang-Heon Lee, Gary S. Firestein & Hae-Rim Kim. (2017) Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. Scientific Reports 7:1.
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Robin L. Thurmond, Jennifer Venable, Brad Savall, David La, Sandra Snook, Paul J. Dunford & James P. Edwards. 2017. Histamine and Histamine Receptors in Health and Disease. Histamine and Histamine Receptors in Health and Disease 301 320 .
Robin L. Thurmond, Andrew Greenspan, Waldemar Radziszewski, Xie L. Xu, Ye Miao, Bin Chen, TingTing Ge, Bei Zhou, Daniel G. Baker, Dace Pavlova, Christopher T. Ritchlin, Yoshiya Tanaka, Tsutomu Takeuchi & Josef S. Smolen. (2016) Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies. The Journal of Rheumatology 43:9, pages 1637-1642.
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Roland Geyer, Uwe Nordemann, Andrea Strasser, Hans-Joachim Wittmann & Armin Buschauer. (2016) Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H 4 Receptor Agonists . Journal of Medicinal Chemistry 59:7, pages 3452-3470.
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Vino Daniel. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1905 2024 .
Silke Beermann, Guenther Bernhardt, Roland Seifert, Armin Buschauer & Detlef Neumann. (2015) Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation. Biochemical Pharmacology 98:3, pages 432-439.
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Silke Beermann, Marcus Vauth, Rabea Hein, Roland Seifert & Detlef Neumann. (2014) Distinct Signalling Pathways of Murine Histamine H1- and H4-Receptors Expressed at Comparable Levels in HEK293 Cells. PLoS ONE 9:9, pages e107481.
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Jeffery M Cowden, Fuqu Yu, Homayon Banie, Mandana Farahani, Ping Ling, Steven Nguyen, Jason P Riley, Mai Zhang, Jian Zhu, Paul J Dunford & Robin L Thurmond. (2014) The histamine H 4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis . Annals of the Rheumatic Diseases 73:3, pages 600-608.
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Emma Boström, Yi-Fang Cheng, Niclas Brynne & Märta Segerdahl. (2013) Prediction of H3 Receptor Occupancy Diurnal Fluctuations Using Population Modeling and Simulation with Focus on Guiding Dose Selection in a Phase IIa Study. Pharmaceutical Research 31:2, pages 489-499.
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Akhilesh K. Verma, Monika Patel, Megha Joshi, Pravin R. Likhar, Rakesh K. Tiwari & Keykavous Parang. (2013) Base-Mediated Chemo- and Stereoselective Addition of 5-Aminoindole/Tryptamine and Histamines onto Alkynes. The Journal of Organic Chemistry 79:1, pages 172-186.
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Vino Daniel. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 137 .
T Somma, L Cinci, G Formicola, A Pini, R Thurmond, M Ennis, D Bani & E Masini. (2013) A selective antagonist of histamine H 4 receptors prevents antigen-induced airway inflammation and bronchoconstriction in guinea pigs: involvement of lipocortin-1 . British Journal of Pharmacology 170:1, pages 200-213.
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B. Chen, T. Ye, Y. Shao, J. Zhang, Q. Zhong, X. Hu, W. Zhang & B. Yu. (2013) Association between copy-number variations of the human histamine H4 receptor gene and atopic dermatitis in a Chinese population. Clinical and Experimental Dermatology 38:3, pages 295-301.
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Charles M. Marson. (2011) Targeting the Histamine H 4 Receptor . Chemical Reviews 111:11, pages 7121-7156.
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A. Leonardi, A. Di Stefano, C. Vicari, L. Motterle & P. Brun. (2011) Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis. Allergy 66:10, pages 1360-1366.
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B. Yu, Y. Shao, P. Li, J. Zhang, Q. Zhong, H. Yang, X. Hu, B. Chen, X. Peng, Q. Wu, Y. Chen, M. Guan, J. Wan & W. Zhang. (2010) Copy number variations of the human histamine H4 receptor gene are associated with systemic lupus erythematosus. British Journal of Dermatology 163:5, pages 935-940.
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Farhad Jadidi-Niaragh & Abbas Mirshafiey. (2010) Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis. Neuropharmacology 59:3, pages 180-189.
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Ruin Moaddel, Harrison K. Musyimi, Mitesh Sanghvi, Charlene Bashore, Chester R. Frazier, Mohammad Khadeer, Prateek Bhatia & Irving W. Wainer. (2010) Synthesis and characterization of a cellular membrane affinity chromatography column containing histamine 1 and P2Y1 receptors: A multiple G-protein coupled receptor column. Journal of Pharmaceutical and Biomedical Analysis 52:3, pages 416-419.
Crossref
B. Yu, Y. Shao, J. Zhang, X.L. Dong, W.L. Liu, H. Yang, L. Liu, M.H. Li, C.F. Yue, Z.Y. Fang, C. Zhang, X.P. Hu, B.C. Chen, Q. Wu, Y.W. Chen, W. Zhang & J. Wan. (2010) Polymorphisms in human histamine receptor H4 gene are associated with atopic dermatitis. British Journal of Dermatology 162:5, pages 1038-1043.
Crossref
Elke Schneider, Maria Leite-de-Moraes & Michel Dy. 2010. Histamine in Inflammation. Histamine in Inflammation 81 94 .
Fuqu Yu, Pascal Bonaventure & Robin L. Thurmond. 2010. Histamine in Inflammation. Histamine in Inflammation 125 140 .
MI Strakhova, CA Cuff, AM Manelli, TL Carr, DG Witte, JL Baranowski, TA Vortherms, TR Miller, L Rundell, MJ McPherson, RM Adair, AA Brito, BM Bettencourt, BB Yao, JM Wetter, KC Marsh, H Liu, MD Cowart, JD Brioni & TA Esbenshade. (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. British Journal of Pharmacology 157:1, pages 44-54.
Crossref
Marina I. Strakhova, Arthur L. Nikkel, Arlene M. Manelli, Gin C. Hsieh, Timothy A. Esbenshade, Jorge D. Brioni & Robert S. Bitner. (2009) Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Research 1250, pages 41-48.
Crossref
Huaqing Liu, Robert J. Altenbach, Tracy L. Carr, Prasant Chandran, Gin C. Hsieh, La Geisha R. Lewis, Arlene M. Manelli, Ivan Milicic, Kennan C. Marsh, Thomas R. Miller, Marina I. Strakhova, Timothy A. Vortherms, Brian D. Wakefield, Jill M. Wetter, David G. Witte, Prisca Honore, Timothy A. Esbenshade, Jorge D. Brioni & Marlon D. Cowart. (2008) cis -4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3- h ]quinazolin-2-amine (A-987306), A New Histamine H 4 R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia . Journal of Medicinal Chemistry 51:22, pages 7094-7098.
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Jia Meng, Xue Ma, Mingkai Li, Min Jia & Xiaoxing Luo. (2008) Histamine H4 receptors regulate ACTH release in AtT-20 cells. European Journal of Pharmacology 587:1-3, pages 336-338.
Crossref
L. Maintz, V. Schwarzer, T. Bieber, K. van der Ven & N. Novak. (2008) Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Human Reproduction Update 14:5, pages 485-495.
Crossref
Maikel Wijtmans, Sylvain Celanire, Erwin Snip, Michel R. Gillard, Edith Gelens, Philippe P. Collart, Bastiaan J. Venhuis, Bernard Christophe, Saskia Hulscher, Henk van der Goot, Florence Lebon, Henk Timmerman, Remko A. Bakker, Bénédicte I. L. F. Lallemand, Rob Leurs, Patrice E. Talaga & Iwan J. P. de Esch. (2008) 4-Benzyl-1 H -imidazoles with Oxazoline Termini as Histamine H 3 Receptor Agonists . Journal of Medicinal Chemistry 51:10, pages 2944-2953.
Crossref
V. Biran, V. Cochois, A. Karroubi, J.M. Arrang, C. Charriaut-Marlangue & A. Héron. (2008) Stroke Induces Histamine Accumulation and Mast Cell Degranulation in the Neonatal Rat Brain. Brain Pathology 18:1, pages 1-9.
Crossref
Agnes Koncz, Maria Pasztoi, Mercedesz Mazan, Ferenc Fazakas, Edit Buzas, Andras Falus & Gyorgy Nagy. (2007) Nitric Oxide Mediates T Cell Cytokine Production and Signal Transduction in Histidine Decarboxylase Knockout Mice. The Journal of Immunology 179:10, pages 6613-6619.
Crossref
Mai Zhang, Robin L. Thurmond & Paul J. Dunford. (2007) The histamine H4 receptor: A novel modulator of inflammatory and immune disorders. Pharmacology & Therapeutics 113:3, pages 594-606.
Crossref
Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 983 1116 .

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