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Review

The potential use of selective 5-HT2C agonists in treating obesity

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Pages 257-266 | Published online: 27 Feb 2006

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Kirsty Kiezebrink, Evleen T. Mann, Sarah R. Bujac, Michael J. Stubbins, David A. Campbell & John E. Blundell. (2010) Evidence of complex involvement of serotonergic genes with restrictive and binge purge subtypes of anorexia nervosa. The World Journal of Biological Psychiatry 11:6, pages 824-833.
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Robert F Kushner. (2008) Anti-obesity drugs. Expert Opinion on Pharmacotherapy 9:8, pages 1339-1350.
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Hari K. Namballa, Sudharshan Madapa, Dilep K. Sigalapalli & Wayne W. Harding. (2022) Semisynthetic Transformations on (+)-Boldine Reveal a 5-HT 2A/2C R Antagonist . Journal of Natural Products 85:9, pages 2149-2158.
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Mohammad Amin Langarizadeh, Khalil Eskandari, Ardavan Abiri, Marziye Ranjbar Tavakoli, Ali Asadipour & Yaghoub Pourshojaei. (2022) A novel dual three and five-component reactions between dimedone, aryl aldehydes, and 1-naphthylamine: synthesis and computational studies. Journal of Molecular Structure 1258, pages 132569.
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Meghan J. Orr, Andrew B. Cao, Charles Tiancheng Wang, Arsen Gaisin, Adam Csakai, Alec P. Friswold, Herbert Y. Meltzer, John D. McCorvy & Karl A. Scheidt. (2022) Discovery of Highly Potent Serotonin 5-HT 2 Receptor Agonists Inspired by Heteroyohimbine Natural Products . ACS Medicinal Chemistry Letters 13:4, pages 648-657.
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Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam & Samit Chattopadhyay. (2021) Epigenetic Regulation of Adipogenesis in Development of Metabolic Syndrome. Frontiers in Cell and Developmental Biology 8.
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Paola Maccioni, Irene Lorrai, Federica Fara, Mauro A M Carai, Gian Luigi Gessa, Young-Won Chin, Jung Hwan Lee, Hak Cheol Kwon, Federico Corelli & Giancarlo Colombo. (2020) Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats. Alcohol and Alcoholism 55:4, pages 367-373.
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Qi Mao, Bingjie Zhang, Wanwan Li, Sheng Tian, Wenqing Shui & Na Ye. (2020) Identification of Novel 1- O -Substituted Aporphine Analogues as Potent 5-HT 2C Receptor Agonists . ACS Chemical Neuroscience 11:4, pages 549-559.
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Yulong Xu, Anna W. Sromek & John L. Neumeyer. (2019) Identification of fluorinated (R)-(−)-aporphine derivatives as potent and selective ligands at serotonin 5-HT2C receptor. Bioorganic & Medicinal Chemistry Letters 29:2, pages 230-233.
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Paola Maccioni, Federica Fara, Gian Luigi Gessa, Mauro A. M. Carai, Young-Won Chin, Jung Hwan Lee, Hak Cheol Kwon & Giancarlo Colombo. (2018) Reducing Effect of Saikosaponin A, an Active Ingredient of Bupleurum falcatum, on Intake of Highly Palatable Food in a Rat Model of Overeating. Frontiers in Psychiatry 9.
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Robert F. Kushner. (2018) Weight Loss Strategies for Treatment of Obesity: Lifestyle Management and Pharmacotherapy. Progress in Cardiovascular Diseases 61:2, pages 246-252.
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Guiping Zhang, Jianjun Cheng, John D. McCorvy, Paul J. Lorello, Barbara J. Caldarone, Bryan L. Roth & Alan P. Kozikowski. (2017) Discovery of N -Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications . Journal of Medicinal Chemistry 60:14, pages 6273-6288.
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Thomas O. Schrader, Michelle Kasem, Albert Ren, Konrad Feichtinger, Bilal Al Doori, Jing Wei, Chunrui Wu, Huong Dang, Minh Le, Joel Gatlin, Kelli Chase, Jenny Dong, Kevin T. Whelan, Carleton Sage, Andrew J. Grottick & Graeme Semple. (2016) Tetrahydroquinoline-based tricyclic amines as potent and selective agonists of the 5-HT 2C receptor. Bioorganic & Medicinal Chemistry Letters 26:24, pages 5877-5882.
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Martin P. Green, Gordon McMurray & R. Ian Storer. (2016) Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines. Bioorganic & Medicinal Chemistry Letters 26:16, pages 4117-4121.
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Navnit Prajapati, Rajani Giridhar, Anshuman Sinha, Ashish M. Kanhed & Mange Ram Yadav. (2015) Regioselective alkylation of 1,3,4,5-tetrahydrobenzo[d]azepin-2-one and biological evaluation of the resulting alkylated products as potentially selective $$\hbox {5-HT}_{\mathrm{2C}}$$ 5-HT 2 C agonists. Molecular Diversity 19:4, pages 653-667.
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Mahesh Shidore, Jatin Machhi, Prashant Murumkar, Mahesh Barmade, Jigar Thanki & Mange Ram Yadav. (2015) 3-Substituted 1-methyl-3-benzazepin-2-ones as 5-HT 2C receptor agonists . RSC Advances 5:111, pages 91908-91921.
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Jianjun Cheng, Patrick M. Giguere, Wei Lv, Bryan L. Roth & Alan P. Kozikowski. (2015) Design and synthesis of (2-(5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a selective serotonin 2C agonist. Tetrahedron Letters 56:23, pages 3420-3422.
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Kathryn M. Hurren & Helen D. Berlie. (2011) Lorcaserin: An investigational serotonin 2C agonist for weight loss. American Journal of Health-System Pharmacy 68:21, pages 2029-2037.
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Mark D. Andrews, Paul V. Fish, Julian Blagg, Tiffini K. Brabham, Paul E. Brennan, Alison Bridgeland, Alan D. Brown, Peter J. Bungay, Kelly M. Conlon, Nicholas J. Edmunds, Kerry af Forselles, Colleen P. Gibbons, Martin P. Green, Giles Hanton, Mark Holbrook, Alan S. Jessiman, Karin McIntosh, Gordon McMurray, Carly L. Nichols, James A. Root, R. Ian Storer, Michael R. Sutton, Robin V. Ward, Dominique Westbrook & Gavin A. Whitlock. (2011) Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence. Bioorganic & Medicinal Chemistry Letters 21:9, pages 2715-2720.
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