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Expert Opinion on Investigational Drugs Volume 16, 2007 - Issue 1
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Review

Dopamine D3 receptor ligands for the treatment of tobacco dependence

Bernard Le Foll Center for Addiction and Mental Health, Department of Family and Community Medicine, Psychiatry and Pharmacology, University of Toronto, 33 Russell Street, Toronto, ON M5S 2S1, Ontario, Canada. [email protected]
,
Steven R Goldberg National Institutes of Drug Abuse, Behavioural Neuroscience Branch, USA
&
Pierre Sokoloff Pierre Fabre Research Center, 81106 Castres, France. [email protected]
Pages 45-57 | Published online: 07 Dec 2006

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N Robson. (2011) Varenicline: a new pharmacotherapy for smoking cessation in primary care practice. South African Family Practice 53:3, pages 217-222.
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Fabrizio Micheli & Christian Heidbreder. (2008) Selective dopamine D3 receptor antagonists. A decade of progress: 1997 – 2007. Expert Opinion on Therapeutic Patents 18:8, pages 821-840.
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Patrik Maurer & Martin F Bachmann. (2007) Vaccination against nicotine: an emerging therapy for tobacco dependence. Expert Opinion on Investigational Drugs 16:11, pages 1775-1783.
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IvanD. Montoya & Frank Vocci. (2007) Medications Development for the Treatment of Nicotine Dependence in Individuals with Schizophrenia. Journal of Dual Diagnosis 3:3-4, pages 113-150.
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Articles from other publishers (31)

Prasanta Kumar Mohapatra, Rajnish Srivastava, Krishna Kumar Varshney & Sarvasudhi Durga Bhavani. (2023) Propranolol as a Model Drug to Treat Smoking Cessation and its Formulation as a Transdermal Patch for Effective Management. Letters in Drug Design & Discovery 20:9, pages 1243-1263.
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Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L. Haass-Koffler & Nazzareno Cannella. (2022) The multitarget FAAH inhibitor/D3 partial agonist ARN15381 decreases nicotine self-administration in male rats. European Journal of Pharmacology 928, pages 175088.
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Srijan Acharya & Kyeong-Man Kim. (2019) α4β2 nicotinic acetylcholine receptor downregulates D3 dopamine receptor expression through protein kinase C activation. Biochemical and Biophysical Research Communications 514:3, pages 665-671.
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Jose M. Trigo & Bernard Le Foll. 2019. Psychiatric Disorders. Psychiatric Disorders 165 193 .
Patricia Di Ciano, Patrick Mc Cormick, Cristiana Stefan, Ernest Wong, Aaron Kim, Gary Remington & Bernard Le Foll. (2017) The effects of buspirone on occupancy of dopamine receptors and the rat gambling task. Psychopharmacology 234:22, pages 3309-3320.
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S. Butini, K. Nikolic, S. Kassel, H. Brückmann, S. Filipic, D. Agbaba, S. Gemma, S. Brogi, M. Brindisi, G. Campiani & H. Stark. (2016) Polypharmacology of dopamine receptor ligands. Progress in Neurobiology 142, pages 68-103.
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A. Micoli, A. De Simone, D. Russo, G. Ottonello, G. Colombano, G. F. RudaT. Bandiera, A. Cavalli & G. Bottegoni. (2016) Aryl and heteroaryl N -[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase . MedChemComm 7:3, pages 537-541.
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Nathan M. Appel, Shou-Hua Li, Tyson H. Holmes & Jane B. Acri. (2015) Dopamine D 3 Receptor Antagonist (GSK598809) Potentiates the Hypertensive Effects of Cocaine in Conscious, Freely-Moving Dogs . Journal of Pharmacology and Experimental Therapeutics 354:3, pages 484-492.
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Bernard Le Foll, Alan A. Wilson, Ariel Graff, Isabelle Boileau & Patricia Di Ciano. (2014) Recent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug development. Frontiers in Pharmacology 5.
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Kori L. Brewer, Christine A. Baran, Brian R. Whitfield, A. Marley Jensen & Stefan Clemens. (2014) Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord. Frontiers in Neural Circuits 8.
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Nancy K Mello, Peter A Fivel, Stephen J Kohut & F Ivy Carroll. (2013) Effects of Chronic Varenicline Treatment on Nicotine, Cocaine, and Concurrent Nicotine+Cocaine Self-Administration. Neuropsychopharmacology 39:5, pages 1222-1231.
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Bernard Le Foll, Mihail Guranda, Alan A Wilson, Sylvain Houle, Pablo M Rusjan, Victoria C Wing, Laurie Zawertailo, Usoa Busto, Peter Selby, Arthur L Brody, Tony P George & Isabelle Boileau. (2013) Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans. Neuropsychopharmacology 39:2, pages 415-424.
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Doris E Payer, Arian Behzadi, Stephen J Kish, Sylvain Houle, Alan A Wilson, Pablo M Rusjan, Junchao Tong, Peter Selby, Tony P George, Tina McCluskey & Isabelle Boileau. (2013) Heightened D3 Dopamine Receptor Levels in Cocaine Dependence and Contributions to the Addiction Behavioral Phenotype: A Positron Emission Tomography Study with [11C]-(+)-PHNO. Neuropsychopharmacology 39:2, pages 311-318.
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Bernard Le Foll, Ginetta Collo, Eugenii A. Rabiner, Isabelle Boileau, Emilio Merlo Pich & Pierre Sokoloff. 2014. Dopamine. Dopamine 255 275 .
Ginetta Collo, Federica Bono, Laura Cavalleri, Laura Plebani, Stefania Mitola, Emilio Merlo Pich, Mark J. Millan, Michele Zoli, Uwe Maskos, PierFranco Spano & Cristina Missale. (2013) Nicotine-Induced Structural Plasticity in Mesencephalic Dopaminergic Neurons Is Mediated by Dopamine D3 Receptors and Akt-mTORC1 Signaling. Molecular Pharmacology 83:6, pages 1176-1189.
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Nancy K Mello, Peter A Fivel & Stephen J Kohut. (2013) Effects of Chronic Buspirone Treatment on Nicotine and Concurrent Nicotine+Cocaine Self-Administration. Neuropsychopharmacology 38:7, pages 1264-1275.
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Pierre Sokoloff, Ludovic Leriche, Jorge Diaz, Jacques Louvel & René Pumain. (2012) Direct and indirect interactions of the dopamine D3 receptor with glutamate pathways: implications for the treatment of schizophrenia. Naunyn-Schmiedeberg's Archives of Pharmacology 386:2, pages 107-124.
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Henri-Jean Aubin, Hans Rollema, Torgny H. Svensson & Georg Winterer. (2012) Smoking, quitting, and psychiatric disease: A review. Neuroscience & Biobehavioral Reviews 36:1, pages 271-284.
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Na Ye, QianQian Wu, Liyuan Zhu, Longtai Zheng, Bo Gao, Xuechu Zhen & Ao Zhang. (2011) Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry 19:6, pages 1999-2008.
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Gabriela Novak, Martha LeBlanc, Clement Zai, Sajid Shaikh, Julien Renou, Vincenzo DeLuca, Natalie Bulgin, James L. Kennedy & Bernard Le Foll. (2010) Association of polymorphisms in the BDNF , DRD1 and DRD3 genes with tobacco smoking in schizophrenia . Annals of Human Genetics 74:4, pages 291-298.
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Laura Orio, Sunmee Wee, Amy H. Newman, Luigi Pulvirenti & George F. Koob. (2010) PRECLINICAL STUDY: FULL ARTICLE: The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended‐access. Addiction Biology 15:3, pages 312-323.
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Christian A. Heidbreder & Amy H. Newman. (2010) Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders. Annals of the New York Academy of Sciences 1187:1, pages 4-34.
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Sandro Fenu, Jadwiga Wardas & Micaela Morelli. (2009) Impulse control disorders and dopamine dysregulation syndrome associated with dopamine agonist therapy in Parkinson's disease. Behavioural Pharmacology 20:5-6, pages 363-379.
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Zheng-xiong Xi, Krista Spiller & Eliot L Gardner. (2009) Mechanism-based medication development for the treatment of nicotine dependence. Acta Pharmacologica Sinica 30:6, pages 723-739.
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Bernard Le Foll, Alexandra Gallo, Yann Le Strat, Lin Lu & Philip Gorwood. (2009) Genetics of dopamine receptors and drug addiction: a comprehensive review. Behavioural Pharmacology 20:1, pages 1-17.
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Bernard Le Foll & Steven R. Goldberg. 2009. Nicotine Psychopharmacology. Nicotine Psychopharmacology 335 367 .
Noel M. Paul, Michelle Taylor, Rakesh Kumar, Jeffrey R. Deschamps, Robert R. Luedtke & Amy Hauck Newman. (2008) Structure−Activity Relationships for a Novel Series of Dopamine D2-like Receptor Ligands Based on N-Substituted 3-Aryl-8-azabicyclo[3.2.1]octan-3-ol. Journal of Medicinal Chemistry 51:19, pages 6095-6109.
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Weihua Huang, Thomas J. Payne, Jennie Z. Ma & Ming D. Li. (2008) A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B:7, pages 1109-1115.
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Bernard Le Foll, Zuzana Justinova, Gianlugi Tanda & Steven R. Goldberg. (2008) Quels futurs traitements pour la dépendance au tabac et au cannabis ?. Bulletin de l'Académie Nationale de Médecine 192:1, pages 45-57.
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Britta C. Sasse, Ulrich R. Mach, Jukka Leppaenen, Thierry Calmels & Holger Stark. (2007) Hybrid approach for the design of highly affine and selective dopamine D3 receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorganic & Medicinal Chemistry 15:23, pages 7258-7273.
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Marcello Leopoldo, Enza Lacivita, Elena Passafiume, Marialessandra Contino, Nicola A. Colabufo, Francesco Berardi & Roberto Perrone. (2007) 4-[ω-[4-Arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2- a ]pyridine Derivatives:  Fluorescent High-Affinity Dopamine D 3 Receptor Ligands as Potential Probes for Receptor Visualization . Journal of Medicinal Chemistry 50:20, pages 5043-5047.
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