Citations (49)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (6)
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino & Girolamo Pelaia. (2021) Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies. Drug Design, Development and Therapy 15, pages 1275-1284.
Read now
Read now
Corrado Pelaia, Alessandro Vatrella, Claudia Crimi, Luca Gallelli, Rosa Terracciano & Girolamo Pelaia. (2020) Clinical relevance of understanding mitogen-activated protein kinases involved in asthma. Expert Review of Respiratory Medicine 14:5, pages 501-510.
Read now
Read now
Corrado Pelaia, Alessandro Vatrella, Angela Sciacqua, Rosa Terracciano & Girolamo Pelaia. (2020) Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives. Expert Review of Respiratory Medicine 14:5, pages 485-491.
Read now
Read now
Elizabeth L. Kramer & John P. Clancy. (2018) TGFβ as a therapeutic target in cystic fibrosis. Expert Opinion on Therapeutic Targets 22:2, pages 177-189.
Read now
Read now
Stefanie Bühler & Stefan A Laufer. (2014) p38 MAPK inhibitors: a patent review (2012 – 2013). Expert Opinion on Therapeutic Patents 24:5, pages 535-554.
Read now
Read now
Maria Gabriella Matera, Luigino Calzetta, Andrea Segreti & Mario Cazzola. (2012) Emerging drugs for chronic obstructive pulmonary disease. Expert Opinion on Emerging Drugs 17:1, pages 61-82.
Read now
Read now
Articles from other publishers (43)
Ali Ahmadi, Sajjad Ahrari, Jafar Salimian, Zahra Salehi, Mehrdad Karimi, Alireza Emamvirdizadeh, Sadegh Azimzadeh Jamalkandi & Mostafa Ghanei. (2023) p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics. Cell Communication and Signaling 21:1.
Crossref
Crossref
Payal Ganguly, Tom Macleod, Chi Wong, Mark Harland & Dennis McGonagle. (2023) Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i). Pharmaceuticals 16:9, pages 1286.
Crossref
Crossref
Yunna Zhang, Jiafeng Fu, Yang Han, Dandan Feng, Shaojie Yue, Yan Zhou & Ziqiang Luo. (2023) Two-Pore-Domain Potassium Channel TREK–1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation. Biomedicines 11:5, pages 1279.
Crossref
Crossref
Ana Carolina Matias Dinelly Pinto, Rodolfo de Melo Nunes, Igor Albuquerque Nogueira, Bernhard Fischer, Rudolf Lucas, Virgínia Claudia Carneiro Girão-Carmona, Vivian Louise Soares de Oliveira, Flavio Almeida Amaral, Georg Schett & Francisco Airton Castro Rocha. (2022) Potent anti-inflammatory activity of the lectin-like domain of TNF in joints. Frontiers in Immunology 13.
Crossref
Crossref
Haichuan Yu, Xiaojie Su, Ting Lei, Lu Zhang, Zhouzhou Feng, Chuchu Zhang, Meng Zhang, Yalei Wang, Xinlong Chen & Jian Liu. (2022) Safety and efficacy of p38 mitogen-activated protein kinase inhibitors (MAPKIs) in COPD. Frontiers in Pharmacology 13.
Crossref
Crossref
Juan Zhang, Ying Ma, Daojun Xie, Yuancheng Bao, Wenming Yang, Han Wang, Huaizhou Jiang, Hui Han & Ting Dong. (2021) Differentially expressed lncRNAs in liver tissues of TX mice with hepatolenticular degeneration. Scientific Reports 11:1.
Crossref
Crossref
Rajesh K. Thimmulappa, Indranil Chattopadhyay & Subbiah Rajasekaran. 2020. Oxidative Stress in Lung Diseases. Oxidative Stress in Lung Diseases
103
137
.
Asha Kumari, D. K. Singh, D. Dash & Rashmi Singh. (2018) Intranasal curcumin protects against LPS-induced airway remodeling by modulating toll-like receptor-4 (TLR-4) and matrixmetalloproteinase-9 (MMP-9) expression via affecting MAP kinases in mouse model. Inflammopharmacology 27:4, pages 731-748.
Crossref
Crossref
Michael P. Madaio, Istvan Czikora, Nino Kvirkvelia, Malgorzata McMenamin, Qiang Yue, Ting Liu, Haroldo A. Toque, Supriya Sridhar, Katherine Covington, Rabei Alaisami, Paul M. O’Connor, Robert W. Caldwell, Jian-Kang Chen, Matthias Clauss, Michael W. Brands, Douglas C. Eaton, Maritza J. Romero & Rudolf Lucas. (2019) The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis. Kidney International 95:6, pages 1359-1372.
Crossref
Crossref
Xiao-Hong Li, Xue-Ming Zhou, Xiao-Juan Li, Yue-Yun Liu, Qun Liu, Xiao-Ling Guo, Li-Qiang Yang & Jia-Xu Chen. (2019) Effects of Xiaoyaosan on the Hippocampal Gene Expression Profile in Rats Subjected to Chronic Immobilization Stress. Frontiers in Psychiatry 10.
Crossref
Crossref
Rakesh Kumar Singh & Abul Kalam Najmi. (2019) Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders. Current Drug Targets 20:4, pages 367-379.
Crossref
Crossref
Dimitrios Toumpanakis, Vyronia Vassilakopoulou, Eleftheria Mizi, Athanasia Chatzianastasiou, Konstantinos Loverdos, Ioanna Vraila, Fotis Perlikos, Dionysios Tsoukalas, Charoula-Eleni Giannakopoulou, Adamantia Sotiriou, Maria Dettoraki, Vassiliki Karavana & Theodoros Vassilakopoulos. (2018) p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation. Inflammation 41:5, pages 1873-1887.
Crossref
Crossref
RK Singh, M Diwan, SG Dastidar & AK Najmi. (2017) Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro. Human & Experimental Toxicology 37:5, pages 521-531.
Crossref
Crossref
Tingting Zheng, Weiheng Zhao, Hongjin Li, Shuxiu XiaoRan HuMiaomiao HanHeng LiuYeqiang LiuKinya Otsu, Xinguang LiuGonghua Huang. (2018) p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation. Science Signaling 11:521.
Crossref
Crossref
Juan Wang, Jing Tan, Yanhong Liu, Linlin Song, Di Li & Xiaoguang Cui. (2017) Amelioration of lung ischemia‑reperfusion injury by JNK and p38 small interfering RNAs in rat pulmonary microvascular endothelial cells in an ischemia‑reperfusion injury lung transplantation model. Molecular Medicine Reports.
Crossref
Crossref
Rakesh Kumar Singh, Abul Kalam Najmi & Sunanda Ghosh Dastidar. (2017) Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases. Pharmacological Reports 69:4, pages 746-756.
Crossref
Crossref
MirHojjat Khorasanizadeh, Mahsa Eskian, Erwin W. Gelfand & Nima Rezaei. (2017) Mitogen-activated protein kinases as therapeutic targets for asthma. Pharmacology & Therapeutics 174, pages 112-126.
Crossref
Crossref
Chi-Fen Chang, Kang-Chun Liao & Chung-Hwan Chen. (2017) 2-Phenylnaphthalene Derivatives Inhibit Lipopolysaccharide-Induced Pro-Inflammatory Mediators by Downregulating of MAPK/NF-κB Pathways in RAW 264.7 Macrophage Cells. PLOS ONE 12:1, pages e0168945.
Crossref
Crossref
Martin A. Bewley, Kylie B. R. Belchamber, Kirandeep K. Chana, Richard C. Budd, Gavin Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Iain Kilty, Louise E. Donnelly, Peter J. Barnes, Dave Singh, Moira K. B. Whyte & David H. Dockrell. (2016) Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD. PLOS ONE 11:9, pages e0163139.
Crossref
Crossref
Paolo Biancheri, Martyn R. Foster, Matthew C. T. Fyfe, Thomas T. MacDonald, Sameer Sirohi, Yemisi Solanke, Eleanor Wood, Adele Rowley, Steve Webber & Claire A. Walshe. (2016) Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis. Inflammatory Bowel Diseases 22:6, pages 1306-1315.
Crossref
Crossref
Chien-Huang Lin, Yuan-Hung Wang, Yu-Wen Chen, Yu-Liang Lin, Bing-Chang Chen & Mei-Chieh Chen. (2015) Transcriptional and posttranscriptional regulation of CXCL8/IL-8 gene expression induced by connective tissue growth factor. Immunologic Research 64:2, pages 369-384.
Crossref
Crossref
Li LiSu TangXiaodong Tang. (2016) Thymic Stromal Lymphopoietin Promotes Fibrosis and Activates Mitogen-Activated Protein Kinases in MRC-5 Cells. Medical Science Monitor 22, pages 2357-2362.
Crossref
Crossref
Michela Bullone & Jean-Pierre Lavoie. (2015) Asthma ?of horses and men??How can equine heaves help us better understand human asthma immunopathology and its functional consequences?. Molecular Immunology 66:1, pages 97-105.
Crossref
Crossref
Satoshi Marumo, Yuma Hoshino, Hirofumi Kiyokawa, Naoya Tanabe, Atsuyasu Sato, Emiko Ogawa, Shigeo Muro, Toyohiro Hirai & Michiaki Mishima. (2014) p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice. BMC Pulmonary Medicine 14:1.
Crossref
Crossref
Dramane Lainé, Matthew Lucas, Francisco Lopez‐Tapia & Stephen Lynch. 2013. Medicinal Chemistry Approaches to Personalized Medicine. Medicinal Chemistry Approaches to Personalized Medicine
255
288
.
C. Compton, D. McBryan, E. Bucchioni & F. Patalano. (2013) The Novartis view on emerging drugs and novel targets for the treatment of chronic obstructive pulmonary disease. Pulmonary Pharmacology & Therapeutics 26:5, pages 562-573.
Crossref
Crossref
Nobuhiro Kanaji, Amy Nelson, Xingqi Wang, Tadashi Sato, Masanori Nakanishi, Yoko Gunji, Hesham Basma, Joel Michalski, Maha Farid, Stephen I. Rennard & Xiangde Liu. (2013) Differential Roles of JNK, ERK1/2, and p38 Mitogen-Activated Protein Kinases on Endothelial Cell Tissue Repair Functions in Response to Tumor Necrosis Factor-a. Journal of Vascular Research 50:2, pages 145-156.
Crossref
Crossref
Yingli Wang, Xueyan Zhou, Kurun Oberoi, Robert Phelps, Ross Couwenhoven, Miao Sun, Am?lie Rezza, Greg Holmes, Christopher J. Percival, Jenna Friedenthal, Pavel Krejci, Joan T. Richtsmeier, David L. Huso, Michael Rendl & Ethylin Wang Jabs. (2012) p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. Journal of Clinical Investigation 122:6, pages 2153-2164.
Crossref
Crossref
Charles R. Myers. (2012) The effects of chromium(VI) on the thioredoxin system: Implications for redox regulation. Free Radical Biology and Medicine 52:10, pages 2091-2107.
Crossref
Crossref
Nobuhiro Kanaji, Amy Nelson, Diane S. Allen-Gipson, Tadashi Sato, Masanori Nakanishi, Xingqi Wang, YingJi Li, Hesham Basma, Joel Michalski, Maha Farid, Stephen I. Rennard & Xiangde Liu. (2011) The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflammation Research 61:3, pages 233-244.
Crossref
Crossref
Umesh CS Yadav, Leopoldo Aguilera-Aguirre, Istvan Boldogh, Kota V Ramana & Satish K Srivastava. (2011) Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma. Respiratory Research 12:1.
Crossref
Crossref
David S. MillanMark E. BunnageJane L. BurrowsKenneth J. ButcherPeter G. DoddTimothy J. EvansDavid A. FairmanSamantha J. HughesIain C. KiltyArnaud LemaitreRussell A. LewthwaiteAxel MahnkeJohn P. MathiasJames PhilipRobert T. SmithMark H. StefaniakMichael YeadonChristopher Phillips. (2011) Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. Journal of Medicinal Chemistry 54:22, pages 7797-7814.
Crossref
Crossref
David S Millan. (2011) What is the potential for inhaled p38 inhibitors in the treatment of chronic obstructive pulmonary disease?. Future Medicinal Chemistry 3:13, pages 1635-1645.
Crossref
Crossref
J. Armstrong, C. Harbron, S. Lea, G. Booth, P. Cadden, K. A. Wreggett & D. Singh. (2011) Synergistic Effects of p38 Mitogen-Activated Protein Kinase Inhibition with a Corticosteroid in Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease. Journal of Pharmacology and Experimental Therapeutics 338:3, pages 732-740.
Crossref
Crossref
Aline C. Brando Lima, Alexandre L. Machado, Patrícia Simon, Moisés M. Cavalcante, Daniele C. Rezende, Gilberto M. Sperandio da Silva, Paulo Gustavo B.D. Nascimento, Luis E.M. Quintas, Fernando Q. Cunha, Eliezer J. Barreiro, Lídia M. Lima & Vera L.G. Koatz. (2011) Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation. Pharmacological Reports 63:4, pages 1029-1039.
Crossref
Crossref
Giorgia Volpi, Fabrizio Facchinetti, Nadia Moretto, Maurizio Civelli & Riccardo Patacchini. (2011) Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts. British Journal of Pharmacology 163:3, pages 649-661.
Crossref
Crossref
Kathryn E. Medders & Marcus Kaul. (2011) Mitogen-Activated Protein Kinase p38 in HIV Infection and Associated Brain Injury. Journal of Neuroimmune Pharmacology 6:2, pages 202-215.
Crossref
Crossref
Rishi B. Patel, Sainath R. Kotha, Shariq I. Sherwani, Sean M. Sliman, Travis O. Gurney, Brooke Loar, Susan O’Connor Butler, Andrew J. Morris, Clay B. Marsh & Narasimham L. Parinandi. (2010) Pulmonary Fibrosis Inducer, Bleomycin, Causes Redox-Sensitive Activation of Phospholipase D and Cytotoxicity Through Formation of Bioactive Lipid Signal Mediator, Phosphatidic Acid, in Lung Microvascular Endothelial Cells. International Journal of Toxicology 30:1, pages 69-90.
Crossref
Crossref
Cheol Park, Cheng-Yun Jin, Gi-Young Kim, JaeHun Cheong, Jee H. Jung, Young Hyun Yoo & Yung Hyun Choi. (2010) A methyl jasmonate derivative, J-7, induces apoptosis in human hepatocarcinoma Hep3B cells in vitro. Toxicology in Vitro 24:7, pages 1920-1926.
Crossref
Crossref
. (2010) Current World Literature. Current Opinion in Pulmonary Medicine 16:2, pages 162-167.
Crossref
Crossref
Ryan P. Wurz, Liping H. Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen J. McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, Faye Hsieh & Andrew S. Tasker. (2010) Part 2: Structure–activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38α mitogen-activated protein kinase. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1680-1684.
Crossref
Crossref
Eric Ho & Jim Woodgett. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling
533
538
.
Haichuan Yu, Xiaojie Su, Ting Lei, Lu Zhang, Zhouzhou Feng, Chuchu Zhang, Meng Zhang, Yalei Wang, Xinlong Chen & Jian Liu. (2022) Safety and Efficacy of p38 MAPKI in COPD: A Systematic Review. SSRN Electronic Journal.
Crossref
Crossref