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Statins: under investigation for increasing bone mineral density and augmenting fracture healing

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Pages 1435-1463 | Published online: 22 Sep 2008

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Naila Goldenberg & Charles Glueck. (2009) Efficacy, effectiveness and real life goal attainment of statins in managing cardiovascular risk. Vascular Health and Risk Management 5, pages 369-376.
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Megan M. Weivoda & Raymond J. Hohl. (2011) The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation. Journal of Cellular Biochemistry 112:6, pages 1506-1513.
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MITUHIRO GOTOH, KENJI MIZUNO, YOSHIAKI ONO & MICHIHIKO TAKAHASHI. (2011) FLUVASTATIN INCREASES BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN. FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 57:1, pages 19-27.
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Sarah A. Holstein. 2011. Protein Prenylation Part B. Protein Prenylation Part B 279 299 .
Caleb E. Finch. 2011. Handbook of the Biology of Aging. Handbook of the Biology of Aging 275 296 .
Nicola J. Sinden & Robert A. Stockley. (2010) Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities. Therapeutic Advances in Chronic Disease 1:2, pages 43-57.
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Jessica A. Cottrell, Francis M. Vales, Deborah Schachter, Scott Wadsworth, Rama Gundlapalli, Rasesh Kapadia & J. Patrick O'Connor. (2010) Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model. Journal of Biomedicine and Biotechnology 2010, pages 1-11.
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Nikolaos K. Kanakaris, George Petsatodis, Magnus Tagil & Peter V. Giannoudis. (2009) Is there a role for bone morphogenetic proteins in osteoporotic fractures?. Injury 40, pages S21-S26.
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Veerle Persy & Patrick D?Haese. (2009) Vascular calcification and bone disease: the calcification paradox. Trends in Molecular Medicine 15:9, pages 405-416.
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Izabela Podgorski. (2009) Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis?. Future Medicinal Chemistry 1:1, pages 21-34.
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Liao Cui, Yu-yu Liu, Tie Wu, Chun-mei Ai & Huai-qing Chen. (2009) Osteogenic effects of D(+)β-3,4-dihydroxyphenyl lactic acid (salvianic acid A, SAA) on osteoblasts and bone marrow stromal cells of intact and prednisone-treated rats. Acta Pharmacologica Sinica 30:3, pages 321-332.
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