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Drug Evaluation

Treatment of hyperlipidaemia with fenofibrate and related fibrates

, MD PhD & , MD PhD
Pages 1599-1614 | Published online: 22 Sep 2008

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Huajun Yu, Yingbao Huang, Lifang Chen, Liuzhi Shi, Yunjun Yang & Weizhi Xia. (2021) Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis. International Journal of General Medicine 14, pages 1709-1717.
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Theodosios Filippatos, Eleftheria Tzavella, Christos Rizos, Moses Elisaf & George Liamis. (2017) Acid-base and electrolyte disorders associated with the use of antidiabetic drugs. Expert Opinion on Drug Safety 16:10, pages 1121-1132.
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Theodosios D Filippatos & Moses S Elisaf. (2015) Safety considerations with fenofibrate/simvastatin combination. Expert Opinion on Drug Safety 14:9, pages 1481-1493.
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Haralampos Milionis. (2014) Combining a statin with a fibrate versus fibrate monotherapy: efficacious but safe?. Expert Opinion on Drug Safety 13:3, pages 267-269.
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Hye Duck Choi & Wan Gyoon Shin. (2014) Safety and efficacy of statin treatment alone and in combination with fibrates in patients with dyslipidemia: a meta-analysis. Current Medical Research and Opinion 30:1, pages 1-10.
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Theodosios D Filippatos & Moses S Elisaf. (2011) Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia. Expert Opinion on Pharmacotherapy 12:12, pages 1945-1958.
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Aris P Agouridis, Theodosios D Filippatos, Vasilios Tsimihodimos & Moses S Elisaf. (2011) Combinations of ezetimibe with nonstatin drug regimens affecting lipid metabolism. Expert Review of Cardiovascular Therapy 9:3, pages 355-366.
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Elisavet Moutzouri, Anastazia Kei, Moses S Elisaf & Haralampos J Milionis. (2010) Management of dyslipidemias with fibrates, alone and in combination with statins: role of delayed-release fenofibric acid. Vascular Health and Risk Management 6, pages 525-539.
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Joe D Strain, Debra K Farver & James R Clem. (2010) A review on the rationale and clinical use of concomitant rosuvastatin and fenofibrate/fenofibric acid therapy. Clinical Pharmacology: Advances and Applications 2, pages 95-104.
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Terry A Jacobson, Peter H Jones & Eli M Roth. (2010) Combination therapy with rosuvastatin and fenofibric acid for mixed dyslipidemia: overview of efficacy and safety. Clinical Lipidology 5:5, pages 627-649.
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Susan M Schima, Stephanie R Maciejewski, Daniel E Hilleman, Mark A Williams & Syed M Mohiuddin. (2010) Fibrate therapy in the management of dyslipidemias, alone and in combination with statins: role of delayed-release fenofibric acid. Expert Opinion on Pharmacotherapy 11:5, pages 731-738.
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Li‐Nien Chien, Yun‐I Chou, Yuan‐Jen Tsai, Li‐Chin Sung, Hung‐Yi Liu, Meng‐Yin Lin, Tsung‐Jen Wang & I‐Chan Lin. (2023) Association of lipid‐lowering agent use and dry eye disease: A nationwide matched case–control study in Taiwan, 2002–2016. Acta Ophthalmologica 101:7, pages 729-736.
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Charlotte C.J.R. Michielsen, Roland W.J. Hangelbroek, Marjolijn C.E. Bragt, Elwin R. Verheij, Suzan Wopereis, Ronald P. Mensink & Lydia A. Afman. (2021) Comparative Analysis of the Effects of Fish Oil and Fenofibrate on Plasma Metabolomic Profiles in Overweight and Obese Individuals. Molecular Nutrition & Food Research 66:2.
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Emese Sipos, Tamás Csatári, Adrienn Kazsoki, Attila Gergely, Enikő Bitay, Zoltán-István Szabó & Romána Zelkó. (2020) Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets. Pharmaceutics 12:7, pages 612.
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Eleni Pappa, Christos V. Rizos, Theodosios D. Filippatos & Moses S. Elisaf. (2019) Emerging Fixed-Dose Combination Treatments for Hyperlipidemia. Journal of Cardiovascular Pharmacology and Therapeutics 24:4, pages 315-322.
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Arrigo F. G. Cicero, Federica Fogacci, Marilisa Bove, Fulvio Ventura, Marina Giovannini & Claudio Borghi. (2018) Optimizing Lipid Pattern by Adding a Combined Nutraceutical or Pravastatin to Fenofibrate Treatment in Hypertriglyceridemic Subjects: Single Site, Randomized, Open-Label, Post-Market Clinical Investigation. High Blood Pressure & Cardiovascular Prevention 25:4, pages 355-359.
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Saranya Ravi, Traci Parry, Monte Willis, Pamela Lockyer, Cam Patterson, James Bain, Robert Stevens, Olga Ilkayeva, Christopher Newgard & Jonathan Schisler. (2018) Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP. Journal of Cardiovascular Development and Disease 5:3, pages 43.
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Amanda J Unsworth, Gagan D Flora & Jonathan M Gibbins. (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research 114:5, pages 645-655.
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Theodosios D. Filippatos, Anastazia Kei, Christos V. Rizos & Moses S. Elisaf. (2017) Effects of PCSK9 Inhibitors on Other than Low-Density Lipoprotein Cholesterol Lipid Variables. Journal of Cardiovascular Pharmacology and Therapeutics 23:1, pages 3-12.
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Tracey G. Simon, Kathleen E. Corey, Raymond T. Chung & Robert Giugliano. (2016) Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe. Digestive Diseases and Sciences 61:12, pages 3425-3435.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 285 315 .
Lori A. Gordon, Christine Y. Malati, Colleen Hadigan, Mary McLaughlin, Raul M. Alfaro, Mónica M. Calderón, Joseph A. Kovacs & Scott R. Penzak. (2016) Lack of an Effect of Ritonavir Alone and Lopinavir-Ritonavir on the Pharmacokinetics of Fenofibric Acid in Healthy Volunteers. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 36:1, pages 49-56.
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Abid Mehmood Yousaf, Dong Wuk Kim, Jin Ki Kim, Jong Oh Kim, Chul Soon Yong & Han-Gon Choi. (2015) Novel fenofibrate-loaded gelatin microcapsules with enhanced solubility and excellent flowability: Preparation and physicochemical characterization. Powder Technology 275, pages 257-262.
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A. Sahebkar & G. F. Watts. (2014) Role of selective peroxisome proliferator-activated receptor modulators in managing cardiometabolic disease: tale of a roller-coaster. Diabetes, Obesity and Metabolism 16:9, pages 780-792.
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Maxwell P Treacy & Tara P Hurst. (2012) The case for intraocular delivery of PPAR agonists in the treatment of diabetic retinopathy. BMC Ophthalmology 12:1.
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M.T. Bergoglio, S. Veses Martín, E. Solá Izquierdo & A. Hernández Mijares. (2012) Paciente varón de 56 años con múltiples factores de riesgo cardiovascular. Medicine - Programa de Formación Médica Continuada Acreditado 11:19, pages 1186.e1-1186.e5.
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Anastazia A. Kei, Theodosios D. Filippatos, Vasilios Tsimihodimos & Moses S. Elisaf. (2012) A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease. Metabolism 61:7, pages 906-921.
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Theodosios D. Filippatos. (2012) A Review of Time Courses and Predictors of Lipid Changes with Fenofibric Acid-Statin Combination. Cardiovascular Drugs and Therapy 26:3, pages 245-255.
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Byounghoon Hwang, Pengfei Wu & Robert A. Harris. (2012) Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme?4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet. FEBS Journal 279:10, pages 1883-1893.
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Ji-Yin Zhou & Shi-Wen Zhou. (2011) Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. Fitoterapia 82:2, pages 184-189.
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Anthony S Wierzbicki. (2010) Fibrates: no ACCORD on their use in the treatment of dyslipidaemia. Current Opinion in Lipidology 21:4, pages 352-358.
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Lily P.H. Yang & Gillian M. Keating. (2009) Fenofibric Acid. American Journal Cardiovascular Drugs 9:6, pages 401-409.
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Catherine Fiévet & Bart Staels. (2009) Combination therapy of statins and fibrates in the management of cardiovascular risk. Current Opinion in Lipidology 20:6, pages 505-511.
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Samer O. Abdul-Hay, Praneeth Edirisinghe & Gregory R. J. Thatcher. (2009) Selective modulation of amyloid-β peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Aβ levels. Journal of Neurochemistry 111:3, pages 683-695.
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Vito Iacobazzi, Paolo Convertini, Vittoria Infantino, Pasquale Scarcia, Simona Todisco & Ferdinando Palmieri. (2009) Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. Biochemical and Biophysical Research Communications 388:4, pages 643-647.
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Andrew D. Patterson, Ondřej Slanař, Kristopher W. Krausz, Fei Li, Constance C. Höfer, František Perlík, Frank J. Gonzalez & Jeffrey R. Idle. (2009) Human Urinary Metabolomic Profile of PPARα Induced Fatty Acid β-Oxidation. Journal of Proteome Research 8:9, pages 4293-4300.
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Anthony S Wierzbicki. (2009) Fibrates in the treatment of cardiovascular risk and atherogenic dyslipidaemia. Current Opinion in Cardiology 24:4, pages 372-379.
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