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Drug Evaluation

Raltegravir: an integrase inhibitor for HIV-1

, MD & , MD
Pages 413-422 | Published online: 06 Mar 2008

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Lidija Kovač & Zdenko Časar. (2020) A literature review of the patent application publications on cabotegravir – an HIV integrase strand transfer inhibitor. Expert Opinion on Therapeutic Patents 30:3, pages 195-208.
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Malika Sharma & Sharon L Walmsley. (2014) Raltegravir as antiretroviral therapy in HIV/AIDS. Expert Opinion on Pharmacotherapy 15:3, pages 395-405.
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Catherine S Adamson, Karl Salzwedel & Eric O Freed. (2009) Virus maturation as a new HIV-1 therapeutic target. Expert Opinion on Therapeutic Targets 13:8, pages 895-908.
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Heba S. Abd-Ellah, Ramesh Mudududdla, Glen P. Carter & Jonathan B. Baell. (2023) Novel Perspectives on the Design and Development of a Long-Acting Subcutaneous Raltegravir Injection for Treatment of HIV—In Vitro and In Vivo Evaluation. Pharmaceutics 15:5, pages 1530.
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Karen Reddy, Nirmal Renuka, Sheena Kumari & Faizal Bux. (2021) Algae-mediated processes for the treatment of antiretroviral drugs in wastewater: Prospects and challenges. Chemosphere 280, pages 130674.
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Sangmi Oh, Yumi Park, Curtis A. Engelhart, Joshua B. Wallach, Dirk Schnappinger, Kriti Arora, Michelle Manikkam, Brian Gac, Hongwu Wang, Nicholas Murgolo, David B. Olsen, Michael Goodwin, Michelle Sutphin, Danielle M. Weiner, Laura E. Via, Helena I. M. Boshoff & Clifton E. BarryIIIIII. (2018) Discovery and Structure–Activity-Relationship Study of N -Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β- d -ribose 2′-Oxidase . Journal of Medicinal Chemistry 61:22, pages 9952-9965.
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Thammarse S. Yamuna, Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan & Manpreet Kaur. (2013) Raltegravir monohydrate. Acta Crystallographica Section E Structure Reports Online 69:12, pages o1743-o1744.
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R. Nageswara Rao, K. Guru Prasad, K. V. Sravan Kumar & B. Ramesh. (2013) Diatomaceous earth supported liquid extraction and LC-MS/MS determination of elvitegravir and ritonavir in rat plasma: application to a pharmacokinetic study. Analytical Methods 5:23, pages 6693.
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Fredy Guevara, Francisco Blanco & Miguel Arredondo. (2010) Inhibidores de la integrasa y raltegravir en el manejo de la infecci?n por virus de la inmunodeficiencia humana en la era de la resistencia a m?ltiples medicamentos. Infectio 14:2, pages 132-142.
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Jian-Hua Liu, Yi Jin & Ya-Qiu Long. (2010) Synthesis of the C5?C30 fragment of cyclodidemniserinol trisulfate via I2-mediated deprotection and ring closure tandem reaction. Tetrahedron 66:6, pages 1267-1273.
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Luca Dori, Anna R Buonomini, Magda Viscione, Loredana Sarmati & Massimo Andreoni. (2010) A case of rhabdomiolysis associated with raltegravir use. AIDS 24:3, pages 473-475.
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Sean Emery & Alan Winston. (2009) Raltegravir: a new choice in HIV and new chances for research. The Lancet 374:9692, pages 764-766.
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Crossref
Stéphane Hué, Robert J. Gifford, David Dunn, Esther Fernhill & Deenan Pillay. (2009) Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naïve Individuals. Journal of Virology 83:6, pages 2645-2654.
Crossref
Ahmad R Sedaghat, Robert F Siliciano & Claus O Wilke. (2009) Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antiviral Therapy 14:2, pages 263-271.
Crossref
Eriketi Z. Loizidou, Ioanna Kousiappa, Constantinos D. Zeinalipour-Yazdi, David A. M. C. Van de Vijver & Leondios G. Kostrikis. (2008) Implications of HIV-1 M Group Polymorphisms on Integrase Inhibitor Efficacy and Resistance: Genetic and Structural in Silico Analyses . Biochemistry 48:1, pages 4-6.
Crossref
Christoph BoeseckeLinda Gelgor. (2009) A Review of Raltegravir and its Use in HIV-1 Infection. Clinical Medicine. Therapeutics 1, pages CMT.S1985.
Crossref
Katrien Busschots, Jan De Rijck, Frauke Christ & Zeger Debyser. (2009) In search of small molecules blocking interactions between HIV proteins and intracellularcofactors. Mol. BioSyst. 5:1, pages 21-31.
Crossref
Alonso Heredia, Olga Latinovic, Robert C. Gallo, Gregory Melikyan, Marv Reitz, Nhut Le & Robert R. Redfield. (2008) Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1. Proceedings of the National Academy of Sciences 105:51, pages 20476-20481.
Crossref
Srinivasan Ramanathan, Thomas N Kakuda, Rebecca Mack, Steve West & Brian P Kearney. (2008) Pharmacokinetics of Elvitegravir and Etravirine following Coadministration of Ritonavir-Boosted Elvitegravir and Etravirine. Antiviral Therapy 13:8, pages 1011-1017.
Crossref
Jessica Marinello, Christophe Marchand, Bryan T. Mott, Anjali Bain, Craig J. Thomas & Yves Pommier. (2008) Comparison of Raltegravir and Elvitegravir on HIV-1 Integrase Catalytic Reactions and on a Series of Drug-Resistant Integrase Mutants. Biochemistry 47:36, pages 9345-9354.
Crossref
Antonio MastrolorenzoAlfonso MarescaStefano RusconiClaudiu T Supuran. (2008) Update on the development of HIV entry inhibitors. Future HIV Therapy 2:5, pages 479-507.
Crossref
Ileana StoicaS Kashif SadiqCatherine V GalePeter V Coveney. (2008) Virtual Physiological Human research initiative: the future for rational HIV treatment design?. Future HIV Therapy 2:5, pages 419-425.
Crossref
Kazuya ShimuraEiichi Kodama. (2008) Elvitegravir: an emerging HIV integrase inhibitor. Future HIV Therapy 2:5, pages 411-418.
Crossref
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Crossref
Li-Fan Zeng, Xiao-Hua Jiang, Tino Sanchez, Hu-Shan Zhang, Raveendra Dayam, Nouri Neamati & Ya-Qiu Long. (2008) Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: Effects of the phenyl substituent and the linker orientation. Bioorganic & Medicinal Chemistry 16:16, pages 7777-7787.
Crossref
Masaaki Takahashi, Mitsuru Konishi, Yuichi Kudaka, Naoya Okumura, Atsushi Hirano, Nami Terahata, Kazuhide Banno & Tsuguhiro Kaneda. (2008) A Conventional LC-MS Method Developed for the Determination of Plasma Raltegravir Concentrations. Biological & Pharmaceutical Bulletin 31:8, pages 1601-1604.
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