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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 4
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Drug Evaluation

Vinflunine: clinical perspectives of an emerging anticancer agent

Adrian Yun-San Yip Comprehensive Centre for Breast Diseases, UNIMED Medical Institute, 10/F, Luk Kwok Centre, 72 Gloucester Road, Wanchai, Hong Kong [email protected]
, BSc,
Eleanor Yuen-Yuen Ong Comprehensive Centre for Breast Diseases, UNIMED Medical Institute, 10/F, Luk Kwok Centre, 72 Gloucester Road, Wanchai, Hong Kong [email protected]
, BSPharm MMedSc &
Louis Wing-Cheong Chow Comprehensive Centre for Breast Diseases, UNIMED Medical Institute, 10/F, Luk Kwok Centre, 72 Gloucester Road, Wanchai, Hong Kong [email protected]; Organisation for Oncology and Translational Research, UNIMED Medical Institute, 10/F, Luk Kwok Centre, 72 Gloucester Road, Wanchai, Hong Kong
, MBBS MS FRCS FACS
Pages 583-591 | Published online: 25 Mar 2008

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Xiaowen Zhou, Zeren Xu, Aijing Li, Zhengqiong Zhang & Sichuan Xu. (2019) Double-sides sticking mechanism of vinblastine interacting with α,β-tubulin to get activity against cancer cells. Journal of Biomolecular Structure and Dynamics 37:15, pages 4080-4091.
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Shaoming Chi, Wei Xie, Jiwei Zhang & Sichuan Xu. (2015) Theoretical insight into the structural mechanism for the binding of vinblastine with tubulin. Journal of Biomolecular Structure and Dynamics 33:10, pages 2234-2254.
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Aakash Deep, Davinder Kumar, Nitin Bansal, Balasubramanian Narasimhan, Rakesh Kumar Marwaha & Prabodh Chander Sharma. (2023) Understanding mechanistic aspects and therapeutic potential of natural substances as anticancer agents. Phytomedicine Plus 3:2, pages 100418.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 507 546 .
Olagoke Zacchaeus Olatunde, Jianping Yong & Canzhong Lu. (2021) The Progress of the Anticancer Agents Related to the Microtubules Target. Mini-Reviews in Medicinal Chemistry 20:20, pages 2165-2192.
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Nadine Houédé & Gérard Milano. (2019) Deuxième ligne thérapeutique des cancers de vessie avancés : une place réelle pour la vinflunine. Bulletin du Cancer 106:5, pages 431-435.
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Emanuela Martino, Giuseppe Casamassima, Sonia Castiglione, Edoardo Cellupica, Serena Pantalone, Francesca Papagni, Marta Rui, Angela Marika Siciliano & Simona Collina. (2018) Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead. Bioorganic & Medicinal Chemistry Letters 28:17, pages 2816-2826.
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Amal A A Alotaibi, Mojgan Najafzadeh, Justin D Davies, Adolf Baumgartner & Diana Anderson. (2017) Inhibition of survivin expression after using oxaliplatin and vinflunine to induce cytogenetic damage in vitro in lymphocytes from colon cancer patients and healthy individuals. Mutagenesis 32:5, pages 517-524.
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Anca Hermenean & Aurel Ardelean. 2017. Cytoskeleton - Structure, Dynamics, Function and Disease. Cytoskeleton - Structure, Dynamics, Function and Disease.
Tawnya C. McKee, Albert W. W. Van Wyk & Emily L. Whitson. 2014. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 39 67 .
Andrea T. Hooper, Frank Loganzo, Chad May & Hans-Peter Gerber. 2013. Natural Products and Cancer Drug Discovery. Natural Products and Cancer Drug Discovery 17 38 .
Susana M. Campos & Don S. Dizon. (2012) Antimitotic Inhibitors. Hematology/Oncology Clinics of North America 26:3, pages 607-628.
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Simon Cotton. 2011. Every Molecule Tells a Story. Every Molecule Tells a Story 190 213 .
Hanna K. Sanoff, Janine M. Davies, Christine Walko, William Irvin, Larry Buie, Kimberly Keller, Anastasia Ivanova, Wing-Keung Chiu, Bert H. O’Neil, Thomas E. Stinchcombe & E. Claire Dees. (2010) A phase I evaluation of the combination of vinflunine and erlotinib in patients with refractory solid tumors. Investigational New Drugs 29:5, pages 978-983.
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Claire Lopez, Bérengère Claude, Philippe Morin, Martine Pelissou, Richard Pena, Jean-Paul Max & Jean-Paul Ribet. (2011) Synthesis and study of a molecularly imprinted polymer for specific solid-phase extraction of vinflunine and its metabolite from biological fluids. Journal of Separation Science 34:15, pages 1902-1909.
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Grégoire Zorza, Delphine Pellerin, Valérie Fortune & Christian Puozzo. (2010) A Simple and Sensitive High-Performance Liquid Chromatographic Method for the Determination of Vinflunine and 4-O-Deacetylvinflunine From Human Blood. Therapeutic Drug Monitoring 32:6, pages 734-740.
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J.C. Soria, C. Massard & T. Le Chevalier. (2010) Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy?. Annals of Oncology 21:12, pages 2324-2332.
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L. M. Skivka, G. V. Gorbik, O. G. Fedorchuk & V. V. Pozur. (2009) Tumor-associated macrophages in the prospect of development of targeted anticancer. Cytology and Genetics 43:4, pages 283-292.
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April L. Risinger, Francis J. Giles & Susan L. Mooberry. (2009) Microtubule dynamics as a target in oncology. Cancer Treatment Reviews 35:3, pages 255-261.
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Xuyi Yue, Xingang Zhang & Feng-Ling Qing. (2008) Highly Diastereoselective Zn/SnCl 2 -Mediated gem -Difluoroallylation of Chiral Hydrazones . Organic Letters 11:1, pages 73-76.
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