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Expert Opinion on Investigational Drugs Volume 17, 2008 - Issue 6
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Acetyl-L-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?

Joanna K Soczynska University of Toronto, Institute of Medical Science, Toronto, ON, Canada; University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada
,
Sidney H Kennedy University of Toronto, Institute of Medical Science, Toronto, ON, Canada; University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada; University of Toronto, Department of Psychiatry, Toronto, ON, Canada
,
Cindy SM Chow University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada
,
Hanna O Woldeyohannes University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada
,
Jakub Z Konarski University of Toronto, Institute of Medical Science, Toronto, ON, Canada; University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada
&
Roger S McIntyre University of Toronto, Institute of Medical Science, Toronto, ON, Canada; University Health Network, Mood Disorders Psychopharmacology Unit, Toronto, ON, Canada; University of Toronto, Department of Psychiatry, Toronto, ON, Canada; University of Toronto, Department of Pharmacology, Toronto, ON, Canada; Associate Professor University Health Network, Mood Disorders Psychopharmacology Unit, Departments of Psychiatry and Pharmacology, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8 +1 416 603 5279; +1 416 603 5368; [email protected]
Pages 827-843 | Published online: 21 May 2008

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Luisa Colucci, Massimiliano Bosco, Antonio Rosario Ziello, Raffaele Rea, Francesco Amenta & Angiola Maria Fasanaro. (2012) Effectiveness of nootropic drugs with cholinergic activity in treatment of cognitive deficit: a review. Journal of Experimental Pharmacology 4, pages 163-172.
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Articles from other publishers (14)

Giselli Scaini, Taylor Andrews, Camila N.C. Lima, Deborah Benevenuto, Emilio L. Streck & João Quevedo. (2021) Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder. Mitochondrion 57, pages 23-36.
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Cara Hoepner, Roger McIntyre & George Papakostas. (2021) Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence. Nutrients 13:3, pages 767.
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Alicia Lopez-Maldonado, Silvia Pastoriza & José Ángel Rufián-Henares. (2021) Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical. Current Research in Food Science 4, pages 336-344.
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Ngala Elvis Mbiydzenyuy, Herbert Izo Ninsiima, Miriela Betancourt Valladares & Constant Anatole Pieme. (2018) Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism. BMC Neuroscience 19:1.
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Beatrice Bortolato, Kamilla W. Miskowiak, Cristiano A. Köhler, Michael Maes, Brisa S. Fernandes, Michael Berk & André F. Carvalho. (2016) Cognitive remission: a novel objective for the treatment of major depression?. BMC Medicine 14:1.
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Giselli Scaini, Gislaine T. Rezin, Andre F. Carvalho, Emilio L. Streck, Michael Berk & João Quevedo. (2016) Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications. Neuroscience & Biobehavioral Reviews 68, pages 694-713.
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Araba F. Chintoh & L. Trevor Young. 2016. Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy. Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy 93 114 .
Márcia Calheiros Chaves Silva, Caren Nádia Soares de Sousa, Luis Rafael Leite Sampaio, Naiara Coelho Ximenes, Paulo Victor Pontes Araújo, Jéssica Calheiros da Silva, Suzyana Lima de Oliveira, Francisca Cléa Florenço Sousa, Danielle Silveira Macêdo & Silvânia Maria Mendes Vasconcelos. (2013) Augmentation therapy with alpha-lipoic acid and desvenlafaxine: A future target for treatment of depression?. Naunyn-Schmiedeberg's Archives of Pharmacology 386:8, pages 685-695.
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Mohammadreza Jalali-Nadoushan & Mehrdad Roghani. (2013) Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism. Brain Research 1505, pages 68-74.
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Andrew A Nierenberg, Christine Kansky, Brian P Brennan, Richard C Shelton, Roy Perlis & Dan V Iosifescu. (2012) Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development. Australian & New Zealand Journal of Psychiatry 47:1, pages 26-42.
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Olav B. Smeland, Tore W. Meisingset, Karin Borges & Ursula Sonnewald. (2012) Chronic acetyl-l-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International 61:1, pages 100-107.
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J. Kalervo Hiltunen, Zhijun Chen, Antti M. Haapalainen, Rik K. Wierenga & Alexander J. Kastaniotis. (2010) Mitochondrial fatty acid synthesis – An adopted set of enzymes making a pathway of major importance for the cellular metabolism. Progress in Lipid Research 49:1, pages 27-45.
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Jinbo Fan, Iuliana Ionita‐Laza, Matthew B. McQueen, Bernie Devlin, Shaun Purcell, Stephen V. Faraone, Michael H. Allen, Charles L. Bowden, Joseph R. Calabrese, Mark D. Fossey, Edward S. Friedman, Laszlo Gyulai, Peter Hauser, Terence B. Ketter, Lauren B. Marangell, David J. Miklowitz, Andrew A. Nierenberg, Jayendra K. Patel, Gary S. Sachs, Michael E. Thase, Francine B. Molay, Michael A. Escamilla, Vishwajit L. Nimgaonkar, Pamela Sklar, Nan M. Laird & Jordan W. Smoller. (2009) Linkage disequilibrium mapping of the chromosome 6q21–22.31 bipolar I disorder susceptibility locus. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 153B:1, pages 29-37.
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Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova‐Kostova & Edward J. Calabrese. (2009) Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis. BioFactors 35:2, pages 146-160.
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