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Review

Heparin as an anticancer therapeutic

, MD & , MD MSc FRCP(C)
Pages 1029-1037 | Published online: 12 Jun 2008

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Laila A. Eissa, Salem A. Habib & Mohammed M. Abdel Latif. (2014) Inhibitory effect of the partially purified protein from Raphnus sativus roots and low-molecular-weight heparin on Ehrlich ascites carcinoma bearing mice. Egyptian Journal of Basic and Applied Sciences 1:2, pages 88-96.
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Articles from other publishers (28)

Yunliang Chen & Michael Scully. (2023) The Tumorigenicity of Breast Cancer Cells Is Reduced upon Treatment with Small Extracellular Vesicles Isolated from Heparin Treated Cell Cultures. International Journal of Molecular Sciences 24:21, pages 15736.
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Mahaveer P. Purohit, Aditya K. Kar, Manisha Kumari, Debabrata Ghosh & Satyakam Patnaik. (2023) Heparin Biofunctionalized Selenium Nanoparticles as Potential Antiangiogenic–Chemotherapeutic Agents for Targeted Doxorubicin Delivery. ACS Applied Materials & Interfaces 15:16, pages 19904-19920.
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Kun Cai, Jie Chen, Yang Liu, Bilal Muhammad Khan & Yongjie Zhao. (2022) Heparin purification by expanded bed anion exchange in a countercurrent chromatography column. Journal of Chromatography A 1681, pages 463455.
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Sizhe Li, Zhen Wang, Gijsbert A. van der Marel & Jeroen D.C. Codée. 2021. Comprehensive Glycoscience. Comprehensive Glycoscience 200 227 .
Anastasiya V. Snigireva, Oleg S. Morenkov, Yuri Y. Skarga, Alexander V. Lisov, Zoya A. Lisova, Alexey A. Leontievsky, Mariya A. Zhmurina, Viktoria S. Petrenko & Veronika V. Vrublevskaya. (2020) A 2,5-Dihydroxybenzoic Acid–Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells. Journal of Functional Biomaterials 11:2, pages 39.
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Radosław Sadowski, Renata Gadzała-Kopciuch & Buszewski Buszewski. (2020) Application of dendrimer-functionalized ion-exchange stationary phases for the retention and separation of low-molecular-weight heparins. Analytical Methods 12:7, pages 977-987.
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Zhe Ma, Bing Zhang, Yuqi Fan, Meng Wang, Dereje Kebebe, Jiawei Li & Zhidong Liu. (2019) Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases. Biomedicine & Pharmacotherapy 117, pages 109128.
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Radosław Sadowski, Renata Gadzała-Kopciuch & Bogusław Buszewski. (2019) Recent Developments in the Separation of Low Molecular Weight Heparin Anticoagulants. Current Medicinal Chemistry 26:1, pages 166-176.
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Xuefei Yan, Ye Yang, Liqin He, Daiyin Peng & Dengke Yin. (2017) Gambogic acid grafted low molecular weight heparin micelles for targeted treatment in a hepatocellular carcinoma model with an enhanced anti-angiogenesis effect. International Journal of Pharmaceutics 522:1-2, pages 110-118.
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Ryan J. Weiss, Jeffrey D. Esko & Yitzhak Tor. (2017) Targeting heparin and heparan sulfate protein interactions. Organic & Biomolecular Chemistry 15:27, pages 5656-5668.
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Marco Mende, Christin Bednarek, Mirella Wawryszyn, Paul Sauter, Moritz B. Biskup, Ute Schepers & Stefan Bräse. (2016) Chemical Synthesis of Glycosaminoglycans. Chemical Reviews 116:14, pages 8193-8255.
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Hao Li, Pingping Song, Benkui Zou, Min Liu, Kai Cui, Pengfei Zhou, Sheng Li & Baijiang Zhang. (2015) Circulating Tumor Cell Analyses in Patients With Esophageal Squamous Cell Carcinoma Using Epithelial Marker-Dependent and -Independent Approaches. Medicine 94:38, pages e1565.
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Rosalie Schnoor, Sybren L. N. Maas & Marike L. D. Broekman. (2015) Heparin in malignant glioma: review of preclinical studies and clinical results. Journal of Neuro-Oncology 124:2, pages 151-156.
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Kun Shi, Karla CS Queiroz, Joris JTH Roelofs, Carel JM van Noesel, Dirk J Richel & C Arnold Spek. (2014) Protease-activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model. The Journal of Pathology 234:3, pages 398-409.
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Zhijay Tu, Hsiao‐Wu Hsieh, Chih‐Ming Tsai, Chia‐Wei Hsu, Shy‐Guey Wang, Kuan‐Jung Wu, Kuo‐I Lin & Chun‐Hung Lin. (2013) Synthesis and Characterization of Sulfated Gal‐ β ‐1,3/4‐GlcNAc Disaccharides through Consecutive Protection/Glycosylation Steps . Chemistry – An Asian Journal 8:7, pages 1536-1550.
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Laurie M. Elit, Agnes Y. Lee, Sameer Parpia, Laura L. Swystun, Patricia C. Liaw, Paul Hoskins, Denise H. Julian, Jim A. Julian & Mark N. Levine. (2012) Dalteparin Low Molecular Weight Heparin (LMWH) in ovarian cancer: A phase II randomized study. Thrombosis Research 130:6, pages 894-900.
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Bo Wang, Lucinda F. Buhse, Ali Al-Hakim, Michael T. Boyne Ii & David A. Keire. (2012) Characterization of currently marketed heparin products: Analysis of heparin digests by RPIP-UHPLC–QTOF-MS. Journal of Pharmaceutical and Biomedical Analysis 67-68, pages 42-50.
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Andrew S. Epstein, Gerald A. Soff, Marinela Capanu, Christopher Crosbie, Manish A. Shah, David P. Kelsen, Brian Denton, Stuart Gardos & Eileen M. O'Reilly. (2011) Analysis of incidence and clinical outcomes in patients with thromboembolic events and invasive exocrine pancreatic cancer. Cancer 118:12, pages 3053-3061.
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Nurkay Katrancioglu, Oguz Karahan, Ahmet Turhan Kilic, Ahmet Altun, Ozgur Katrancioglu & Zubeyde Akin Polat. (2012) Comparison of the antiangiogenic effects of heparin sodium, enoxaparin sodium, and tinzaparin sodium by using chorioallantoic membrane assay. Blood Coagulation & Fibrinolysis 23:3, pages 218-221.
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Agnes Y.Y. Lee. (2012) Treatment of established thrombotic events in patients with cancer. Thrombosis Research 129, pages S146-S153.
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Adam M. Brustkern, Lucinda F. Buhse, Moheb Nasr, Ali Al-Hakim & David A. Keire. (2010) Characterization of Currently Marketed Heparin Products: Reversed-Phase Ion-Pairing Liquid Chromatography Mass Spectrometry of Heparin Digests. Analytical Chemistry 82:23, pages 9865-9870.
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Luise Erpenbeck & Michael P. Schön. (2010) Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood 115:17, pages 3427-3436.
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Lubor Borsig. (2010) Antimetastatic activities of heparins and modified heparins. Experimental evidence. Thrombosis Research 125, pages S66-S71.
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Agnes Y.Y. Lee. (2010) The roles of anticoagulants in patients with cancer. Thrombosis Research 125, pages S8-S11.
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I Debergh, N Van Damme, P Pattyn, M Peeters & W P Ceelen. (2010) The low-molecular-weight heparin, nadroparin, inhibits tumour angiogenesis in a rodent dorsal skinfold chamber model. British Journal of Cancer 102:5, pages 837-843.
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Sailaja Arungundram, Kanar Al-Mafraji, Jinkeng Asong, Franklin E. LeachIIIIII, I. Jonathan Amster, Andre Venot, Jeremy E. Turnbull & Geert-Jan Boons. (2009) Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies. Journal of the American Chemical Society 131:47, pages 17394-17405.
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F. Langer, K. Holstein, B. Eifrig & C. Bokemeyer. (2009) Thromboembolische Komplikationen – Prophylaxe und Therapie im FokusThromboembolic complications – Focus on prophylaxis and therapy. Der Onkologe 15:2, pages 150-156.
Crossref
Yang Liu. (2022) Purification of Heparin by Expanded Bed Countercurrent Chromatography. SSRN Electronic Journal.
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