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HIF prolyl hydroxylase inhibitors for anemia

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Pages 645-656 | Published online: 16 Mar 2011

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Fanwei Meng. (2019) A novel role of HIF-1α/PROX-1/LYVE-1 axis on tissue regeneration after renal ischaemia/reperfusion in mice. Archives of Physiology and Biochemistry 125:4, pages 321-331.
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Sucharita Sen Banerjee, Mahesh Thirunavukkarasu, Muhammad Tipu Rishi, Juan A. Sanchez, Nilanjana Maulik & Gautam Maulik. (2012) HIF–prolyl hydroxylases and cardiovascular diseases. Toxicology Mechanisms and Methods 22:5, pages 347-358.
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Xin Zheng, Xia Chen, Tao Liu, Ji Jiang, Xinge Cui, Qian Zhao & Pei Hu. (2022) Liquid chromatography-tandem mass spectrometry methods for quantification of roxadustat (FG-4592) in human plasma and urine and the applications in two clinical pharmacokinetic studies. Journal of Chromatography B 1203, pages 123274.
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Zhouliang Guo, Jiayu Zi, Yanfei Hao, Yuyin Li, Zhenxing Liu, Qing Zhao, Limin Hao & Aipo Diao. (2022) Production of functional recombinant prolyl hydroxylase-2 enzyme in insect cells for small molecule inhibitor screening studies. Protein Expression and Purification 194, pages 106073.
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Mingsong Shi, Xin Zhou, Yao Cai, Penghui Li, Dengxue Qin, Xinrong Yan, Meng Du, Shuo Li & Dingguo Xu. (2021) Inhibition mechanism of hydroxyproline-like small inhibitors to disorder HIF-VHL interaction by molecular dynamic simulations and binding free energy calculations. Chinese Journal of Chemical Physics 34:6, pages 814-824.
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Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma & Chung-Hang Leung. (2021) A small molecule HIF-1α stabilizer that accelerates diabetic wound healing. Nature Communications 12:1.
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Akira Mima. (2021) Hypoxia-inducible factor-prolyl hydroxylase inhibitors for renal anemia in chronic kidney disease: Advantages and disadvantages. European Journal of Pharmacology 912, pages 174583.
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Michaela A.A. Fuchs, Katharina A.E. Broeker, Julia Schrankl, Nicolai Burzlaff, Carsten Willam, Charlotte Wagner & Armin Kurtz. (2021) Inhibition of transforming growth factor β1 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice. Kidney International 100:1, pages 122-137.
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Monica Mazzarino, Ilaria Perretti, Carlotta Stacchini, Fabio Comunità, Xavier de la Torre & Francesco Botrè. (2021) UPLC–MS-Based Procedures to Detect Prolyl-Hydroxylase Inhibitors of HIF in Urine. Journal of Analytical Toxicology 45:2, pages 184-194.
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Qiyan Zheng, Yahui Wang, Huisheng Yang, Luying Sun, Xinwen Fu, Ruojun Wei, Yu Ning Liu & Wei Jing Liu. (2021) Efficacy and Safety of Daprodustat for Anemia Therapy in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology 11.
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Yi Liu, Yu Lei, Sheng Guo & Zhili Zuo. (2020) Ensemble-based virtual screening in discovering potent inhibitors targeting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. Life Sciences 262, pages 118495.
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Tetsuya Kondo, Kenji Takeda, Ryo Muko, Akihiro Ito, Young-Chae Chang, Junji Magae & Takao Kataoka. (2019) 4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate. The Journal of Antibiotics 72:5, pages 271-281.
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Mukul Jain, Amit Joharapurkar, Vishal Patel, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Hiren Patel & Pankaj R. Patel. (2019) Pharmacological inhibition of prolyl hydroxylase protects against inflammation-induced anemia via efficient erythropoiesis and hepcidin downregulation. European Journal of Pharmacology 843, pages 113-120.
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Hartmut Beck, Mario Jeske, Kai Thede, Friederike Stoll, Ingo Flamme, Metin Akbaba, Jens-Kerim Ergüden, Gunter Karig, Jörg Keldenich, Felix Oehme, Hans-Christian Militzer, Ingo V. Hartung & Uwe Thuss. (2018) Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia. ChemMedChem 13:10, pages 988-1003.
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