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New JAK2 inhibitors for myeloproliferative neoplasms

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Pages 961-972 | Published online: 27 Apr 2011

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Adriana Zámečníkova. (2014) Novel approaches to the development of tyrosine kinase inhibitors and their role in the fight against cancer. Expert Opinion on Drug Discovery 9:1, pages 77-92.
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Pearlie K Epling-Burnette, Jessica McDaniel, Sheng Wei & Alan F List. (2012) Emerging immunosuppressive drugs in myelodysplastic syndromes. Expert Opinion on Emerging Drugs 17:4, pages 519-541.
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Peter Norman. (2012) Selective JAK1 inhibitor and selective Tyk2 inhibitor patents. Expert Opinion on Therapeutic Patents 22:10, pages 1233-1249.
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Brian L Harry, S. Gail Eckhardt & Antonio Jimeno. (2012) JAK2 inhibition for the treatment of hematologic and solid malignancies. Expert Opinion on Investigational Drugs 21:5, pages 637-655.
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Hao Wu, Min Huang, Peng Cao, Tongshan Wang, Yongqian Shu & Ping Liu. (2012) MiR-135a targets JAK2 and inhibits gastric cancer cell proliferation. Cancer Biology & Therapy 13:5, pages 281-288.
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Articles from other publishers (14)

Mengze Hu, Rong Liu, Juanjuan Li, Lei Zhang, Jing Cao, Mei Yue, Dixiao Zhong & Ruihong Tang. (2023) Clinical features and prognosis of pediatric acute lymphocytic leukemia with JAK-STAT pathway genetic abnormalities: a case series. Annals of Hematology.
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Klara Klein, Dagmar Stoiber, Veronika Sexl & Agnieszka Witalisz-Siepracka. (2021) Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?. Cancers 13:11, pages 2611.
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Sathya Babu, Santhosh Kumar Nagarajan & Thirumurthy Madhavan. (2019) Understanding the structural features of JAK2 inhibitors: a combined 3D-QSAR, DFT and molecular dynamics study. Molecular Diversity 23:4, pages 845-874.
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Sathya Babu, Santhosh Kumar Nagarajan & Thirumurthy Madhavan. (2019) Investigation of Empirical and Semi‐Empirical Charges to Study the Effects of Partial Charges on Quality and Prediction Accuracy in 3D‐QSAR. ChemistrySelect 4:14, pages 3990-4002.
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Tadashi Kasahara. (2015) Study of Cytokine Signaling: The Quest for Immunomodulatory Drugs Interacting with Cytokine Production and Activityサイトカインシグナル解析—サイトカインシグナル系に作用する薬物の解析と探索. YAKUGAKU ZASSHI 135:3, pages 431-447.
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Qibin Su, Stephanos Ioannidis, Claudio Chuaqui, Lynsie Almeida, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Michael Block, Tina Howard, Shan Huang, Dennis Huszar, Jon A. Read, Caroline Rivard Costa, Jie Shi, Mei Su, Minwei Ye & Michael Zinda. (2013) Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors . Journal of Medicinal Chemistry 57:1, pages 144-158.
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Min-Yi Li, Yan Tian, Li Shen, Ralf Buettner, Hong-Zhi Li, Lucy Liu, Yate-Ching Yuan, Qiang Xiao, Jun Wu & Richard Jove. (2013) 3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells. Biochemical Pharmacology 86:10, pages 1411-1418.
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Michael Siu, Richard Pastor, Wendy Liu, Kathy Barrett, Megan Berry, Wade S. Blair, Christine Chang, Jacob Z. Chen, Charles Eigenbrot, Nico Ghilardi, Paul Gibbons, Haiying He, Christopher A. Hurley, Jane R. Kenny, S. Cyrus Khojasteh, Hoa Le, Leslie Lee, Joseph P. Lyssikatos, Steve Magnuson, Rebecca Pulk, Vickie Tsui, Mark Ultsch, Yisong Xiao, Bing-yan Zhu & Deepak Sampath. (2013) 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 23:17, pages 5014-5021.
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Xiaoyun Wu, Shanhe Wan & Jiajie Zhang. (2013) Three Dimensional Quantitative Structure-Activity Relationship of 5H-Pyrido[4,3-b]indol-4-carboxamide JAK2 Inhibitors. International Journal of Molecular Sciences 14:6, pages 12037-12053.
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Emna Abdelhamid, Martin Figeac, Aline Renneville, Sabine Quief, Céline Villenet, Thomas Boyer, Olivier Nibourel, Valerie Coiteux, Bruno Cassinat, Eric Lippert, Nathalie Helevaut, Zohra Soua & Claude Preudhomme. (2013) Quantification of JAK2V617F mutation by next‐generation sequencing technology. American Journal of Hematology 88:6, pages 536-537.
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Huiping Guan, Michelle L. Lamb, Bo Peng, Shan Huang, Nancy DeGrace, Jon Read, Syeed Hussain, Jiaquan Wu, Caroline Rivard, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Minwei Ye, Michael Zinda & Stephanos Ioannidis. (2013) Discovery of novel Jak2?Stat pathway inhibitors with extended residence time on target. Bioorganic & Medicinal Chemistry Letters 23:10, pages 3105-3110.
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Rachel R. Stine & Erika L. Matunis. 2013. Transcriptional and Translational Regulation of Stem Cells. Transcriptional and Translational Regulation of Stem Cells 247 267 .
Vibe Skov, Mads Thomassen, Caroline H. Riley, Morten K. Jensen, Ole Weis Bjerrum, Torben A. Kruse, Hans Carl Hasselbalch & Thomas Stauffer Larsen. (2012) Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis. Experimental Hematology 40:9, pages 771-780.e19.
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I-Ming Wang, David J. Stone, David Nickle, Andrey Loboda, Oscar Puig & Christopher Roberts. 2013. Systems Biology. Systems Biology 169 199 .

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