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Expert Opinion on Investigational Drugs Volume 20, 2011 - Issue 7
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Combining temozolomide with other antitumor drugs and target-based agents in the treatment of brain metastases: an unending quest or chasing a chimera?

Raffaele Addeo“S.Giovanni di Dio” Hospital, Oncology Department, ASLNA2Nord Via Pirozzi 80027 Frattamaggiore, Naples, Italy+39 081 8891233; +39 081 8891353; [email protected]
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Michele CaragliaSecond University of Naples, Department of Biochemistry and Biophysics, Via Costantinopoli, 16, 80138 Naples, Italy
Pages 881-895 | Published online: 02 May 2011

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Read on this site (3)

Raffaele Addeo. (2021) Silibinin: A New Opportunity for the Treatment of Brain Metastasis from Lung Cancer. Journal of Experimental Pharmacology 13, pages 901-903.
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Ying Gao, Fei Gao, Jin-lu Ma & Dong-li Zhao. (2015) Palliative whole-brain radiotherapy and health- related quality of life for patients with brain metastasis in cancer. Neuropsychiatric Disease and Treatment 11, pages 2185-2190.
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Raffaele Addeo, Silvia Zappavigna, Amalia Luce, Sergio Facchini & Michele Caraglia. (2013) Chemotherapy in the management of brain metastases: the emerging role of fotemustine for patients with melanoma and NSCLC. Expert Opinion on Drug Safety 12:5, pages 729-740.
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Articles from other publishers (8)

Valentina Fonsato, Michela De Lena, Stefania Tritta, Alessia Brossa, Ruggero Calvetti, Ciro Tetta, Giovanni Camussi & Benedetta Bussolati. (2018) Human liver stem cell-derived extracellular vesicles enhance cancer stem cell sensitivity to tyrosine kinase inhibitors through Akt/mTOR/PTEN combined modulation. Oncotarget 9:90, pages 36151-36165.
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S. Zappavigna, M. Scuotto, A. M. Cossu, D. Ingrosso, M. De Rosa, C. Schiraldi, R. Filosa & M. Caraglia. (2016) The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells. Journal of Experimental & Clinical Cancer Research 35:1.
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Hong Qin, Feng Pan, Jianjun Li, Xiaoli Zhang, Houjie Liang & Zhihua Ruan. (2014) Whole Brain Radiotherapy Plus Concurrent Chemotherapy in Non-Small Cell Lung Cancer Patients with Brain Metastases: A Meta-Analysis. PLoS ONE 9:10, pages e111475.
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E. de Azambuja, D. Zardavas, M. Lemort, J. Rossari, C. Moulin, A. Buttice, V. D'Hondt, F. Lebrun, Y. Lalami, F. Cardoso, C. Sotiriou, T. Gil, D. Devriendt, M. Paesmans, M. Piccart-Gebhart & A. Awada. (2013) Phase I trial combining temozolomide plus lapatinib for the treatment of brain metastases in patients with HER2-positive metastatic breast cancer: the LAPTEM trial. Annals of Oncology 24:12, pages 2985-2989.
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Frits Thorsen, Brett Fite, Lisa M. Mahakian, Jai W. Seo, Shengping Qin, Victoria Harrison, Sarah Johnson, Elizabeth Ingham, Charles Caskey, Terje Sundstr?m, Thomas J. Meade, Patrick N. Harter, Kai Ove Skaftnesmo & Katherine W. Ferrara. (2013) Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. Journal of Controlled Release 172:3, pages 812-822.
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C. Faivre, D. Barbolosi, E. Pasquier & N. André. (2013) A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens. Cancer Chemotherapy and Pharmacology 71:4, pages 1013-1019.
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Raffaele Addeo, Pasquale Sperlongano, Liliana Montella, Bruno Vincenzi, Marco Carraturo, Patrizia Iodice, Paola Russo, Ciro Parlato, Antonio Salzano, Gregorio Cennamo, Angela Lombardi, Rossella Sperlongano, Salvatore Del Prete & Michele Caraglia. (2012) Protracted low dose of oral vinorelbine and temozolomide with whole-brain radiotherapy in the treatment for breast cancer patients with brain metastases. Cancer Chemotherapy and Pharmacology 70:4, pages 603-609.
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. (2012) Current World Literature. Current Opinion in Supportive & Palliative Care 6:1, pages 109-125.
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