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Editorial

P2X7 receptor antagonism in the treatment of cancers

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Pages 875-880 | Published online: 27 May 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Chunping Zhang, Siwei Peng, Bing Wu, Huaide Jiang, Xiang Li, Gang Li & Jing Wang. (2016) Role of P2X7 on steroid synthesis in murine luteal cells. Biotechnology & Biotechnological Equipment 30:2, pages 319-323.
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Karl Göran Ronquist, Claire Sanchez, Louise Dubois, Dimitris Chioureas, Pedro Fonseca, Anders Larsson, Anders Ullén, Jeffrey Yachnin, Gunnar Ronquist & Theocharis Panaretakis. (2016) Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells. Journal of Extracellular Vesicles 5:1.
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Jingqin Fang, Xiao Chen, Shunan Wang, Tian Xie, Xuesong Du, Heng Liu, Sumei Wang, Xue Li, Jinhua Chen, Bo Zhang, Huaping Liang, Yizeng Yang & Weiguo Zhang. (2015) The expression of P2X7 receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas. Cancer Biology & Therapy 16:4, pages 498-510.
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George C. Prendergast & Richard Metz. (2012) A perspective on new immune adjuvant principles. OncoImmunology 1:6, pages 924-929.
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Articles from other publishers (49)

Qingqing Yu, Xin Wang, Xinyu Li, Xue Bai, Ronglan Zhao & Xiaoxiang Peng. (2023) Purinergic P2X7R as a potential target for pancreatic cancer. Clinical and Translational Oncology 25:8, pages 2297-2305.
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Yi-Wen Chang, Chia-Chi Wang, Chieh-Fan Yin, Chang-Hsun Wu, Hsuan-Cheng Huang & Hsueh-Fen Juan. (2022) Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation. Molecular & Cellular Proteomics 21:6, pages 100237.
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J.C.C. Arruda, N.C. Rocha, E.G. Santos, L.G.B. Ferreira, M.L. Bello, C. Penido, T.E.M.M. Costa, J.A.A. Santos, I.M. Ribeiro, T.C.B. Tomassini & R.X. Faria. (2021) Physalin pool from Physalis angulata L. leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo. Biomedicine & Pharmacotherapy 142, pages 112006.
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Yonglin Mai, Zhihua Guo, Weiqiang Yin, Nanshan Zhong, Peter V. Dicpinigaitis & Ruchong Chen. (2021) P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review. Frontiers in Oncology 11.
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Matthew Drill, Nigel C. Jones, Martin Hunn, Terence J. O’Brien & Mastura Monif. (2021) Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer. Purinergic Signalling 17:2, pages 215-227.
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Pablo Pelegrin. (2021) P2X7 receptor and the NLRP3 inflammasome: Partners in crime. Biochemical Pharmacology 187, pages 114385.
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Xiaodi Zhu, Qianqian Li, Wei Song, Xiaoxiang Peng & Ronglan Zhao. (2021) P2X7 receptor: a critical regulator and potential target for breast cancer. Journal of Molecular Medicine 99:3, pages 349-358.
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Marta Schmidt Pfaffenzeller, Maria Luiza Mukai Franciosi & Andréia Machado Cardoso. 2021. Sinalização purinérgica: implicações fisiopatológicas. Sinalização purinérgica: implicações fisiopatológicas 108 122 .
Ivana Novak, Haoran Yu, Lara Magni & Ganga Deshar. (2020) Purinergic Signaling in Pancreas—From Physiology to Therapeutic Strategies in Pancreatic Cancer. International Journal of Molecular Sciences 21:22, pages 8781.
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Mélanie Demeules, Allan Scarpitta, Catalina Abad, Henri Gondé, Romain Hardet, Carolina Pinto-Espinoza, Anna Marei Eichhoff, Waldemar Schäfer, Friedrich Haag, Friedrich Koch-Nolte & Sahil Adriouch. (2020) Evaluation of P2X7 Receptor Function in Tumor Contexts Using rAAV Vector and Nanobodies (AAVnano). Frontiers in Oncology 10.
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Hui Yang, Yue-Hang Geng, Peng Wang, Han Yang, Yan-Ting Zhou, Hong-Quan Zhang, Hui-Ying He, Wei-Gang Fang & Xin-Xia Tian. (2020) Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling. Oncogene 39:35, pages 5795-5810.
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Lucie Brisson, Stéphanie Chadet, Osbaldo Lopez-Charcas, Bilel Jelassi, David Ternant, Julie Chamouton, Stéphanie Lerondel, Alain Le Pape, Isabelle Couillin, Aurélie Gombault, Fabrice Trovero, Stéphan Chevalier, Pierre Besson, Lin-Hua Jiang & Sébastien Roger. (2020) P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment. Cancers 12:9, pages 2342.
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Shengchao Xu, Xizhe Li, Yuanqi Liu, Yu Xia, Ruimin Chang & Chunfang Zhang. (2019) Inflammasome inhibitors: promising therapeutic approaches against cancer. Journal of Hematology & Oncology 12:1.
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Letícia Scussel Bergamin, Marina Capece, Erica Salaro, Alba Clara Sarti, Simonetta Falzoni, Mery Stéfani Leivas Pereira, Marco Antônio De Bastiani, Juliete Nathali Scholl, Ana Maria O. Battastini & Francesco Di Virgilio. (2019) Role of the P2X7 receptor in in vitro and in vivo glioma tumor growth . Oncotarget 10:47, pages 4840-4856.
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Giorgia Scarpellino, Tullio Genova & Luca Munaron. (2019) Purinergic P2X7 Receptor: A Cation Channel Sensitive to Tumor Microenvironment. Recent Patents on Anti-Cancer Drug Discovery 14:1, pages 32-38.
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Fabio Morandi, Alberto L. Horenstein, Valeria Quarona, Angelo Corso Faini, Barbara Castella, Raghuraman C. Srinivasan, Stephen C. Strom, Fabio Malavasi & Roberto Gramignoli. (2019) Ectonucleotidase Expression on Human Amnion Epithelial Cells: Adenosinergic Pathways and Dichotomic Effects on Immune Effector Cell Populations. The Journal of Immunology 202:3, pages 724-735.
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Luis Zapata, Oriol Pich, Luis Serrano, Fyodor A. Kondrashov, Stephan Ossowski & Martin H. Schaefer. (2018) Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome. Genome Biology 19:1.
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Chris N. J. Young & Dariusz C. Górecki. (2018) P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?. Frontiers in Chemistry 6.
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Henning Ulrich, Mariusz Z. Ratajczak, Gabriela Schneider, Elena Adinolfi, Elisa Orioli, Enéas G. Ferrazoli, Talita Glaser, Juliana Corrêa-Velloso, Poliana C. M. Martins, Fernanda Coutinho, Ana P. J. Santos, Micheli M. Pillat, Ulrich Sack & Claudiana Lameu. (2018) Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis. Frontiers in Pharmacology 9.
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Natalia Prevarskaya, Roman Skryma & Yaroslav Shuba. (2018) Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?. Physiological Reviews 98:2, pages 559-621.
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Altaf Mohammed, Naveena B. Janakiram, Venkateshwar Madka, Gopal Pathuri, Qian Li, Rebekah Ritchie, Laura Biddick, Hannah Kutche, Yuting Zhang, Anil Singh, Hariprasad Gali, Stan Lightfoot, Vernon E. Steele, Chen S. Suen & Chinthalapally V. Rao. (2017) Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer. Oncotarget 8:58, pages 97822-97834.
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Akira Karasawa, Kevin Michalski, Polina Mikhelzon & Toshimitsu Kawate. (2017) The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition. eLife 6.
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André A SantosJrJr, Angélica R Cappellari, Fernanda O de Marchi, Marina P Gehring, Aline Zaparte, Caroline A Brandão, Tiago Giuliani Lopes, Vinicius D da Silva, Luis Felipe Ribeiro Pinto, Luiz Eduardo Baggio Savio, Aline Cristina Abreu Moreira-Souza, Robson Coutinho-Silva, Juliano D Paccez, Luiz F Zerbini & Fernanda B Morrone. (2017) Potential role of P2X7R in esophageal squamous cell carcinoma proliferation. Purinergic Signalling 13:3, pages 279-292.
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Marta Barniol-Xicota, Seung-Hwa Kwak, So-Deok Lee, Emily Caseley, Elena Valverde, Lin-Hua Jiang, Yong-Chul Kim & Santiago Vázquez. (2017) Escape from adamantane: Scaffold optimization of novel P2X7 antagonists featuring complex polycycles. Bioorganic & Medicinal Chemistry Letters 27:4, pages 759-763.
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Andrea Giannuzzo, Mara Saccomano, Joanna Napp, Maria Ellegaard, Frauke Alves & Ivana Novak. (2016) Targeting of the P2X7 receptor in pancreatic cancer and stellate cells. International Journal of Cancer 139:11, pages 2540-2552.
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Fernanda B. Morrone, Marina P. Gehring & Natália F. Nicoletti. (2016) Calcium Channels and Associated Receptors in Malignant Brain Tumor Therapy. Molecular Pharmacology 90:3, pages 403-409.
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Ying Liu, Su An, Richard Ward, Yang Yang, Xiao-Xi Guo, Wei Li & Tian-Rui Xu. (2016) G protein-coupled receptors as promising cancer targets. Cancer Letters 376:2, pages 226-239.
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Andrea Giannuzzo, Stine Falsig Pedersen & Ivana Novak. (2015) The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Molecular Cancer 14:1.
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Jin-Hee Park, Ga-Eun Lee, So-Deok Lee, Hyojin Ko & Yong-Chul Kim. (2015) Structure?activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists. European Journal of Medicinal Chemistry 106, pages 180-193.
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Marina P. Gehring, Franciele Kipper, Natália F. Nicoletti, Nathalia D. Sperotto, Rafael Zanin, Alessandra S.K. Tamajusuku, Debora G. Flores, Luise Meurer, Rafael Roesler, Aroldo B. Filho, Guido Lenz, Maria M. Campos & Fernanda B. Morrone. (2015) P2X7 receptor as predictor gene for glioma radiosensitivity and median survival. The International Journal of Biochemistry & Cell Biology 68, pages 92-100.
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Sébastien Roger, Bilel Jelassi, Isabelle Couillin, Pablo Pelegrin, Pierre Besson & Lin-Hua Jiang. (2015) Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:10, pages 2584-2602.
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Zheng Liu, Yidong Liu, Le Xu, Huimin An, Yuan Chang, Yuanfeng Yang, Weijuan Zhang & Jiejie Xu. (2015) P2X7 receptor predicts postoperative cancer‐specific survival of patients with clear‐cell renal cell carcinoma. Cancer Science 106:9, pages 1224-1231.
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George I. Gorodeski. (2015) Purinergic Signalling in the Reproductive System. Autonomic Neuroscience 191, pages 82-101.
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Iolanda D?Alimonte, Eleonora Nargi, Mariachiara Zuccarini, Paola Lanuti, Patrizia Di Iorio, Patricia Giuliani, Lucia Ricci-Vitiani, Roberto Pallini, Francesco Caciagli & Renata Ciccarelli. (2015) Potentiation of temozolomide antitumor effect by purine receptor ligands able to restrain the in vitro growth of human glioblastoma stem cells. Purinergic Signalling 11:3, pages 331-346.
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Laura Boldrini, Mirella Giordano, Greta Alì, Adele Servadio, Serena Pelliccioni, Cristina Niccoli, Alfredo Mussi & Gabriella Fontanini. (2014) P2X7 protein expression and polymorphism in non-small cell lung cancer (NSCLC). Journal of Negative Results in BioMedicine 13:1.
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Kurt A. Schalper, Daniel Carvajal-Hausdorf & Mauricio P. Oyarzo. (2014) Possible role of hemichannels in cancer. Frontiers in Physiology 5.
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St?phanie Chadet, Bilel Jelassi, Ramez Wannous, Denis Angoulvant, St?phan Chevalier, Pierre Besson & S?bastien Roger. (2014) The activation of P2Y2 receptors increases MCF-7 breast cancer cells migration through the MEK-ERK1/2 signalling pathway. Carcinogenesis 35:6, pages 1238-1247.
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K.R. Atanasova & ?. Yilmaz. (2014) Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association . Molecular Oral Microbiology 29:2, pages 55-66.
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Torben Madsen Kvist, Peter Schwarz & Niklas Rye Jørgensen. (2014) The P2X7 Receptor: A Key Player in Immune-Mediated Bone Loss?. The Scientific World Journal 2014, pages 1-10.
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Alberto Baroja-Mazo, Maria Barber?-Cremades & Pablo Pelegr?n. (2013) P2X7 Receptor Activation Impairs Exogenous MHC Class I Oligopeptides Presentation in Antigen Presenting Cells. PLoS ONE 8:8, pages e70577.
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Bilel Jelassi, Monique Anchelin, Julie Chamouton, Mar?a Luisa Cayuela, Lucie Clarysse, Junying Li, Jacques Gor?Lin-Hua Jiang & S?bastien Roger. (2013) Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors. Carcinogenesis 34:7, pages 1487-1496.
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Jingqin Fang, Xiao Chen, Letian Zhang, Jinhua Chen, Yi Liang, Xue Li, Jianbo Xiang, Lili Wang, Guangkuo Guo, Bo Zhang & Weiguo Zhang. (2013) P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway. The International Journal of Biochemistry & Cell Biology 45:6, pages 1109-1120.
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George I. Gorodeski. (2012) P2X7 receptors and epithelial cancers. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1:3, pages 349-371.
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