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CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies

, MD, &
Pages 15-22 | Published online: 24 Nov 2011

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Niknam Riyahi, Ava Safaroghli-Azar, Negar Sheikh-Zeineddini, Mohamad Sayyadi & Davood Bashash. (2019) Synergistic Effects of PI3K and c-Myc Co-targeting in Acute Leukemia: Shedding New Light on Resistance to Selective PI3K-δ Inhibitor CAL-101. Cancer Investigation 37:7, pages 311-324.
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Jorge J Castillo, Meera Iyengar, Benjamin Kuritzky & Kenneth D Bishop. (2014) Isotype-specific inhibition of the phosphatidylinositol-3-kinase pathway in hematologic malignancies. OncoTargets and Therapy 7, pages 333-342.
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Jingyu Zhu, Kan Li, Lei Xu, Yanfei Cai, Yun Chen, Xinling Zhao, Huazhong Li, Gang Huang & Jian Jin. (2022) Discovery of novel selective PI3Kγ inhibitors through combining machine learning-based virtual screening with multiple protein structures and bio-evaluation. Journal of Advanced Research 36, pages 1-13.
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Cristina Cuesta, Cristina Arévalo-Alameda & Esther Castellano. (2021) The Importance of Being PI3K in the RAS Signaling Network. Genes 12:7, pages 1094.
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Jingyu Zhu, Kan Li, Li Yu, Yun Chen, Yanfei Cai, Jian Jin & Tingjun Hou. (2020) Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors. Medicinal Research Reviews 41:3, pages 1599-1621.
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Seulki Lee, Eun Ji Choi, Eun Ju Cho, Yun Bin Lee, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon & Yoon Jun Kim. (2020) Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway. Clinical and Molecular Hepatology 26:4, pages 529-539.
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Lydia Xenou & Evangelia A. Papakonstanti. (2020) p110δ PI3K as a therapeutic target of solid tumours. Clinical Science 134:12, pages 1377-1397.
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Rand Arafeh & Yardena Samuels. (2019) PIK3CA in cancer: The past 30 years. Seminars in Cancer Biology 59, pages 36-49.
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Claudio ScuoppoJiguang WangMirjana PersaudSandeep K. MittanKatia BassoLaura PasqualucciRaul RabadanGiorgio InghiramiCarla GrandoriFrancesc BoschRiccardo Dalla-Favera. (2019) Repurposing dasatinib for diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences 116:34, pages 16981-16986.
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Xiliang Du, Xiaobing Li, Liang Chen, Min Zhang, Lin Lei, Wenwen Gao, Zhen Shi, Yuhao Dong, Zhe Wang, Xinwei Li & Guowen Liu. (2018) Hepatic miR‐125b inhibits insulin signaling pathway by targeting PIK3CD. Journal of Cellular Physiology 233:8, pages 6052-6066.
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Evangelia Goulielmaki, Miriam Bermudez-Brito, Margarita Andreou, Niki Tzenaki, Maria Tzardi, Eelco de Bree, Eleftheria Tsentelierou, Antonis Makrigiannakis & Evangelia A. Papakonstanti. (2018) Pharmacological inactivation of the PI3K p110δ prevents breast tumour progression by targeting cancer cells and macrophages. Cell Death & Disease 9:6.
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Michelle S. Miller, Sweta Maheshwari, Fiona M. McRobb, Kenneth W. Kinzler, L. Mario Amzel, Bert Vogelstein & Sandra B. Gabelli. (2017) Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. Bioorganic & Medicinal Chemistry 25:4, pages 1481-1486.
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Klemens Hoegenauer, Nicolas Soldermann, Christina Hebach, Gregory J. Hollingworth, Ian Lewis, Anette von Matt, Alexander B. Smith, Romain M. Wolf, Rainer Wilcken, Dorothea Haasen, Christoph Burkhart & Frédéric Zécri. (2016) Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties. Bioorganic & Medicinal Chemistry Letters 26:23, pages 5657-5662.
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Chen Zhang, Bingfei Xu & Pian Liu. (2016) Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer. Tumor Biology 37:11, pages 14831-14839.
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Wenli Cui, Shutao Zheng, Xinxia Li, Yuqing Ma, Wei Sang, Ming Liu, Wei Zhang & Xiaoyan Zhou. (2016) PIK3CD promoted proliferation in diffuse large B cell lymphoma through upregulation of c-myc. Tumor Biology 37:9, pages 12767-12777.
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Ingrid A. MayerCarlos L. Arteaga. (2016) The PI3K/AKT Pathway as a Target for Cancer Treatment. Annual Review of Medicine 67:1, pages 11-28.
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Jorge J. Castillo, Steven P. Treon & Matthew S. Davids. (2016) Inhibition of the Bruton Tyrosine Kinase Pathway in B-Cell Lymphoproliferative Disorders. The Cancer Journal 22:1, pages 34-39.
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Charles B Goodwin & Rebecca J. Chan. 2016. PI3K-mTOR in Cancer and Cancer Therapy. PI3K-mTOR in Cancer and Cancer Therapy 181 229 .
Andreas Viardot & Christian Buske. 2015. Management of Hematological Cancer in Older People. Management of Hematological Cancer in Older People 129 141 .
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Agata Majchrzak, Magdalena Witkowska & Piotr Smolewski. (2014) Inhibition of the PI3K/Akt/mTOR Signaling Pathway in Diffuse Large B-Cell Lymphoma: Current Knowledge and Clinical Significance. Molecules 19:9, pages 14304-14315.
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Yujeong Jeong, Daeil Kwon & Sungwoo Hong. (2014) Selective and potent small-molecule inhibitors of PI3Ks. Future Medicinal Chemistry 6:7, pages 737-756.
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Fabienne Schmit, Tamara Utermark, Sen Zhang, Qi Wang, Thanh Von, Thomas M. Roberts & Jean J. Zhao. (2014) PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proceedings of the National Academy of Sciences 111:17, pages 6395-6400.
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