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Current and prospective disease-modifying therapies for amyotrophic lateral sclerosis

, MD MBBS (Hons) & , MD MSc MHSA FACP
Pages 297-320 | Published online: 06 Feb 2012

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Jinsy A. Andrews, Carlayne E. Jackson, Terry D. Heiman-Patterson, Paolo Bettica, Benjamin Rix Brooks & Erik P. Pioro. (2020) Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:7-8, pages 509-518.
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Malgorzata Gawel, Magdalena Kuzma-Kozakiewicz, Elzbieta Szmidt-Salkowska & Anna Kamińska. (2014) Are we really closer to improving the diagnostic sensitivity in ALS patients with Awaji criteria?. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 15:3-4, pages 257-261.
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Catherine A. Blizzard, Katherine A. Southam, Edgar Dawkins, Katherine E. Lewis, Anna E. King, Jayden A. Clark & Tracey C. Dickson. (2015) Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity. Disease Models & Mechanisms 8:3, pages 215-224.
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M. Dadon-Nachum, K. Ben-Yaacov, T. Ben-Zur, Y. Barhum, D. Yaffe, E. Perlson & D. Offen. (2014) Transplanted Modified Muscle Progenitor Cells Expressing a Mixture of Neurotrophic Factors Delay Disease Onset and Enhance Survival in the SOD1 Mouse Model of ALS. Journal of Molecular Neuroscience 55:3, pages 788-797.
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Nam-Hee KimMin Oh Lee. (2015) Update of Therapeutic Clinical Trials for Amyotrophic Lateral Sclerosis. Korean Journal of Clinical Neurophysiology 17:1, pages 1.
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Christopher J Donnelly, Jonathan C Grima & Rita Sattler. (2014) Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?. Neurodegenerative Disease Management 4:6, pages 417-437.
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H.-Q. Jiang, M. Ren, H.-Z. Jiang, J. Wang, J. Zhang, X. Yin, S.-Y. Wang, Y. Qi, X.-D. Wang & H.-L. Feng. (2014) Guanabenz delays the onset of disease symptoms, extends lifespan, improves motor performance and attenuates motor neuron loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neuroscience 277, pages 132-138.
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Christina M Lewis & Masatoshi Suzuki. (2014) Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis. Stem Cell Research & Therapy 5:2.
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Xenia Kobeleva & Susanne Petri. (2013) Barriers to novel therapeutics in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 3:6, pages 525-537.
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Merit E Cudkowicz, Leonard H van den Berg, Jeremy M Shefner, Hiroshi Mitsumoto, Jesus S Mora, Albert Ludolph, Orla Hardiman, Michael E Bozik, Evan W Ingersoll, Donald Archibald, Adam L Meyers, Yingwen Dong, Wildon R Farwell & Douglas A Kerr. (2013) Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial. The Lancet Neurology 12:11, pages 1059-1067.
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H. Hovden, J. L. Frederiksen & S. W. Pedersen. (2013) Immune system alterations in amyotrophic lateral sclerosis. Acta Neurologica Scandinavica, pages n/a-n/a.
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Anuradha Duleep & Jeremy Shefner. (2013) Electrodiagnosis of Motor Neuron Disease. Physical Medicine and Rehabilitation Clinics of North America 24:1, pages 139-151.
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Waltteri Siirala, Tarja Saaresranta, Arno Vuori, Sanna Salanterä, Klaus T Olkkola & Riku Aantaa. (2012) Using respiratory rate and thoracic movement to assess respiratory insufficiency in amyotrophic lateral sclerosis: a preliminary study. BMC Palliative Care 11:1.
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Frank S. Walsh & Julia Lynn Rutkowski. (2012) Myostatin as a therapeutic target in Amyotrophic Lateral Sclerosis. Neurochemistry International 61:6, pages 931-935.
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