832
Views
74
CrossRef citations to date
0
Altmetric
Reviews

Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation

, , &
Pages 819-831 | Published online: 16 Apr 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Yi Wang, Pengcheng Wang, Xiaoli Zheng & Xing Du. (2018) Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis. OncoTargets and Therapy 11, pages 7895-7908.
Read now
Damla Çetin Altındal & Menemşe Gümüşderelioğlu. (2016) Melatonin releasing PLGA micro/nanoparticles and their effect on osteosarcoma cells. Journal of Microencapsulation 33:1, pages 53-63.
Read now
Silvia Rivara, Daniele Pala, Annalida Bedini & Gilberto Spadoni. (2015) Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 – 2014). Expert Opinion on Therapeutic Patents 25:4, pages 425-441.
Read now
Sara Proietti, Gianfranco Carlomagno, Simona Dinicola & Mariano Bizzarri. (2014) Soft gel capsules improve melatonin’s bioavailability in humans. Expert Opinion on Drug Metabolism & Toxicology 10:9, pages 1193-1198.
Read now
Renata Kontek & Hanna Nowicka. (2013) The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells. Drug and Chemical Toxicology 36:3, pages 335-342.
Read now
Mustafa Nazıroğlu, Sümeyye Tokat & Seda Demirci. (2012) Role of melatonin on electromagnetic radiation-induced oxidative stress and Ca2+ signaling molecular pathways in breast cancer. Journal of Receptors and Signal Transduction 32:6, pages 290-297.
Read now

Articles from other publishers (68)

Belle H. de Rooij, Imogen Ramsey, Felix J. Clouth, Nadia Corsini, Jane S. Heyworth, Brigid M. Lynch, Jeff K. Vallance & Terry Boyle. (2022) The association of circadian parameters and the clustering of fatigue, depression, and sleep problems in breast cancer survivors: a latent class analysis. Journal of Cancer Survivorship 17:5, pages 1405-1415.
Crossref
Elvina C Lingas. (2023) A Narrative Review of the Carcinogenic Effect of Night Shift and the Potential Protective Role of Melatonin. Cureus.
Crossref
Chien-Pin Lai, Yong-Syuan Chen, Tsung-Ho Ying, Cheng-Yen Kao, Hui-Ling Chiou, Shao-Hsuan Kao & Yi-Hsien Hsieh. (2023) Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis. Kidney Research and Clinical Practice 42:4, pages 487-500.
Crossref
Vanesa Postigo, Margarita García & Teresa Arroyo. (2023) Study of a First Approach to the Controlled Fermentation for Lambic Beer Production. Microorganisms 11:7, pages 1681.
Crossref
Bangjie Chen, Tao Jin, Ziyue Fu, Haiwen Li, Junfa Yang, Yucheng Liu, Yanxun Han, Xinyi Wang, Zhengwei Wu & Tao Xu. (2023) Non-thermal plasma-treated melatonin inhibits the biological activity of HCC cells by increasing intracellular ROS levels and reducing RRM2 expression. Heliyon, pages e15992.
Crossref
Vanesa Postigo, Sergio Esteban & Teresa Arroyo. (2023) Lachancea thermotolerans, an Innovative Alternative for Sour Beer Production. Beverages 9:1, pages 20.
Crossref
Suman Rohilla, Mahaveer Singh, Sakshi Priya, Waleed Hassan Almalki, Shahril Mohamed Haniffa, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria, Mahendran Sekar, Sachin Kumar Singh, Niraj Kumar Jha, Dinesh Kumar Chellappan, Poonam Negi, Kamal Dua & Gaurav Gupta. (2023) Exploring the Mechanical Perspective of a New Anti-Tumor Agent: Melatonin. Journal of Environmental Pathology, Toxicology and Oncology 42:1, pages 1-16.
Crossref
Alexey I. Lomovsky, Yulia L. Baburina, Roman S. Fadeev, Yana V. Lomovskaya, Margarita I. Kobyakova, Roman R. Krestinin, Linda D. Sotnikova & Olga V. Krestinina. (2023) Melatonin Can Enhance the Effect of Drugs Used in the Treatment of Leukemia. Biochemistry (Moscow) 88:1, pages 73-85.
Crossref
Ananyaa Mohan, Inge Huybrechts & Nathalie Michels. (2022) Psychosocial stress and cancer risk: a narrative review. European Journal of Cancer Prevention 31:6, pages 585-599.
Crossref
Vanesa Postigo, Ana Sánchez, Juan Mariano Cabellos & Teresa Arroyo. (2022) New Approaches for the Fermentation of Beer: Non-Saccharomyces Yeasts from Wine. Fermentation 8:6, pages 280.
Crossref
M. Gallardo-Fernández, J. Valls-Fonayet, E. Valero, R. Hornedo-Ortega, T. Richard, A.M. Troncoso & M.C. Garcia-Parrilla. (2022) Isotopic labelling-based analysis elucidates biosynthesis pathways in Saccharomyces cerevisiae for Melatonin, Serotonin and Hydroxytyrosol formation. Food Chemistry 374, pages 131742.
Crossref
Allan Saj PorcacchiaDiana Aparecida Dias Câmara, Monica Levy Andersen & Sergio Tufik. (2021) Sleep disorders and prostate cancer prognosis: biology, epidemiology, and association with cancer development risk. European Journal of Cancer Prevention 31:2, pages 178-189.
Crossref
Russel J. Reiter, Ramaswamy Sharma, Carmen Rodriguez, Vanesa Martin, Sergio Rosales-Corral, Debora Aparecida Pires de Campos Zuccari & Luiz Gustavo de Almeida Chuffa. (2021) Part-time cancers and role of melatonin in determining their metabolic phenotype. Life Sciences 278, pages 119597.
Crossref
Maryam Ezzati, Kobra Velaei & Raziyeh Kheirjou. (2021) Melatonin and its mechanism of action in the female reproductive system and related malignancies. Molecular and Cellular Biochemistry 476:8, pages 3177-3190.
Crossref
Lijie Zhou, Cai Zhang, Xiong Yang, Lilong Liu, Junyi Hu, Yaxin Hou, Hong Tao, Haruhiko Sugimura, Zhaohui Chen, Liang Wang & Ke Chen. (2021) Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1. Clinical and Translational Medicine 11:6.
Crossref
Wamidh H. Talib, Ahmad Riyad Alsayed, Alaa Abuawad, Safa Daoud & Asma Ismail Mahmod. (2021) Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities. Molecules 26:9, pages 2506.
Crossref
Eva Costanzi, Carolina Simioni, Ilaria Conti, Ilaria Laface, Gabriele Varano, Cinzia Brenna & Luca M. Neri. (2020) Two neuroendocrine G protein‐coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives. Journal of Cellular Physiology 236:4, pages 2505-2518.
Crossref
Daniel L. KrinskyCydney E. McQueen & Katherine Kelly Orr. 2020. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 20th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 20th Edition.
Alexey Lomovsky, Yulia Baburina, Irina Odinokova, Margarita Kobyakova, Yana Evstratova, Linda Sotnikova, Roman Krestinin & Olga Krestinina. (2020) Melatonin Can Modulate the Effect of Navitoclax (ABT-737) in HL-60 Cells. Antioxidants 9:11, pages 1143.
Crossref
Shahrokh Iravani, Pegah Eslami, Arash Dooghaie Moghadam, Bobak Moazzami, Azim Mehrvar, Mahmood Reza Hashemi, Fariborz Mansour-Ghanaei, Alireza Mansour-Ghanaei & Keivan Majidzadeh-A. (2019) The Role of Melatonin in Colorectal Cancer. Journal of Gastrointestinal Cancer 51:3, pages 748-753.
Crossref
Ruchi Goyal, Tulika Gupta, Amanjit Bal, Daisy Sahni & Gurpreet Singh. (2020) Role of Melatonin in Breast Carcinoma: Correlation of Expression Patterns of Melatonin-1 Receptor With Estrogen, Progesterone, and HER2 Receptors. Applied Immunohistochemistry & Molecular Morphology 28:7, pages 518-523.
Crossref
Russel J. Reiter, Ramaswamy Sharma, Qiang Ma, Sergio Rorsales-Corral & Luiz G. de Almeida Chuffa. (2020) Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis. Cellular and Molecular Life Sciences 77:13, pages 2527-2542.
Crossref
Zhiqiang Ma, Liqun Xu, Dong Liu, Xiaoyan Zhang, Shouyin Di, Weimiao Li, Jiao Zhang, Russel J. Reiter, Jing Han, Xiaofei Li & Xiaolong Yan. (2020) Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing. Oxidative Medicine and Cellular Longevity 2020, pages 1-20.
Crossref
Ana Claudia Souza Palmer, Maxciel Zortea, Andressa Souza, Vinicius Santos, Jorge Villanova Biazús, Iraci L. S. Torres, Felipe Fregni & Wolnei Caumo. (2020) Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: A randomized, double-blind, placebo-controlled trial. PLOS ONE 15:4, pages e0231379.
Crossref
Enrico Moretti, Gaia Favero, Luigi Fabrizio Rodella & Rita Rezzani. (2020) Melatonin’s Antineoplastic Potential Against Glioblastoma. Cells 9:3, pages 599.
Crossref
Ko-Hsiu Lu, Chiao-Wen Lin, Yi-Hsien Hsieh, Shih-Chi Su, Russel J. Reiter & Shun-Fa Yang. (2020) New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence. Cancer and Metastasis Reviews 39:1, pages 303-320.
Crossref
Ko-Hsiu Lu, Renn-Chia Lin, Jia-Sin Yang, Wei-En Yang, Russel J. Reiter & Shun-Fa Yang. (2019) Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma. Cells 8:12, pages 1618.
Crossref
Geir Bjørklund, Samiul Alam Rajib, Nadia Saffoon, Joeri J. Pen & Salvatore Chirumbolo. (2019) Insights on Melatonin as an Active Pharmacological Molecule in Cancer Prevention: What’s New?. Current Medicinal Chemistry 26:34, pages 6304-6320.
Crossref
Wei-Sheng Chung & Cheng-Li Lin. (2019) Sleep disorders associated with risk of prostate cancer: a population-based cohort study. BMC Cancer 19:1.
Crossref
Emilio Gil‐Martín, Javier Egea, Russel J. Reiter & Alejandro Romero. (2019) The emergence of melatonin in oncology: Focus on colorectal cancer. Medicinal Research Reviews 39:6, pages 2239-2285.
Crossref
Keywan Mortezaee, Masoud Najafi, Bagher Farhood, Amirhossein Ahmadi, Dheyauldeen Shabeeb & Ahmed E. Musa. (2019) NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity. Journal of Cellular Physiology 234:10, pages 17187-17204.
Crossref
Bin Zhou, Haige Ye, Chongyun Xing, Bin Liang, Haiying Li, Linling Chen, Xingzhou Huang, Yanfei Wu & Shenmeng Gao. (2019) Targeting miR‐193a‐AML1‐ETO‐β‐catenin axis by melatonin suppresses the self‐renewal of leukaemia stem cells in leukaemia with t (8;21) translocation. Journal of Cellular and Molecular Medicine 23:8, pages 5246-5258.
Crossref
Bagher Farhood, Nasser Hashemi Goradel, Keywan Mortezaee, Neda Khanlarkhani, Masoud Najafi & Amirhossein Sahebkar. (2018) Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment. Journal of Cellular Physiology 234:5, pages 5613-5627.
Crossref
Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Maira Smaniotto Cucielo, Henrique Spaulonci Silveira, Russel J. Reiter & Luiz Antonio Lupi. (2018) Mitochondrial functions and melatonin: a tour of the reproductive cancers. Cellular and Molecular Life Sciences 76:5, pages 837-863.
Crossref
Annalida Bedini, Alessandra Fraternale, Rita Crinelli, Michele Mari, Silvia Bartolucci, Laura Chiarantini & Gilberto Spadoni. (2018) Design, Synthesis, and Biological Activity of Hydrogen Peroxide Responsive Arylboronate Melatonin Hybrids. Chemical Research in Toxicology 32:1, pages 100-112.
Crossref
Bianka Bojková, Peter Kubatka, Tawar Qaradakhi, Anthony Zulli & Karol Kajo. (2018) Melatonin May Increase Anticancer Potential of Pleiotropic Drugs. International Journal of Molecular Sciences 19:12, pages 3910.
Crossref
Pawel P. Posadzki, Ram Bajpai, Bhone Myint Kyaw, Nicola J. Roberts, Amnon Brzezinski, George I. Christopoulos, Ushashree Divakar, Shweta Bajpai, Michael Soljak, Gerard Dunleavy, Krister Jarbrink, Ei Ei Khaing Nang, Chee Kiong Soh & Josip Car. (2018) Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action. BMC Medicine 16:1.
Crossref
Wamidh Talib. (2018) Melatonin and Cancer Hallmarks. Molecules 23:3, pages 518.
Crossref
Peter Kubatka, Pavol Zubor, Dietrich Busselberg, Taeg Kyu Kwon, Mariusz Adamek, Daniel Petrovic, Radka Opatrilova, Katarina Gazdikova, Martin Caprnda, Luis Rodrigo, Jan Danko & Peter Kruzliak. (2018) Melatonin and breast cancer: Evidences from preclinical and human studies. Critical Reviews in Oncology/Hematology 122, pages 133-143.
Crossref
Daniel L. Krinsky, Stefanie P. Ferreri, Brian Hemstreet, Anne L. Hume, Gail D. Newton, Carol J. Rollins & Karen J. TietzeCydney E. McQueen & Katherine Kelly Orr. 2017. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 19th Edition.
Ya Li, Sha Li, Yue Zhou, Xiao Meng, Jiao-Jiao Zhang, Dong-Ping Xu & Hua-Bin Li. (2017) Melatonin for the prevention and treatment of cancer. Oncotarget 8:24, pages 39896-39921.
Crossref
Ricássio S. Barberino, Vanúzia G. Menezes, Anita E. A. S. Ribeiro, Raimundo C. Palheta Jr, Xuejun Jiang, Johan E. J. Smitz & Maria Helena T. Matos. (2017) Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity†. Biology of Reproduction 96:6, pages 1244-1255.
Crossref
Carlos Martínez-Campa, Javier Menéndez-Menéndez, Carolina Alonso-González, Alicia González, Virginia Álvarez-García & Samuel Cos. (2017) What is known about melatonin, chemotherapy and altered gene expression in breast cancer. Oncology Letters 13:4, pages 2003-2014.
Crossref
Jie Wen, Prasanth S. Ariyannur, Rachel Ribeiro, Mikiei Tanaka, John R. Moffett, Batool F. Kirmani, Aryan M.A. Namboodiri & Yumin Zhang. (2016) Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis. Journal of Neuroimmune Pharmacology 11:4, pages 763-773.
Crossref
Hui-Yen Chuang, Jeng-Jong Hwang & Chun-Kai Fang. 2016. Serotonin and Melatonin. Serotonin and Melatonin 467 498 .
Yumi Fukuda & Takeshi Morita. 2016. Serotonin and Melatonin. Serotonin and Melatonin 297 304 .
Bianka Bojková, Peter Orendáš, Karol Kajo, Peter Kubatka, Desanka Výbohová, Soňa Bálentová, Peter Kružliak, Anthony Zulli, Vlasta Demečková, Martin Péč & Marián Adamkov. (2016) Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer. European Journal of Cancer Prevention 25:5, pages 395-403.
Crossref
Erin Sweet, Fred Dowd, May Zhou, Leanna J. Standish & M. Robyn Andersen. (2016) The Use of Complementary and Alternative Medicine Supplements of Potential Concern during Breast Cancer Chemotherapy. Evidence-Based Complementary and Alternative Medicine 2016, pages 1-8.
Crossref
Thaiz Ferraz Borin, Ali Syed Arbab, Gabriela Bottaro Gelaleti, Lívia Carvalho Ferreira, Marina Gobbe Moschetta, Bruna Victorasso Jardim-Perassi, ASM Iskander, Nadimpalli Ravi S. Varma, Adarsh Shankar, Verena Benedick Coimbra, Vanessa Alves Fabri, Juliana Garcia de Oliveira & Debora Aparecida Pires de Campos Zuccari. (2016) Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. Journal of Pineal Research 60:1, pages 3-15.
Crossref
Cydney E. McQueen & Katherine Kelly Orr. 2015. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition. Handbook of Nonprescription Drugs: An Interactive Approach to Self-Care, 18th Edition.
S. Altug Kesikli & Nilufer Guler. 2015. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease 291 333 .
Karolina Jablonska, Bartosz Pula, Agata Zemla, Christopher Kobierzycki, Witold Kedzia, Ewa Nowak-Markwitz, Marek Spaczynski, Maciej Zabel, Marzenna Podhorska-Okolow & Piotr Dziegiel. (2014) Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells. International Journal of Molecular Sciences 15:12, pages 23074-23089.
Crossref
Haruna Fukushige, Yumi Fukuda, Mizuho Tanaka, Kaoru Inami, Kai Wada, Yuki Tsumura, Masayuki Kondo, Tetsuo Harada, Tomoko Wakamura & Takeshi Morita. (2014) Effects of tryptophan-rich breakfast and light exposure during the daytime on melatonin secretion at night. Journal of Physiological Anthropology 33:1.
Crossref
Peter Orendáš, Peter Kubatka, Bianka Bojková, Monika Kassayová, Karol Kajo, Desanka Výbohová, Peter Kružliak, Martin Péč, Marián Adamkov, Andrea Kapinová, Katarína Adamicová, Vladimíra Sadloňová, Martina Chmelová & Nadežda Stollárová. (2014) Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model. International Journal of Experimental Pathology 95:6, pages 401-410.
Crossref
Yang Yang, Yang Sun, Wei Yi, Yue Li, Chongxi Fan, Zhenlong Xin, Shuai Jiang, Shouyin Di, Yan Qu, Russel J. Reiter & Dinghua Yi. (2014) A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. Journal of Pineal Research 57:4, pages 357-366.
Crossref
Peter Kubatka, Bianka Bojková, Monika Kassayová, Peter Orendáš, Karol Kajo, Desanka Výbohová, Peter Kružliak, Katarína Adamicová, Martin Péč, Nadežda Stollárová & Marián Adamkov. (2014) Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model. Acta Histochemica 116:8, pages 1454-1461.
Crossref
R. Rezzani, L.F. Rodella, G. Favero, G. Damiani, C. Paganelli & R.J. Reiter. (2014) Attenuation of ultraviolet A ‐induced alterations in NIH 3 T 3 dermal fibroblasts by melatonin . British Journal of Dermatology 170:2, pages 382-391.
Crossref
Kangsadarn Bennukul. (2014) Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions . World Journal of Hepatology 6:4, pages 230.
Crossref
Michelle Basler, Alexander Jetter, Daniel Fink, Burkhardt Seifert, Gerd A. Kullak-Ublick & Andreas Trojan. (2014) Urinary Excretion of Melatonin and Association with Breast Cancer: Meta-Analysis and Review of the Literature. Breast Care 9:3, pages 182-187.
Crossref
Xuan Zhang, Zhilong Wang, Qingqing Huang, Yu Luo, Xin Xie & Wei Lu. (2014) Design, synthesis, and biological evaluation of a new class of MT 2 -selective agonists . RSC Adv. 4:49, pages 25871-25874.
Crossref
Nori Tolosa de Talamoni, Vanessa Andrea Areco, Maria Elena Peralta Lopez, Gabriela Diaz de Barboza, Maria Angelica Rivoira & Agata Rita Carpentieri. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 27 42 .
Emilio J. Sanchez-Barcelo, Maria D. Mediavilla Aguado & Samuel Cos Corral. 2014. Melatonin and Melatonergic Drugs in Clinical Practice. Melatonin and Melatonergic Drugs in Clinical Practice 171 181 .
Moshe Frenkel, Donald I. Abrams, Elena J. Ladas, Gary Deng, Mary Hardy, Jillian L. Capodice, Mary F. Winegardner, J. K. Gubili, K. Simon Yeung, Heidi Kussmann & Keith I. Block. (2013) Integrating Dietary Supplements Into Cancer Care. Integrative Cancer Therapies 12:5, pages 369-384.
Crossref
Yedong Cheng, Liping Cai, Peng Jiang, Jiabo Wang, Chao Gao, Haibo Feng, Changchao Wang, Haiyuan Pan & Yang Yang. (2013) SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells. European Journal of Pharmacology 715:1-3, pages 219-229.
Crossref
H. Garcia-Moreno, J. R. Calvo & M. D. Maldonado. (2013) High levels of melatonin generated during the brewing process. Journal of Pineal Research 55:1, pages 26-30.
Crossref
Sara Proietti, Alessandra Cucina, Russel J. Reiter & Mariano Bizzarri. (2012) Molecular mechanisms of melatonin’s inhibitory actions on breast cancers. Cellular and Molecular Life Sciences 70:12, pages 2139-2157.
Crossref
Armando Morera-Fumero & Pedro Abreu-Gonzalez. (2013) Role of Melatonin in Schizophrenia. International Journal of Molecular Sciences 14:5, pages 9037-9050.
Crossref
Karolina Jablonska, Bartosz Pula, Agata Zemla, Tomasz Owczarek, Andrzej Wojnar, Janusz Rys, Aleksandra Ambicka, Marzena Podhorska‐Okolow, Maciej Ugorski & Piotr Dziegiel. (2013) Expression of melatonin receptor MT 1 in cells of human invasive ductal breast carcinoma . Journal of Pineal Research 54:3, pages 334-345.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.