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Activin receptor antagonists for cancer-related anemia and bone disease

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Pages 87-101 | Published online: 06 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Alexander Ries, Karin Schelch, David Falch, Laura Pany, Mir Alireza Hoda & Michael Grusch. (2020) Activin A: an emerging target for improving cancer treatment?. Expert Opinion on Therapeutic Targets 24:10, pages 985-996.
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Maria Gavriatopoulou, Meletios A. Dimopoulos, Efstathios Kastritis & Evangelos Terpos. (2017) Emerging treatment approaches for myeloma-related bone disease. Expert Review of Hematology 10:3, pages 217-228.
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Gaetano Leto, Lorena Incorvaia, Carla Flandina, Chiara Ancona, Fabio Fulfaro, Marilena Crescimanno, Maria Vittoria Sepporta & Giuseppe Badalamenti. (2016) Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report. Cancer Investigation 34:9, pages 415-423.
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Holger Schmid & Wolfgang Jelkmann. (2016) Investigational therapies for renal disease-induced anemia. Expert Opinion on Investigational Drugs 25:8, pages 901-916.
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Ugo Testa, Germana Castelli & Pelosi Elvira. (2015) Experimental and investigational therapies for chemotherapy-induced anemia. Expert Opinion on Investigational Drugs 24:11, pages 1433-1445.
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Balan Louis Gaspar, Prashant Sharma & Reena Das. (2015) Anemia in malignancies: Pathogenetic and diagnostic considerations. Hematology 20:1, pages 18-25.
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Articles from other publishers (44)

Szabina Szófia Szilágyi, Ayelet R. Amsalem-Zafran, Keren E. Shapira, Marcelo Ehrlich & Yoav I. Henis. (2022) Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways. BMC Biology 20:1.
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Valentina Rausch, Valentina Sala, Fabio Penna, Paolo Ettore Porporato & Alessandra Ghigo. (2021) Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia. Oncogenesis 10:1.
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Lanting Liu, Zhen Yu, Hui Cheng, Xuehan Mao, Weiwei Sui, Shuhui Deng, Xiaojing Wei, Junqiang Lv, Chenxing Du, Jie Xu, Wenyang Huang, Shuang Xia, Gang An, Wen Zhou, Xiaoke Ma, Tao Cheng, Lugui Qiu & Mu Hao. (2020) Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment. Scientific Reports 10:1.
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Atsutaka Masuda, Toru Nakamura, Mitsuhiko Abe, Hideki  Iwamoto, Takahiko Sakaue, Toshimitsu Tanaka, Hiroyuki  Suzuki, Hironori Koga & Takuji Torimura. (2020) Promotion of liver regeneration and anti‑fibrotic effects of the TGF‑β receptor kinase inhibitor galunisertib in CCl4‑treated mice. International Journal of Molecular Medicine 46:1, pages 427-438.
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Lisha Xiang & Daniele Gilkes. (2019) The Contribution of the Immune System in Bone Metastasis Pathogenesis. International Journal of Molecular Sciences 20:4, pages 999.
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Wolfgang Jelkmann. (2018) Activin receptor ligand traps in chronic kidney disease. Current Opinion in Nephrology and Hypertension 27:5, pages 351-357.
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Prithviraj Bose & Srdan Verstovsek. (2018) Management of Myelofibrosis-Related Cytopenias. Current Hematologic Malignancy Reports 13:3, pages 164-172.
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Nadia Danilova, Mark Wilkes, Elena Bibikova, Min-Young Youn, Kathleen M. Sakamoto & Shuo Lin. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports 8:1.
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Olivier Salamin, Tiia Kuuranne, Martial Saugy & Nicolas Leuenberger. (2018) Erythropoietin as a performance-enhancing drug: Its mechanistic basis, detection, and potential adverse effects. Molecular and Cellular Endocrinology 464, pages 75-87.
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Nesreen Nabil Omar, Rasha R. Rashed, Rania M. El-Hazek, Walaa A. El-Sabbagh, Engy R. Rashed & Mona A. El-Ghazaly. (2018) Platelet-rich plasma-induced feedback inhibition of activin A/follistatin signaling: A mechanism for tumor-low risk skin rejuvenation in irradiated rats. Journal of Photochemistry and Photobiology B: Biology 180, pages 17-24.
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Valeria Santini. (2018) Of blood and bone: the sotatercept adventure. The Lancet Haematology 5:2, pages e54-e55.
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Giacomina Brunetti, Maria Felicia Faienza, Graziana Colaianni, Maria Grano & Silvia Colucci. (2017) Mechanisms of Altered Bone Remodeling in Multiple Myeloma. Clinical Reviews in Bone and Mineral Metabolism 15:4, pages 151-161.
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Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller & Joachim Nickel. (2017) Utilizing BMP-2 muteins for treatment of multiple myeloma. PLOS ONE 12:5, pages e0174884.
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Mark Sabat, Haixia Wang, Nick Scorah, J. David Lawson, Joy Atienza, Ruhi Kamran, Mark S. Hixon & Douglas R. Dougan. (2017) Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors. Bioorganic & Medicinal Chemistry Letters 27:9, pages 1955-1961.
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Anja Verhulst, Ellen Neven & Patrick C. D'Haese. (2017) Characterization of an Animal Model to Study Risk Factors and New Therapies for the Cardiorenal Syndrome, a Major Health Issue in Our Aging Population. Cardiorenal Medicine 7:3, pages 234-244.
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Chenglin Mo, Zhiying Wang, Lynda Bonewald & Marco Brotto. 2017. Bone Toxicology. Bone Toxicology 281 316 .
Wei-Min Chang, Yuan-Feng Lin, Chia-Yi Su, Hsuan-Yu Peng, Yu-Chan Chang, Tsung-Ching Lai, Guan-Hsun Wu, Yuan-Ming Hsu, Li-Hsing Chi, Jenn-Ren Hsiao, Chi-Long Chen, Jang-Yang Chang, Yi-Shing Shieh, Michael Hsiao & Shine-Gwo Shiah. (2016) Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. Cancer Research 76:24, pages 7140-7150.
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E Terpos, D Christoulas, E Kastritis, T Bagratuni, M Gavriatopoulou, M Roussou, A Papatheodorou, E Eleutherakis-Papaiakovou, N Kanellias, C Liakou, I Panagiotidis, M Migkou, P Kokkoris, L A Moulopoulos & M A Dimopoulos. (2016) High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer Journal 6:10, pages e482-e482.
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Haralambos Raftopoulos, Abderrahmane Laadem, Paul J. Hesketh, Jerome Goldschmidt, Nashat Gabrail, Cynthia Osborne, Muhammad Ali, Matthew L. Sherman, Ding Wang, John A. Glaspy, Marie Puccio-Pick, Jun Zou & Jeffrey Crawford. (2015) Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies. Supportive Care in Cancer 24:4, pages 1517-1525.
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Clara Camaschella & Antonella Nai. (2016) Ineffective erythropoiesis and regulation of iron status in iron loading anaemias. British Journal of Haematology 172:4, pages 512-523.
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Martin Mørck Mortensen, Søren Høyer, Anne-Sophie Lynnerup, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Michael Borre & Lars Dyrskjøt. (2015) Expression profiling of prostate cancer tissue delineates genes associated with recurrence after prostatectomy. Scientific Reports 5:1.
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Siyuan Xiong, Christian Klausen, Jung-Chien Cheng, Hua Zhu & Peter C.K. Leung. (2015) Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling. Oncotarget 6:31, pages 31659-31673.
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Inkyu Hwang & Nguyet Nguyen. (2015) Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects. Archives of Pharmacal Research 38:8, pages 1415-1433.
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Jie Zhu, Rama K. Mishra, Gary E. Schiltz, Yogeshwar Makanji, Karl A. Scheidt, Andrew P. Mazar & Teresa K. Woodruff. (2015) Virtual High-Throughput Screening To Identify Novel Activin Antagonists. Journal of Medicinal Chemistry 58:14, pages 5637-5648.
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Li-Min Sun, Cheng-Li Lin, Ming-Chia Lin, Ji-An Liang & Chia-Hung Kao. (2015) Radiotherapy- and Chemotherapy-Induced Myelodysplasia Syndrome. Medicine 94:17, pages e737.
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W. Jelkmann. (2014) The ESA scenario gets complex: from biosimilar epoetins to activin traps. Nephrology Dialysis Transplantation 30:4, pages 553-559.
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Nicola Giuliani, Marina Bolzoni & Regis Bataille. 2015. Bone Cancer. Bone Cancer 491 500 .
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Aaron Raymond, Bin Liu, Hong Liang, Caimiao Wei, Michele Guindani, Yue Lu, Shoudan Liang, Lisa S. St. John, Jeff Molldrem & Lalitha Nagarajan. (2014) A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy . Oncotarget 5:24, pages 12675-12693.
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Mathias Rask-Andersen, Jin Zhang, Doriano Fabbro & Helgi B. Schiöth. (2014) Advances in kinase targeting: current clinical use and clinical trials. Trends in Pharmacological Sciences 35:11, pages 604-620.
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Toril Holien & Anders Sundan. (2014) The role of bone morphogenetic proteins in myeloma cell survival. Cytokine & Growth Factor Reviews 25:3, pages 343-350.
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Gunnar Birgegård. (2014) Does anything work for anaemia in myelofibrosis?. Best Practice & Research Clinical Haematology 27:2, pages 175-185.
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Lorenz C Hofbauer, Tilman D Rachner, Robert E Coleman & Franz Jakob. (2014) Endocrine aspects of bone metastases. The Lancet Diabetes & Endocrinology 2:6, pages 500-512.
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Laura Breda & Stefano Rivella. (2014) Modulators of Erythropoiesis. Hematology/Oncology Clinics of North America 28:2, pages 375-386.
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Jean-Paul Thissen & Audrey Loumaye. (2013) Rôle de l’Activine A et de la Myostatine dans la cachexie cancéreuse. Annales d'Endocrinologie 74:2, pages 79-81.
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