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Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus

& , BSc (Hons) PhD FBPharmacolS
Pages 463-486 | Published online: 01 Mar 2013

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Suhani Sinha, Sonali, Vandana Garg, Sonia Thapa, Shashank Singh, Mahima Chauhan, Rohit Dutt & Rahul Pratap Singh. (2022) Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and its in-vitro anticancer activity. Drug Development and Industrial Pharmacy 48:7, pages 279-291.
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Bryce C Simes & Gordon G MacGregor. (2019) Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors: A Clinician’s Guide. Diabetes, Metabolic Syndrome and Obesity 12, pages 2125-2136.
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Vani P Sanon, Shalin Patel, Saurabh Sanon, Ruben Rodriguez, Son V Pham & Robert Chilton. (2017) Differential cardiovascular profiles of sodium-glucose cotransporter 2 inhibitors: critical evaluation of empagliflozin. Therapeutics and Clinical Risk Management 13, pages 603-611.
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Hala Ahmadieh, Nisrine Ghazal & Sami T Azar. (2017) Role of sodium glucose cotransporter-2 inhibitors in type I diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity 10, pages 161-167.
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Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan & Zhong-Min Liu. (2017) Evaluation of the pharmacokinetics, pharmacodynamics and clinical efficacy of empagliflozin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 211-223.
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Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas. (2016) Pharmacokinetic and pharmacodynamic drug evaluation of tofogliflozin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 12:11, pages 1367-1380.
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Masatoshi Hasegawa, Yukihiro Chino, Nobuko Horiuchi, Kenji Hachiuma, Masahiro Ishida, Yoshiki Fukasawa, Yasuhiro Nakai & Jun-ichi Yamaguchi. (2015) Preclinical metabolism and disposition of luseogliflozin, a novel antihyperglycemic agent. Xenobiotica 45:12, pages 1105-1115.
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Giorgio Gentile, Daniela Mastroluca, Piero Ruggenenti & Giuseppe Remuzzi. (2014) Novel effective drugs for diabetic kidney disease? or not?. Expert Opinion on Emerging Drugs 19:4, pages 571-601.
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André J Scheen. (2014) Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations. Expert Opinion on Drug Metabolism & Toxicology 10:5, pages 647-663.
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Articles from other publishers (54)

Tania Sundra, Guy Lester, Gabriele Rossi & David Rendle. (2023) Sodium–glucose cotransporter 2 inhibitors in horses—Magic bullet or latest fad?. Equine Veterinary Journal 55:4, pages 559-562.
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Tania Sundra, Erin Kelty & David Rendle. (2022) Preliminary observations on the use of ertugliflozin in the management of hyperinsulinaemia and laminitis in 51 horses: A case series. Equine Veterinary Education 35:6, pages 311-320.
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Xianghong Wang, Niujian Wu, Chuanchuan Sun, Donghua Jin & Hongyun Lu. (2023) Effects of SGLT-2 inhibitors on adipose tissue distribution in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Diabetology & Metabolic Syndrome 15:1.
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Eman A. Bahgat, Hisham Hashem, Hanaa Saleh, Ebraam B. Kamel & Maya S. Eissa. (2023) HPLC-DAD technique for the quantification of a recently approved anti-diabetic triple combination along with two toxic official impurities: Toxicity confirmation aided by molecular docking application. BMC Chemistry 17:1.
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Manuel A. Cornejo, Eira Jardines, Akira Nishiyama, Daisuke Nakano & Rudy M. Ortiz. (2023) Simultaneous SGLT2 inhibition and caloric restriction improves insulin resistance and kidney function in OLETF rats. Molecular and Cellular Endocrinology 560, pages 111811.
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Despina Sanoudou, Christos S. Mantzoros & Michael A. Hill. (2022) Sodium-glucose cotransporter-2 inhibitors: A treatment option for recurrent vasovagal syndrome?. Metabolism 137, pages 155309.
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Suiyuan Hu, Chu Lin, Xiaoling Cai, Xingyun Zhu, Fang Lv, Wenjia Yang & Linong Ji. (2022) Disparities in efficacy and safety of sodium-glucose cotransporter 2 inhibitor among patients with different extents of renal dysfunction: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Pharmacology 13.
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Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Namba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito, Kentaro Ejiri, Toru Miyoshi, Kazufumi Nakamura, Hiroshi Ito, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Namba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Tetsuya Sato, Soichiro Fuke, Masaki Yoshikawa, Hiroyasu Sugiyama, Michio Imai, Naoki Gotoh, Tomonori Segawa, Toshiyuki Noda & Masatoshi Koshiji. (2022) Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure. Scientific Reports 12:1.
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Theocharis Koufakis, Symeon Metallidis, Pantelis Zebekakis & Kalliopi Kotsa. (2021) Intestinal SGLT1 as a therapeutic target in COVID‐19‐related diabetes: A “two‐edged sword” hypothesis. British Journal of Clinical Pharmacology 87:10, pages 3643-3646.
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Adeboye Olakunle Bamgboye, Isaac Oluwadamilare Oni & Andrew Collier. (2020) Predisposing factors for the development of diabetic ketoacidosis with lower than anticipated glucose levels in type 2 diabetes patients on SGLT2-inhibitors: a review. European Journal of Clinical Pharmacology 77:5, pages 651-657.
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Charalampos I. Liakos, Dimitrios P. Papadopoulos, Elias A. Sanidas, Maria I. Markou, Erifili E. Hatziagelaki, Charalampos A. Grassos, Maria L. Velliou & John D. Barbetseas. (2020) Blood Pressure-Lowering Effect of Newer Antihyperglycemic Agents (SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors). American Journal of Cardiovascular Drugs 21:2, pages 123-137.
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Najeeb Shah, Mohammed Altigani Abdalla, Harshal Deshmukh & Thozhukat Sathyapalan. (2021) Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism 12, pages 204201882110421.
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Theocharis Koufakis, Nikolaos Papanas, George Dimitriadis, Pantelis Zebekakis & Kalliopi Kotsa. (2020) Interpreting the results of the VERTIS‐CV trial: Is this the end of the “class effect” perspective? . Journal of Diabetes 12:12, pages 942-945.
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Xiangyang Liu, Chaofei Xu, Linxin Xu, Xiaoyu Li, Hongxi Sun, Mei Xue, Ting Li, Xiaochen Yu, Bei Sun & Liming Chen. (2020) Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway. Metabolism 111, pages 154334.
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Kentaro Ejiri, Toru Miyoshi, Hajime Kihara, Yoshiki Hata, Toshihiko Nagano, Atsushi Takaishi, Hironobu Toda, Seiji Nanba, Yoichi Nakamura, Satoshi Akagi, Satoru Sakuragi, Taro Minagawa, Yusuke Kawai, Nobuhiro Nishii, Soichiro Fuke, Masaki Yoshikawa, Kazufumi Nakamura, Hiroshi Ito, Tetsuya Sato, Hiroyasu Sugiyama, Michio Imai, Naoki Gotoh, Tomonori Segawa, Toshiyuki Noda & Masatoshi Koshiji. (2020) Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus. Journal of the American Heart Association 9:16.
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Ryoichi Ishibashi, Yoko Takatsuna, Masaya Koshizaka, Tomoaki Tatsumi, Sho Takahashi, Kengo Nagashima, Noriko Asaumi, Miyuki Arai, Fumio Shimada, Kaori Tachibana, Yoshihiro Watanabe, Ko Ishikawa, Akiko Hoshino, Kyohei Yamamoto, Mariko Kubota-Taniai, Takafumi Mayama, Shuichi Yamamoto & Koutaro Yokote. (2020) Safety and Efficacy of Ranibizumab and Luseogliflozin Combination Therapy in Patients with Diabetic Macular Edema: Protocol for a Multicenter, Open-Label Randomized Controlled Trial. Diabetes Therapy 11:8, pages 1891-1905.
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T. S. Panevin, M. S. Eliseev, M. V. Shestakova & E. L. Nasonov. (2020) Advantages of therapy with sodium glucose cotransporter type 2 inhibitors in patients with type 2 diabetes mellitus in combination with hyperuricemia and gout. Terapevticheskii arkhiv 92:5, pages 110-118.
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Canan ERSOY. (2020) SGLT 2 inhibitors: Antidiabetic agents with promising effects beyond glucose control. Turkish Journal of Internal Medicine 2:1, pages 1-4.
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Belma Turan. 2020. Biochemistry of Cardiovascular Dysfunction in Obesity. Biochemistry of Cardiovascular Dysfunction in Obesity 125 144 .
Chiara Maria Assunta Cefalo, Francesca Cinti, Simona Moffa, Flavia Impronta, Gian Pio Sorice, Teresa Mezza, Alfredo Pontecorvi & Andrea Giaccari. (2019) Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives. Cardiovascular Diabetology 18:1.
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Priyanka A. Shah, Pranav S. Shrivastav, Vinay Sharma & Manish S. Yadav. (2019) Challenges in simultaneous extraction and chromatographic separation of metformin and three SGLT-2 inhibitors in human plasma using LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 175, pages 112790.
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Oğuz Akkuş, Gamze Akkuş & Onur Kaypaklı. (2019) The Possible Effects of Dapagliflozin on 12-derived Electrocardiogram in Patients with Type 2 Diabetes Mellitus. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:2, pages 207-213.
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Yajing Zhang, Huazhuo Ban, Runan Yu, Zhijian Wang & Dayong Zhang. (2018) Recent progress of sodium-glucose transporter 2 inhibitors as potential antidiabetic agents. Future Medicinal Chemistry 10:10, pages 1261-1276.
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Hala AhmadiehSami Azar. (2017) Effects of Sodium Glucose Cotransporter-2 Inhibitors on Serum Uric Acid in Type 2 Diabetes Mellitus. Diabetes Technology & Therapeutics 19:9, pages 507-512.
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Hermann Koepsell. (2017) The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer. Pharmacology & Therapeutics 170, pages 148-165.
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Volker Vallon & Scott C. Thomson. (2016) Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. Diabetologia 60:2, pages 215-225.
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Naveed Sattar, James McLaren, S?ren L. Kristensen, David Preiss & John J. McMurray. (2016) SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?. Diabetologia 59:7, pages 1333-1339.
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