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Drug Evaluations

Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib

, MD & , MD
Pages 775-785 | Published online: 26 Feb 2013

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Phoebe F. Lamie & John N. Philoppes. (2020) 2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 864-879.
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Hui Gao, Songqing Mei, Jing Zhao, Kangcheng Zheng & Siyan Liao. (2019) Study on the binding mode of a pyrrolotriazin derivative with JAK2 by docking and MD simulation. Molecular Simulation 45:3, pages 230-238.
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Pan Xu, Guang Hu, Cheng Luo & Zhongjie Liang. (2016) DNA methyltransferase inhibitors: an updated patent review (2012-2015). Expert Opinion on Therapeutic Patents 26:9, pages 1017-1030.
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Eleftheria Hatzimichael, Evangelos Tsolas & Evangelos Briasoulis. (2014) Profile of pacritinib and its potential in the treatment of hematologic disorders. Journal of Blood Medicine 5, pages 143-152.
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Tariq I. Mughal, Saulius Girnius, Steven T. Rosen, Shaji Kumar, Adrian Wiestner, Omar Abdel-Wahab, Jean-Jacques Kiladjian, Wyndham H. Wilson & Richard A. Van Etten. (2014) Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies. Leukemia & Lymphoma 55:9, pages 1968-1979.
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Naveen Pemmaraju, Hagop Kantarjian, Michael Andreeff, Jorge Cortes & Farhad Ravandi. (2014) Investigational FMS-like tyrosine kinase 3 inhibitors in treatment of acute myeloid leukemia. Expert Opinion on Investigational Drugs 23:7, pages 943-954.
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Tomi K Sawyer, Joe C Wu, Jonathon R Sawyer & Jessie M English. (2013) Protein kinase inhibitors: breakthrough medicines and the next generation. Expert Opinion on Investigational Drugs 22:6, pages 675-678.
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Articles from other publishers (21)

Yang Zhang, Ji Li, Haiying Zhong, Xiang Xiao, Zhihua Wang, Zhao Cheng, Cunhong Hu, Guangsen Zhang & Sufang Liu. (2021) The JAK2 inhibitor TG101209 exhibits anti-tumor and chemotherapeutic sensitizing effects on Burkitt lymphoma cells by inhibiting the JAK2/STAT3/c-MYB signaling axis. Cell Death Discovery 7:1.
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Boheng Li, Qin Wan, Zhubo Li & Wee-Joo Chng. (2021) Janus Kinase Signaling: Oncogenic Criminal of Lymphoid Cancers. Cancers 13:20, pages 5147.
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Patricia Johansson, Ludger Klein-Hitpass, Bettina Budeus, Matthias Kuhn, Chris Lauber, Michael Seifert, Ingo Roeder, Roman Pförtner, Martin Stuschke, Ulrich Dührsen, Anja Eckstein, Jan Dürig & Ralf Küppers. (2020) Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing. Cancers 12:4, pages 986.
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Moses Kasembeli, Uddalak Bharadwaj, Prema Robinson & David Tweardy. (2018) Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. International Journal of Molecular Sciences 19:8, pages 2299.
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Charles J. Malemud. (2018) The role of the JAK/STAT signal pathway in rheumatoid arthritis. Therapeutic Advances in Musculoskeletal Disease 10:5-6, pages 117-127.
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Anas Younes, Stephen Ansell, Nathan Fowler, Wyndham Wilson, Sven de Vos, John Seymour, Ranjana Advani, Andres Forero, Franck Morschhauser, Marie Jose Kersten, Kensei Tobinai, Pier Luigi Zinzani, Emanuele Zucca, Jeremy Abramson & Julie Vose. (2016) The landscape of new drugs in lymphoma. Nature Reviews Clinical Oncology 14:6, pages 335-346.
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Charles Malemud. (2017) Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis. International Journal of Molecular Sciences 18:3, pages 484.
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Yazhou Wang, Wei Huang, Minhang Xin, Pan Chen, Li Gui, Xinge Zhao, Feng Tang, Jia Wang & Fei Liu. (2017) Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors. Bioorganic & Medicinal Chemistry 25:1, pages 75-83.
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Daniel Beck, Jenny Zobel, Ruth Barber, Sian Evans, Larissa Lezina, Rebecca L. Allchin, Matthew Blades, Richard Elliott, Christopher J. Lord, Alan Ashworth, Andrew C.G. Porter & Simon D. Wagner. (2016) Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. Journal of Biological Chemistry 291:32, pages 16686-16698.
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Tingfang Wang, Xiaofei Liu, Meixi Hao, Jianan Qiao, Caoyun Ju, Lingjing Xue & Can Zhang. (2016) Design, synthesis and evaluation of pyrrolo[2,3-d]pyrimidine-phenylamide hybrids as potent Janus kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters 26:12, pages 2936-2941.
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E. V. Pankratova, A. G. Stepchenko, I. D. Krylova, T. N. Portseva & S. G. Georgieva. (2016) Involvement of transcription factor Oct-1 in the regulation of JAK–STAT signaling pathway in cells of Burkitt lymphoma. Doklady Biochemistry and Biophysics 468:1, pages 229-231.
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Melissa M. Vasbinder, Marat Alimzhanov, Martin Augustin, Geraldine Bebernitz, Kirsten Bell, Claudio Chuaqui, Tracy Deegan, Andrew D. Ferguson, Kelly Goodwin, Dennis Huszar, Aarti Kawatkar, Sameer Kawatkar, Jon Read, Jie Shi, Stefan Steinbacher, Holger Steuber, Qibin Su, Dorin Toader, Haixia Wang, Richard Woessner, Allan Wu, Minwei Ye & Michael Zinda. (2016) Identification of azabenzimidazoles as potent JAK1 selective inhibitors. Bioorganic & Medicinal Chemistry Letters 26:1, pages 60-67.
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Uddalak Bharadwaj, Moses M. Kasembeli & David J. Tweardy. 2016. STAT Inhibitors in Cancer. STAT Inhibitors in Cancer 95 161 .
Rosalba Camicia, Hans C. Winkler & Paul O. Hassa. (2015) Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Molecular Cancer 14:1.
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Stephanie C. Casey, Amedeo Amedei, Katia Aquilano, Asfar S. Azmi, Fabian Benencia, Dipita Bhakta, Alan E. Bilsland, Chandra S. Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G. Georgakilas, Gunjan Guha, Dorota Halicka, William G. Helferich, Petr Heneberg, Kanya Honoki, W. Nicol Keith, Sid P. Kerkar, Sulma I. Mohammed, Elena Niccolai, Somaira Nowsheen, H.P. Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H. Talib, Vasundara Venkateswaran, Richard L. Whelan, Xujuan Yang & Dean W. Felsher. (2015) Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology 35, pages S199-S223.
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Xiao Xiong, Haoliang Yuan, Yanmin Zhang, Jinxing Xu, Ting Ran, Haichun Liu, Shuai Lu, Anyang Xu, Hongmei Li, Yulei Jiang, Tao Lu & Yadong Chen. (2015) Protein flexibility oriented virtual screening strategy for JAK2 inhibitors. Journal of Molecular Structure 1097, pages 136-144.
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Kurt Zimmermann, Xiaopeng Sang, Harold A. Mastalerz, Walter L. Johnson, Guifen Zhang, Qingjie Liu, Douglas Batt, Louis J. Lombardo, Dinesh Vyas, George L. Trainor, John S. Tokarski, Matthew V. Lorenzi, Dan You, Marco M. Gottardis, Jonathan Lippy, Javed Khan, John S. Sack & Ashok V. Purandare. (2015) 9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors. Bioorganic & Medicinal Chemistry Letters 25:14, pages 2809-2812.
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Lohith S Bachegowda & Stefan K Barta. (2014) Genetic and molecular targets in lymphoma: implications for prognosis and treatment. Future Oncology 10:15, pages 2509-2528.
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Yordanka Tirefort, Xuan-Cuong Pham, Yasmine Lucile Ibrahim, Thomas Pierre Lecompte, Thomas Matthes, Christa Prins, Begonia Cortes, Michael Bernimoulin, Yves Chalandon & Kaveh Samii. (2014) A rare case of primary cutaneous follicle centre lymphoma presenting as a giant tumour of the scalp and combined with JAK2V617F positive essential thrombocythaemia. Biomarker Research 2:1.
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Anders Poulsen, Anthony D. William & Brian W. Dymock. 2014. Macrocycles in Drug Discovery. Macrocycles in Drug Discovery 141 205 .
Zheng-Yan Chang, Ran Sun, Yu-Shui Ma, Da Fu, Xiao-Long Lai, Yu-Sheng Li, Xing-Hong Wang, Xiao-Ping Zhang, Zhong-Wei Lv, Xian-Ling Cong & Wen-Ping Li. (2014) Differential gene expression of the key signalling pathway in para-carcinoma, carcinoma and relapse human pancreatic cancer. Cell Biochemistry and Function 32:3, pages 258-267.
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