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Expert Opinion on Investigational Drugs Volume 22, 2013 - Issue 4
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Is GPR119 agonism an appropriate treatment modality for the safe amelioration of metabolic diseases?

Lauren M CornallVictoria University, College of Health and Biomedicine, Biomedical and Lifestyle Diseases Unit, Melbourne, [email protected]
,
Michael L MathaiVictoria University, College of Health and Biomedicine, Biomedical and Lifestyle Diseases Unit, Melbourne, [email protected];The University of Melbourne, Howard Florey Institute, Melbourne, Australia
,
Deanne H HryciwThe University of Melbourne, Department of Physiology, Melbourne, Australia
&
Andrew J McAinchVictoria University, College of Health and Biomedicine, Biomedical and Lifestyle Diseases Unit, Melbourne, [email protected]
Pages 487-498 | Published online: 27 Feb 2013

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Huilan Li, Yuanying Fang, Shuchun Guo & Zunhua Yang. (2021) GPR119 agonists for the treatment of type 2 diabetes: an updated patent review (2014-present). Expert Opinion on Therapeutic Patents 31:9, pages 795-808.
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Articles from other publishers (16)

Jianan Zhao, Yu Zhao, Yiyang Hu & Jinghua Peng. (2021) Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease. Cellular & Molecular Biology Letters 26:1.
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Hermann AM Mucke. (2018) Patent highlights from December 2017 to January 2018. Pharmaceutical Patent Analyst 7:3, pages 111-119.
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Iain R Tough, Sarah Forbes, Herbert Herzog, Robert M Jones, Thue W Schwartz & Helen M Cox. (2018) Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa. Endocrinology 159:4, pages 1704-1717.
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Qiankun Bao, Yajin Liu, Hao Song, Nan Yang, Ding Ai, Yi Zhu & Xu Zhang. (2018) Spectrum evaluation-assisted eicosanoid metabolomics for global eicosanoid profiling in human vascular endothelial cells. Clinical and Experimental Pharmacology and Physiology 45:1, pages 98-108.
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Yuanying Fang, Zunhua Yang, Shankariah Gundeti, Jongkook Lee & Haeil Park. (2017) Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists. Bioorganic & Medicinal Chemistry 25:1, pages 254-260.
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Tian Zhou, Jia-wang Ding, Xin-An Wang & Xia-xia Zheng. (2016) Long noncoding RNAs and atherosclerosis. Atherosclerosis 248, pages 51-61.
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Kurt Ritter, Christian Buning, Nis Halland, Christoph Pöverlein & Lothar Schwink. (2015) G Protein-Coupled Receptor 119 (GPR119) Agonists for the Treatment of Diabetes: Recent Progress and Prevailing Challenges. Journal of Medicinal Chemistry 59:8, pages 3579-3592.
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Brian M. Moran, Peter R. Flatt & Aine M. McKillop. (2016) G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis. Acta Diabetologica 53:2, pages 177-188.
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Daryl Hodge, Leslie L. Glass, Eleftheria Diakogiannaki, Ramona Pais, Carol Lenaghan, David M. Smith, Marianne Wedin, Mohammad Bohlooly-Y, Fiona M. Gribble & Frank Reimann. (2016) Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 77, pages 16-20.
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Jin Won Yang, Hyo Seon Kim, Ji Hye Im, Ji Won Kim, Dae Won Jun, Sung Chul Lim, Kyeong Lee, Jong Min Choi, Sang Kyum Kim & Keon Wook Kang. (2015) GPR119: a promising target for nonalcoholic fatty liver disease. The FASEB Journal 30:1, pages 324-335.
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J. Daniel Hothersall, Charlotte E. Bussey, Alastair J. Brown, James S. Scott, Ian Dale & Philip Rawlins. (2015) Sustained wash-resistant receptor activation responses of GPR119 agonists. European Journal of Pharmacology 762, pages 430-442.
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Lauren M. Cornall, Deanne H. Hryciw, Michael L. Mathai & Andrew J. McAinch. (2015) Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity. Molecular and Cellular Endocrinology 402, pages 72-85.
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Shuyong Zhang, Yuyong Ma, Jing Li, Junjun Ma, Biao Yu & Xin Xie. (2014) Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder . Proceedings of the National Academy of Sciences 111:40, pages 14571-14576.
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S Patel, O J Mace, I R Tough, J White, T-A Cock, U Warpman Berglund, M Schindler & H M Cox. (2014) Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes. International Journal of Obesity 38:10, pages 1365-1373.
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Yingcai Wang, Ming Yu, Jiang Zhu, Jian (Ken) Zhang, Frank Kayser, Julio C. Medina, Karen Siegler, Marion Conn, Bei Shan, Mark P. Grillo, Jiwen (Jim) Liu & Peter Coward. (2014) Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel gpr119 agonists. Bioorganic & Medicinal Chemistry Letters 24:4, pages 1133-1137.
Crossref
Sang-Uk Kang. (2013) GPR119 agonists: a promising approach for T2DM treatment? A SWOT analysis of GPR119. Drug Discovery Today 18:23-24, pages 1309-1315.
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