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Therapeutic potential of serum and glucocorticoid inducible kinase inhibition

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Pages 701-714 | Published online: 19 Mar 2013

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Inés Maestro, Patricia Boya & Ana Martinez. (2020) Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases. Expert Opinion on Therapeutic Targets 24:3, pages 231-243.
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Guilai Liu, Sabina Honisch, Guoxing Liu, Sebastian Schmidt, Stavros Pantelakos, Saad Alkahtani, Mahmoud Toulany, Florian Lang & Christos Stournaras. (2015) Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells. Cancer Biology & Therapy 16:1, pages 52-59.
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Daphne W Bell. (2014) Novel genetic targets in endometrial cancer. Expert Opinion on Therapeutic Targets 18:7, pages 725-730.
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Florian Lang, Christos Stournaras & Ioana Alesutan. (2014) Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1. Molecular Membrane Biology 31:1, pages 29-36.
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Tomi K Sawyer, Joe C Wu, Jonathon R Sawyer & Jessie M English. (2013) Protein kinase inhibitors: breakthrough medicines and the next generation. Expert Opinion on Investigational Drugs 22:6, pages 675-678.
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Florian Lang, Konstantinos Alevizopoulos & Christos Stournaras. (2013) Targeting membrane androgen receptors in tumors. Expert Opinion on Therapeutic Targets 17:8, pages 951-963.
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Maressa A Bruhn, Richard B Pearson, Ross D Hannan & Karen E Sheppard. (2013) AKT-independent PI3-K signaling in cancer – emerging role for SGK3. Cancer Management and Research 5, pages 281-292.
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Articles from other publishers (63)

Violina Kakoty, Sarathlal Kalarikkal Chandran, Monica Gulati, Bey Hing Goh, Kamal Dua & Sachin Kumar Singh. (2023) Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson’s Disease. Drug Discovery Today 28:6, pages 103582.
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Hyunsoo Jang, Youngjun Park & Jaebong Jang. (2022) Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors. Frontiers in Pharmacology 13.
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Hui Zhang, Chen Shen, Hong-Rui Zhang, Hua-Zhao Qi, Mei-Ling Hu & Qing-Qing Luo. (2022) Identification of Novel Inhibitors Targeting SGK1 via Ensemble-Based Virtual Screening Method, Biological Evaluation and Molecular Dynamics Simulation. International Journal of Molecular Sciences 23:15, pages 8635.
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Junshi Zhang, Chunhua Han, Zhenjie Xiong, Manman Qiu, Xiaopeng Tuo, Chenchen Wang, Wentao Qiao & Juan Tan. (2022) SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication. Microbiology Spectrum 10:3.
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Xiaowen Huang, Yan Wang, Yumei Qiu, Qinbo Shi, Danqin Sun, Junwei Yang, Chunsun Dai & Weichun He. (2022) Resveratrol ameliorates high-phosphate-induced VSMCs to osteoblast-like cells transdifferentiation and arterial medial calcification in CKD through regulating Wnt/β-catenin signaling. European Journal of Pharmacology 925, pages 174953.
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Sean J. Miller, Cameron E. Campbell, Helen A. Jimenez-Corea, Guan-Hui Wu & Robert Logan. (2022) Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease. Frontiers in Neuroscience 16.
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Mengyang Cai, Ningzhi Zhang, Dong Yang, Qibin Jiao, Peng Qu & Yuanyuan Zhang. (2022) High expression of SGK1 in thrombosis of acute ST-segment elevation myocardial infarction: Based on proteomics analysis of intracoronary thrombosis. Revista Portuguesa de Cardiologia 41:4, pages 271-279.
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Nis Halland, Friedemann Schmidt, Tilo Weiss, Ziyu Li, Jörg Czech, Joachim Saas, Danping Ding-Pfennigdorff, Matthias K. Dreyer, Carsten Strübing & Marc Nazare. (2021) Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. Journal of Medicinal Chemistry 65:2, pages 1567-1584.
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Taj Mohammad & Md. Imtaiyaz Hassan. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors 223 238 .
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Enrico Rango, Lucia D'Antona, Giulia Iovenitti, Annalaura Brai, Arianna Mancini, Claudio Zamperini, Claudia Immacolata Trivisani, Stefano Marianelli, Anna Lucia Fallacara, Alessio Molinari, Annarita Cianciusi, Silvia Schenone, Nicola Perrotti, Elena Dreassi & Maurizio Botta. (2021) Si113-prodrugs selectively activated by plasmin against hepatocellular and ovarian carcinoma. European Journal of Medicinal Chemistry 223, pages 113653.
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Natalia de las Heras, Adrián Galiana, Sandra Ballesteros, Elena Olivares-Álvaro, Peter J. Fuller, Vicente Lahera & Beatriz Martín-Fernández. (2021) Proanthocyanidins Maintain Cardiac Ionic Homeostasis in Aldosterone-Induced Hypertension and Heart Failure. International Journal of Molecular Sciences 22:17, pages 9602.
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Baowen Liu, Ningbo Li, Zhigang He, Xianwei Zhang & Guangyou Duan. (2021) Emerging Role of Serum Glucocorticoid-Regulated Kinase 1 in Pathological Pain. Frontiers in Molecular Neuroscience 14.
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Min Zhang, Huan Chen, Meng‐si Liu, Ke‐ying Zhu, Yan Hao, Da‐long Zhu & Ping Li. (2021) Serum‐ and glucocorticoid‐inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1. Diabetes/Metabolism Research and Reviews 37:4.
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Oh‐Chan Kwon, Jae‐Jin Song, Yunseon Yang, Seong‐Hoon Kim, Ji Young Kim, Min‐Jong Seok, Inhwa Hwang, Je‐Wook Yu, Jenisha Karmacharya, Han‐Joo Maeng, Jiyoung Kim, Eek‐hoon Jho, Seung Yeon Ko, Hyeon Son, Mi‐Yoon Chang & Sang‐Hun Lee. (2021) SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models. EMBO Molecular Medicine 13:4.
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Miguel Olivas-Aguirre, Liliana Torres-López, Igor Pottosin & Oxana Dobrovinskaya. (2021) Overcoming Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: Repurposed Drugs Can Improve the Protocol. Frontiers in Oncology 11.
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Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl & Ioana Alesutan. (2021) Acid sphingomyelinase promotes SGK1-dependent vascular calcification. Clinical Science 135:3, pages 515-534.
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Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Shiori Seki, Yoshika Tomonari, Shoutaro Koizumi, Miki Nagatakiya, Mai Katsuyama, Yuuta Yamamoto, Katsumasa Tsurushima, Toshihiko Ishizaka & Shozo Nishida. (2021) Activation of Serum/Glucocorticoid Regulated Kinase 1/Nuclear Factor-κB Pathway Are Correlated with Low Sensitivity to Bortezomib and Ixazomib in Resistant Multiple Myeloma Cells. Biomedicines 9:1, pages 33.
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Florian Lang, Janet Rajaxavier, Yogesh Singh, Sara Y. Brucker & Madhuri S. Salker. (2020) The Enigmatic Role of Serum & Glucocorticoid Inducible Kinase 1 in the Endometrium. Frontiers in Cell and Developmental Biology 8.
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Florian Poetsch, Laura A. Henze, Misael Estepa, Barbara Moser, Burkert Pieske, Florian Lang, Kai-Uwe Eckardt, Ioana Alesutan & Jakob Voelkl. (2020) Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions. International Journal of Molecular Sciences 21:19, pages 7207.
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Hermann Koepsell. (2020) Glucose transporters in the small intestine in health and disease. Pflügers Archiv - European Journal of Physiology 472:9, pages 1207-1248.
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Vincenzo Dattilo, Rosario Amato, Nicola Perrotti & Massimo Gennarelli. (2020) The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms. Frontiers in Genetics 11.
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Taj Mohammad, Shiza Siddiqui, Anas Shamsi, Mohamed F. Alajmi, Afzal Hussain, Asimul Islam, Faizan Ahmad & Md. Imtaiyaz Hassan. (2020) Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies. Molecules 25:4, pages 823.
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Lisann Pelzl, Itishri Sahu, Ke Ma, David Heinzmann, Abdulla Al Mamun Bhuyan, Tamer al-Maghout, Basma Sukkar, Yamini Sharma, Irene Marini, Flaviana Rigoni, Ferruh Artunc, Hang Cao, Ravi Gutti, Jakob Voelkl, Burkert Pieske, Meinrad Gawaz, Tamam Bakchoul & Florian Lang. (2020) Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca2+ Entry in Megakaryocytes. Scientific Reports 10:1.
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Silvia Matteoni, Claudia Abbruzzese, Paola Matarrese, Gabriele De Luca, Anna M. Mileo, Stefania Miccadei, Silvia Schenone, Francesca Musumeci, Tobias L. Haas, Giovanni Sette, Carmine M. Carapella, Rosario Amato, Nicola Perrotti, Michele Signore & Marco G. Paggi. (2019) The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. Journal of Experimental & Clinical Cancer Research 38:1.
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Narges Dastmalchi, Seyed Mahdi Banan Khojasteh, Mirsaed Miri Nargesi & Reza Safaralizadeh. (2020) The correlation between lncRNAs and Helicobacter pylori in gastric cancer . Pathogens and Disease 77:9.
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Claudia Abbruzzese, Silvia Matteoni, Michele Persico, Barbara Ascione, Silvia Schenone, Francesca Musumeci, Rosario Amato, Nicola Perrotti, Paola Matarrese & Marco G. Paggi. (2019) The small molecule SI113 hinders epithelial‐to‐mesenchymal transition and subverts cytoskeletal organization in human cancer cells. Journal of Cellular Physiology 234:12, pages 22529-22542.
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Daofang Jiang, Chensheng Fu, Jing Xiao, Zhenxing Zhang, Jianan Zou, Zhibin Ye & Xiaoli Zhang. (2019) SGK1 Attenuates Oxidative Stress-Induced Renal Tubular Epithelial Cell Injury by Regulating Mitochondrial Function. Oxidative Medicine and Cellular Longevity 2019, pages 1-12.
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Lucia D'Antona, Vincenzo Dattilo, Giada Catalogna, Domenica Scumaci, Claudia Vincenza Fiumara, Francesca Musumeci, Giuseppe Perrotti, Silvia Schenone, Rossana Tallerico, Cristina B. Spoleti, Nicola Costa, Rodolfo Iuliano, Giovanni Cuda, Rosario Amato & Nicola Perrotti. (2019) In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity. Translational Oncology 12:8, pages 1045-1055.
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Nadeshda Schelski, Trang T. D. Luong, Florian Lang, Burkert Pieske, Jakob Voelkl & Ioana Alesutan. (2019) SGK1-dependent stimulation of vascular smooth muscle cell osteo-/chondrogenic transdifferentiation by interleukin-18. Pflügers Archiv - European Journal of Physiology 471:6, pages 889-899.
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Jakob Voelkl, Florian Lang, Kai-Uwe Eckardt, Kerstin Amann, Makoto Kuro-o, Andreas Pasch, Burkert Pieske & Ioana Alesutan. (2019) Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cellular and Molecular Life Sciences.
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Rashad Tuffaha, Jakob Voelkl, Burkert Pieske, Florian Lang & Ioana Alesutan. (2018) Role of PKB/SGK-dependent phosphorylation of GSK-3α/β in vascular calcification during cholecalciferol overload in mice. Biochemical and Biophysical Research Communications 503:3, pages 2068-2074.
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Wenqiang Gan, Tiegang Li, Jingyuan Ren, Chenghe Li, Ziliang Liu & Min Yang. (2017) Serum–glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts. Molecular and Cellular Biochemistry 445:1-2, pages 67-78.
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Jakob Voelkl, Trang T.D. Luong, Rashad Tuffaha, Katharina Musculus, Tilman Auer, Xiaoming Lian, Christoph Daniel, Daniel Zickler, Beate Boehme, Michael Sacherer, Bernhard Metzler, Dietmar Kuhl, Maik Gollasch, Kerstin Amann, Dominik N. Müller, Burkert Pieske, Florian Lang & Ioana Alesutan. (2018) SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling. Journal of Clinical Investigation 128:7, pages 3024-3040.
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Jakob Voelkl, Rashad Tuffaha, Trang T.D. Luong, Daniel Zickler, Jaber Masyout, Martina Feger, Nicolas Verheyen, Florian Blaschke, Makoto Kuro-o, Andreas Tomaschitz, Stefan Pilz, Andreas Pasch, Kai-Uwe Eckardt, Juergen E. Scherberich, Florian Lang, Burkert Pieske & Ioana Alesutan. (2018) Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB. Journal of the American Society of Nephrology 29:6, pages 1636-1648.
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Claudia Abbruzzese, Giada Catalogna, Enzo Gallo, Simona di Martino, Anna M. Mileo, Mariantonia Carosi, Vincenzo Dattilo, Silvia Schenone, Francesca Musumeci, Patrizia Lavia, Nicola Perrotti, Rosario Amato & Marco G. Paggi. (2017) The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget 8:67, pages 110743-110755.
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