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Next generation of mammalian target of rapamycin inhibitors for the treatment of cancer

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Pages 715-722 | Published online: 02 Apr 2013

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Nisha A. Mohindra & Leonidas C. Platanias. (2015) Catalytic mammalian target of rapamycin inhibitors as antineoplastic agents. Leukemia & Lymphoma 56:9, pages 2518-2523.
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Nisha A Mohindra, Francis J Giles & Leonidas C Platanias. (2014) Use of mTOR inhibitors in the treatment of malignancies. Expert Opinion on Pharmacotherapy 15:7, pages 979-990.
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Xiaoqing Lv, Xiaodong Ma & Yongzhou Hu. (2013) Furthering the design and the discovery of small molecule ATP-competitive mTOR inhibitors as an effective cancer treatment. Expert Opinion on Drug Discovery 8:8, pages 991-1012.
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Tomi K Sawyer, Joe C Wu, Jonathon R Sawyer & Jessie M English. (2013) Protein kinase inhibitors: breakthrough medicines and the next generation. Expert Opinion on Investigational Drugs 22:6, pages 675-678.
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Zhaoming Lu, Xiaojing Shi, Fanghua Gong, Shenglei Li, Yang Wang, Yandan Ren, Mengyin Zhang, Bin Yu, Yan Li, Wen Zhao, Jianying Zhang & Guiqin Hou. (2020) RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma. Acta Pharmaceutica Sinica B 10:6, pages 1004-1019.
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Lauren Herschbein & Jane L. Liesveld. (2018) Dueling for dual inhibition: Means to enhance effectiveness of PI3K/Akt/mTOR inhibitors in AML. Blood Reviews 32:3, pages 235-248.
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Joshua M. Gammon, Emily A. Gosselin, Lisa H. Tostanoski, Yu-Chieh Chiu, Xiangbin Zeng, Qin Zeng & Christopher M. Jewell. (2017) Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells. Journal of Controlled Release 263, pages 151-161.
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Marianna Hösel, Anke Huber, Susanne Bohlen, Julie Lucifora, Giuseppe Ronzitti, Francesco Puzzo, Florence Boisgerault, Ulrich T. Hacker, Wilhelmus J. Kwanten, Nora Klöting, Matthias Blüher, Alexander Gluschko, Michael Schramm, Olaf Utermöhlen, Wilhelm Bloch, Federico Mingozzi, Oleg Krut & Hildegard Büning. (2017) Autophagy determines efficiency of liver‐directed gene therapy with adeno‐associated viral vectors. Hepatology 66:1, pages 252-265.
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David R. Driscoll, Saadia A Karim, Makoto Sano, David M. Gay, Wright Jacob, Jun Yu, Yusuke Mizukami, Aarthi Gopinathan, Duncan I. Jodrell, T.R. Jeffry Evans, Nabeel Bardeesy, Michael N. Hall, Brian J. Quattrochi, David S. Klimstra, Simon T. Barry, Owen J. Sansom, Brian C. Lewis & Jennifer P. Morton. (2016) mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer. Cancer Research 76:23, pages 6911-6923.
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Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 549 572 .
Michael P. Sanderson, Joshua Apgar, Pilar Garin-Chesa, Marco H. Hofmann, Dirk Kessler, Jens Quant, Alexander Savchenko, Otmar Schaaf, Matthias Treu, Heather Tye, Stephan K. Zahn, Andreas Zoephel, Eric Haaksma, Günther R. Adolf & Norbert Kraut. (2015) BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Molecular Cancer Therapeutics 14:12, pages 2762-2772.
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Laura Falasca, Francesco Torino, Matteo Marconi, Manuela Costantini, Vincenzo Pompeo, Steno Sentinelli, Laura De Salvo, Mario Patrizio, Cristiano Padula, Michele Gallucci, Mauro Piacentini & Walter Malorni. (2015) AMBRA1 and SQSTM1 expression pattern in prostate cancer. Apoptosis 20:12, pages 1577-1586.
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HI Onen, A Yilmaz, E Alp, A Celik, SM Demiroz, E Konac, IC Kurul & ES Menevse. (2014) EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells. Human & Experimental Toxicology 34:2, pages 117-126.
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Francesca Chiarini, Camilla Evangelisti, James A. McCubrey & Alberto M. Martelli. (2015) Current treatment strategies for inhibiting mTOR in cancer. Trends in Pharmacological Sciences 36:2, pages 124-135.
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Diana Saleiro & Leonidas C. Platanias. (2015) Intersection of mTOR and STAT signaling in immunity. Trends in Immunology 36:1, pages 21-29.
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JULIETA AFONSO, ADHEMAR LONGATTO-FILHO, VITOR MOREIRA DA SILVA, TERESINA AMARO & LÚCIO L. SANTOS. (2014) Phospho-mTOR in non-tumour and tumour bladder urothelium: Pattern of expression and impact on urothelial bladder cancer patients. Oncology Letters 8:4, pages 1447-1454.
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Jessica K. Altman, Amy Szilard, Dennis J. Goussetis, Antonella Sassano, Marco Colamonici, Elias Gounaris, Olga Frankfurt, Francis J. Giles, Elizabeth A. Eklund, Elspeth M. Beauchamp & Leonidas C. Platanias. (2014) Autophagy Is a Survival Mechanism of Acute Myelogenous Leukemia Precursors during Dual mTORC2/mTORC1 Targeting. Clinical Cancer Research 20:9, pages 2400-2409.
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