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Expert Opinion on Investigational Drugs Volume 22, 2013 - Issue 10
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Drug Evaluations

Perifosine – a new option in treatment of acute myeloid leukemia?

Janusz KrawczykGalway University Hospital, Newcastle Rd, Galway, [email protected]
, MSc MRCPI FRCPpath,
Niamh KeaneNational University of Ireland, Clinical Research Facility, Galway, Ireland
, MB BCh BAO MRCPI,
Ronan SwordsUniversity of Miami, Sylvester Comprehensive Cancer Center, Division of Hematology/Oncology, Leukemia Program, 1475 NW 12th Avenue, Miami, FL 33136, USA
, MD PhD FRCPI FRCPath,
Michael O'DwyerNational University of Ireland, School of Medicine, Galway, Ireland
, MD FRCPI FRCPath,
Ciara L FreemanBarts and the Royal London NHS Trust, Department of Haematology, London, E1 2ES, UK
, MB BCh BAO MRCPI &
Francis J GilesNational University of Ireland Galway & Trinity College, HRB Clinical Research Facility, Dublin, Ireland
, MB MD FRCPI FRCPath
Pages 1315-1327 | Published online: 09 Aug 2013

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Benedito A Carneiro, Jason B Kaplan, Jessica K Altman, Francis J Giles & Leonidas C Platanias. (2015) Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia. Cancer Biology & Therapy 16:5, pages 648-656.
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Articles from other publishers (8)

Nne E. Uko, Osman F. Güner, Diane F. Matesic & J. Phillip Bowen. (2020) Akt Pathway Inhibitors. Current Topics in Medicinal Chemistry 20:10, pages 883-900.
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Yiran Chen, Xiaoling Xie, Anqin Wu, Lei Wang, Yuxing Hu, Honghao Zhang & Yuhua Li. (2018) A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia. Journal of Experimental & Clinical Cancer Research 37:1.
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Paul-Alain Jaffrès, Consuelo Gajate, Ana Maria Bouchet, Hélène Couthon-Gourvès, Aurélie Chantôme, Marie Potier-Cartereau, Pierre Besson, Philippe Bougnoux, Faustino Mollinedo & Christophe Vandier. (2016) Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy. Pharmacology & Therapeutics 165, pages 114-131.
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Maximilian Stahl, Tae Kon Kim & Amer M Zeidan. (2016) Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities. World Journal of Stem Cells 8:10, pages 316.
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Jie Shen, Yue Hong, Qiong Zhao & Jian-li Zhang. (2015) Preclinical evaluation of perifosine as a potential promising anti-rhabdomyosarcoma agent. Tumor Biology 37:1, pages 1025-1033.
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Benedito A. Carneiro, Joshua J. Meeks, Timothy M. Kuzel, Mariana Scaranti, Sarki A. Abdulkadir & Francis J. Giles. (2015) Emerging therapeutic targets in bladder cancer. Cancer Treatment Reviews 41:2, pages 170-178.
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Nadine Houédé & Philippe Pourquier. (2015) Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers. Pharmacology & Therapeutics 145, pages 1-18.
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Natalie G. Sanders, David J. Sullivan, Godfree Mlambo, George Dimopoulos & Abhai K. Tripathi. (2014) Gametocytocidal Screen Identifies Novel Chemical Classes with Plasmodium falciparum Transmission Blocking Activity. PLoS ONE 9:8, pages e105817.
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