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Investigational drugs in Alzheimer's disease: current progress

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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Floriana De Vanna, Dominga Laporta, Maria F. De Caro & Katia Pinto. (2020) Smartphone technology for fostering goal-directed ambulation and object use in people with moderate Alzheimer’s disease. Disability and Rehabilitation: Assistive Technology 15:7, pages 754-761.
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Jie Xiang, Kun Cao, Yang-Ting Dong, Yi Xu, Yi Li, Hui Song, Xiao-Xiao Zeng, Long-Yan Ran, Wei Hong & Zhi-Zhong Guan. (2020) Lithium chloride reduced the level of oxidative stress in brains and serums of APP/PS1 double transgenic mice via the regulation of GSK3β/Nrf2/HO-1 pathway. International Journal of Neuroscience 130:6, pages 564-573.
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Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yuting Qiao, Hongzhi Lin, Feng Feng, Wenyuan Liu, Yao Chen, Zongliang Liu & Haopeng Sun. (2020) Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 330-343.
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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D'Amico, Katia Pinto, Floriana De Vanna & Alessandro O. Caffò. (2018) Promoting supported ambulation in persons with advanced Alzheimer’s disease: a pilot study. Disability and Rehabilitation: Assistive Technology 13:1, pages 101-106.
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Jie Zhu, Hongyu Yang, Yao Chen, Hongzhi Lin, Qi Li, Jun Mo, Yaoyao Bian, Yuqiong Pei & Haopeng Sun. (2018) Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 496-506.
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Keshav Anand & Marwan Sabbagh. (2015) Early investigational drugs targeting tau protein for the treatment of Alzheimer’s disease. Expert Opinion on Investigational Drugs 24:10, pages 1355-1360.
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Qianyu Cai, Xian Guo, Yutong Chen, Jie Liu & Yanan Liu. (2023) Selenium-Doped 3D Porous Molybdenum Carbide Nanospheres Improve Mitochondrial Function by Reducing Oxidative Stress in Alzheimer’s Disease. ACS Applied Nano Materials 6:23, pages 22496-22505.
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Nan Li, Yu-han Duan, Lei Chen & Kun Zhang. (2023) Iron metabolism: An emerging therapeutic target underlying the anti-Alzheimer's disease effect of ginseng. Journal of Trace Elements in Medicine and Biology 79, pages 127252.
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Jiahao Li, Feng Zhang, Li Zhao & Chunbo Dong. (2023) Microbiota–gut–brain axis and related therapeutics in Alzheimer’s disease: prospects for multitherapy and inflammation control. Reviews in the Neurosciences 34:6, pages 695-718.
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Shuntai Chen, Dian Zhang, Honggang Zheng, Tianyu Cao, Kun Xia, Mingwan Su & Qinggang Meng. (2023) The association between retina thinning and hippocampal atrophy in Alzheimer’s disease and mild cognitive impairment: a meta-analysis and systematic review. Frontiers in Aging Neuroscience 15.
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Qian Li, Xi Yang, Jie Xu, Yi Guo, Xing He, Hui Hu, Tianchen Lyu, David Marra, Amber Miller, Glenn Smith, Steven DeKosky, Richard D. Boyce, Karen Schliep, Elizabeth Shenkman, Demetrius Maraganore, Yonghui Wu & Jiang Bian. (2023) Early prediction of Alzheimer's disease and related dementias using real‐world electronic health records. Alzheimer's & Dementia 19:8, pages 3506-3518.
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Xiaochu Tong, Dingyan Wang, Xiaoyu Ding, Xiaoqin Tan, Qun Ren, Geng Chen, Yu Rong, Tingyang Xu, Junzhou Huang, Hualiang Jiang, Mingyue Zheng & Xutong Li. (2022) Blood–brain barrier penetration prediction enhanced by uncertainty estimation. Journal of Cheminformatics 14:1.
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Afreen Hashmi, Vivek Srivastava, Syed Abul Kalam & Devesh Kumar Mishra. 2022. Alzheimer's Disease. Alzheimer's Disease.
Masoumeh Pourhadi, Hakimeh Zali, Rasoul Ghasemi & Saeed Vafaei-Nezhad. (2022) Promising Role of Oral Cavity Mesenchymal Stem Cell-Derived Extracellular Vesicles in Neurodegenerative Diseases. Molecular Neurobiology 59:10, pages 6125-6140.
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Anling Luo, Pingping Ning, Haitao Lu, Hongyan Huang, Qiuyan Shen, Dan Zhang, Fang Xu, Li Yang & Yanming Xu. (2022) Association Between Metformin and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Clinical Observational Studies. Journal of Alzheimer's Disease 88:4, pages 1311-1323.
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Rahat Ullah, Tae Ju Park, Xu Huang & Myeong Ok Kim. (2021) Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery. Ageing Research Reviews 71, pages 101451.
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Lechan Tao, Qi Liu, Fuli Zhang, Yuting Fu, Xi Zhu, Xiaofu Weng, Hongbin Han, Yong Huang, Yuanzhen Suo, Liang Chen, Xiaoling Gao & Xunbin Wei. (2021) Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model. Light: Science & Applications 10:1.
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Xian Guo, Qiaoshan Lie, Yanan Liu, Zhi Jia, Youcong Gong, Xiaoyu Yuan & Jie Liu. (2021) Multifunctional Selenium Quantum Dots for the Treatment of Alzheimer’s Disease by Reducing Aβ-Neurotoxicity and Oxidative Stress and Alleviate Neuroinflammation. ACS Applied Materials & Interfaces 13:26, pages 30261-30273.
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Jéssica Wouk, Daniele Zendrini Rechenchoski, Bianca Cerqueira Dias Rodrigues, Elisa Vicente Ribelato & Ligia Carla Faccin-Galhardi. (2021) Viral infections and their relationship to neurological disorders. Archives of Virology 166:3, pages 733-753.
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Ningbo Wang, Yongtao Zhou, Longhe Zhao, Caiding Wang, Wuli Ma, Guangfei Ge, Yu Wang, Inam Ullah, Fahim Muhammad, Dhafer Alwayli, Dejuan Zhi & Hongyu Li. (2020) Ferulic acid delayed amyloid β-induced pathological symptoms by autophagy pathway via a fasting-like effect in Caenorhabditis elegans. Food and Chemical Toxicology 146, pages 111808.
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Elahe Zarini-Gakiye, Javad Amini, Nima Sanadgol, Gholamhassan Vaezi & Kazem Parivar. (2020) Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials. Current Molecular Pharmacology 13:4, pages 273-294.
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Zhangjin Qin, Min Gu, Jian Zhou, Wenbo Zhang, Nan Zhao, Yang Lü & Weihua Yu. (2020) Triggering receptor expressed on myeloid cells 2 activation downregulates toll‐like receptor 4 expression and ameliorates cognitive impairment in the Aβ 1‐42 ‐induced Alzheimer's disease mouse model . Synapse 74:10.
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Satya P. Gupta & Vaishali M. Patil. (2020) Recent Studies on Design and Development of Drugs Against Alzheimer’s Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents. Current Topics in Medicinal Chemistry 20:13, pages 1195-1213.
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Cheng Kun, Sun Feiyi, Dong Jian, Chen Feng, Wu Guihua, Zhu Jiangping, Ji Jianwu, Liu Hong & Han Xiaowei. (2020) Network pharmacology-based study on the mechanism of Schisandra chinensis for treating Alzheimer's disease. Indian Journal of Pharmacology 52:2, pages 94.
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Federico Massa, Lucia Farotti, Paolo Eusebi, Elisabetta Capello, Massimo E. Dottorini, Cristina Tranfaglia, Matteo Bauckneht, Silvia Morbelli, Flavio Nobili & Lucilla Parnetti. (2019) Reciprocal Incremental Value of 18F-FDG-PET and Cerebrospinal Fluid Biomarkers in Mild Cognitive Impairment Patients Suspected for Alzheimer’s Disease and Inconclusive First Biomarker. Journal of Alzheimer's Disease 72:4, pages 1193-1207.
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Jun Mo, Hongyu Yang, Tingkai Chen, Qihang Li, Hongzhi Lin, Feng Feng, Wenyuan Liu, Wei Qu, Qinglong Guo, Heng Chi, Yao Chen & Haopeng Sun. (2019) Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors. Bioorganic Chemistry 93, pages 103310.
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Hongyu Yang, Chenxi Du, Qihang Li, Tingkai Chen, Xin Lu, Qi Li, Feng Feng, Yao Chen, Wenyuan Liu & Haopeng Sun. (2019) Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening. Bioorganic Chemistry 92, pages 103294.
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Armine Hovakimyan, Tatevik Antonyan, Sepideh Kiani Shabestari, Olga Svystun, Gor Chailyan, Morgan A. Coburn, William Carlen-Jones, Irina Petrushina, Jean Paul Chadarevian, Karen Zagorski, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Anahit Ghochikyan & Hayk Davtyan. (2019) A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice. Scientific Reports 9:1.
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Javier Fernández‐Ruiz. (2018) The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid‐based therapies to improve on the poor current therapeutic outcomes. British Journal of Pharmacology 176:10, pages 1370-1383.
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Eduarda G Z Centeno, Helena Cimarosti & Angela Bithell. (2018) 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. Molecular Neurodegeneration 13:1.
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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Dominga Laporta, Maria Giovanna Cattaneo, Antonella Scordamaglia & Katia Pinto. (2018) Technology-Based Behavioral Interventions for Daily Activities and Supported Ambulation in People With Alzheimer’s Disease. American Journal of Alzheimer's Disease & Other Dementiasr 33:5, pages 318-326.
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Liang Zhao, Yan Xiao, Jin Xiu, Long-Chun Tan & Zhi-Zhong Guan. (2018) Protection against the Neurotoxic Effects of β-Amyloid Peptide on Cultured Neuronal Cells by Lovastatin Involves Elevated Expression of α7 Nicotinic Acetylcholine Receptors and Activating Phosphorylation of Protein Kinases. The American Journal of Pathology 188:4, pages 1081-1093.
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Jun Wang, Ben J. Gu, Colin L. Masters & Yan-Jiang Wang. (2017) A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain. Nature Reviews Neurology 13:10, pages 612-623.
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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Katia Pinto & Claudia Chiapparino. (2017) Supporting Simple Activity Engagement in Persons With Moderate to Severe Alzheimer’s Disease Through a Technology-Aided Program. American Journal of Alzheimer's Disease & Other Dementiasr 32:3, pages 137-144.
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Javier Fernández-Ruiz, María Gómez-Ruiz, Concepción García, Mariluz Hernández & José A. Ramos. 2017. Cannabinoids and Their Receptors. Cannabinoids and Their Receptors 175 198 .
Jeffrey Cummings, Travis Morstorf & Garam Lee. (2016) Alzheimer's drug‐development pipeline: 2016. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2:4, pages 222-232.
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Geert Jan Groeneveld, Justin Luke Hay & Johannes Marinus Van Gerven. (2016) Measuring blood–brain barrier penetration using the NeuroCart, a CNS test battery. Drug Discovery Today: Technologies 20, pages 27-34.
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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Caterina Renna & Katia Pinto. (2016) Technology-Aided Programs to Support Positive Verbal and Physical Engagement in Persons with Moderate or Severe Alzheimer’s Disease. Frontiers in Aging Neuroscience 8.
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Jun Wang, Lan Tan & Jin-tai Yu. (2016) Prevention Trials in Alzheimer’s Disease: Current Status and Future Perspectives. Journal of Alzheimer's Disease 50:4, pages 927-945.
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Jaume Folch, Dmitry Petrov, Miren Ettcheto, Sonia Abad, Elena Sánchez-López, M. Luisa García, Jordi Olloquequi, Carlos Beas-Zarate, Carme Auladell & Antoni Camins. (2016) Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment. Neural Plasticity 2016, pages 1-15.
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Ya-lin Tu, Qiu-he Chen, Sheng-nan Wang, Asko Uri, Xiao-hong Yang, Jia-qi Chu, Jing-kao Chen, Bing-ling Luo, Xiao-hong Chen, Shi-jun Wen & Rong-biao Pi. (2016) Discovery of lipoic acid-4-phenyl-1H-pyrazole hybrids as novel bifunctional ROCK inhibitors with antioxidant activity. RSC Advances 6:63, pages 58516-58520.
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Javier Fernández-Ruiz, María A. Moro & José Martínez-Orgado. (2015) Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications. Neurotherapeutics 12:4, pages 793-806.
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Jong Hwan Kwak, Zhigang Yang, Byungkwon Yoon, Yanxia He, Soojin Uhm, Hyeon-Cheol Shin, Bong Ho Lee, Yung Choon Yoo, Kyung Bok Lee, Seung-Yun Han & Jong Seung Kim. (2015) Blood-brain barrier-permeable fluorone-labeled dieckols acting as neuronal ER stress signaling inhibitors. Biomaterials 61, pages 52-60.
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Giulio E. Lancioni, Nirbhay N. Singh, Mark F. O’Reilly, Jeff Sigafoos, Fiora D’Amico, Gabriele Ferlisi, Floriana Denitto, Floriana De Vanna & Marta Olivetti Belardinelli. (2015) Patients with moderate Alzheimer’s disease engage in verbal reminiscence with the support of a computer-aided program: a pilot study. Frontiers in Aging Neuroscience 7.
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Javier Fernández-Ruiz, Julián Romero & José A. Ramos. 2015. Endocannabinoids. Endocannabinoids 233 259 .

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