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Drug Evaluations

Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes

, MD, , BS & , MBBS FRCP FACP

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Suhani Sinha, Sonali, Vandana Garg, Sonia Thapa, Shashank Singh, Mahima Chauhan, Rohit Dutt & Rahul Pratap Singh. (2022) Empagliflozin containing chitosan-alginate nanoparticles in orodispersible film: preparation, characterization, pharmacokinetic evaluation and its in-vitro anticancer activity. Drug Development and Industrial Pharmacy 48:7, pages 279-291.
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Jyotsana Pandey & Akhilesh K Tamrakar. (2019) SGLT2 inhibitors for the treatment of diabetes: a patent review (2013-2018). Expert Opinion on Therapeutic Patents 29:5, pages 369-384.
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Anda Mihaela Naciu & Paolo Pozzilli. (2018) Novel blood glucose lowering therapies for managing type 1 diabetes in paediatric patients. Expert Opinion on Pharmacotherapy 19:4, pages 355-364.
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Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas. (2017) Dapagliflozin for the treatment of type 1 diabetes mellitus. Expert Opinion on Investigational Drugs 26:7, pages 873-881.
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Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan & Zhong-Min Liu. (2017) Evaluation of the pharmacokinetics, pharmacodynamics and clinical efficacy of empagliflozin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 211-223.
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Jay H Shubrook, Babak Baradar Bokaie & Sarah E Adkins. (2015) Empagliflozin in the treatment of type 2 diabetes: evidence to date. Drug Design, Development and Therapy 9, pages 5793-5803.
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Vlado Perkovic, Meg Jardine, Ujjwala Vijapurkar & Gary Meininger. (2015) Renal effects of canagliflozin in type 2 diabetes mellitus. Current Medical Research and Opinion 31:12, pages 2219-2231.
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Kashif M Munir & Stephen N Davis. (2015) The treatment of type 1 diabetes mellitus with agents approved for type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 16:15, pages 2331-2341.
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Roxana Pérez-Villavicencio, Javier Flores-Estrada, Martha Franco, Bruno Escalante, Oscar Pérez-Méndez, Adriana Mercado & Rocio Bautista-Pérez. (2022) Effect of Empagliflozin on Sphingolipid Catabolism in Diabetic and Hypertensive Rats. International Journal of Molecular Sciences 23:5, pages 2883.
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Donald J. AbrahamAna R. Jesus, Bryce A. Harrison & Timothy M. Dore. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 30 .
Idrisu Sanusi, Alexander Sarnowski, David Russell-Jones & Lui G. Forni. (2020) A potential diagnostic problem on the ICU: Euglycaemic diabetic Ketoacidosis associated with SGLT2 inhibition. Journal of Critical Care 57, pages 19-22.
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Ken Kanazawa, Hiroshi Uchino, Fumika Shigiyama, Hiroyuki Igarashi, Kayoko Ikehara, Fukumi Yoshikawa, Shuki Usui, Masahiko Miyagi, Hiroshi Yoshino, Yasuyo Ando, Naoki Kumashiro & Takahisa Hirose. (2019) Sustained fasting glucose oxidation and postprandial lipid oxidation associated with reduced insulin dose in type 2 diabetes with sodium–glucose cotransporter 2 inhibitor: A randomized, open‐label, prospective study. Journal of Diabetes Investigation 10:4, pages 1022-1031.
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Joanna Parkinson, Weifeng Tang, Magnus Åstrand, Johanna Melin, Ella Ekholm, Bengt Hamrén & David W. Boulton. (2019) Model‐based characterization of the relationship between dapagliflozin systemic exposure and HbA1c response in patients with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism 21:6, pages 1381-1387.
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A Lakshmana Rao, T. Prasanthi & E. L Anusha. (2019) RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LINAGLIPTIN AND EMPAGLIFLOZIN. INDIAN DRUGS 56:05, pages 68-71.
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Ewa Otto-Buczkowska & Natalia Jainta. (2017) Pharmacological Treatment in Diabetes Mellitus Type 1 – Insulin and What Else?. International Journal of Endocrinology and Metabolism 16:1.
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Nabila Ahmed-Sarwar, Angela K. Nagel, Samantha Leistman & Kevin Heacock. (2017) SGLT-2 Inhibitors: Is There a Role in Type 1 Diabetes Mellitus Management?. Annals of Pharmacotherapy 51:9, pages 791-796.
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Leyna Leite Santos, Fernando José Camello de Lima, Célio Fernando de Sousa-Rodrigues & Fabiano Timbó Barbosa. (2017) Use of SGLT-2 inhibitors in the treatment of type 2 diabetes mellitus. Revista da Associação Médica Brasileira 63:7, pages 636-641.
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Ralph A. DeFronzo, Luke Norton & Muhammad Abdul-Ghani. (2016) Renal, metabolic and cardiovascular considerations of SGLT2 inhibition. Nature Reviews Nephrology 13:1, pages 11-26.
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Vasileios Andrianesis, Spyridoula Glykofridi & John Doupis. (2016) The renal effects of SGLT2 inhibitors and a mini-review of the literature. Therapeutic Advances in Endocrinology and Metabolism 7:5-6, pages 212-228.
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Jamila A. Benmoussa, Matthew Clarke, Amulya Penmetsa, Le Yu Khine, Lina Leykina, Keith Diaz & Philip Otterbeck. (2016) Euglycemic diabetic ketoacidosis: The clinical concern of SGLT2 inhibitors. Journal of Clinical and Translational Endocrinology: Case Reports 2, pages 17-19.
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Andrew C. Flick, Hong X. Ding, Carolyn A. Leverett, Robert E. KyneJr.Jr., Kevin K.-C. Liu, Sarah J. Fink & Christopher J. O’Donnell. (2016) Synthetic approaches to the 2014 new drugs. Bioorganic & Medicinal Chemistry 24:9, pages 1937-1980.
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Morgan Comee & Anne Peters. (2016) The changing therapeutic armamentarium for patients with type 1 diabetes. Current Opinion in Endocrinology, Diabetes & Obesity 23:2, pages 106-110.
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Sam Tsz Wai Cheng, Lihua Chen, Stephen Yu Ting Li, Eric Mayoux & Po Sing Leung. (2016) The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLOS ONE 11:1, pages e0147391.
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Sudesna Chatterjee & Melanie J Davies. (2015) Current management of diabetes mellitus and future directions in care. Postgraduate Medical Journal 91:1081, pages 612-621.
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Hector E. Tamez, Alejandra L. Tamez, Lucas A. Garza, Mayra I. Hernandez & Ana C. Polanco. (2015) Dapagliflozin as an adjunct therapy to insulin in the treatment of patients with type 1 diabetes mellitus. Journal of Diabetes & Metabolic Disorders 14:1.
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Rebecca Schechter & Sirimon Reutrakul. (2015) Management of Severe Insulin Resistance in Patients with Type 1 Diabetes. Current Diabetes Reports 15:10.
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Anne L. Peters, Elizabeth O. Buschur, John B. Buse, Pejman Cohan, Jamie C. Diner & Irl B. Hirsch. (2015) Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium–Glucose Cotransporter 2 Inhibition. Diabetes Care 38:9, pages 1687-1693.
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Julia Hine, Heather Paterson, Esha Abrol, David Russell-Jones & Roselle Herring. (2015) SGLT inhibition and euglycaemic diabetic ketoacidosis. The Lancet Diabetes & Endocrinology 3:7, pages 503-504.
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Deborah Hinnen. (2015) Short commentary on empagliflozin and its potential clinical impact. Therapeutic Advances in Endocrinology and Metabolism 6:2, pages 68-81.
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P. Darmon. (2015) Inhibiteurs de SGLT2 dans le diabète de type 1 : vraie perspective ou fausse bonne idée ?. Médecine des Maladies Métaboliques 9:1, pages S59-S63.
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André J. Scheen. (2014) Pharmacodynamics, Efficacy and Safety of Sodium–Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus. Drugs 75:1, pages 33-59.
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B Haas, N Eckstein, V Pfeifer, P Mayer & M D S Hass. (2014) Efficacy, safety and regulatory status of SGLT2 inhibitors: focus on canagliflozin. Nutrition & Diabetes 4:11, pages e143-e143.
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Mark S. Butler, Avril A. B. Robertson & Matthew A. Cooper. (2014) Natural product and natural product derived drugs in clinical trials. Nat. Prod. Rep. 31:11, pages 1612-1661.
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