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Drugs currently in Phase II clinical trials for cocaine addiction

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Leigh C Walker & Andrew J Lawrence. (2018) Investigational drug therapies in phase I and phase II clinical trials for alcohol use disorders. Expert Opinion on Investigational Drugs 27:8, pages 677-690.
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Sandra MW van de Wiel, Michel M Verheij & Judith R Homberg. (2014) Designing modulators of 5-hydroxytryptamine signaling to treat abuse disorders. Expert Opinion on Drug Discovery 9:11, pages 1293-1306.
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Shradhha Kaushik, Faraz Ahmad, Sunita Choudhary, Darin Mansor Mathkor, Bhartendu Nath Mishra, Vineeta Singh & Shafiul Haque. (2023) Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxiety. Neuroscience & Biobehavioral Reviews 152, pages 105270.
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Aleksandr M. Potapkin, Valerii E. Gmiro & Petr D. Shabanov. (2023) Selective antagonists of calcium-permeable GluA1 AMPA-receptors as potential antiaddictive agents. Psychopharmacology & biological narcology 13:3, pages 7-30.
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Andrea Cippitelli, Gilles Zribi & Lawrence Toll. (2022) PPL-103: A mixed opioid partial agonist with desirable anti-cocaine properties. Progress in Neuro-Psychopharmacology and Biological Psychiatry 119, pages 110599.
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Andrea Cippitelli, Madeline Martinez, Gilles Zribi, Gerta Cami-Kobeci, Stephen M. Husbands & Lawrence Toll. (2022) PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats. Neuropharmacology 211, pages 109045.
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Lorenzo Zamboni, Francesco Centoni, Francesca Fusina, Elisa Mantovani, Francesca Rubino, Fabio Lugoboni & Angela Federico. (2021) The Effectiveness of Cognitive Behavioral Therapy Techniques for the Treatment of Substance Use Disorders. Journal of Nervous & Mental Disease 209:11, pages 835-845.
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Maria Carolina Machado da Silva, Giovanni Freitas Gomes, Heliana de Barros Fernandes, Aristóbolo Mendes da Silva, Antônio Lúcio Teixeira, Fabrício A. Moreira, Aline Silva de Miranda & Antônio Carlos Pinheiro de Oliveira. (2021) Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine. Scientific Reports 11:1.
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Henry Lowe, Ngeh Toyang, Blair Steele, Henkel Valentine, Justin Grant, Amza Ali, Wilfred Ngwa & Lorenzo Gordon. (2021) The Therapeutic Potential of Psilocybin. Molecules 26:10, pages 2948.
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Isis Gil-Miravet, Alejandro Fuertes-Saiz, Ana Benito, Isabel Almodóvar, Enrique Ochoa & Gonzalo Haro. (2021) Prepulse Inhibition in Cocaine Addiction and Dual Pathologies. Brain Sciences 11:2, pages 269.
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Gregory L. Powell, Annika Vannan, Ryan M. Bastle, Melissa A. Wilson, Michela Dell’Orco, Nora I. Perrone-Bizzozero & Janet L. Neisewander. (2020) Environmental enrichment during forced abstinence from cocaine self-administration opposes gene network expression changes associated with the incubation effect. Scientific Reports 10:1.
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Shannon R. Kenney, Bradley J. Anderson, Genie L. Bailey & Michael D. Stein. (2018) Expectations about alcohol, cocaine, and benzodiazepine abstinence following inpatient heroin withdrawal management. The American Journal on Addictions 28:1, pages 36-42.
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M. C. Arenas, C. I. Navarro-Francés, S. Montagud-Romero, J. Miñarro & C. Manzanedo. (2018) Baseline prepulse inhibition of the startle reflex predicts the sensitivity to the conditioned rewarding effects of cocaine in male and female mice. Psychopharmacology 235:9, pages 2651-2663.
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Despina E. Ganella, Liubov Lee-Kardashyan, Sophia J. Luikinga, Danny L. D. Nguyen, Heather B. Madsen, Isabel C. Zbukvic, Russell Coulthard, Andrew J. Lawrence & Jee Hyun Kim. (2017) Aripiprazole Facilitates Extinction of Conditioned Fear in Adolescent Rats. Frontiers in Behavioral Neuroscience 11.
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Isabel C. Zbukvic, Chun Hui J. Park, Despina E. Ganella, Andrew J. Lawrence & Jee Hyun Kim. (2017) Prefrontal Dopaminergic Mechanisms of Extinction in Adolescence Compared to Adulthood in Rats. Frontiers in Behavioral Neuroscience 11.
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C. J. Perry & A. J. Lawrence. (2017) Addiction, cognitive decline and therapy: seeking ways to escape a vicious cycle. Genes, Brain and Behavior 16:1, pages 205-218.
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Guang-Zhou LiDianping Tang. (2017) Bioresponsive controlled glucose release from TiO 2 nanotube arrays: a simple and portable biosensing system for cocaine with a glucometer readout . Journal of Materials Chemistry B 5:28, pages 5573-5579.
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Christina J. Perry, M. Foster Olive & Andrew J. Lawrence. 2017. mGLU Receptors. mGLU Receptors 1 14 .
Kanna Hayashi, Evan Wood, Thomas Kerr, Huiru Dong, Paul Nguyen, Cathy M. Puskas, Silvia Guillemi, Julio S. G. Montaner & Michael-John Milloy. (2016) Factors associated with optimal pharmacy refill adherence for antiretroviral medications and plasma HIV RNA non-detectability among HIV-positive crack cocaine users: a prospective cohort study. BMC Infectious Diseases 16:1.
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M. C. Arenas, A. Mateos-García, C. Manzanedo, M. Rodríguez-Arias, M. A. Aguilar, F. Navarrete, M. S. García Gutiérrez, J. Manzanares & J. Miñarro. (2016) Topiramate increases the rewarding properties of cocaine in young-adult mice limiting its clinical usefulness. Psychopharmacology 233:23-24, pages 3849-3859.
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Mohit Singh, Dipinder Keer, Jan Klimas, Evan Wood & Dan Werb. (2016) Topiramate for cocaine dependence: a systematic review and meta-analysis of randomized controlled trials. Addiction 111:8, pages 1337-1346.
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Isabel C. Zbukvic, Despina E. Ganella, Christina J. Perry, Heather B. Madsen, Christopher R. Bye, Andrew J. Lawrence & Jee Hyun Kim. (2016) Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats. Cerebral Cortex 26:6, pages 2895-2904.
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R M Beiter, A B Peterson, J Abel & W J Lynch. (2016) Exercise during early, but not late abstinence, attenuates subsequent relapse vulnerability in a rat model. Translational Psychiatry 6:4, pages e792-e792.
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Perrine Roux. (2016) Cocaïne et méthylphénidate : quelques données épidémiologiques. Psychotropes Vol. 21:4, pages 41-54.
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Christelle Froger-Colléaux & Vincent Castagné. (2016) Effects of baclofen and raclopride on reinstatement of cocaine self-administration in the rat. European Journal of Pharmacology 777, pages 147-155.
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Christina J Perry, Felicia Reed, Isabel C Zbukvic, Jee Hyun Kim & Andrew J Lawrence. (2016) The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues. British Journal of Pharmacology 173:6, pages 1085-1094.
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Kevin Lee, Lucy Goodman, Chantelle Fourie, Susan Schenk, Beulah Leitch & Johanna M. Montgomery. 2016. Ion Channels as Therapeutic Targets, Part A. Ion Channels as Therapeutic Targets, Part A 203 261 .
Christina J. Perry & Andrew J. Lawrence. 2016. Neuropathology of Drug Addictions and Substance Misuse. Neuropathology of Drug Addictions and Substance Misuse 86 96 .
Orit Cohen‐Barak, Jacqueline Wildeman, Jeroen van de Wetering, Judith Hettinga, Petra Schuilenga‐Hut, Aviva Gross, Shane Clark, Merav Bassan, Yossi Gilgun‐Sherki, Boaz Mendzelevski & Ofer Spiegelstein. (2015) Safety, pharmacokinetics, and pharmacodynamics of TV‐1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects. The Journal of Clinical Pharmacology 55:5, pages 573-583.
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Lucyna Pomierny-Chamiolo, Joanna Miszkiel, Ma?gorzata Frankowska, Bartosz Pomierny, Ewa Niedzielska, Irena Smaga, Fabio Fumagalli & Ma?gorzata Filip. (2014) Withdrawal from Cocaine Self-administration and Yoked Cocaine Delivery Dysregulates Glutamatergic mGlu5 and NMDA Receptors in the Rat Brain. Neurotoxicity Research 27:3, pages 246-258.
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Andrea Cippitelli, Madeline Martinez, Gilles Zribi, Gerta Cami-Kobeci, Stephen M. Husbands & Lawrence Toll. (2021) PPL-138 (BU10038): A Bifunctional NOP/Mu Partial Agonist that Reduces Cocaine Self-Administration in Rats. SSRN Electronic Journal.
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