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Investigational drugs in Phase II clinical trials for the treatment of obesity: implications for future development of novel therapies

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Julia Lazareva, Sheila M. Brady & Jack A. Yanovski. (2023) An evaluation of setmelanotide injection for chronic weight management in adult and pediatric patients with obesity due to Bardet–Biedl syndrome. Expert Opinion on Pharmacotherapy 24:6, pages 667-674.
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María Calderon-Dominguez , Joan F. Mir, Raquel Fucho, Minéia Weber, Dolors Serra & Laura Herrero. (2016) Fatty acid metabolism and the basis of brown adipose tissue function. Adipocyte 5:2, pages 98-118.
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V Margaret Jackson, Danna M Breen, Jean-Philippe Fortin, Alice Liou, J Brent Kuzmiski, A Katrina Loomis, Marie-Laure Rives, Bhavik Shah & Philip A Carpino. (2015) Latest approaches for the treatment of obesity. Expert Opinion on Drug Discovery 10:8, pages 825-839.
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Marcin Kosmalski, Kacper Deska, Bartłomiej Bąk, Monika Różycka-Kosmalska & Tadeusz Pietras. (2023) Pharmacological Support for the Treatment of Obesity—Present and Future. Healthcare 11:3, pages 433.
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Jing Li, Hongli Duan, Yan Liu, Lu Wang & Xing Zhou. (2022) Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities. Pharmaceutics 14:7, pages 1445.
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Marialuisa de Ceglia, Juan Decara, Silvana Gaetani & Fernando Rodríguez de Fonseca. (2021) Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?. Pharmaceuticals 14:10, pages 1002.
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Beatriz T. Meneguetti, Marlon H. Cardoso, Camila F.A. Ribeiro, Mário R. Felício, Ingrid B. Pinto, Nuno C. Santos, Cristiano M.E. Carvalho & Octávio L. Franco. (2019) Neuropeptide receptors as potential pharmacological targets for obesity. Pharmacology & Therapeutics 196, pages 59-78.
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Tao Tong, Rina Yu & Taesun Park. (2018) α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3. International Journal of Obesity 43:1, pages 202-216.
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Karine Clément, Heike Biebermann, I. Sadaf Farooqi, Lex Van der Ploeg, Barbara Wolters, Christine Poitou, Lia Puder, Fred Fiedorek, Keith Gottesdiener, Gunnar Kleinau, Nicolas Heyder, Patrick Scheerer, Ulrike Blume-Peytavi, Irina Jahnke, Shubh Sharma, Jacek Mokrosinski, Susanna Wiegand, Anne Müller, Katja Weiß, Knut Mai, Joachim Spranger, Annette Grüters, Oliver Blankenstein, Heiko Krude & Peter Kühnen. (2018) MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency. Nature Medicine 24:5, pages 551-555.
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Vidya Narayanaswami & Linda P. Dwoskin. (2017) Obesity: Current and potential pharmacotherapeutics and targets. Pharmacology & Therapeutics 170, pages 116-147.
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Fabien Plisson, Timothy A. Hill, Justin M. Mitchell, Huy N. Hoang, Aline D. de Araujo, Weijun Xu, Adam Cotterell, David J. Edmonds, Robert V. Stanton, David R. Derksen, Paula M. Loria, David A. Griffith, David A. Price, Spiros Liras & David P. Fairlie. (2017) Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European Journal of Medicinal Chemistry 127, pages 703-714.
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Clinton T. Elfers & Christian L. Roth. (2017) Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology 158:1, pages 41-55.
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Tushar Madaan, Mohd. Akhtar & Abul Kalam Najmi. (2016) Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. European Journal of Pharmaceutical Sciences 93, pages 244-252.
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Jonathan R. S. Arch. (2015) Horizons in the Pharmacotherapy of Obesity. Current Obesity Reports 4:4, pages 451-459.
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Thinzar Min & Jeffrey Wayne Stephens. (2015) Targeting abdominal obesity in diabetes. Diabetes Management 5:4, pages 301-309.
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S. Wharton & K. J. Serodio. (2015) Next Generation of Weight Management Medications: Implications for Diabetes and CVD Risk. Current Cardiology Reports 17:5.
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Esther CY Lee & Philip A Carpino. (2015) Melanocortin-4 receptor modulators for the treatment of obesity: a patent analysis (2008–2014). Pharmaceutical Patent Analyst 4:2, pages 95-107.
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Luca Costantino & Daniela Barlocco. (2015) New perspectives on the development of antiobesity drugs. Future Medicinal Chemistry 7:3, pages 315-336.
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Laurent Gautron, Joel K. Elmquist & Kevin W. Williams. (2015) Neural Control of Energy Balance: Translating Circuits to Therapies. Cell 161:1, pages 133-145.
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