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Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies

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Glen I. Spielmans & Elaine M. Ellefson. (2023) Small Effects, Questionable Outcomes: Bremelanotide for Hypoactive Sexual Desire Disorder. The Journal of Sex Research 0:0, pages 1-22.
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Rossella E Nappi & Laura Cucinella. (2015) Advances in pharmacotherapy for treating female sexual dysfunction. Expert Opinion on Pharmacotherapy 16:6, pages 875-887.
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Antonio Argiolas, Francesco Mario Argiolas, Giacomo Argiolas & Maria Rosaria Melis. (2023) Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies. Brain Sciences 13:5, pages 802.
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Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu & Jennifer W. Hill. (2023) Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice. Frontiers in Endocrinology 14.
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Miteshkumar Rajaram Maurya, Renuka Munshi & Sachin Zambare. (2023) Melanocortin Receptors: Emerging Targets for the Treatment of Pigmentation, Inflammation, Stress, Weight Disorders and Sexual Dysfunction. Current Drug Targets 24:2, pages 151-156.
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James G. Pfaus, Amama Sadiq, Carl Spana & Anita H. Clayton. (2021) The neurobiology of bremelanotide for the treatment of hypoactive sexual desire disorder in premenopausal women. CNS Spectrums 27:3, pages 281-289.
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Alexandra Siegal & Barbara M. Chubak. (2021) Pharmaceutical and Energy-Based Management of Sexual Problems in Women. Urologic Clinics of North America 48:4, pages 473-486.
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Uru Malik, Lai Yue Chan, Minying Cai, Victor J. Hruby, Quentin Kaas, Norelle L. Daly & David J. Craik. (2020) Development of novel frog‐skin peptide scaffolds with selectivity towards melanocortin receptor subtypes. Peptide Science 113:4.
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Danielle N. Adank, Mary M. Lunzer, Mark D. Ericson, Zoe M. Koeperich, Stacey L. Wilber, Katlyn A. Fleming & Carrie Haskell-Luevano. (2020) Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice. ACS Chemical Neuroscience 11:19, pages 3051-3063.
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Jian-Ching Wu, Han-En Tsai, Yi-Hsiang Hsiao, Ji-Syuan Wu, Chieh-Shan Wu & Ming-Hong Tai. (2020) Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. International Journal of Molecular Sciences 21:2, pages 681.
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Cody J. Lensing, Katie T. Freeman, Sathya M. Schnell, Robert C. Speth, Adam T. Zarth & Carrie Haskell-Luevano. (2018) Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors. Journal of Medicinal Chemistry 62:1, pages 144-158.
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Nur Syazwani Roslan, Nik Ruzyanei Nik Jaafar, Hatta Sidi, Najwa Baharudin, Jaya Kumar, Srijit Das & Nik Hazlina Nik Hussain. (2018) The Bio-Psycho-Social Dimension in Women’s Sexual Desire: ‘Argumentum ad novitatem’. Current Drug Targets 20:2, pages 146-157.
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Jennifer W. Hill & Carol F. Elias. (2018) Neuroanatomical Framework of the Metabolic Control of Reproduction. Physiological Reviews 98:4, pages 2349-2380.
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Sheryl A. Kingsberg, Stanley Althof, James A. Simon, Andrea Bradford, Johannes Bitzer, Joana Carvalho, Kathryn E. Flynn, Rossella E. Nappi, Jennifer B. Reese, Roya L. Rezaee, Leslie Schover & Jan L. Shifrin. (2017) Female Sexual Dysfunction—Medical and Psychological Treatments, Committee 14. The Journal of Sexual Medicine 14:12, pages 1463-1491.
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Mark D. Ericson, Cody J. Lensing, Katlyn A. Fleming, Katherine N. Schlasner, Skye R. Doering & Carrie Haskell-Luevano. (2017) Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:10, pages 2414-2435.
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Cody J. Lensing, Danielle N. Adank, Stacey L. Wilber, Katie T. Freeman, Sathya M. Schnell, Robert C. Speth, Adam T. Zarth & Carrie Haskell-Luevano. (2017) A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH 2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH 2 : A Bivalent Advantage . ACS Chemical Neuroscience 8:6, pages 1262-1278.
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Lesley Marson & Ursula Wesselmann. 2017. Principles of Gender-Specific Medicine. Principles of Gender-Specific Medicine 45 60 .
Thomas Parisi, Robert N. Pechnick & Waguih William IsHak. 2017. The Textbook of Clinical Sexual Medicine. The Textbook of Clinical Sexual Medicine 387 411 .
Cody J. Lensing, Danielle N. Adank, Skye R. Doering, Stacey L. Wilber, Amy Andreasen, Jay W. Schaub, Zhimin Xiang & Carrie Haskell-Luevano. (2016) Ac-Trp-DPhe(p-I)-Arg-Trp-NH 2 , a 250-Fold Selective Melanocortin-4 Receptor (MC4R) Antagonist over the Melanocortin-3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently . ACS Chemical Neuroscience 7:9, pages 1283-1291.
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Cody J. Lensing, Katie T. Freeman, Sathya M. Schnell, Danielle N. Adank, Robert C. Speth & Carrie Haskell-Luevano. (2016) An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers. Journal of Medicinal Chemistry 59:7, pages 3112-3128.
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Giovanni Corona, Andrea M. Isidori, Antonio Aversa, Arthur L. Burnett & Mario Maggi. (2016) Endocrinologic Control of Men’s Sexual Desire and Arousal/Erection. The Journal of Sexual Medicine 13:3, pages 317-337.
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Sheila Leone, Giorgio Noera & Alfio Bertolini. (2015) Developments and new vistas in the field of melanocortins. Biomolecular Concepts 6:5-6.
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