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Expert Opinion on Investigational Drugs Volume 23, 2014 - Issue 11
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The role of arginine and the modified arginine deiminase enzyme ADI-PEG 20 in cancer therapy with special emphasis on Phase I/II clinical trials

Anna SynakiewiczMedical University of Gdansk, Department of Pediatrics, Hematology and Oncology, 7 Debinki Street, 80-211 Gdansk, Poland+48 58 3492880; +48 58 349 2847; [email protected]
,
Teresa Stachowicz-StencelMedical University of Gdansk, Department of Pediatrics, Hematology and Oncology, 7 Debinki Street, 80-211 Gdansk, Poland+48 58 3492880; +48 58 349 2847; [email protected]
&
Elzbieta Adamkiewicz-DrozynskaMedical University of Gdansk, Department of Pediatrics, Hematology and Oncology, 7 Debinki Street, 80-211 Gdansk, Poland+48 58 3492880; +48 58 349 2847; [email protected]
Pages 1517-1529 | Published online: 26 Jun 2014

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Joséphine Carpentier, Iuliia Pavlyk, Uma Mukherjee, Peter E Hall & Peter W Szlosarek. (2022) Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy. Lung Cancer: Targets and Therapy 13, pages 53-66.
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Fabricio Loayza-Puch & Reuven Agami. (2016) Monitoring amino acid deficiencies in cancer. Cell Cycle 15:17, pages 2229-2230.
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Articles from other publishers (32)

Xinlei Wei, Ho-Yin Chow, Hiu-Chi Chong, Siu-Lun Leung, Mei-Ki Ho, Man-Yuen Lee & Yun-Chung Leung. (2023) Arginine Is a Novel Drug Target for Arginine Decarboxylase in Human Colorectal Cancer Cells. International Journal of Molecular Sciences 24:18, pages 13741.
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Ahad Hussain, Li Xie, Guozhe Deng & Xuejun Kang. (2023) Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients. Amino Acids.
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Seoungkyun Kim, Dong Hee Kim, Jinhwan Cho, Jaeyun Kim & Inchan Kwon. (2022) Charge Booster Tags for Controlled Release of Therapeutics from a Therapeutic Carrier. Advanced Functional Materials 33:11.
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Vadim S. Pokrovsky, Louay Abo Qoura, Elena Morozova & Victoria I. Bunik. (2022) Predictive markers for efficiency of the amino-acid deprivation therapies in cancer. Frontiers in Medicine 9.
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Mahboubeh Zarei, Soudabeh Sabetian, Mohammad Reza Rahbar & Manica Negahdaripour. (2022) Methanol and Sorbitol Affect the Molecular Dynamics of Arginine Deiminase: Insights for Improving its Stability. Current Proteomics 19:5, pages 380-387.
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Na Liu, Feng Shi, Lifang Yang, Weihua Liao & Ya Cao. (2022) Oncogenic viral infection and amino acid metabolism in cancer progression: Molecular insights and clinical implications. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:3, pages 188724.
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Donatella Coradduzza, Tatiana Solinas, Emanuela Azara, Nicola Culeddu, Sara Cruciani, Angelo Zinellu, Serenella Medici, Margherita Maioli, Massimo Madonia & Ciriaco Carru. (2022) Plasma Polyamine Biomarker Panels: Agmatine in Support of Prostate Cancer Diagnosis. Biomolecules 12:4, pages 514.
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Kexin Fan, Zhan Liu, Min Gao, Kangsheng Tu, Qiuran Xu & Yilei Zhang. (2022) Targeting Nutrient Dependency in Cancer Treatment. Frontiers in Oncology 12.
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Yiming Zhang, Cassandra B. Higgins, Brian A. Van Tine, John S. Bomalaski & Brian J. DeBosch. (2022) Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism. Cell Reports Medicine 3:1, pages 100498.
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Alexandra Giatromanolaki, Adrian L. Harris & Michael I. Koukourakis. (2021) The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer. Cancer & Metabolism 9:1.
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Ziyu Wang, Qinghong Xie, Haifeng Zhou, Min Zhang, Jie Shen & Dianwen Ju. (2021) Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy. Frontiers in Pharmacology 11.
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Robert Fried, Richard M. Carlton & Dennis A. Fried. 2021. Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression. Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression 25 111 .
Pini Matzner, Elad Sandbank, Elad Neeman, Oded Zmora, Vijaya Gottumukkala & Shamgar Ben-Eliyahu. (2020) Harnessing cancer immunotherapy during the unexploited immediate perioperative period. Nature Reviews Clinical Oncology 17:5, pages 313-326.
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Kiran Bala, Islam Husain & Anjana Sharma. (2020) Arginine deaminase from Pseudomonas aeruginosa PS2: purification, biochemical characterization and in-vitro evaluation of anticancer activity. 3 Biotech 10:5.
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Giulia Agnello, Susan E. Alters & Scott W. Rowlinson. (2020) Preclinical safety and antitumor activity of the arginine-degrading therapeutic enzyme pegzilarginase, a PEGylated, cobalt-substituted recombinant human arginase 1. Translational Research 217, pages 11-22.
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Mahboubeh Zarei, Mohammad Reza Rahbar, Manica Negahdaripour, Mohammad Hossein Morowvat, Navid Nezafat & Younes Ghasemi. (2020) Cell Penetrating Peptide: Sequence-Based Computational Prediction for Intercellular Delivery of Arginine Deiminase. Current Proteomics 17:2, pages 117-131.
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Mahboubeh Zarei, Mohammad Reza Rahbar, Mohammad Hossein Morowvat, Navid Nezafat, Manica Negahdaripour, Aydin Berenjian & Younes Ghasemi. (2019) Arginine Deiminase: Current Understanding and Applications. Recent Patents on Biotechnology 13:2, pages 124-136.
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Vadim S. Pokrovsky, Olga E. Chepikova, Denis Zh. Davydov, Andrey A. Zamyatnin Jr, Alexander N. Lukashev & Elena V. Lukasheva. (2019) Amino Acid Degrading Enzymes and their Application in Cancer Therapy. Current Medicinal Chemistry 26:3, pages 446-464.
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Marcus Kwong Lam Fung & Godfrey Chi-Fung Chan. (2017) Drug-induced amino acid deprivation as strategy for cancer therapy. Journal of Hematology & Oncology 10:1.
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Claudia Maletzki, Yvonne Rosche, Christin Riess, Aline Scholz, Doreen William, Carl Friedrich Classen, Bernd Kreikemeyer, Michael Linnebacher & Tomas Fiedler. (2017) Deciphering molecular mechanisms of arginine deiminase-based therapy – Comparative response analysis in paired human primary and recurrent glioblastomas. Chemico-Biological Interactions 278, pages 179-188.
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Anjana Sharma, Kiran Bala & Islam Husain. (2017) Preliminary evaluation of arginine deiminase activity of indigenous bacterial strains for suitable chemotherapeutic applications. Biocatalysis and Agricultural Biotechnology 12, pages 66-77.
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Hui Jiang, Song Guo, Dan Xiao, Xuzhao Bian, Jie Wang, Ying Wang, Huiting Zhou, Jun Cai & Zhongliang Zheng. (2017) Arginine deiminase expressed in vivo , driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency . Oncotarget 8:23, pages 37694-37704.
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Takafumi MiyamotoPaulisally Hau Yi LoNaomi SaichiKoji Ueda, Makoto Hirata, Chizu TanikawaKoichi Matsuda. (2017) Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53. Science Advances 3:5.
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Marjorie G. Zauderer. 2017. Asbestos and Mesothelioma. Asbestos and Mesothelioma 313 345 .
Catherine J McNeal, Cynthia J Meininger, Deepika Reddy, Colin D Wilborn & Guoyao Wu. (2016) Safety and Effectiveness of Arginine in Adults. The Journal of Nutrition 146:12, pages 2587S-2593S.
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M D Patil, J Bhaumik, S Babykutty, U C Banerjee & D Fukumura. (2016) Arginine dependence of tumor cells: targeting a chink in cancer’s armor. Oncogene 35:38, pages 4957-4972.
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Matthew Locke, Essam Ghazaly, Marta O. Freitas, Mikaella Mitsinga, Laura Lattanzio, Cristiana Lo Nigro, Ai Nagano, Jun Wang, Claude Chelala, Peter Szlosarek & Sarah A. Martin. (2016) Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1. Cell Reports 16:6, pages 1604-1613.
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Mahesh D. Patil, Kiran D. Shinde, Gopal Patel, Yusuf Chisti & Uttam Chand Banerjee. (2016) Use of response surface method for maximizing the production of arginine deiminase by Pseudomonas putida. Biotechnology Reports 10, pages 29-37.
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Fuming Qiu, Jian Huang & Meihua Sui. (2015) Targeting arginine metabolism pathway to treat arginine-dependent cancers. Cancer Letters 364:1, pages 1-7.
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Ann E. Walts, John S. Bomalaski, Delma Ines & Sandra Orsulic. (2014) Argininosuccinate synthetase (ASS) deficiency in high-grade pulmonary neuroendocrine carcinoma: an opportunity for personalized targeted therapy. Journal of Cancer Research and Clinical Oncology 141:8, pages 1363-1369.
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William Plunkett. (2015) Arginine addiction in AML. Blood 125:26, pages 3971-3972.
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Francis MussaiSharon EganJoseph Higginbotham-JonesTracey PerryAndrew BeggsElena OdintsovaJustin LokeGuy PrattKin Pong U, Anthony Lo, Margaret Ng, Pamela KearnsPaul Cheng & Carmela De Santo. (2015) Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target. Blood 125:15, pages 2386-2396.
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