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Drug Evaluations

Tivantinib: critical review with a focus on hepatocellular carcinoma

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Cilong Chu, Zixuan Rao, Qingshan Pan & Wufu Zhu. (2022) An updated patent review of small-molecule c-Met kinase inhibitors (2018-present). Expert Opinion on Therapeutic Patents 32:3, pages 279-298.
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Xiaofei Li, Jia Wan, Zhenping Wu, Juncai Tu, Yongtao Hu, Shuang Wu & Lianqing Lou. (2018) Fatal adverse events with molecular targeted agents in the treatment of advanced hepatocellular carcinoma: a meta-analysis of randomized controlled trials. Drug Design, Development and Therapy 12, pages 3043-3049.
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Eva Juárez-Hernández, Daniel Motola-Kuba, Norberto Carlos Chávez-Tapia, Misael Uribe & Varenka Barbero Becerra. (2017) Biomarkers in hepatocellular carcinoma: an overview. Expert Review of Gastroenterology & Hepatology 11:6, pages 549-558.
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Miner Hu, Xiaojun Xia, Lichao Chen, Yunpeng Jin, Zhenhua Hu, Shudong Xia & Xudong Yao. (2023) Emerging biomolecules for practical theranostics of liver hepatocellular carcinoma. Annals of Hepatology 28:6, pages 101137.
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Kai-Chun Zhao, Yi-Ying Zhuang, Tian-Hong Jing, Guang-Hui Shi, Lin Guo, Xiao-Li Zhao, Yong Lu & Ye Liu. (2023) Pd-catalyzed tandem bis-hydroaminocarbonylation of terminal alkynes for synthesis of N-aryl substituted succinimides with involvement of ionic P, O-hybrid ligand. Journal of Catalysis 417, pages 248-259.
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Jiahui Yan, Lin Chen, Li Zhang, Zhaohuan Zhang, Yong Zhao, Yuan Wang & Jie Ou. (2022) New Insights Into the Persistent Effects of Acute Exposure to AFB1 on Rat Liver. Frontiers in Microbiology 13.
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Shankun Zhao, Weizhou Wu, Hao Jiang, Lei Ma, Chengyi Pan, Chong Jin, Jinggang Mo, Liezhi Wang & Kunpeng Wang. (2021) Selective Inhibitor of the c-Met Receptor Tyrosine Kinase in Advanced Hepatocellular Carcinoma: No Beneficial Effect With the Use of Tivantinib?. Frontiers in Immunology 12.
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Federico Riu, Luca Sanna, Roberta Ibba, Sandra Piras, Valentina Bordoni, M. Andrea Scorciapino, Michele Lai, Simona Sestito, Luigi Bagella & Antonio Carta. (2021) A comprehensive assessment of a new series of 5′,6′-difluorobenzotriazole-acrylonitrile derivatives as microtubule targeting agents (MTAs). European Journal of Medicinal Chemistry 222, pages 113590.
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Consolato M. Sergi. 2021. Liver Cancer. Liver Cancer 1 38 .
Víctor Samper Barceló & Stefan Bienz. (2018) Synthesis of Highly Substituted 3-Pyrrolin-2-ones from N,N -Disubstituted α-Amino Acids . The Journal of Organic Chemistry 83:5, pages 2734-2743.
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Peng Han, Hali Li, Xian Jiang, Bo Zhai, Gang Tan, Dali Zhao, Haiquan Qiao, Bing Liu, Hongchi Jiang & Xueying Sun. (2017) Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells. Molecular Oncology 11:3, pages 320-334.
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M. Simonelli, P. Zucali, A. Santoro, M.B. Thomas, F.G. de Braud, H. Borghaei, J. Berlin, C.S. Denlinger, C. Noberasco, L. Rimassa, T.-Y. Kim, P.A. English, A. Abbattista, C. Gallo Stampino, M. Carpentieri & J.A. Williams. (2016) Phase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase-1, in patients with hepatocellular carcinoma. Annals of Oncology 27:9, pages 1782-1787.
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Yan-li Bai, Hong-chang Yuan, Dong-tao Zhang, Yuan Liu & Yin Zhang. (2016) Quantitative analysis of tivantinib in rat plasma using ultra performance liquid chromatography with tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 126, pages 98-102.
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Yuxi Wang, Hang Zhang, Beno?t Gigant, Yamei Yu, Yangping Wu, Xiangzheng Chen, Qinhuai Lai, Zhaoya Yang, Qiang Chen & Jinliang Yang. (2016) Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. FEBS Journal 283:1, pages 102-111.
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Maocai Yan, Huiyun Wang, Qibao Wang, Zhen Zhang & Chunyan Zhang. (2016) Allosteric inhibition of c-Met kinase in sub-microsecond molecular dynamics simulations induced by its inhibitor, tivantinib. Physical Chemistry Chemical Physics 18:15, pages 10367-10374.
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Shunchao Yan, Xin Jiao, Huawei Zou & Kai Li. (2015) Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases. Diagnostic Pathology 10:1.
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Jiang Chen, Renan Jin, Jie Zhao, Jinghua Liu, Hanning Ying, Han Yan, Senjun Zhou, Yuelong Liang, Diyu Huang, Xiao Liang, Hong Yu, Hui Lin & Xiujun Cai. (2015) Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma. Cancer Letters 367:1, pages 1-11.
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Simona Gurzu. (2015) Epithelial-mesenchymal, mesenchymal-epithelial, and endothelial-mesenchymal transitions in malignant tumors: An update. World Journal of Clinical Cases 3:5, pages 393.
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