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Drug Evaluations

Eravacycline for the treatment of intra-abdominal infections

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Alessandro Russo, Paolo Fusco, Helen Linda Morrone, Enrico Maria Trecarichi & Carlo Torti. (2023) New advances in management and treatment of multidrug-resistant Klebsiella pneumoniae. Expert Review of Anti-infective Therapy 21:1, pages 41-55.
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Matteo Bassetti, Alessandro Russo, Alessia Carnelutti & Mark Wilcox. (2019) Emerging drugs for treating methicillin-resistant Staphylococcus aureus. Expert Opinion on Emerging Drugs 24:3, pages 191-204.
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Daniele Roberto Giacobbe, Malgorzata Mikulska & Claudio Viscoli. (2018) Recent advances in the pharmacological management of infections due to multidrug-resistant Gram-negative bacteria. Expert Review of Clinical Pharmacology 11:12, pages 1219-1236.
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Jin-xin Zheng, Zhi-wei Lin, Xiang Sun, Wei-hong Lin, Zhong Chen, Yang Wu, Guo-bin Qi, Qi-wen Deng, Di Qu & Zhi-jian Yu. (2018) Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae. Emerging Microbes & Infections 7:1, pages 1-11.
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Matteo Bassetti, Elda Righi, Alessia Carnelutti, Elena Graziano & Alessandro Russo. (2018) Multidrug-resistant Klebsiella pneumoniae: challenges for treatment, prevention and infection control. Expert Review of Anti-infective Therapy 16:10, pages 749-761.
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Matteo Bassetti, Alessandro Russo, Alessia Carnelutti, Alessandro La Rosa & Elda Righi. (2018) Antimicrobial resistance and treatment: an unmet clinical safety need. Expert Opinion on Drug Safety 17:7, pages 669-680.
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Richie Rashmin Bhandare, Benjamin E. Blass & Daniel J. Canney. 2023. Medicinal Chemistry of Chemotherapeutic Agents. Medicinal Chemistry of Chemotherapeutic Agents 115 133 .
Bisma Jan, Rafia Jan, Suhaib Afzal, Mehrose Ayoub & Mubashir Hussain Masoodi. 2023. Non-traditional Approaches to Combat Antimicrobial Drug Resistance. Non-traditional Approaches to Combat Antimicrobial Drug Resistance 79 100 .
Sunil Kumar, Razique Anwer, Mukesh Yadav, Gourav Vats, Shivali Thakur, Nirmala Sehrawat, Vikas Kumar & Manoj Singh. (2022) An Update on Advancements in Treatment Options for Managing Klebsiella pneumoniae Infections. Current Pharmacology Reports 8:6, pages 439-449.
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Christopher E. Morgan, Zhemin Zhang, Robert A. Bonomo & Edward W. Yu. (2022) An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. mBio 13:1.
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Irfan Ahmad Khan. 2022. Beta-Lactam Resistance in Gram-Negative Bacteria. Beta-Lactam Resistance in Gram-Negative Bacteria 287 298 .
Zhemin Zhang, Christopher E. Morgan, Robert A. Bonomo & Edward W. Yu. (2021) Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. mBio 12:3.
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Matteo Bassetti, Elda Righi & Murat Akova. 2021. Infection Management in Hematology. Infection Management in Hematology 161 179 .
Yue Shi, Xiaoting Hua, Qingye Xu, Yunxing Yang, Linyue Zhang, Jintao He, Xinli Mu, Lihua Hu, Sebastian Leptihn & Yunsong Yu. (2020) Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC. Infection, Genetics and Evolution 80, pages 104185.
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Ann A Elshamy & Khaled M Aboshanab. (2020) A review on bacterial resistance to carbapenems: epidemiology, detection and treatment options. Future Science OA 6:3.
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Yasunari Otsuka. (2020) Potent Antibiotics Active against Multidrug-Resistant Gram-Negative Bacteria. Chemical and Pharmaceutical Bulletin 68:3, pages 182-190.
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Ian Morrissey, Stephen Hawser, Sibylle H. Lob, James A. Karlowsky, Matteo Bassetti, G. Ralph Corey, Melanie Olesky, Joseph Newman & Corey Fyfe. (2020) In Vitro Activity of Eravacycline against Gram-Positive Bacteria Isolated in Clinical Laboratories Worldwide from 2013 to 2017 . Antimicrobial Agents and Chemotherapy 64:3.
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Ian Morrissey, Melanie Olesky, Stephen Hawser, Sibylle H. Lob, James A. Karlowsky, G. Ralph Corey, Matteo Bassetti & Corey Fyfe. (2020) In Vitro Activity of Eravacycline against Gram-Negative Bacilli Isolated in Clinical Laboratories Worldwide from 2013 to 2017 . Antimicrobial Agents and Chemotherapy 64:3.
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George G. Zhanel, Jenine Esquivel, Sheryl Zelenitsky, Courtney K. Lawrence, Heather J. Adam, Alyssa Golden, Rachel Hink, Liam Berry, Frank Schweizer, Michael A. Zhanel, Denice Bay, Philippe R. S. Lagacé-Wiens, Andrew J. Walkty, Joseph P. LynchIIIIII & James A. Karlowsky. (2020) Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs 80:3, pages 285-313.
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Matthew W. McCarthy. (2019) Clinical Pharmacokinetics and Pharmacodynamics of Eravacycline. Clinical Pharmacokinetics 58:9, pages 1149-1153.
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Suay-García & Pérez-Gracia. (2019) Present and Future of Carbapenem-resistant Enterobacteriaceae (CRE) Infections. Antibiotics 8:3, pages 122.
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Anna Maria Peri, Yohei Doi, Brian A. Potoski, Patrick N.A. Harris, David L. Paterson & Elda Righi. (2019) Antimicrobial treatment challenges in the era of carbapenem resistance. Diagnostic Microbiology and Infectious Disease 94:4, pages 413-425.
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Ilias Karaiskos, Styliani Lagou, Konstantinos Pontikis, Vasiliki Rapti & Garyphallia Poulakou. (2019) The “Old” and the “New” Antibiotics for MDR Gram-Negative Pathogens: For Whom, When, and How. Frontiers in Public Health 7.
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Matteo Bassetti, Elda Righi, Alessandro Russo & Alessia Carnelutti. (2018) New Antibiotics for Pneumonia. Clinics in Chest Medicine 39:4, pages 853-869.
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Vidmantas Petraitis, Ruta Petraitiene, Bo Bo W. Maung, Farehin Khan, Ieva Alisauskaite, Melanie Olesky, Joseph Newman, Abdul Mutlib, Xiaoyun Niu, Michael Satlin, Ravi S. Singh, Harmut Derendorf & Thomas J. Walsh. (2018) Pharmacokinetics and Comprehensive Analysis of the Tissue Distribution of Eravacycline in Rabbits. Antimicrobial Agents and Chemotherapy 62:9.
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Adrian Brink. 2018. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill 73 99 .
H. Wright, R.A. Bonomo & D.L. Paterson. (2017) New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?. Clinical Microbiology and Infection 23:10, pages 704-712.
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Matteo Bassetti & Elda Righi. 2017. Anti-infectives and the Lung. Anti-infectives and the Lung 1 20 .
L. Mayrink Assis, M. Nedeljković & A. Dessen. (2017) New strategies for targeting and treatment of multi-drug resistant Staphylococcus aureus. Drug Resistance Updates 31, pages 1-14.
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Shawn H. MacVane. (2016) Antimicrobial Resistance in the Intensive Care Unit. Journal of Intensive Care Medicine 32:1, pages 25-37.
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Dana R. Bowers & Vanthida Huang. (2016) Emerging Issues and Treatment Strategies in Carbapenem-Resistant Enterobacteriaceae (CRE). Current Infectious Disease Reports 18:12.
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Dmitriy M. Martirosov & Thomas P. Lodise. (2016) Emerging trends in epidemiology and management of infections caused by carbapenem-resistant Enterobacteriaceae. Diagnostic Microbiology and Infectious Disease 85:2, pages 266-275.
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Sebastiano Leone, Silvana Noviello & Silvano Esposito. (2015) Combination antibiotic therapy for the treatment of infective endocarditis due to enterococci. Infection 44:3, pages 273-281.
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Matteo Bassetti, Elda Righi & Alessia Carnelutti. (2016) New therapeutic options for respiratory tract infections. Current Opinion in Infectious Diseases 29:2, pages 178-186.
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Ling-Shan Syue, Yen-Hsu Chen, Wen-Chien Ko & Po-Ren Hsueh. (2016) New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance. International Journal of Antimicrobial Agents 47:4, pages 250-258.
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George G. Zhanel, Doris Cheung, Heather Adam, Sheryl Zelenitsky, Alyssa Golden, Frank Schweizer, Bala Gorityala, Philippe R. S. Lagacé-Wiens, Andrew Walkty, Alfred S. Gin, Daryl J. Hoban & James A. Karlowsky. (2016) Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent. Drugs 76:5, pages 567-588.
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David Brown. (2015) Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?. Nature Reviews Drug Discovery 14:12, pages 821-832.
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B. Clouzeau, A. Boyer, F. M’Zali, M. Kann & D. Gruson. (2015) Nouvelles stratégies thérapeutiques contre les entérobactéries productrices de β-lactamases à spectre étenduNew treatment strategies for extended-spectrum β-lactamase-producing enterobacteriaceae. Réanimation 24:3, pages 270-277.
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