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Targeting of cancer stem cells by inhibitors of DNA and histone methylation

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Hao Hu, Kun Qian, Meng-Chiao Ho & Y. George Zheng. (2016) Small Molecule Inhibitors of Protein Arginine Methyltransferases. Expert Opinion on Investigational Drugs 25:3, pages 335-358.
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Elham Barazeghi, Per Hellman, Olov Norlén, Gunnar Westin & Peter Stålberg. (2021) EZH2 presents a therapeutic target for neuroendocrine tumors of the small intestine. Scientific Reports 11:1.
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Daniel Desaulniers, Paule Vasseur, Abigail Jacobs, M. Cecilia Aguila, Norman Ertych & Miriam N. Jacobs. (2021) Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications. International Journal of Molecular Sciences 22:20, pages 10969.
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Gera Narendra, Baddipadige Raju, Himanshu Verma & Om Silakari. (2021) Identification of potential genes associated with ALDH1A1 overexpression and cyclophosphamide resistance in chronic myelogenous leukemia using network analysis. Medical Oncology 38:10.
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Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein & Andrew A. Lane. (2020) Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Nature Communications 11:1.
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Hua Liang, Qiong Huang, Mei-juan Liao, Feng Xu, Tao Zhang, Jian He, Lei Zhang & Hong-zhen Liu. (2019) EZH2 plays a crucial role in ischemia/reperfusion-induced acute kidney injury by regulating p38 signaling. Inflammation Research 68:4, pages 325-336.
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Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith & Catherine A. O’Brien. (2019) Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells. Nature Communications 10:1.
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Evelina Miele, Sergio Valente, Vincenzo Alfano, Marianna Silvano, Paolo Mellini, Diana Borovika, Biagina Marrocco, Agnese Po, Zein Mersini Besharat, Giuseppina Catanzaro, Giuseppe Battaglia, Luana Abballe, Clemens Zwergel, Giulia Stazi, Ciro Milite, Sabrina Castellano, Marco Tafani, Peteris Trapencieris, Antonello Mai & Elisabetta Ferretti. (2017) The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells. Oncotarget 8:40, pages 68557-68570.
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Abhijeet Deshmukh, Mudra Binju, Frank Arfuso, Philip Newsholme & Arun Dharmarajan. (2017) Role of epigenetic modulation in cancer stem cell fate. The International Journal of Biochemistry & Cell Biology.
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Raushan T. Kurmasheva, Melissa Sammons, Edward Favours, Jianwrong Wu, Dias Kurmashev, Katherine Cosmopoulos, Heike Keilhack, Christine R. Klaus, Peter J. Houghton & Malcolm A. Smith. (2017) Initial testing (stage 1) of tazemetostat (EPZ-6438), a novel EZH2 inhibitor, by the Pediatric Preclinical Testing Program. Pediatric Blood & Cancer 64:3, pages e26218.
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