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Review

Investigational drugs for hyperuricemia

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Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Tomohiko Ishikawa, Toshinari Takahashi, Tetsuya Taniguchi & Tatsuo Hosoya. (2021) Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout. Expert Opinion on Pharmacotherapy 22:11, pages 1397-1406.
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Mizuki Yamane, Fumihiko Igarashi, Tsuyoshi Yamauchi & Toshito Nakagawa. (2021) Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout. Xenobiotica 51:1, pages 61-71.
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Naoyuki Otani, Motoshi Ouchi, Hideo Kudo, Shuichi Tsuruoka, Ichiro Hisatome & Naohiko Anzai. (2020) Recent approaches to gout drug discovery: an update. Expert Opinion on Drug Discovery 15:8, pages 943-954.
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Ying Pan & Ling-Dong Kong. (2016) Urate transporter URAT1 inhibitors: a patent review (2012 - 2015). Expert Opinion on Therapeutic Patents 26:10, pages 1129-1138.
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Articles from other publishers (38)

Zhongqi Shi, Xueli Ge, Shuna Zheng, Pengjiao Zeng, Zhenguo Su, Xiulian Li & Jiayu Zhang. (2023) Mangiferin reduces uric acid via regulation of amino acid and lipid metabolism. Journal of Functional Foods 108, pages 105716.
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Xiaoyu Cao, Jingyuan Cai, Yu Zhang, Chao Liu, Meijie Song, Qianqian Xu, Yang Liu & Hai Yan. (2023) Biodegradation of Uric Acid by Bacillus paramycoides-YC02. Microorganisms 11:8, pages 1989.
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Emmanuel A. Adomako & Orson W. Moe. (2023) Uric acid transport, transporters, and their pharmacological targeting. Acta Physiologica 238:2.
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Danni Song, Changqing Xie, Rong Yang, Aijinxiu Ma, Honghui Zhao, Fengmao Zou, Xiangrong Zhang & Xu Zhao. (2023) An application of citric acid as a carrier for solid dispersion to improve the dissolution and uric acid-lowering effect of kaempferol. International Journal of Food Engineering 19:1-2, pages 49-60.
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Peng Zhang, Zhengqiang Jiang, Jia Lei, Qiaojuan Yan & Chang Chang. (2023) Novel hemoglobin-derived xanthine oxidase inhibitory peptides: Enzymatic preparation and inhibition mechanisms. Journal of Functional Foods 102, pages 105459.
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Jia-jun Luo, Xin-hua Chen, Peng-ying Liang, Zean Zhao, Ting Wu, Zhong-huang Li, Shan-he Wan, Jian Luo, Jian-xin Pang, Jia-jie Zhang & Yuan-xin Tian. (2023) Mechanism of anti-hyperuricemia of isobavachin based on network pharmacology and molecular docking. Computers in Biology and Medicine 155, pages 106637.
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Reeta James & Binoy J. Paul. (2023) New and emerging therapies in gout. Rheumatology & Autoimmunity.
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Zhenjie Mao, Hong Jiang & Xiangzhao Mao. (2023) Identification and Anti-Hyperuricemic Activity of Xanthine Oxidase Inhibitory Peptides from Pacific White Shrimp and Swimming Crab Based on Molecular Docking Screening. Journal of Agricultural and Food Chemistry 71:3, pages 1620-1627.
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Xiaoyu Zi, Xi Zhang, Chuan Hao & Zhenxing Wang. (2023) Risk factors and management of hyperuricemia after renal transplantation. Frontiers in Surgery 9.
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玉珩 李. (2023) Research Progress of Traditional Chinese and Western Medicine on Hyperuricemia. Advances in Clinical Medicine 13:09, pages 14901-14907.
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Ya-Jia Li, Li-Rong Chen, Zhong-Lei Yang, Ping Wang, Fang-Fang Jiang, Yu Guo, Kai Qian, Mei Yang, Sun-Jun Yin & Gong-Hao He. (2022) Comparative efficacy and safety of uricosuric agents in the treatment of gout or hyperuricemia: a systematic review and network meta-analysis. Clinical Rheumatology 42:1, pages 215-224.
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Yajun Yang, Dingan Yan, Hanzeng Cheng, Guanglei Nan, Xianxin Hou, Long Ren, Ying Yang, Xuechen Li, Jinying Tian, Fei Ye & Zhiyan Xiao. (2022) Discovery of novel 1,2,4-triazole derivatives as xanthine oxidoreductase inhibitors with hypouricemic effects. Bioorganic Chemistry 129, pages 106162.
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Lei Zhao, Xin Ai, Fei Pan, Na Zhou, Liang Zhao, Shengbao Cai & Xiaoning Tang. (2022) Novel peptides with xanthine oxidase inhibitory activity identified from macadamia nuts: integrated in silico and in vitro analysis. European Food Research and Technology 248:8, pages 2031-2042.
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Baixi Shan, Ting Chen, Bixia Huang, Yang Liu & Jun Chen. (2021) Untargeted metabolomics reveal the therapeutic effects of Ermiao wan categorized formulas on rats with hyperuricemia. Journal of Ethnopharmacology 281, pages 114545.
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Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai & Ziren Su. (2021) Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice . Food & Function 12:19, pages 9416-9431.
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Tao Han Lee, Jia-Jin Chen, Chao-Yi Wu, Chih-Wei Yang & Huang-Yu Yang. (2021) Hyperuricemia and Progression of Chronic Kidney Disease: A Review from Physiology and Pathogenesis to the Role of Urate-Lowering Therapy. Diagnostics 11:9, pages 1674.
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Danni Song, Xu Zhao, Fuqi Wang & Gang Wang. (2021) A brief review of urate transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia and gout: Current therapeutic options and potential applications. European Journal of Pharmacology 907, pages 174291.
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Haiyan Zhou, Guorui Zhong, Jing Bai, Xiaolei Li, Wen Peng, Lei Zhang & Jing Li. (2021) Development of a fluorescence-based assay for screening of urate transporter 1 inhibitors using 6-carboxyfluorescein. Analytical Biochemistry 626, pages 114246.
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Hao-lu Sun, Yi-wan Wu, He-ge Bian, Hui Yang, Heng Wang, Xiao-ming Meng & Juan Jin. (2021) Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia. Frontiers in Pharmacology 12.
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Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng & Jiang Zheng. (2020) An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents. Journal of Chromatography B 1159, pages 122336.
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Tong Zhao, Qing Meng, Zhuosen Sun, Yanyu Chen, Wei Ai, Zean Zhao, Dongwei Kang, Yue Dong, Ruipeng Liang, Ting Wu, Jianxin Pang, Xinyong Liu & Peng Zhan. (2020) Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability. Journal of Medicinal Chemistry 63:19, pages 10829-10854.
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Xiao-Yun Xiong, Jun Liang, Sheng-Ya Guo, Ming-Zhu Dai, Jia-Li Zhou, Yong Zhang & Yi Liu. (2020) A natural complex product Yaocha reduces uric acid level in a live zebrafish model. Journal of Pharmacological and Toxicological Methods 102, pages 106681.
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Xin Zhang, Dapeng Wan, Guosheng Yang, Qingping Peng & Xiaohui Wang. (2019) Febuxostat is superior to allopurinol in delaying the progression of renal impairment in patients with chronic kidney disease and hyperuricemia. International Urology and Nephrology 51:12, pages 2273-2283.
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Shuangshuang Zhang, Yong Wang, Jinsong Cheng, Ning Huangfu, Ruochi Zhao, Zhenyu Xu, Fuxing Zhang, Wenyuan Zheng & Dandan Zhang. (2019) Hyperuricemia and Cardiovascular Disease. Current Pharmaceutical Design 25:6, pages 700-709.
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Weiwei He, Guowan Su, Dongxiao Sun-Waterhouse, Geoffrey I.N. Waterhouse, Mouming Zhao & Yang Liu. (2019) In vivo anti-hyperuricemic and xanthine oxidase inhibitory properties of tuna protein hydrolysates and its isolated fractions. Food Chemistry 272, pages 453-461.
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Caroline L. Benn, Pinky Dua, Rachel Gurrell, Peter Loudon, Andrew Pike, R. Ian Storer & Ciara Vangjeli. (2018) Physiology of Hyperuricemia and Urate-Lowering Treatments. Frontiers in Medicine 5.
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Danling Liang, Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Xinxin Zhou, Dan Li, Muxia Li, Lu Su & Dan Zuo. (2018) Hypouricemic Effect of 2,5-Dihydroxyacetophenone, a Computational Screened Bioactive Compound from Ganoderma applanatum, on Hyperuricemic Mice. International Journal of Molecular Sciences 19:5, pages 1394.
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Qibiao Su, Hua Su, Zhihuan Nong, Dongmei Li, Laiyou Wang, Shifeng Chu, Lizhen Liao, Jie Zhao, Xianbiao Zeng, Qikang Ya, Fei He, Wenjie Lu, Baowei Wei, Guining Wei & Naihong Chen. (2018) Hypouricemic and Nephroprotective Effects of an Active Fraction from <b><i>Polyrhachis Vicina Roger</i></b> On Potassium Oxonate-Induced Hyperuricemia in Rats. Kidney and Blood Pressure Research 43:1, pages 220-233.
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Xiaokui Huo & Kexin Liu. (2018) Renal organic anion transporters in drug–drug interactions and diseases. European Journal of Pharmaceutical Sciences 112, pages 8-19.
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Ting Wu, Jiasheng Chen, Shuai Dong, Haixin Li, Ying Cao, Yuanxin Tian, Weimin Fu, Pingzheng Zhou, Baomin Xi & Jianxin Pang. (2017) Identification and characterization of a potent and selective inhibitor of human urate transporter 1. Pharmacological Reports 69:5, pages 1103-1112.
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Jianfei Wang, Wenqin Zeng, Shaohua Li, Liang Shen, Zhengxian Gu, Yang Zhang, Jian Li, Shuhui Chen & Xiangbo Jia. (2017) Discovery and Assessment of Atropisomers of (±)-Lesinurad. ACS Medicinal Chemistry Letters 8:3, pages 299-303.
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Wenqing Cai, Wei Liu, Yafei Xie, Jingwei Wu, Yuqiang Liu, Changying Liu, Weiren Xu, Lida Tang, Jianwu Wang & Guilong Zhao. (2017) Design, synthesis and biological activity of tetrazole-bearing uric acid transporter 1 inhibitors. Chemical Research in Chinese Universities 33:1, pages 49-60.
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Jasvinder A. Singh. (2016) Gout: will the ?King of Diseases? be the first rheumatic disease to be cured?. BMC Medicine 14:1.
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He Tian, Wei Liu, Zhixing Zhou, Qian Shang, Yuqiang Liu, Yafei Xie, Changying Liu, Weiren Xu, Lida Tang, Jianwu Wang & Guilong Zhao. (2016) Discovery of a Flexible Triazolylbutanoic Acid as a Highly Potent Uric Acid Transporter 1 (URAT1) Inhibitor. Molecules 21:11, pages 1543.
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R. Ian Storer, Robert M. Owen, Andy Pike, Caroline L. Benn, Emma Armstrong, David C. Blakemore, Magda Bictash, Kathryn Costelloe, Emma Impey, Philip H. Milliken, Elisabeth Mortimer-Cassen, Hannah J. Pearce, Benjamin Pibworth & Gianna Toschi. (2016) The discovery and evaluation of diaryl ether heterocyclic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm 7:8, pages 1587-1595.
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Jiao Chen, Jia Zhou, Shuangshuang Wei, Zhijun Xie, Chengping Wen & Guowang Xu. (2016) Effect of a traditional Chinese medicine prescription Quzhuotongbi decoction on hyperuricemia model rats studied by using serum metabolomics based on gas chromatography–mass spectrometry. Journal of Chromatography B 1026, pages 272-278.
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S. O. Ahn, S. Ohtomo, J. Kiyokawa, T. Nakagawa, M. Yamane, K. J. Lee, K. H. Kim, B. H. Kim, J. Tanaka, Y. Kawabe & N. Horiba. (2016) Stronger Uricosuric Effects of the Novel Selective URAT1 Inhibitor UR-1102 Lowered Plasma Urate in Tufted Capuchin Monkeys to a Greater Extent than Benzbromarone. Journal of Pharmacology and Experimental Therapeutics 357:1, pages 157-166.
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Andy Pike, R. Ian Storer, Robert M. Owen, Emma Armstrong, Caroline L. Benn, Magda Bictash, Kathy F. K. Cheung, Kathryn Costelloe, Emmanuel Dardennes, Emma Impey, Philip H. Milliken, Elisabeth Mortimer-Cassen & Hannah J. Pearce. (2016) The design, synthesis and evaluation of low molecular weight acidic sulfonamides as URAT1 inhibitors for the treatment of gout. MedChemComm 7:8, pages 1572-1579.
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