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Novel drugs in clinical development for hepatocellular carcinoma

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Alessandro Rizzo, Riccardo Carloni, Angela Dalia Ricci, Antonio Cusmai, Mariarita Laforgia, Concetta Calabrò, Valentina Ungaro, Donato Oreste, Mario Sollitto, Gennaro Palmiotti & Giovanni Brandi. (2023) Treatment-related adverse events of first-line immunotherapy versus sorafenib for advanced hepatocellular carcinoma: a meta-analysis. Expert Opinion on Drug Safety 22:4, pages 323-329.
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Alessandro Rizzo & Angela Dalia Ricci. (2022) PD-L1, TMB, and other potential predictors of response to immunotherapy for hepatocellular carcinoma: how can they assist drug clinical trials?. Expert Opinion on Investigational Drugs 31:4, pages 415-423.
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Alessandro Rizzo, Vincenzo Dadduzio, Angela Dalia Ricci, Francesco Massari, Alessandro Di Federico, Gennaro Gadaleta-Caldarola & Giovanni Brandi. (2022) Lenvatinib plus pembrolizumab: the next frontier for the treatment of hepatocellular carcinoma?. Expert Opinion on Investigational Drugs 31:4, pages 371-378.
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Alessandro Rizzo, Angela Dalia Ricci, Gennaro Gadaleta-Caldarola & Giovanni Brandi. (2021) First-line immune checkpoint inhibitor-based combinations in unresectable hepatocellular carcinoma: current management and future challenges. Expert Review of Gastroenterology & Hepatology 15:11, pages 1245-1251.
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Hui Li. (2021) Angiogenesis in the progression from liver fibrosis to cirrhosis and hepatocelluar carcinoma. Expert Review of Gastroenterology & Hepatology 15:3, pages 217-233.
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Yike Huang, Lu Hu, Shan Huang, Wanjun Xu, Jingyuan Wan, Dandan Wang, Guocan Zheng & Zhining Xia. (2018) Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration. International Journal of Nanomedicine 13, pages 8309-8323.
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Oliver Waidmann. (2018) Recent developments with immunotherapy for hepatocellular carcinoma. Expert Opinion on Biological Therapy 18:8, pages 905-910.
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Articles from other publishers (25)

Alessandro Rizzo, Angela Dalia Ricci, Alessandro Di Federico, Giorgio Frega, Andrea Palloni, Simona Tavolari & Giovanni Brandi. (2021) Predictive Biomarkers for Checkpoint Inhibitor-Based Immunotherapy in Hepatocellular Carcinoma: Where Do We Stand?. Frontiers in Oncology 11.
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Alessandro Rizzo. (2021) Optimizing outcomes in HCC: Comment on “optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis” by Jiang et al.. Translational Oncology 14:12, pages 101246.
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Alessandro Rizzo, Angela Dalia Ricci & Giovanni Brandi. (2021) Atezolizumab in advanced hepatocellular carcinoma: good things come to those who wait. Immunotherapy 13:8, pages 637-644.
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Consolato M. Sergi. 2021. Liver Cancer. Liver Cancer 1 38 .
Alessandro Rizzo. (2021) The evolving landscape of systemic treatment for advanced hepatocellular carcinoma and biliary tract cancer. Cancer Treatment and Research Communications 27, pages 100360.
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Alessandro Rizzo & Giovanni Brandi. (2021) Biochemical predictors of response to immune checkpoint inhibitors in unresectable hepatocellular carcinoma. Cancer Treatment and Research Communications 27, pages 100328.
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Yin Zongyi & Li Xiaowu. (2020) Immunotherapy for hepatocellular carcinoma. Cancer Letters 470, pages 8-17.
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Hye Won Lee, Kyung Joo Cho, Soon Young Shin, Ha Yan Kim, Eun Ju Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn & Kwang-Hyub Han. (2019) Serum PD-1 Levels Change with Immunotherapy Response but Do Not Predict Prognosis in Patients with Hepatocellular Carcinoma. Journal of Liver Cancer 19:2, pages 108-116.
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Brynjar Mauseth, Ketil André Camilio, Jihua Shi, Clara Louise Hammarström, Øystein Rekdal, Baldur Sveinbjørnsson & Pål-Dag Line. (2019) The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma. Molecular Therapy - Oncolytics 14, pages 139-148.
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Elena De Mattia, Erika Cecchin, Michela Guardascione, Luisa Foltran, Tania Di Raimo, Francesco Angelini, Mario D’Andrea & Giuseppe Toffoli. (2019) Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma. World Journal of Gastroenterology 25:29, pages 3870-3896.
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Chih-Ling Chung, Shih-Wei Wang, Wei-Chih Sun, Chih-Wen Shu, Yu-Chen Kao, Meng-Shin Shiao & Chun-Lin Chen. (2018) Sorafenib suppresses TGF-β responses by inducing caveolae/lipid raft-mediated internalization/degradation of cell-surface type II TGF-β receptors: Implications in development of effective adjunctive therapy for hepatocellular carcinoma. Biochemical Pharmacology 154, pages 39-53.
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Wenjing Jiang, Guangxin Li, Weidong Li, Ping Wang, Peng Xiu, Xian Jiang, Bing Liu, Xueying Sun & Hongchi Jiang. (2018) Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways. Scientific Reports 8:1.
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Jordan N. Markowitz & Karen M. Fancher. (2018) Cabozantinib: A Multitargeted Oral Tyrosine Kinase Inhibitor. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:3, pages 357-369.
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A-Rum Yoon, JinWoo Hong, Minjung Kim & Chae-Ok Yun. (2018) Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions. Scientific Reports 8:1.
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Galina Khemlina, Sadakatsu Ikeda & Razelle Kurzrock. (2017) The biology of Hepatocellular carcinoma: implications for genomic and immune therapies. Molecular Cancer 16:1.
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Rinku Dutta & Ram I. Mahato. (2017) Recent advances in hepatocellular carcinoma therapy. Pharmacology & Therapeutics 173, pages 106-117.
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David J. Pinato, Alessia Dalla Pria, Rohini Sharma & Mark Bower. (2017) Hepatocellular carcinoma. AIDS 31:5, pages 603-611.
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Peng Han, Hali Li, Xian Jiang, Bo Zhai, Gang Tan, Dali Zhao, Haiquan Qiao, Bing Liu, Hongchi Jiang & Xueying Sun. (2017) Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells. Molecular Oncology 11:3, pages 320-334.
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Jian Niu, Yue Wang, Ji Wang, Liu Bin & Xin Hu. (2016) Delivery of sFIT-1 engineered MSCs in combination with a continuous low-dose doxorubicin treatment prevents growth of liver cancer. Aging 8:12, pages 3520-3534.
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Shuyao Tang, Gang Tan, Xian Jiang, Peng Han, Bo Zhai, Xuesong Dong, Haiquan Qiao, Hongchi Jiang & Xueying Sun. (2016) An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells. Oncotarget 7:45, pages 73257-73269.
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B. Bock, D. Hasdemir, F. Wandrer, T. Rodt, M. P. Manns, K. Schulze-Osthoff & H. Bantel. (2016) Serum cell death biomarker mirrors liver cancer regression after transarterial chemoembolisation. Alimentary Pharmacology & Therapeutics 44:7, pages 747-754.
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Jella-Andrea Abraham & Olga Golubnitschaja. (2016) Time for paradigm change in management of hepatocellular carcinoma: is a personalized approach on the horizon?. Personalized Medicine 13:5, pages 455-467.
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Joerg Trojan & Christoph Sarrazin. (2016) Complete Response of Hepatocellular Carcinoma in a Patient With End-stage Liver Disease treated With Nivolumab: Whishful thinking or Possible?. American Journal of Gastroenterology 111:8, pages 1208-1209.
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Fabian Finkelmeier, Özge Canli, Andrea Tal, Thomas Pleli, Jörg Trojan, Michael Schmidt, Bernd Kronenberger, Stefan Zeuzem, Albrecht Piiper, Florian R. Greten & Oliver Waidmann. (2016) High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis. European Journal of Cancer 59, pages 152-159.
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Jörg Trojan, Stephan Zangos & Andreas A. Schnitzbauer. (2016) Diagnostics and Treatment of Hepatocellular Carcinoma in 2016: Standards and Developments. Visceral Medicine 32:2, pages 116-120.
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