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Drug Evaluation

Beclabuvir for the treatment of hepatitis C

, MD, , , &

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Riccardo Scotto, Antonio Riccardo Buonomo, Stefania De Pascalis, Mariagiovanna Nerilli, Biagio Pinchera, Laura Staiano, Simona Mercinelli, Letizia Cattaneo, Maria Stanzione, Gianfranca Stornaiuolo, Salvatore Martini, Vincenzo Messina, Carmine Coppola, Nicola Coppola & Ivan Gentile. (2021) Changing epidemiology of patients treated with direct acting antivirals for HCV and persistently high SVR12 in an endemic area for HCV infection in Italy: real-life ‘LIver Network Activity’ (LINA) cohort update results. Expert Review of Gastroenterology & Hepatology 15:9, pages 1057-1063.
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Emanuela Zappulo, Riccardo Scotto, Antonio Riccardo Buonomo, Alberto Enrico Maraolo, Biagio Pinchera & Ivan Gentile. (2020) Efficacy and safety of a fixed dose combination tablet of asunaprevir + beclabuvir + daclatasvir for the treatment of Hepatitis C. Expert Opinion on Pharmacotherapy 21:3, pages 261-273.
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Isabella Esposito, Sebastián Marciano & Julieta Trinks. (2018) Pharmacokinetic and pharmacodynamic evaluation of daclatasvir, asunaprevir plus beclabuvir as a fixed-dose co-formulation for the treatment of hepatitis C. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 649-657.
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Guglielmo Borgia, Alberto Enrico Maraolo, Salvatore Nappa, Ivan Gentile & Antonio Riccardo Buonomo. (2018) NS5B polymerase inhibitors in phase II clinical trials for HCV infection. Expert Opinion on Investigational Drugs 27:3, pages 243-250.
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Helga Rübsamen‐Schaeff & Helmut BuschmannMichael J. Sofia. 2022. New Drug Development for Known and Emerging Viruses. New Drug Development for Known and Emerging Viruses 13 57 .
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Anna Inyutina, Dmitry Dar'in, Grigory Kantin & Mikhail Krasavin. (2021) Tricyclic 2-benzazepines obtained via an unexpected cyclization involving nitrilium ylides . Organic & Biomolecular Chemistry 19:23, pages 5068-5071.
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Lei Tian, Taotao Qiang, Chengyuan Liang, Xiaodong Ren, Minyi Jia, Jiayun Zhang, Jingyi Li, Minge Wan, Xin YuWen, Han Li, Wenqiang Cao & Hong Liu. (2021) RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic. European Journal of Medicinal Chemistry 213, pages 113201.
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Chi Xu, Zunhui Ke, Chuandong Liu, Zhihao WangDenghui Liu, Lei Zhang, Jingning Wang, Wenjun He, Zhimeng Xu, Yanqing Li, Yanan Yang, Zhaowei Huang, Panjing Lv, Xin Wang, Dali Han, Yan Li, Nan Qiao & Bing Liu. (2020) Systemic In Silico Screening in Drug Discovery for Coronavirus Disease (COVID-19) with an Online Interactive Web Server . Journal of Chemical Information and Modeling 60:12, pages 5735-5745.
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Qingmei Ye, Yande Huang, Stephen Grier & Scott A. Miller. (2019) Oxidative degradation pathways of beclabuvir hydrochloride mediated by hydrogen peroxide and UV/Vis light. Journal of Pharmaceutical and Biomedical Analysis 172, pages 388-394.
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Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Emanuela Zappulo, Riccardo Scotto, Biagio Pinchera & Ivan Gentile. (2019) Unsolved Issues in the Treatment of Spontaneous Peritonitis in Patients with Cirrhosis: Nosocomial Versus Community-acquired Infections and the Role of Fungi. Reviews on Recent Clinical Trials 14:2, pages 129-135.
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Tushar Garimella, Xiaolu Tao, Karen Sims, Yi-Ting Chang, Jignasa Rana, Elsa Myers, Megan Wind-Rotolo, Rahul Bhatnagar, Timothy Eley, Frank LaCreta & Malaz AbuTarif. (2017) Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects. Drugs in R&D 18:1, pages 55-65.
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Barbara Zhizhen Zheng, Stanley V. D'Andrea, Umesh Hanumegowda, Jay O. Knipe, Kathy Mosure, Xiaoliang Zhuo, Julie A. Lemm, Mengping Liu, Karen L. Rigat, Ying-Kai Wang, Hua Fang, Chris Poronsky, Jingfang Cutrone, Dauh-Rurng Wu, Pirama Nayagam Arunachalam, T.J. Balapragalathan, Arunachalam Arumugam, Arvind Mathur, Nicholas A. Meanwell, Min Gao, Susan B. Roberts & John F. Kadow. (2017) Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase. Bioorganic & Medicinal Chemistry Letters 27:15, pages 3294-3300.
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Nicholas A. Meanwell. (2016) 2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph. Journal of Medicinal Chemistry 59:16, pages 7311-7351.
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Sara E. Williford & David R. McGivern. 2016. Hepatitis C Virus II. Hepatitis C Virus II 287 301 .

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