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Investigational drugs for the treatment of osteoarthritis

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Sarah C Porto, Alexandra Rogers-DeCotes, Emmaline Schafer & Christine B Kern. (2023) The adaptive response of the mandibular condyle to increased load is disrupted by ADAMTS5 deficiency. Connective Tissue Research 64:1, pages 93-104.
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Zhongxing Liu, Jian Cao, Limin Zhang, Jinlong Li, Tinghan Yan, Peng Zhou & Sidi Zhang. (2022) Knockdown of circ-PRKCH alleviates IL-1β-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis. Autoimmunity 55:3, pages 179-191.
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Peihua Cao, Yamin Li, Yujin Tang, Changhai Ding & David J. Hunter. (2020) Pharmacotherapy for knee osteoarthritis: current and emerging therapies. Expert Opinion on Pharmacotherapy 21:7, pages 797-809.
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Shan-Chi Liu, Chun-Hao Tsai, Tung-Ying Wu, Chang-Hai Tsai, Fuu-Jen Tsai, Jing-Gung Chung, Chih-Yang Huang, Jai-Sing Yang, Yuan-Man Hsu, Mei-Chin Yin, Yang-Chang Wu & Chih-Hsin Tang. (2019) Soya-cerebroside reduces IL-1β-induced MMP-1 production in chondrocytes and inhibits cartilage degradation: implications for the treatment of osteoarthritis. Food and Agricultural Immunology 30:1, pages 620-632.
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Zhaohua Zhu, Jia Li, Guangfeng Ruan, Guoliang Wang, Cibo Huang & Changhai Ding. (2018) Investigational drugs for the treatment of osteoarthritis, an update on recent developments. Expert Opinion on Investigational Drugs 27:11, pages 881-900.
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Weiyu Han, Shicai Fan, Xiaochun Bai & Changhai Ding. (2017) Strontium ranelate, a promising disease modifying osteoarthritis drug. Expert Opinion on Investigational Drugs 26:3, pages 375-380.
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Shuang Zheng, David J. Hunter, Jianhua Xu & Changhai Ding. (2016) Monoclonal antibodies for the treatment of osteoarthritis. Expert Opinion on Biological Therapy 16:12, pages 1529-1540.
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Articles from other publishers (36)

Hai Xiong, Te-Yang Huang, Yu-Lo Chang & Wen-Ta Su. (2023) Achyranthes bidentate extracts protect the IL-1β-induced osteoarthritis of SW1353 chondrocytes. Journal of Bioscience and Bioengineering 136:6, pages 462-470.
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Zhiqiang Jin, Yanting Zhan, Li Zheng, Qingjun Wei, Sheng Xu & Zainen Qin. (2023) Cannabidiol‐Loaded Poly Lactic‐Co‐Glycolic Acid Nanoparticles with Improved Bioavailability as a Potential for Osteoarthritis Therapeutic. ChemBioChem 24:9.
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Sara Aviles-Gaxiola, Marilyn S. Criollo-Mendoza, Melissa García-Carrasco, Erick P. Gutiérrez-Grijalva, Israel García-Aguiar & J. Basilio Heredia. 2023. Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals. Phytochemical Nanodelivery Systems as Potential Biopharmaceuticals 29 69 .
Ana Divjak, Ivan Jovanovic, Aleksandar Matic, Aleksandra Tomic Lucic, Nevena Gajovic, Milena Jurisevic, Aleksandra Jurisic Skevin & Mirjana Veselinovic. (2022) The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunologic Research.
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Mohammed A. S. Abourehab, Shreya Baisakhiya, Akanksha Aggarwal, Anshul Singh, Mohamed A. Abdelgawad, A. Deepak, Mohammad Javed Ansari & Sheersha Pramanik. (2022) Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications. Journal of Materials Chemistry B 10:44, pages 9125-9178.
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Reena Sharma, Kaushik Kuche, Pradip Thakor, Valamla Bhavana, Saurabh Srivastava, Neelesh Kumar Mehra & Sanyog Jain. (2022) Chondroitin Sulfate: Emerging biomaterial for biopharmaceutical purpose and tissue engineering. Carbohydrate Polymers 286, pages 119305.
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Juntao Zhang, Fangyang Fan, Aifeng Liu, Chao Zhang, Qi Li, Chenglong Zhang, Feng He & Man Shang. (2022) Icariin: A Potential Molecule for Treatment of Knee Osteoarthritis. Frontiers in Pharmacology 13.
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Chih-Chung Liu, Hoong-Chien Lee, Yi-Shian Peng, Ailun Heather Tseng, Jia-Lin Wu, Wei-Yuan Tsai, Chih-Shung Wong & Li-Jen Su. (2019) Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression. CARTILAGE 13:2_suppl, pages 1249S-1262S.
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J.P.M. Vrouwe, J. Burggraaf, M. Kloppenburg & F.E. Stuurman. (2021) Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments. Osteoarthritis and Cartilage Open 3:4, pages 100212.
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Xuan Liu, Wenbo Chen, Yu Fang, Siqi Yang, Liuping Chang, Xingyu Chen, Haidong Ye, Xinyu Tang, Shan Zhong, Wen Zhang, Zhiqiang Dong, Leng Han & Chunjiang He. (2021) ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues. Briefings in Bioinformatics 22:6.
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Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang & Chunli Wang. (2021) Hesperetin Exhibits Anti-Inflammatory Effects on Chondrocytes via the AMPK Pathway to Attenuate Anterior Cruciate Ligament Transection-Induced Osteoarthritis. Frontiers in Pharmacology 12.
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Long Sun, Wei Zheng, Qian-Dong Liu & Lei Ge. (2021) Valproic Acid Protects Chondrocytes from LPS-Stimulated Damage via Regulating miR-302d-3p/ITGB4 Axis and Mediating the PI3K-AKT Signaling Pathway. Frontiers in Molecular Biosciences 8.
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Dandan Guo, Liming He, Yaoxin Gao, Chenxu Jin, Haizhen Lin, Li Zhang, Liting Wang, Ying Zhou, Jie Yao, Yixin Duan, Renzheng Yang, Wenwei Qiu & Wenzheng Jiang. (2021) Obeticholic Acid Derivative, T-2054 Suppresses Osteoarthritis via Inhibiting NF-κB-Signaling Pathway. International Journal of Molecular Sciences 22:8, pages 3807.
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Zhiyong Fan, Yinghui Liu, Zhengliang Shi, Kai Deng, Hua Zhang, Qiutong Li, Shuxing Cao, Shentai Li & Hongliang Zhang. (2020) MiR‐155 promotes interleukin‐1β‐induced chondrocyte apoptosis and catabolic activity by targeting PIK3R1‐mediated PI3K/Akt pathway. Journal of Cellular and Molecular Medicine 24:15, pages 8441-8451.
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Laura Micheli, Lorenzo Di Cesare Mannelli, Luisa Mattoli, Sara Tamimi, Enrico Flamini, Stefano Garetto, Jacopo Lucci, Emiliano Giovagnoni, Lorenzo Cinci, Mario D’Ambrosio, Cristina Luceri & Carla Ghelardini. (2020) Intra-Articular Route for the System of Molecules 14G1862 from Centella asiatica: Pain Relieving and Protective Effects in a Rat Model of Osteoarthritis. Nutrients 12:6, pages 1618.
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Mohammad Alsalem, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Ahmad Altarifi, Sahar M. Jaffal, Manal A. Abbas, Nour Aldaoud & Khalid El-Salem. (2019) Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound. Inflammopharmacology 27:6, pages 1131-1142.
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Loren E. DupuisE. Lockett NelsonBrittany HozikSarah C. PortoAlexandra Rogers-DeCotesAmanda FosangChristine B. Kern. (2019) Adamts5 −/− Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies . Arteriosclerosis, Thrombosis, and Vascular Biology 39:10, pages 2067-2081.
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Susanna Piluso, Yang Li, Florencia Abinzano, Riccardo Levato, Liliana Moreira Teixeira, Marcel Karperien, Jeroen Leijten, René van Weeren & Jos Malda. (2019) Mimicking the Articular Joint with In Vitro Models. Trends in Biotechnology 37:10, pages 1063-1077.
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Giustino Varrassi, Eli Alon, Michela Bagnasco, Luigi Lanata, Victor Mayoral-Rojals, Antonella Paladini, Joseph V. Pergolizzi, Serge Perrot, Carmelo Scarpignato & Thomas Tölle. (2019) Towards an Effective and Safe Treatment of Inflammatory Pain: A Delphi-Guided Expert Consensus. Advances in Therapy 36:10, pages 2618-2637.
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L. Zerrillo, I. Que, O. Vepris, L.N. Morgado, A. Chan, K. Bierau, Y. Li, F. Galli, E. Bos, R. Censi, P. Di Martino, G.J.V.M. van Osch & L.J. Cruz. (2019) pH-responsive poly(lactide-co-glycolide) nanoparticles containing near-infrared dye for visualization and hyaluronic acid for treatment of osteoarthritis. Journal of Controlled Release 309, pages 265-276.
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Shannon Brown, Jake Pistiner, Isaac M. Adjei & Blanka Sharma. (2017) Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake. Molecular Pharmaceutics 16:2, pages 469-479.
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Toby O. Smith, Andrew Kemp & Michael J. Twigg. (2018) Medication taking in people with hip and knee osteoarthritis: An analysis of the English Longitudinal Study of Ageing. Musculoskeletal Care 16:4, pages 450-457.
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Tsung‐Ju Wu, Chih‐Yang Lin, Chun‐Hao Tsai, Yuan‐Li Huang & Chih‐Hsin Tang. (2018) Glucose suppresses IL‐1β‐induced MMP‐1 expression through the FAK, MEK, ERK, and AP‐1 signaling pathways. Environmental Toxicology 33:10, pages 1061-1068.
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Zhengping Huang, Changhai Ding, Tianwang Li & Shirley Pei-Chun Yu. (2018) Current status and future prospects for disease modification in osteoarthritis. Rheumatology 57:suppl_4, pages iv108-iv123.
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Kai Fu, Sarah R Robbins & Jason J McDougall. (2018) Osteoarthritis: the genesis of pain. Rheumatology 57:suppl_4, pages iv43-iv50.
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Kadir Oznam, Duygu Yasar Sirin, Ibrahim Yilmaz, Yasin Emre Kaya, Mehmet Isyar, Seyit Ali Gumustas, Hanefi Ozbek, Semih Akkaya, Arda Kayhan & Mahir Mahirogullari. (2017) Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes. Journal of Orthopaedic Surgery and Research 12:1.
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Teng Dai, Keqing Shi, Gang Chen, Yimin Shen & Ting Pan. (2017) Malvidin attenuates pain and inflammation in rats with osteoarthritis by suppressing NF-κB signaling pathway. Inflammation Research 66:12, pages 1075-1084.
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F.B. Ma, N. Liu, N. Hu, C.Y. Wen & B. Tang. (2017) Synthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritis. Carbohydrate Polymers 170, pages 217-225.
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Mariella Fusco, Stephen D. Skaper, Stefano Coaccioli, Giustino Varrassi & Antonella Paladini. (2017) Degenerative Joint Diseases and Neuroinflammation. Pain Practice 17:4, pages 522-532.
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XinGang Lu, YingXiu Pu, WeiGuang Kong, XiaoDan Tang, JiAn Zhou, HaiXin Gou, Xiao Song, HaiFeng Zhou, NingZhou Gao & Jie Shen. (2017) Antidesmone, a unique tetrahydroquinoline alkaloid, prevents acute lung injury via regulating MAPK and NF-κB activities. International Immunopharmacology 45, pages 34-42.
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Cui-Cui Liu, Yanmin Zhang, Bing-Ling Dai, Yu-Jiao Ma, Qian Zhang, Yi Wang & Hao Yang. (2017) Chlorogenic acid prevents inflammatory responses in IL-1β-stimulated human SW-1353 chondrocytes, a model for osteoarthritis. Molecular Medicine Reports 16:2, pages 1369-1375.
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Xian-Xiang Xu, Xiao-Hong Zhang, Yong Diao & Yu-Xiang Huang. (2017) Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro. The Kaohsiung Journal of Medical Sciences 33:2, pages 62-68.
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Hiroshi Nara, Akira Kaieda, Kenjiro Sato, Takako Naito, Hideyuki Mototani, Hideyuki Oki, Yoshio Yamamoto, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa & Masakuni Kori. (2017) Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach. Journal of Medicinal Chemistry 60:2, pages 608-626.
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Hiroshi Nara, Kenjiro Sato, Akira Kaieda, Hideyuki Oki, Haruhiko Kuno, Takashi Santou, Naoyuki Kanzaki, Jun Terauchi, Osamu Uchikawa & Masakuni Kori. (2016) Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors. Bioorganic & Medicinal Chemistry 24:23, pages 6149-6165.
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Sergio Portal-Núñez, Pedro Esbrit, María José Alcaraz & Raquel Largo. (2016) Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis. Biochemical Pharmacology 108, pages 1-10.
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Yaqiang Li, Jiaji Yue & Chunxi Yang. (2016) Unraveling the role of Mg++ in osteoarthritis. Life Sciences 147, pages 24-29.
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