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Expert Opinion on Investigational Drugs Volume 24, 2015 - Issue 2
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Review

Investigational parathyroid hormone receptor analogs for the treatment of osteoporosis

Stergios A PolyzosHarvard Medical School, Beth Israel Deaconess Medical Center, Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Boston, MA, USA
,
Polyzois MakrasDepartment of Endocrinology and Diabetes, 251 Hellenic Air Force and VA General Hospital, Athens, Greece
,
Zoe Efstathiadou"Hippokration" General Hospital of Thessaloniki, Department of Endocrinology, Thessaloniki, Greece
&
Athanasios D Anastasilakis424 General Military Hospital, Department of Endocrinology, Ring Road, 564 29 N.Efkarpia, Thessaloniki, Greece+30 2310 381 697; +30 2310 381 010; [email protected]
, MD PhD
Pages 145-157 | Published online: 15 Oct 2014

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Anastasia D Dede, Polyzois Makras & Athanasios D. Anastasilakis. (2017) Investigational anabolic agents for the treatment of osteoporosis: an update on recent developments. Expert Opinion on Investigational Drugs 26:10, pages 1137-1144.
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Articles from other publishers (14)

Mikkel Bo Brent. (2023) Pharmaceutical treatment of bone loss: From animal models and drug development to future treatment strategies. Pharmacology & Therapeutics 244, pages 108383.
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Li Chen, Lei Xiong, Lingling Yao, Jinxiu Pan, Emily Arzola, Xiaojuan Zhu, Lin Mei & Wen-Cheng Xiong. (2023) Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone. Alzheimer's Research & Therapy 15:1.
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João Ricardo Almeida Grossi, Tatiana Miranda Deliberador, Allan Fernando Giovanini, João César Zielak, Aline Sebastiani, Carla Castiglia Gonzaga, Paulo G. Coelho, André Luis Zétola, Fernando P. Weiss, Ernesto B. Benalcázar Jalkh, Carmen Lucia Mueller Storrer & Lukasz Witek. (2022) Effects of local single dose administration of parathormone on the early stages of osseointegration: A pre‐clinical study. Journal of Biomedical Materials Research Part B: Applied Biomaterials 110:8, pages 1806-1813.
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Mikkel Bo Brent, Andreas Lodberg, Frederik Duch Bromer, Bram C.J. van der Eerden, Marco Eijken, Annemarie Brüel & Jesper Skovhus Thomsen. (2021) Activin type IIA decoy receptor and intermittent parathyroid hormone in combination overturns the bone loss in disuse-osteopenic mice. Bone 142, pages 115692.
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Subhashis Pal, Konica Porwal, Kunal Khanna, Manoj Kumar Gautam, Mohd Yaseen Malik, Mamunur Rashid, R. John Macleod, Muhammad Wahajuddin, Venkitanarayanan Parameswaran, Jayesh R. Bellare & Naibedya Chattopadhyay. (2019) Oral dosing of pentoxifylline, a pan-phosphodiesterase inhibitor restores bone mass and quality in osteopenic rabbits by an osteogenic mechanism: A comparative study with human parathyroid hormone. Bone 123, pages 28-38.
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Stergios A. Polyzos, Leonidas Duntas & Jens Bollerslev. (2017) The intriguing connections of leptin to hyperparathyroidism. Endocrine 57:3, pages 376-387.
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Benjamin Z. Leder. (2017) Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy. Current Osteoporosis Reports 15:2, pages 110-119.
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Denise Wootten, Laurence J. Miller, Cassandra Koole, Arthur Christopoulos & Patrick M. Sexton. (2016) Allostery and Biased Agonism at Class B G Protein-Coupled Receptors. Chemical Reviews 117:1, pages 111-138.
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Jun Guo, Ashok Khatri, Akira Maeda, John T PottsJrJr, Harald Jüppner & Thomas J Gardella. (2017) Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. Journal of Bone and Mineral Research 32:1, pages 86-98.
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Pedro Esbrit, Sabina Herrera, Sergio Portal-Núñez, Xavier Nogués & Adolfo Díez-Pérez. (2015) Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies. Calcified Tissue International 98:4, pages 359-369.
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Ross W. Cheloha, Samuel H. Gellman, Jean-Pierre Vilardaga & Thomas J. Gardella. (2015) PTH receptor-1 signalling—mechanistic insights and therapeutic prospects. Nature Reviews Endocrinology 11:12, pages 712-724.
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Elaine Quinlan, Emmet M. Thompson, Amos Matsiko, Fergal J. O'Brien & Adolfo L?pez-Noriega. (2015) Functionalization of a Collagen-Hydroxyapatite Scaffold with Osteostatin to Facilitate Enhanced Bone Regeneration. Advanced Healthcare Materials 4:17, pages 2649-2656.
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Polyzois Makras, Sideris Delaroudis & Athanasios D. Anastasilakis. (2015) Novel therapies for osteoporosis. Metabolism 64:10, pages 1199-1214.
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Paul D Miller. (2014) Chronic kidney disease and the skeleton. Bone Research 2:1.
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