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Neurokinin receptor antagonists

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Pages 735-746 | Published online: 24 Feb 2005

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K. Sigfridsson, M. Ahlqvist, A. Carlsson & A. Fridström. (2011) Early development evaluation of AZD8081: a substrate for the NK receptors. Drug Development and Industrial Pharmacy 37:6, pages 702-713.
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Kalle Sigfridsson, Matti Ahlqvist, Martin Lindsjö & Stefan Paulsson. (2018) Salt formation improved the properties of a candidate drug during early formulation development. European Journal of Pharmaceutical Sciences 120, pages 162-171.
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Olivier Van der Poorten, Astrid Knuhtsen, Daniel Sejer Pedersen, Steven Ballet & Dirk Tourwé. (2016) Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design. Journal of Medicinal Chemistry 59:24, pages 10865-10890.
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Georg Pongratz & Rainer H. Straub. (2012) Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Nature Reviews Rheumatology 9:2, pages 117-126.
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Junya Shirai, Takeshi Yoshikawa, Masayuki Yamashita, Yasuharu Yamamoto, Makiko Kawamoto, Naoki Tarui, Izumi Kamo, Tadatoshi Hashimoto & Yoshinori Ikeura. (2011) Design, structure–activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists. Bioorganic & Medicinal Chemistry 19:21, pages 6430-6446.
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Steven Ballet, Debby Feytens, Koen Buysse, Nga N. Chung, Carole Lemieux, Suneeta Tumati, Attila Keresztes, Joost Van Duppen, Josephine Lai, Eva Varga, Frank Porreca, Peter W. Schiller, Jozef Vanden Broeck & Dirk Tourwé. (2011) Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist. Journal of Medicinal Chemistry 54:7, pages 2467-2476.
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Donald J. AbrahamRandy L. Webb & Gary M. Ksander. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 515 566 .
Riccardo Patacchini & Carlo A. Maggi. 2009. Neurogenic Inflammation in Health and Disease. Neurogenic Inflammation in Health and Disease 289 320 .
Susanna Engberg, Ingela Ahlstedt, Agnes Leffler, Erik Lindström, Elin Kristensson, Arne Svensson, Ingrid Påhlman, Anders Johansson, Tomas Drmota & Bengt von Mentzer. (2007) Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors. Biochemical Pharmacology 73:2, pages 259-269.
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Christiane Hesse, Steffen P. Luntz, Heike Siedler, Kristina Unnebrink, Gerd Mikus, Marianne de Bruijn, Edu Zondag, Michiel de Vries, Monika Seibert-Grafe & Walter E. Haefeli. (2006) Kinetics and dynamics of the peripheral neurokinin-1 receptor antagonist SLV317 in healthy individuals. British Journal of Clinical Pharmacology 61:4, pages 414-419.
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Naïma Hanoun, Elisabeth Mocaër, Pierre-Alain Boyer, Michel Hamon & Laurence Lanfumey. (2004) Differential effects of the novel antidepressant agomelatine (S 20098) versus fluoxetine on 5-HT1A receptors in the rat brain. Neuropharmacology 47:4, pages 515-526.
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A.J. Nimmo, I. Cernak, D.L. Heath, X. Hu, C.J. Bennett & R. Vink. (2004) Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats. Neuropeptides 38:1, pages 40-47.
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S. B. Mazzone & B. J. Canning. 2004. Tachykinins. Tachykinins 245 271 .
Aurelio Orjales, Ramón Mosquera, Antonio Toledo, M. Carmen Pumar, Neftalí García, Lourdes Cortizo, Luis Labeaga & Ana Innerárity. (2003) Syntheses and Binding Studies of New [(Aryl)(aryloxy)methyl]piperidine Derivatives and Related Compounds as Potential Antidepressant Drugs with High Affinity for Serotonin (5-HT) and Norepinephrine (NE) Transporters. Journal of Medicinal Chemistry 46:25, pages 5512-5532.
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Frederik J.R Rombouts, Jeroen Van den Bossche, Suzanne M Toppet, Frans Compernolle & Georges J Hoornaert. (2003) Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold. Tetrahedron 59:26, pages 4721-4731.
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Konrad H Bleicher, Yves Wüthrich, Geo Adam, Torsten Hoffmann & Andrew J Sleight. (2002) Parallel solution- and solid-phase synthesis of spiropyrrolo-Pyrroles as novel neurokinin receptor ligands. Bioorganic & Medicinal Chemistry Letters 12:21, pages 3073-3076.
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M G C van der Hart, B Czéh, G de Biurrun, T Michaelis, T Watanabe, O Natt, J Frahm & E Fuchs. (2002) Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Molecular Psychiatry 7:9, pages 933-941.
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Konrad H. Bleicher, Yves Wüthrich, Maxime De Boni, Sabine Kolczewski, Torsten Hoffmann & Andrew J. Sleight. (2002) Parallel solution- and solid-Phase synthesis of spirohydantoin derivatives as neurokinin-1 receptor ligands. Bioorganic & Medicinal Chemistry Letters 12:18, pages 2519-2522.
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A. B. Kay, E. W. Gelfand, L. J. Smith & D. Tashkin. (2002) Natural history of asthma from childhood to adulthood. Clinical & Experimental Allergy Reviews 2:4, pages 117-127.
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Laura C Cooper, Emma J Carlson, Jose L Castro, Gary G Chicchi, Kevin Dinnell, Jerry Di Salvo, Jason M Elliott, Gregory J Hollingworth, Marc M Kurtz, Mark P Ridgill, Wayne Rycroft, Kwei-Lan Tsao & Christopher J Swain. (2002) 4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II. Bioorganic & Medicinal Chemistry Letters 12:13, pages 1759-1762.
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Valerie A. Ashwood, Mark J. Field, David C. Horwell, Christine Julien-Larose, Russell A. Lewthwaite, Scott McCleary, Martyn C. Pritchard, Jenny Raphy & Lakhbir Singh. (2001) Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK 1 Receptor Antagonist . Journal of Medicinal Chemistry 44:14, pages 2276-2285.
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Kevin Dinnell, Gary G Chicchi, Madhumeeta J Dhar, Jason M Elliott, Gregory J Hollingworth, Marc M Kurtz, Mark P Ridgill, Wayne Rycroft, Kwei-Lan Tsao, Angela R Williams & Christopher J Swain. (2001) 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-Aryl ring and the indole nitrogen substituent. Bioorganic & Medicinal Chemistry Letters 11:9, pages 1237-1240.
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Laura C. Cooper, Gary G. Chicchi, Kevin Dinnell, Jason M. Elliott, Gregory J. Hollingworth, Marc M. Kurtz, Karen L. Locker, Denise Morrison, Duncan E. Shaw, Kwei-Lan Tsao, Alan P. Watt, Angela R. Williams & Christopher J. Swain. (2001) 2-Aryl Indole NK1 receptor antagonists: optimisation of indole substitution. Bioorganic & Medicinal Chemistry Letters 11:9, pages 1233-1236.
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J. Herrstedt. (2001) Potential new agents in the prophylaxis and treatment of chemotherapy-induced emesis. European Journal of Cancer 37:7, pages 823-825.
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