216
Views
73
CrossRef citations to date
0
Altmetric
Review

Apoptosis modulators in the therapy of neurodegenerative diseases

, &
Pages 747-764 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Cuiping Zhao, Zhaohong Xie, Ping Wang, Yun Wang, Chao Lai, Zhengyu Zhu, Zhen Liu, Yanbin Cong, Yanxin Zhao, Chengyun Zheng & Jianzhong Bi. (2011) Granulocyte-colony stimulating factor protects memory impairment in the senescence-accelerated mouse (SAM)-P10. Neurological Research 33:4, pages 354-359.
Read now
Susan L Perlman. (2003) Spinocerebellar degeneration. Expert Opinion on Pharmacotherapy 4:10, pages 1637-1641.
Read now
Thomas Müller. (2002) Dopaminergic substitution in Parkinson’s disease. Expert Opinion on Pharmacotherapy 3:10, pages 1393-1403.
Read now
Benjamin Drukarch & Freek L van Muiswinkel. (2001) Neuroprotection for Parkinson’s disease: a new approach for a new millennium. Expert Opinion on Investigational Drugs 10:10, pages 1855-1868.
Read now
Helmut Weicker, Ralf Kinscherf, Karin Diserens, Hans-Peter Deigner & Heiko Strüder. (2001) Physiology and pathophysiology of basalganglia: Impact on motor system function. European Journal of Sport Science 1:2, pages 1-46.
Read now
AJ Larner. (2000) Neuronal apoptosis as a therapeutic target in neurodegenerative disease. Expert Opinion on Therapeutic Patents 10:10, pages 1493-1518.
Read now

Articles from other publishers (67)

Phei Er Saw & Erwei Song. 2023. Tumor Ecosystem. Tumor Ecosystem 497 510 .
Hamad Ghaleb Dailah. (2022) Potential of Therapeutic Small Molecules in Apoptosis Regulation in the Treatment of Neurodegenerative Diseases: An Updated Review. Molecules 27:21, pages 7207.
Crossref
Mayuri Shukla, Vorapin Chinchalongporn, Piyarat Govitrapong & Russel J. Reiter. (2019) The role of melatonin in targeting cell signaling pathways in neurodegeneration. Annals of the New York Academy of Sciences 1443:1, pages 75-96.
Crossref
Huynh Nhu Mai, Lan Thuy Ty Nguyen, Eun-Joo Shin, Dae-Joong Kim, Ji Hoon Jeong, Yoon Hee Chung, Xin Gen Lei, Naveen Sharma, Choon-Gon Jang, Toshitaka Nabeshima & Hyoung-Chun Kim. (2019) Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling. Free Radical Biology and Medicine 131, pages 408-431.
Crossref
Nitya Beriwal, Tashi Namgyal, Pema Sangay & Asmaa Monther Al Quraan. (2019) Role of immune-pineal axis in neurodegenerative diseases, unraveling novel hybrid dark hormone therapies. Heliyon 5:1, pages e01190.
Crossref
Asiyeh Golabchi, Bingchen Wu, Xia Li, Diane L. Carlisle, Takashi D.Y. Kozai, Robert M. Friedlander & Xinyan Tracy Cui. (2018) Melatonin improves quality and longevity of chronic neural recording. Biomaterials 180, pages 225-239.
Crossref
Stefania Schiavone, Margherita Neri, Emanuela Mhillaj, Cristoforo Pomara, Luigia Trabace & Emanuela Turillazzi. (2016) The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review. Toxicology Letters 258, pages 29-35.
Crossref
Sahar M.A. HassaneinShaymaa M. DeifallaMoustafa El-HoussinieSomaia A. Mokbel. (2016) Safety and Efficacy of Cerebrolysin in Infants with Communication Defects due to Severe Perinatal Brain Insult: A Randomized Controlled Clinical Trial. Journal of Clinical Neurology 12:1, pages 79.
Crossref
Ramesh B. Badisa, Sanjay S. Kumar, Elizabeth Mazzio, Rasheda D. Haughbrook, John R. Allen, Michael W. Davidson, Cheryl A. Fitch-Pye & Carl B. Goodman. (2015) N-Acetyl Cysteine Mitigates the Acute Effects of Cocaine-Induced Toxicity in Astroglia-Like Cells. PLOS ONE 10:1, pages e0114285.
Crossref
Nicole Arend, Christian Wertheimer, Peter Laubichler, Armin Wolf, Anselm Kampik & Marcus Kernt. (2015) Idebenone Prevents Oxidative Stress, Cell Death and Senescence of Retinal Pigment Epithelium Cells by Stabilizing BAX/Bcl-2 Ratio. Ophthalmologica 234:2, pages 73-82.
Crossref
Xin Wang, Yingjun Guan, Wenyu Fu, Shuanhu Zhou & Zheng-Hong Qin. 2014. Melatonin. Melatonin 111 132 .
Ramesh Badisa, Cheryl Fitch-Pye, Maryam Agharahimi, Donald Palm, Lekan Latinwo & Carl Goodman. (2014) Milk thistle seed extract protects rat�C6�astroglial�cells from acute cocaine toxicity. Molecular Medicine Reports.
Crossref
. 2014. Platelets and Aspirin-Induced Asthma. Platelets and Aspirin-Induced Asthma 103 136 .
Marcus Kernt, Nicole Arend, Alexandra Buerger, Thomas Mann, Christos Haritoglou, Michael W. Ulbig, Anselm Kampik & Christoph Hirneiss. (2013) Idebenone Prevents Human Optic Nerve Head Astrocytes From Oxidative Stress, Apoptosis, and Senescence by Stabilizing BAX/Bcl-2 Ratio. Journal of Glaucoma 22:5, pages 404-412.
Crossref
Tilman Grune, Betul Catalgol & Tobias Jung. 2012. Protein Oxidation and Aging. Protein Oxidation and Aging 295 415 .
Arpád Dobolyi, Csilla Vincze, Gabriella Pál & Gábor Lovas. (2012) The Neuroprotective Functions of Transforming Growth Factor Beta Proteins. International Journal of Molecular Sciences 13:7, pages 8219-8258.
Crossref
Linnea R. Freeman & Jeffrey N. Keller. (2012) Oxidative stress and cerebral endothelial cells: Regulation of the blood–brain-barrier and antioxidant based interventions. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:5, pages 822-829.
Crossref
Dave Lanoix, Andrée-Anne Lacasse, Russel J. Reiter & Cathy Vaillancourt. (2012) Melatonin: The smart killer. Molecular and Cellular Endocrinology 348:1, pages 1-11.
Crossref
Susan L. Perlman. 2012. Ataxic Disorders. Ataxic Disorders 635 654 .
Zhiyou Cai, Bin Zhao & Anna Ratka. (2011) Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease. NeuroMolecular Medicine 13:4, pages 223-250.
Crossref
Edward Rockenstein, Kiren Ubhi, Emiley Pham, Sarah Michael, Edith Doppler, Philipp Novak, Chandra Inglis, Michael Mante, Anthony Adame, X. Anton Alvarez, Herbert Moessler & Eliezer Masliah. (2011) Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease. Journal of Neuroscience Research 89:11, pages 1812-1821.
Crossref
Johannes Kornhuber, Markus Muehlbacher, Stefan Trapp, Stefanie Pechmann, Astrid Friedl, Martin Reichel, Christiane Mühle, Lothar Terfloth, Teja W. Groemer, Gudrun M. Spitzer, Klaus R. Liedl, Erich Gulbins & Philipp Tripal. (2011) Identification of Novel Functional Inhibitors of Acid Sphingomyelinase. PLoS ONE 6:8, pages e23852.
Crossref
Tatiana Brustovetsky, Tsyregma Li, Youyun Yang, Jiang-Ting Zhang, Bruno Antonsson & Nickolay Brustovetsky. (2010) BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: Role of permeability transition and SH-redox regulation. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1797:11, pages 1795-1806.
Crossref
Clara Sciorati, Roberta Buono, Emanuele Azzoni, Silvana Casati, Pierangela Ciuffreda, Grazia D'Angelo, Dario Cattaneo, Silvia Brunelli & Emilio Clementi. (2010) Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans. British Journal of Pharmacology 160:6, pages 1550-1560.
Crossref
Marina V. Chuenkova & Mercio PereiraPerrin. (2010) Trypanosoma cruzi -Derived Neurotrophic Factor: Role in Neural Repair and Neuroprotection . Journal of Neuroparasitology 1, pages 1-6.
Crossref
Xin Wang. (2009) The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases. CNS Neuroscience & Therapeutics 15:4, pages 345-357.
Crossref
Mario B. Marrero & Merouane Bencherif. (2009) Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: Central role for JAK2 activation of STAT3 and NF-κB. Brain Research 1256, pages 1-7.
Crossref
Yang-Deok Lee, Ju-Young Kim, Ki-Ho Lee, Yoon-Jin Kwak, Seong-Kyu Lee, Ok-Soon Kim, Dae-Yong Song, Ji-Hye Lee, Tai-Kyoung Baik, Byung-Joon Kim, Ji-Young Kim & Haing-Woon Baik. (2009) Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice. Journal of Pineal Research 46:1, pages 53-57.
Crossref
Hyo Jin Kim, Ki Won Lee, Mi-Sung Kim & Hyong Joo Lee. (2008) Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. The Journal of Nutritional Biochemistry 19:7, pages 459-466.
Crossref
Johannes Kornhuber, Philipp Tripal, Martin Reichel, Lothar Terfloth, Stefan Bleich, Jens Wiltfang & Erich Gulbins. (2007) Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model. Journal of Medicinal Chemistry 51:2, pages 219-237.
Crossref
Gulay Filiz, Aphrodite Caragounis, Laura Bica, Tai Du, Colin L. Masters, Peter J. Crouch & Anthony R. White. (2008) Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity. The International Journal of Biochemistry & Cell Biology 40:5, pages 1030-1042.
Crossref
Masahiro OkouchiOleksandr EkshyyanMagdalena MaracineTak Yee Aw. (2007) Neuronal Apoptosis in Neurodegeneration. Antioxidants & Redox Signaling 9:8, pages 1059-1096.
Crossref
Hiroyuki Kashiwagi, Jonathan E. McDunn, Peter S. Goedegebuure, Mary C. Gaffney, Katherine Chang, Kathryn Trinkaus, David Piwnica-Worms, Richard S. Hotchkiss & William G. Hawkins. (2007) TAT-Bim Induces Extensive Apoptosis in Cancer Cells. Annals of Surgical Oncology 14:5, pages 1763-1771.
Crossref
Michelle E. Farah & David C. Amberg. (2007) Conserved Actin Cysteine Residues Are Oxidative Stress Sensors That Can Regulate Cell Death in Yeast. Molecular Biology of the Cell 18:4, pages 1359-1365.
Crossref
Gerard D’Souza, Sarathi Boddapati, Shing-Ming Cheng & Volkmar Weissig. 2006. Nanotechnology for Cancer Therapy. Nanotechnology for Cancer Therapy 787 802 .
Sabrina Paratore, Rosalba Parenti, Antonietta Torrisi, Agata Copani, Federico Cicirata & Sebastiano Cavallaro. (2006) Genomic profiling of cortical neurons following exposure to β-amyloid. Genomics 88:4, pages 468-479.
Crossref
R. Pignatello, V.D. Intravaia & G. Puglisi. (2006) A calorimetric evaluation of the interaction of amphiphilic prodrugs of idebenone with a biomembrane model. Journal of Colloid and Interface Science 299:2, pages 626-635.
Crossref
M E van Meeteren, C E Teunissen, C D Dijkstra & E A F van Tol. (2005) Antioxidants and polyunsaturated fatty acids in multiple sclerosis. European Journal of Clinical Nutrition 59:12, pages 1347-1361.
Crossref
Egemen Savaskan, Rivka Ravid, Fides Meier, Franz Müller-Spahn & Ralf Jockers. (2005) Immunohistochemical Localization of Fas-Associated Phosphatase-1 (FAP-1) in Alzheimer Disease Hippocampus. Applied Immunohistochemistry & Molecular Morphology 13:2, pages 190-193.
Crossref
Ralf A. Claus, Annette Wüstholz, Stefan Müller, Clemens L. Bockmeyer, Norman H. Riedel, Ralf Kinscherf & Hans-Peter Deigner. (2005) Synthesis and Antiapoptotic Activity of a Novel Analogue of the Neutral Sphingomyelinase Inhibitor Scyphostatin. ChemBioChem 6:4, pages 726-737.
Crossref
Thomas Debeir, M. Marien, J. Ferrario, P. Rizk, A. Prigent, F. Colpaert & R. Raisman-Vozari. (2004) In vivo upregulation of endogenous NGF in the rat brain by the alpha2-adrenoreceptor antagonist dexefaroxan: potential role in the protection of the basalocortical cholinergic system during neurodegeneration. Experimental Neurology 190:2, pages 384-395.
Crossref
Isaac Túnez, Pedro Montilla, M. del Carmen Muñoz, Montserrat Feijóo & Manuel Salcedo. (2004) Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. Journal of Pineal Research 37:4, pages 252-256.
Crossref
Susan L. Perlman. (2004) Symptomatic and Disease-Modifying Therapy for the Progressive Ataxias. The Neurologist 10:5, pages 275-289.
Crossref
N. Grois, H. Prosch, F. Waldhauser, M. Minkov, G. Strasser, M. Steiner, E. Unger & D. Prayer. (2004) Pineal gland abnormalities in Langerhans cell histiocytosis. Pediatric Blood & Cancer 43:3, pages 261-266.
Crossref
T D Gould, J A Quiroz, J Singh, C A ZarateJrJr & H K Manji. (2004) Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Molecular Psychiatry 9:8, pages 734-755.
Crossref
Michael A Taffe, Michael R Weed, Tannia Gutierrez, Sophia A Davis & Lisa H Gold. (2004) Modeling a task that is sensitive to dementia of the Alzheimer’s type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys. Behavioural Brain Research 149:2, pages 123-133.
Crossref
Rinat Tabakman, Shimon Lecht, Stela Sephanova, Hadar Arien-Zakay & Philip Lazarovici. 2004. NGF and Related Molecules in Health and Disease. NGF and Related Molecules in Health and Disease 385 401 .
Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D’Agostini, Maria Bagnasco & Roumen Balansky. 2004. Cancer Chemoprevention. Cancer Chemoprevention 37 67 .
Robert Goggs, Stuart D. Carter, Gundula Schulze-Tanzil, Mehdi Shakibaei & Ali Mobasheri. (2003) Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. The Veterinary Journal 166:2, pages 140-158.
Crossref
Timur Albayrak, Volker Scherhammer, Nicole Schoenfeld, Erik Braziulis, Thomas Mund, Manuel K.A. Bauer, Immo E. Scheffler & Stefan Grimm. (2003) The Tumor Suppressor cybL, a Component of the Respiratory Chain, Mediates Apoptosis Induction. Molecular Biology of the Cell 14:8, pages 3082-3096.
Crossref
C Lautrette, S Giraud, C Vermot-Desroches, J.L Preud?homme & M.O Jauberteau. (2003) Expression of a functional Fas death receptor by human foetal motoneurons. Neuroscience 119:2, pages 377-385.
Crossref
Annamaria Bevilacqua, Maria Cristina Ceriani, Sergio Capaccioli & Angelo Nicolin. (2003) Post-transcriptional regulation of gene expression by degradation of messenger RNAs. Journal of Cellular Physiology 195:3, pages 356-372.
Crossref
Jonathan Zuess. (2016) An Integrative Approach to Depression: Part 2—Assessment and Treatment. Complementary health practice review 8:2, pages 99-115.
Crossref
Marios Kyriazis. (2003) Neuroprotective, Anti-Apoptotic Effects of Apomorphine. Journal of Anti-Aging Medicine 6:1, pages 21-28.
Crossref
Susan G. Wynn & Steve Marsden. 2003. Manual of Natural Veterinary Medicine. Manual of Natural Veterinary Medicine 447 498 .
Aurelio Jara-Prado, Alberto Ortega-Vazquez, Leticia Martinez Ruano, Camilo Rios & Abel Santamaria. (2003) Homocysteine-induced brain lipid peroxidation: Effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotoxicity Research 5:4, pages 237-243.
Crossref
D.S. Tews. (2002) Apoptosis and muscle fibre loss in neuromuscular disorders. Neuromuscular Disorders 12:7-8, pages 613-622.
Crossref
Neil Howell. (2002) Navigating between Scylla and Charybdis: Mitochondria are both precedented and novel targets for drug development. Drug Development Research 57:2, pages 75-82.
Crossref
Yara D Fragoso & Daniel Chagas Dantas. (2002) Cerebrolysin for Alzheimer's disease. Cochrane Database of Systematic Reviews.
Crossref
Egemen Savaskan. (2002) Melatonin in aging and neurodegeneration. Drug Development Research 56:3, pages 482-490.
Crossref
Gary K. Smith, David G. Barrett, Kevin Blackburn, Michael Cory, Walter S. Dallas, Roderick Davis, Daniel Hassler, Randy McConnell, Mary Moyer & Kurt Weaver. (2002) Expression, Preparation, and High-Throughput Screening of Caspase-8: Discovery of Redox-Based and Steroid Diacid Inhibition. Archives of Biochemistry and Biophysics 399:2, pages 195-205.
Crossref
Nancy L. Oleinick, Rachel L. Morris & Irina Belichenko. (2002) The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochemical & Photobiological Sciences 1:1, pages 1-21.
Crossref
Piotr P. Graczyk. 2002. 1 72 .
Ana Maria Lennon, Martine Ramauge & Michel Pierre. (2002) Role of redox status on the activation of mitogen-activated protein kinase cascades by NSAIDs. Biochemical Pharmacology 63:2, pages 163-170.
Crossref
Julie K. Andersen, Jyothi Kumar, Bharath Srinivas, Deepinder Kaur, Michael Hsu & Subramanian Rajagopalan. (2001) The Hunt for a Cure for Parkinson’s Disease. Science of Aging Knowledge Environment 2001:1.
Crossref
Rachel Ginham, David C. Harrison, Laura Facci, Stephen Skaper & Karen L. Philpott. (2001) Upregulation of death pathway molecules in rat cerebellar granule neurons undergoing apoptosis. Neuroscience Letters 302:2-3, pages 113-116.
Crossref
Daniela Krahe, Kevin Woeppel, Qianru Yang, Neetu Kushwah & Xinyan T. Cui. (2022) Melatonin Decreases Acute Inflammatory Response to Neural Probe Insertion. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.