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Review

Mechanisms of action and resistance to tubulin-binding agents

Pages 779-788 | Published online: 24 Feb 2005

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BJ Fennell, JA Naughton, J Barlow, G Brennan, I Fairweather, E Hoey, N McFerran, A Trudgett & A Bell. (2008) Microtubules as antiparasitic drug targets. Expert Opinion on Drug Discovery 3:5, pages 501-518.
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Federico Pellegrini & Daniel R Budman. (2005) Review: Tubulin Function, Action of Antitubulin Drugs, and New Drug Development. Cancer Investigation 23:3, pages 264-273.
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Qun Li & Hing L Sham. (2002) Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer. Expert Opinion on Therapeutic Patents 12:11, pages 1663-1702.
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Maurie Markman & Tarek M Mekhail. (2002) Paclitaxel in cancer therapy. Expert Opinion on Pharmacotherapy 3:6, pages 755-766.
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Changfa Shu, Xi Zheng, Alafate Wuhafu, Danielle Cicka, Sean Doyle, Qiankun Niu, Dacheng Fan, Kun Qian, Andrey A. Ivanov, Yuhong Du, Xiulei Mo & Haian Fu. (2022) Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells. Acta Pharmacologica Sinica 43:9, pages 2419-2428.
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Xuebao Wang, Ying Lu, Doudou Sun, Jinheng Qian, Sijun Tu, Weixia Yue, Humin Lin, Haijie Tang, Fanxi Meng, Qin He, Zixin Xie, Yuan Zhang, Huijun Chen, Shumei Ma, Zhigui Zuo & Faqing Ye. (2022) Discovery of 4-methoxy-N-(1-naphthyl)benzenesulfonamide derivatives as small molecule dual-target inhibitors of tubulin and signal transducer and activator of transcription 3 (STAT3) based on ABT-751. Bioorganic Chemistry 125, pages 105864.
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Chang Yu, Edward A. Rietman, Hava T. Siegelmann, Marco Cavaglia & Jack A. Tuszynski. (2021) Application of Thermodynamics and Protein–Protein Interaction Network Topology for Discovery of Potential New Treatments for Temporal Lobe Epilepsy. Applied Sciences 11:17, pages 8059.
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Adam McCluskey & Cecilia Russell. 2021. Translational Research in Cancer. Translational Research in Cancer.
Valerie Stock, Andreas Sutter, Marian Raschke & Nina Queisser. (2018) A tripartite mode of action approach for investigating the impact of aneugens on tubulin polymerization. Environmental and Molecular Mutagenesis 59:3, pages 188-201.
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Marcelo Gomes, Eugene Muratov, Maristela Pereira, Josana Peixoto, Lucimar Rosseto, Pedro Cravo, Carolina Andrade & Bruno Neves. (2017) Chalcone Derivatives: Promising Starting Points for Drug Design. Molecules 22:8, pages 1210.
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M Farhat, A Poissonnier, A Hamze, C Ouk-Martin, J-D Brion, M Alami, J Feuillard & C Jayat-Vignoles. (2014) Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases. Cell Death & Disease 5:5, pages e1201-e1201.
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A. Yu. Nyporko & Ya. B. Blume. (2014) Structural mechanisms of interaction of cyanolcrylates with plant tubulin. Cytology and Genetics 48:1, pages 7-14.
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Tobias J. Zimmermann, Sayantani Roy, Nancy E. Martinez, Slava Ziegler, Christian Hedberg & Herbert Waldmann. (2013) Biology‐Oriented Synthesis of a Tetrahydroisoquinoline‐Based Compound Collection Targeting Microtubule Polymerization. ChemBioChem 14:3, pages 295-300.
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A. Yu. Nyporko, A. I. Yemets, V. N. Brytsun, M. O. Lozinsky & Ya. B. Blume. (2009) Structural and biological characterization of the tubulin interaction with dinitroanilines. Cytology and Genetics 43:4, pages 267-282.
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Sarah A. Holstein & Raymond J. Hohl. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics 83 90 .
Alexey Y. Nyporko & Yaroslav B. Blume. 2009. The Plant Cytoskeleton: a Key Tool for Agro-Biotechnology. The Plant Cytoskeleton: a Key Tool for Agro-Biotechnology 397 417 .
Nizar M. Mhaidat, Rick F. Thorne, Charles Edo de Bock, Xu Dong Zhang & Peter Hersey. (2008) Melanoma cell sensitivity to Docetaxel-induced apoptosis is determined by class III ?-tubulin levels. FEBS Letters 582:2, pages 267-272.
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Peng-Fei Yu, Hong Chen, Jing Wang, Chun-Xian He, Bo Cao, Min Li, Na Yang, Zhi-Yong Lei & Mao-Sheng Cheng. (2008) Design, Synthesis and Cytotoxicity of Novel Podophyllotoxin Derivatives. CHEMICAL & PHARMACEUTICAL BULLETIN 56:6, pages 831-834.
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Lee M. Greenberger & Frank Loganzo. 2008. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology 227 258 .
Gaganmeet Singh, K. G. Jayanarayan & Chinmoy S. Dey. 2008. Drug Targets in Kinetoplastid Parasites. Drug Targets in Kinetoplastid Parasites 1 8 .
Kamlesh K. Gupta, Shubhada S. Bharne, Krishnan Rathinasamy, Nishigandha R. Naik & Dulal Panda. (2006) Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS Journal 273:23, pages 5320-5332.
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Malathi Hari, Frank Loganzo, Tami Annable, Xingzhi Tan, Sylvia Musto, Daniel B. Morilla, James H. Nettles, James P. Snyder & Lee M. Greenberger. (2006) Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules. Molecular Cancer Therapeutics 5:2, pages 270-278.
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K. G. JAYANARAYAN & C. S. DEY. (2005) Altered tubulin dynamics, localization and post-translational modifications in sodium arsenite resistant Leishmania donovani in response to paclitaxel, trifluralin and a combination of both and induction of apoptosis-like cell death. Parasitology 131:2, pages 215-230.
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V. M. Borges, U. G. Lopes, W. De Souza & M. A. Vannier-Santos. (2004) Cell structure and cytokinesis alterations in multidrug-resistant Leishmania (Leishmania) amazonensis. Parasitology Research 95:2, pages 90-96.
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Manon T. Huizing. 2005. Drugs Affecting Growth of Tumours. Drugs Affecting Growth of Tumours 101 131 .
Frank Loganzo, Malathi Hari, Tami Annable, Xingzhi Tan, Daniel B. Morilla, Sylvia Musto, Arie Zask, Joshua Kaplan, Albert A. MinnickJr.Jr., Michael K. May, Semiramis Ayral-Kaloustian, Marianne S. Poruchynsky, Tito Fojo & Lee M. Greenberger. (2004) Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in α-tubulin. Molecular Cancer Therapeutics 3:10, pages 1319-1327.
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Weiguang Mao, Elizabeth Luis, Sarajane Ross, Johnny Silva, Christine Tan, Craig Crowley, Clarissa Chui, Gretchen Franz, Peter Senter, Hartmut Koeppen & Paul Polakis. (2004) EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer. Cancer Research 64:3, pages 781-788.
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Christos D. Katsetos, Agustin Legido, Elias Perentes & Sverre J. Mörk. (2016) Class III β-Tubulin Isotype: A Key Cytoskeletal Protein at the Crossroads of Developmental Neurobiology and Tumor Neuropathology. Journal of Child Neurology 18:12, pages 851-866.
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Emmanuelle Mounetou, Jean Legault, Jacques Lacroix & René C.-Gaudreault. (2003) A New Generation of N -Aryl- N ‘-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics . Journal of Medicinal Chemistry 46:23, pages 5055-5063.
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Nicole M. Verrills, Claudia L. Flemming, Marjorie Liu, Michael T. Ivery, Gary S. Cobon, Murray D. Norris, Michelle Haber & Maria Kavallaris. (2003) Microtubule Alterations and Mutations Induced by Desoxyepothilone B. Chemistry & Biology 10:7, pages 597-607.
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Christos D. Katsetos, Mary M. Herman & Sverre J. Mörk. (2003) Class III β‐tubulin in human development and cancer. Cell Motility 55:2, pages 77-96.
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Giulia Taraboletti, Gianluca Micheletti, Raffaella Giavazzi & Antonella Riva. (2003) IDN 5390: a new concept in taxane development. Anti-Cancer Drugs 14:4, pages 255-258.
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Neeraj R. Agrawal, Ram Ganapathi & Tarek Mekhail. (2003) Tubulin interacting agents: Novel taxanes and epothilones. Current Oncology Reports 5:2, pages 89-98.
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K. G. Jayanarayan & C. S. Dey. (2002) Microtubules: dynamics, drug interaction and drug resistance in Leishmania. Journal of Clinical Pharmacy and Therapeutics 27:5, pages 313-320.
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Christos D. Katsetos, Luis Del Valle, Jennian F. Geddes, Ken Aldape, James C. Boyd, Agustin Legido, Kamel Khalili, Elias Perentes & Sverre J. M?rk. (2002) Localization of the Neuronal Class III ?-Tubulin in Oligodendrogliomas: Comparison with Ki-67 Proliferative Index and 1p/19q Status. Journal of Neuropathology & Experimental Neurology 61:4, pages 307-320.
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Javier Abel Menéendez, Santiago Ropero, Maria del Mar Barbacid, Sagrario Montero, Montserrat Solanas, Eduard Escrich, Hernán Cortés-Funes & Ramon Colomer. (2002) Synergistic Interaction Between Vinorelbine and Gamma-Linolenic Acid in Breast Cancer Cells. Breast Cancer Research and Treatment 72:3, pages 203-219.
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Qun Li, Keith W. Woods, Akiyo Claiborne, Stephen L. Gwaltney, II, Kenneth J. Barr, Gang Liu, Laura Gehrke, R.Bruce Credo, Yu Hua Hui, Jang Lee, Robert B. Warner, Peter Kovar, Michael A. Nukkala, Nicolette A. Zielinski, Stephen K. Tahir, Michael Fitzgerald, Ki H. Kim, Kennan Marsh, David Frost, Shi-Chung Ng, Saul Rosenberg & Hing L. Sham. (2002) Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent. Bioorganic & Medicinal Chemistry Letters 12:3, pages 465-469.
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