90
Views
35
CrossRef citations to date
0
Altmetric
Review

The role of NPY in metabolic homeostasis: implications for obesity therapy

, , &
Pages 1327-1346 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ranjan Chakrabarti. (2009) Pharmacotherapy of obesity: emerging drugs and targets. Expert Opinion on Therapeutic Targets 13:2, pages 195-207.
Read now
Harold Bays & Carlos Dujovne. (2002) Anti-obesity drug development. Expert Opinion on Investigational Drugs 11:9, pages 1189-1204.
Read now

Articles from other publishers (33)

Diana Sousa, Eduardo Lopes, Daniela Rosendo-Silva & Paulo Matafome. (2023) The Bidirectional Relationship of NPY and Mitochondria in Energy Balance Regulation. Biomedicines 11:2, pages 446.
Crossref
Lydiane Funkelstein, W. Douglas Lu, Britta Koch, Charles Mosier, Thomas Toneff, Laurent Taupenot, Daniel T. O'Connor, Thomas Reinheckel, Christoph Peters & Vivian Hook. (2012) Human Cathepsin V Protease Participates in Production of Enkephalin and NPY Neuropeptide Neurotransmitters. Journal of Biological Chemistry 287:19, pages 15232-15241.
Crossref
Michael Fichtner, Eunsun Lee, Elizabeth Tomlinson, Dennis Scott, Peter Cornelius, Terrell A. Patterson & Philip A. Carpino. (2012) Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorganic & Medicinal Chemistry Letters 22:8, pages 2738-2743.
Crossref
Vivian Hook, Lydiane Funkelstein, Jill Wegrzyn, Steven Bark, Mark Kindy & Gregory Hook. (2012) Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1824:1, pages 89-104.
Crossref
David A. Griffith, Diane M. Hargrove, Tristan S. Maurer, Charles A. Blum, Stéphane De Lombaert, John K. Inthavongsay, Lee E. Klade, Christine M. Mack, Colin R. Rose, Martin J. Sanders & Philip A. Carpino. (2011) Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 21:9, pages 2641-2645.
Crossref
Francis I Achike, Nim-Hin Peter To, Huidi Wang & Chiu-Yin Kwan. (2011) Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clinical and Experimental Pharmacology and Physiology 38:1, pages 1-10.
Crossref
Lydiane Funkelstein & Vivian Hook. 2011. Proprotein Convertases. Proprotein Convertases 107 125 .
Lydiane Funkelstein, Margery Beinfeld, Ardalan Minokadeh, James Zadina & Vivian Hook. (2010) Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides. Neuropeptides 44:6, pages 457-466.
Crossref
Jie Qiu, Yu-hui Ni, Rong-hua Chen, Chen-bo Ji, Feng Liu, Chun-mei Zhang, Chun-lin Gao, Xiao-hui Chen, Mei-ling Tong, Xia Chi, Xiao-yu Zhou & Xi-rong Guo. (2008) Gene expression profiles of adipose tissue of obese rats after central administration of neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides by cDNA microarrays. Peptides 29:11, pages 2052-2060.
Crossref
Lydiane Funkelstein, Thomas Toneff, Shin-Rong Hwang, Thomas Reinheckel, Christoph Peters & Vivian Hook. (2008) Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. Journal of Neurochemistry 106:1, pages 384-391.
Crossref
I. Dijkraaf & H. J. Wester. 2008. Molecular Imaging II. Molecular Imaging II 61 92 .
Alessandra Oberto, Elena Acquadro, Thorsten Bus, Rolf Sprengel & Carola Eva. (2007) Expression patterns of promoters for NPY Y1 and Y5 receptors in Y5RitTA and Y1RVenus BAC-transgenic mice. European Journal of Neuroscience 26:1, pages 155-170.
Crossref
Vivian Y. H. Hook. (2006) Protease Pathways in Peptide Neurotransmission and Neurodegenerative Diseases. Cellular and Molecular Neurobiology 26:4-6, pages 447-467.
Crossref
Kerri L. Palamara, Harriette R. Mogul, Stephen J. Peterson & William H. Frishman. (2006) Obesity. Cardiology in Review 14:5, pages 238-258.
Crossref
Kevin W. Gillman, Mendi A. Higgins, Graham S. Poindexter, Marc Browning, Wendy J. Clarke, Sharon Flowers, James E. GraceJr.Jr., John B. Hogan, Rachel T. McGovern, Lawrence G. Iben, Gail K. Mattson, Astrid Ortiz, Stefanie Rassnick, John W. Russell & Ildiko Antal-Zimanyi. (2006) Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists. Bioorganic & Medicinal Chemistry 14:16, pages 5517-5526.
Crossref
Vivian Y H Hook. (2006) Neuroproteases in Peptide Neurotransmission and Neurodegenerative Diseases. BioDrugs 20:2, pages 105-119.
Crossref
Vivian Y.H. Hook. (2006) Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biological Chemistry 387:10/11.
Crossref
Frank M. Dautzenberg & Shiva Neysari. (2005) Irreversible Binding Kinetics of Neuropeptide Y Ligands to Y<sub>2</sub> but Not to Y<sub>1</sub> and Y<sub>5</sub> Receptors. Pharmacology 75:1, pages 21-29.
Crossref
Frank M. Dautzenberg, Jacqueline Higelin, Philippe Pflieger, Werner Neidhart & Wolfgang Guba. (2005) Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist. Neuropharmacology 48:7, pages 1043-1055.
Crossref
Frank M. Dautzenberg. (2005) Stimulation of neuropeptide Y-mediated calcium responses in human SMS-KAN neuroblastoma cells endogenously expressing Y2 receptors by co-expression of chimeric G proteins. Biochemical Pharmacology 69:10, pages 1493-1499.
Crossref
Antoni Torrens, Josep Mas, Adriana Port, José Aurelio Castrillo, Olga Sanfeliu, Xavier Guitart, Alberto Dordal, Gonzalo Romero, M Angeles Fisas, Elisabeth Sánchez, Enrique Hernández, Pilar Pérez, Raquel Pérez & Helmut Buschmann. (2004) Synthesis of New Benzoxazinone Derivatives as Neuropeptide Y5 Antagonists for the Treatment of Obesity. Journal of Medicinal Chemistry 48:6, pages 2080-2092.
Crossref
David A. Vincent, Tord D. Alden, Toshifumi Kamiryo, Beatrice Lopez, Dilantha Ellegala, Jeffrey J. Laurent, Michael Butler, Mary Lee Vance & Edward R. Laws, Jr.. (2005) The Baromodulatory Effect of Gamma Knife Irradiation of the Hypothalamus in the Obese Zucker Rat. Stereotactic and Functional Neurosurgery 83:1, pages 6-11.
Crossref
Harold E. Bays. (2012) Current and Investigational Antiobesity Agents and Obesity Therapeutic Treatment Targets. Obesity Research 12:8, pages 1197-1211.
Crossref
Pascal Bonaventure, Diane Nepomuceno, Curt Mazur, Brian Lord, Dale A. Rudolph, Jill A. Jablonowski, Nicholas I. Carruthers & Timothy W. Lovenberg. (2004) Characterization of N -(1-Acetyl-2,3-dihydro-1 H -indol-6-yl)-3-(3-cyano-phenyl)- N -[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a Small Molecule Antagonist of the Neuropeptide Y Y 2 Receptor . Journal of Pharmacology and Experimental Therapeutics 308:3, pages 1130-1137.
Crossref
V. Hook, S. Yasothornsrikul, D. Greenbaum, K.F. Medzihradszky, K. Troutner, T. Toneff, R. Bundey, A. Logrinova, T. Reinheckel, C. Peters & M. Bogyo. (2004) Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biological Chemistry 385:6.
Crossref
Jeffrey S Flier. (2004) Obesity Wars. Cell 116:2, pages 337-350.
Crossref
John H. Kehne, George D. Maynard, Stéphane De Lombaert & James E. Krause. 2003. 11 20 .
Antonio P Silva, Claudia Cavadas & Eric Grouzmann. (2002) Neuropeptide Y and its receptors as potential therapeutic drug targets. Clinica Chimica Acta 326:1-2, pages 3-25.
Crossref
J. R. S. Arch. (2014) Lessons in obesity from transgenic animals. Journal of Endocrinological Investigation 25:10, pages 867-875.
Crossref
Andrew V. TurnbullLaraine EllershawDave J. MastersSusan BirtlesScott BoyerDebbie CarrollPaul ClarksonSue J.G. LoxhamPat McAulayJoanne L. TeagueKevin M. FooteJ. Elizabeth PeaseMichael H. Block. (2002) Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats. Diabetes 51:8, pages 2441-2449.
Crossref
Michael H. Block, Scott Boyer, Wayne Brailsford, David R. Brittain, Debra Carroll, Steve Chapman, David S. Clarke, Craig S. Donald, Kevin M. Foote, Linda Godfrey, Anthony Ladner, Peter R. Marsham, David J. Masters, Christine D. Mee, Michael R. O'Donovan, J. Elizabeth Pease, Adrian G. Pickup, John W. Rayner, Andrew Roberts, Paul Schofield, Abid Suleman & Andrew V. Turnbull. (2002) Discovery and Optimization of a Series of Carbazole Ureas as NPY5 Antagonists for the Treatment of Obesity. Journal of Medicinal Chemistry 45:16, pages 3509-3523.
Crossref
Eric Parker, Margaret Van Heek & Andrew Stamford. (2002) Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. European Journal of Pharmacology 440:2-3, pages 173-187.
Crossref
Brian L Largent, Albert J Robichaud & Keith J Miller. 2002. Annual Reports in Medicinal Chemistry Volume 37. Annual Reports in Medicinal Chemistry Volume 37 1 10 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.