393
Views
103
CrossRef citations to date
0
Altmetric
Drug Evaluation

TNP-470: an angiogenesis inhibitor in clinical development for cancer

&
Pages 1383-1396 | Published online: 24 Feb 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Anton Yuryev, Ekaterina Kotelnikova & Nikolai Daraselia. (2009) Ariadne's ChemEffect and Pathway Studio knowledge base. Expert Opinion on Drug Discovery 4:12, pages 1307-1318.
Read now
Ofra Benny & Pouya Pakneshan. (2009) Novel technologies for antiangiogenic drug delivery in the brain. Cell Adhesion & Migration 3:2, pages 224-229.
Read now
Tillmann Cyrus, Gregory M. Lanza & Samuel A. Wickline. (2007) Molecular Imaging by Cardiovascular MR. Journal of Cardiovascular Magnetic Resonance 9:6, pages 827-843.
Read now
Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Chawalit Pairojkul, O-Tur Saeseow, Gregory J. Riggins, Norie Araki & Sopit Wongkham. (2007) Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: Potential for drug target. Acta Oncologica 46:3, pages 378-385.
Read now
Ralph A Bradshaw. (2004) Methionine aminopeptidase 2 inhibition: antiangiogenesis and tumour therapy. Expert Opinion on Therapeutic Patents 14:1, pages 1-6.
Read now
Richard D Connell & Jean S Beebe. (2001) Patent focus on cancer chemotherapeutics. III Angiogenesis agents: October 2000 – March 2001. Expert Opinion on Therapeutic Patents 11:7, pages 1171-1203.
Read now
Richard D Connell & Jean S Beebe. (2001) Patent focus on cancer chemotherapeutics. II Angiogenesis agents: April 2000 - September 2000. Expert Opinion on Therapeutic Patents 11:1, pages 77-114.
Read now

Articles from other publishers (96)

Timo Heinrich, Frank T. Zenke, Jörg Bomke, Jakub Gunera, Ansgar Wegener, Manja Friese-Hamim, Philip Hewitt, Djordje Musil & Felix Rohdich. 2024. Metalloenzymes. Metalloenzymes 343 373 .
Michael A. Carducci, Ding Wang, Christina Habermehl, Matthias Bödding, Felix Rohdich, Floriane Lignet, Klaus Duecker, Oleksandr Karpenko, Linda Pudelko, Claude Gimmi & Patricia LoRusso. (2023) A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors. Cancer Research Communications 3:8, pages 1638-1647.
Crossref
Yie-Hwa Chang. (2023) Impact of Protein Nα-Modifications on Cellular Functions and Human Health. Life 13:7, pages 1613.
Crossref
Rawnaq Esa, Eliana Steinberg, Arie Dagan, Zhanna Yekhtin, Katerina Tischenko & Ofra Benny. (2022) Newly synthesized methionine aminopeptidase 2 inhibitor hinders tumor growth. Drug Delivery and Translational Research 13:5, pages 1170-1182.
Crossref
Behzad Ensan, Parsa Bathaei, Mohammadreza Nassiri, Majid Khazaei, Seyed Mahdi Hassanian, Abbas Abdollahi, Hamid Reza Ghorbani, Mohsen Aliakbarian, Gordon A. Ferns & Amir Avan. (2022) The Therapeutic Potential of Targeting Key Signaling Pathways as a Novel Approach to Ameliorating Post-Surgical Adhesions. Current Pharmaceutical Design 28:45, pages 3592-3617.
Crossref
Ashok K. Shakya & Rajashri R. Naik. (2022) The Chemotherapeutic Potentials of Compounds Isolated from the Plant, Marine, Fungus, and Microorganism: Their Mechanism of Action and Prospects. Journal of Tropical Medicine 2022, pages 1-17.
Crossref
Hitesh Chopra, Shabana Bibi, Awdhesh Kumar Mishra, Vineet Tirth, Sree Vandana Yerramsetty, Sree Varshini Murali, Syed Umair Ahmad, Yugal Kishore Mohanta, Mohamed S. Attia, Ali Algahtani, Fahadul Islam, Abdul Hayee, Saiful Islam, Atif Amin Baig & Talha Bin Emran. (2022) Nanomaterials: A Promising Therapeutic Approach for Cardiovascular Diseases. Journal of Nanomaterials 2022, pages 1-25.
Crossref
Andrea Goya Grocin, Wouter W. Kallemeijn & Edward W. Tate. (2021) Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity. Trends in Pharmacological Sciences 42:10, pages 870-882.
Crossref
Jinghang Xie, Meghan A. Rice, Zixin Chen, Yunfeng Cheng, En-Chi Hsu, Min Chen, Guosheng Song, Liyang Cui, Kaixiang Zhou, Jessa B. Castillo, Chiyuan A. Zhang, Bin Shen, Frederick T. Chin, Christian A. Kunder, James D. Brooks, Tanya Stoyanova & Jianghong Rao. (2021) In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification . Cancer Research 81:9, pages 2510-2521.
Crossref
Sarah L. Craig, Victor A. Gault, Peter R. Flatt & Nigel Irwin. (2021) The methionine aminopeptidase 2 inhibitor, TNP-470, enhances the antidiabetic properties of sitagliptin in mice by upregulating xenin. Biochemical Pharmacology 183, pages 114355.
Crossref
Megan L. Peach, Shaunna L. Beedie, Cindy H. Chau, Matthew K. Collins, Suzana Markolovic, Weiming Luo, David Tweedie, Christian Steinebach, Nigel H. Greig, Michael Gütschow, Neil Vargesson, Marc C. Nicklaus & William D. Figg. (2020) Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs. Molecules 25:23, pages 5683.
Crossref
Yuta Tsunematsu, Yuichiro Hirayama, Takahiro Masuya & Kenji Watanabe. 2020. Comprehensive Natural Products III. Comprehensive Natural Products III 479 505 .
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Frank Becker, Beatrix Blume, Jörg Bomke, Melanie Dietz, Uwe Eckert, Manja Friese-Hamim, Jakub Gunera, Kerrin Hansen, Birgitta Leuthner, Djordje Musil, Jens Pfalzgraf, Felix Rohdich, Christian Siegl, Dieter Spuck, Ansgar Wegener & Frank T. Zenke. (2019) Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891 : A Clinical Compound for the Treatment of Cancer . Journal of Medicinal Chemistry 62:24, pages 11119-11134.
Crossref
Eva Abramov, Ouri Schwob & Ofra Benny. (2019) Film‐ and ointment‐based delivery systems for the transdermal delivery of TNP‐470. Polymers for Advanced Technologies 30:10, pages 2586-2595.
Crossref
Yun Hong & Yuefeng Rao. (2019) Current status of nanoscale drug delivery systems for colorectal cancer liver metastasis. Biomedicine & Pharmacotherapy 114, pages 108764.
Crossref
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini, Uwe Eckert, Manja Friese-Hamim, Rainer Kohl, Martin Lehmann, Birgitta Leuthner, Djordje Musil, Felix Rohdich & Frank T. Zenke. (2019) Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. Journal of Medicinal Chemistry 62:10, pages 5025-5039.
Crossref
Allie Y. Chen, Rebecca N. Adamek, Benjamin L. Dick, Cy V. Credille, Christine N. Morrison & Seth M. Cohen. (2018) Targeting Metalloenzymes for Therapeutic Intervention. Chemical Reviews 119:2, pages 1323-1455.
Crossref
Paige J. Monsen & Frederick A. Luzzio. (2018) Antiangiogenic Activity and Chemical Derivatization of the Neurotoxic Acetogenin Annonacin Isolated from Asimina triloba . Journal of Natural Products 81:8, pages 1905-1909.
Crossref
Derek Hoi-Hang Ho & Roger Hoi-Fung Wong. (2018) TNP-470 skews DC differentiation to Th1-stimulatory phenotypes and can serve as a novel adjuvant in a cancer vaccine. Blood Advances 2:14, pages 1664-1679.
Crossref
Isabel Pont, Aracely Calatayud-Pascual, Alicia López-Castellano, Elena P. Albelda, Enrique García-España, Luis Martí-Bonmatí, Juan C. Frias & M. Teresa Albelda. (2018) Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice. PLOS ONE 13:1, pages e0190540.
Crossref
Timo Heinrich, Hans-Peter Buchstaller, Bertram Cezanne, Felix Rohdich, Jörg Bomke, Manja Friese-Hamim, Mireille Krier, Thorsten Knöchel, Djordje Musil, Birgitta Leuthner & Frank Zenke. (2017) Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclic templates. Bioorganic & Medicinal Chemistry Letters 27:3, pages 551-556.
Crossref
Duong Thanh Nguyen, Yantao Fan, Yasemin M Akay & Metin Akay. (2016) TNP-470 Reduces Glioblastoma Angiogenesis in Three Dimensional GelMA Microwell Platform. IEEE Transactions on NanoBioscience 15:7, pages 683-688.
Crossref
Shaunna L. Beedie, Chris Mahony, Heather M. Walker, Cindy H. Chau, William D. Figg & Neil Vargesson. (2016) Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model. Scientific Reports 6:1.
Crossref
John L Hamilton, Masashi Nagao, Brett R Levine, Di Chen, Bjorn R Olsen & Hee‐Jeong Im. (2016) Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain. Journal of Bone and Mineral Research 31:5, pages 911-924.
Crossref
Ali SalajeghehAli Salajegheh. 2016. Angiogenesis in Health, Disease and Malignancy. Angiogenesis in Health, Disease and Malignancy 37 42 .
Yu Wang, Da-Hong Li, Zhan-Lin Li, Yan-Jun Sun, Hui-Ming Hua, Tao Liu & Jiao Bai. (2015) Terpenoids from the Marine-Derived Fungus Aspergillus fumigatus YK-7. Molecules 21:1, pages 31.
Crossref
Ankur Omer, Venkatesan Suryanarayanan, Chandrabose Selvaraj, Sanjeev Kumar Singh & Poonam Singh. 2015. Combined Quantum Mechanical and Molecular Mechanical Modelling of Biomolecular Interactions. Combined Quantum Mechanical and Molecular Mechanical Modelling of Biomolecular Interactions 89 112 .
Bruce C Baguley & Mark J McKeage. (2014) Therapeutic targeting of tumor angiogenesis: how far have we come?. Clinical Investigation 4:12, pages 1113-1122.
Crossref
Jabeena Khazir, Darren L. Riley, Lynne A. Pilcher, Pieter De-Maayer & Bilal Ahmad Mir. (2014) Anticancer Agents from Diverse Natural Sources. Natural Product Communications 9:11, pages 1934578X1400901.
Crossref
Hye Jin Jung, Misun Cho, Yonghyo Kim, Gyoonhee Han & Ho Jeong Kwon. (2014) Development of a Novel Class of Mitochondrial Ubiquinol–Cytochrome c Reductase Binding Protein (UQCRB) Modulators as Promising Antiangiogenic Leads . Journal of Medicinal Chemistry 57:19, pages 7990-7998.
Crossref
Hsiao-Ching Lin, Yuta Tsunematsu, Sourabh Dhingra, Wei Xu, Manami Fukutomi, Yit-Heng Chooi, David E. Cane, Ana M. Calvo, Kenji Watanabe & Yi Tang. (2014) Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway. Journal of the American Chemical Society 136:11, pages 4426-4436.
Crossref
Kenji Watanabe. (2014) Effective Use of Heterologous Hosts for Characterization of Biosynthetic Enzymes Allows Production of Natural Products and Promotes New Natural Product Discovery. Chemical and Pharmaceutical Bulletin 62:12, pages 1153-1165.
Crossref
Yunfei Wang, Peifeng Liu, Yourong Duan, Xia Yin, Qi Wang, Xiaofei Liu, Xinran Wang, Jinhua Zhou, Wenwen Wang, Lihua Qiu & Wen Di. (2014) Specific cell targeting with APRPG conjugated PEG–PLGA nanoparticles for treating ovarian cancer. Biomaterials 35:3, pages 983-992.
Crossref
Tanja Bladt, Jens Frisvad, Peter Knudsen & Thomas Larsen. (2013) Anticancer and Antifungal Compounds from Aspergillus, Penicillium and Other Filamentous Fungi. Molecules 18:9, pages 11338-11376.
Crossref
Wen-Long Wang, Li-Jun Song, Xia Chen, Xu-Ren Yin, Wen-Hua Fan, Gu-Ping Wang, Chuan-Xin Yu & Bainian Feng. (2013) Synthesis and SAR Studies of Praziquantel Derivatives with Activity against Schistosoma japonicum. Molecules 18:8, pages 9163-9178.
Crossref
Feiran Zhang, Shridhar Bhat, Sandra B. Gabelli, Xiaochun Chen, Michelle S. Miller, Benjamin A. Nacev, Yim Ling Cheng, David J. Meyers, Karen Tenney, Joong Sup Shim, Phillip Crews, L. Mario Amzel, Dawei Ma & Jun O. Liu. (2013) Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in Cells. Journal of Medicinal Chemistry 56:10, pages 3996-4016.
Crossref
Pengtao Zhang, Xinye Yang, Feiran Zhang, Sandra B. Gabelli, Renxiao Wang, Yihua Zhang, Shridhar Bhat, Xiaochun Chen, Manuel Furlani, L. Mario Amzel, Jun O. Liu & Dawei Ma. (2013) Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorganic & Medicinal Chemistry 21:9, pages 2600-2617.
Crossref
Hsiao-Ching Lin, Yit-Heng Chooi, Sourabh Dhingra, Wei Xu, Ana M. Calvo & Yi Tang. (2013) The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β- trans -Bergamotene . Journal of the American Chemical Society 135:12, pages 4616-4619.
Crossref
Elena Pentsova & Andrew B. Lassman. 2013. Fertility Preservation in Male Cancer Patients. Fertility Preservation in Male Cancer Patients 150 160 .
. 2013. Fertility Preservation in Male Cancer Patients. Fertility Preservation in Male Cancer Patients 104 171 .
Hye Jin Jung & Ho Jeong Kwon. (2013) Exploring the role of mitochondrial UQCRB in angiogenesis using small molecules. Molecular BioSystems 9:5, pages 930.
Crossref
Ryan E. Tomlinson, Jennifer A. McKenzie, Anne H. Schmieder, Gregory R. Wohl, Gregory M. Lanza & Matthew J. Silva. (2013) Angiogenesis is required for stress fracture healing in rats. Bone 52:1, pages 212-219.
Crossref
M.W. Laschke & M.D. Menger. (2012) Anti-angiogenic treatment strategies for the therapy of endometriosis. Human Reproduction Update 18:6, pages 682-702.
Crossref
Curtis R. Chong. 2012. Drug Repositioning. Drug Repositioning 345 388 .
Yu Wang, Zhan‐Lin Li, Jiao Bai, Li‐Min Zhang, Xin Wu, Lin Zhang, Yue‐Hu Pei, Yong‐Kui Jing & Hui‐Ming Hua. (2012) 2,5‐Diketopiperazines from the Marine‐Derived Fungus Aspergillus fumigatus YK‐7 . Chemistry & Biodiversity 9:2, pages 385-393.
Crossref
William W. Li, Vincent W. Li, Michelle Hutnik & Albert S. Chiou. (2012) Tumor Angiogenesis as a Target for Dietary Cancer Prevention. Journal of Oncology 2012, pages 1-23.
Crossref
Thomas?B. Sundberg, Nicole Darricarrere, Pasquale Cirone, Xia Li, Lucy McDonald, Xue Mei, Christopher?J. Westlake, Diane?C. Slusarski, Robert?J. Beynon & Craig?M. Crews. (2011) Disruption of Wnt Planar Cell Polarity Signaling by Aberrant Accumulation of the MetAP-2 Substrate Rab37. Chemistry & Biology 18:10, pages 1300-1311.
Crossref
Yasuko Naganuma, Batsuren Choijamts, Kyoko Shirota, Kyoko Nakajima, Shigenori Ogata, Shingo Miyamoto, Tatsuhiko Kawarabayashi & Makoto Emoto. (2011) Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts. Cancer Science 102:8, pages 1545-1552.
Crossref
Ehud Segal, Huaizhong Pan, Liat Benayoun, Pavla Kope?kov?Yuval Shaked, Jind?ich Kope?ek & Ronit Satchi-Fainaro. (2011) Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances. Biomaterials 32:19, pages 4450-4463.
Crossref
MW Laschke, AE Vorsterman van Oijen, C Scheuer & MD Menger. (2011) In vitro and in vivo evaluation of the anti‐angiogenic actions of 4‐hydroxybenzyl alcohol . British Journal of Pharmacology 163:4, pages 835-844.
Crossref
Joong Sup Shim, Yoshiyuki Matsui, Shridhar Bhat, Benjamin A. Nacev, Jing Xu, Hyo-eun C. Bhang, Surajit Dhara, Kee Chung Han, Curtis R. Chong, Martin G. Pomper, Alan So & Jun O. Liu. (2010) Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer. JNCI: Journal of the National Cancer Institute 102:24, pages 1855-1873.
Crossref
Markus A. Altmeyer, Aline Marschner, Rolf Schiffmann & Christian D. Klein. (2010) Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors. Bioorganic & Medicinal Chemistry Letters 20:14, pages 4038-4044.
Crossref
EKATERINA KOTELNIKOVA, ANTON YURYEV, ILYA MAZO & NIKOLAI DARASELIA. (2011) COMPUTATIONAL APPROACHES FOR DRUG REPOSITIONING AND COMBINATION THERAPY DESIGN. Journal of Bioinformatics and Computational Biology 08:03, pages 593-606.
Crossref
LENE SYLVEST, CHRISTINE DAM BENDIKSEN & GUNNAR HOUEN. (2009) Phosphatase inhibitors with anti‐angiogenic effect in vitro . APMIS 118:1, pages 49-59.
Crossref
Sarah J. Smith, Kieran S. Hadler, Gerhard Schenk, Graeme R. Hanson & Nataša Mitić. 2010. Metals in Biology. Metals in Biology 273 341 .
Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Umashankar Das, Hari N Pati, Jonathan R Dimmock & Rajendra K Sharma. (2009) NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells. Molecular Cancer 8:1.
Crossref
Omonike A. Olaleye, William R. Bishai & Jun O. Liu. (2009) Targeting the role of N-terminal methionine processing enzymes in Mycobacterium tuberculosis. Tuberculosis 89, pages S55-S59.
Crossref
Xiaochun Chen, Suji Xie, Shridhar Bhat, Nirbhay Kumar, Theresa A. Shapiro & Jun O. Liu. (2009) Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo. Chemistry & Biology 16:2, pages 193-202.
Crossref
Sanghamitra Mitra, Brian Bennett & Richard C. Holz. (2009) Mutation of H63 and its catalytic affect on the methionine aminopeptidase from Escherichia coli. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1794:1, pages 137-143.
Crossref
Ofra Benny, Ofer Fainaru, Avner Adini, Flavia Cassiola, Lauren Bazinet, Irit Adini, Elke Pravda, Yaakov Nahmias, Samir Koirala, Gabriel Corfas, Robert J D'Amato & Judah Folkman. (2008) An orally delivered small-molecule formulation with antiangiogenic and anticancer activity. Nature Biotechnology 26:7, pages 799-807.
Crossref
L A Tucker, Q Zhang, G S Sheppard, P Lou, F Jiang, E McKeegan, R Lesniewski, S K Davidsen, R L Bell & J Wang. (2008) Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation. Oncogene 27:28, pages 3967-3976.
Crossref
Martin O'Rourke, Claire Ward, Jenny Worthington, Julie McKenna, Andrea Valentine, Tracy Robson, David G. Hirst & Stephanie R. McKeown. (2008) Evaluation of the Antiangiogenic Potential of AQ4N. Clinical Cancer Research 14:5, pages 1502-1509.
Crossref
Robert A. SchwartzRobert A. Schwartz. 2008. Skin Cancer. Skin Cancer 118 140 .
Ana R. Quesada, Miguel Ángel Medina & Emilio Alba. (2007) Playing only one instrument may be not enough: Limitations and future of the antiangiogenic treatment of cancer. BioEssays 29:11, pages 1159-1168.
Crossref
Gary T. Wang, Robert A. Mantei, Megumi Kawai, Jason S. Tedrow, David M. Barnes, Jieyi Wang, Qian Zhang, Pingping Lou, Lora A. Garcia, Jennifer Bouska, Melinda Yates, Chang Park, Russell A. Judge, Richard Lesniewski, George S. Sheppard & Randy L. Bell. (2007) Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids. Bioorganic & Medicinal Chemistry Letters 17:10, pages 2817-2822.
Crossref
Sarah Bhargava, Birgit Hotz, O. Joe Hines, Howard A. Reber, Heinz J. Buhr & Hubert G. Hotz. (2007) Suramin Inhibits Not Only Tumor Growth and Metastasis but Also Angiogenesis in Experimental Pancreatic Cancer. Journal of Gastrointestinal Surgery 11:2, pages 171-178.
Crossref
Sanghamitra Mitra, Anna M. Dygas-Holz, Jiri Jiracek, Miroslava Zertova, Lenka Zakova & Richard C. Holz. (2006) A new colorimetric assay for methionyl aminopeptidases: Examination of the binding of a new class of pseudopeptide analog inhibitors. Analytical Biochemistry 357:1, pages 43-49.
Crossref
Randall T. Peterson. (2006) A Noncanonical Path to Mechanism of Action. Chemistry & Biology 13:9, pages 924-926.
Crossref
Jing-Ruey J. YehRong JuCathleen M. BrdlikWenjun ZhangYi ZhangMary E. MatyskielaJoseph D. ShotwellCraig M. Crews. (2006) Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proceedings of the National Academy of Sciences 103:27, pages 10379-10384.
Crossref
Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Jonathan R. Dimmock & Rajendra K. Sharma. (2006) Methionine aminopeptidase 2 and cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1765:2, pages 148-154.
Crossref
Min Huang, Sheng-Xue Xie, Ze-Qiang Ma, Robert P. Hanzlik & Qi-Zhuang Ye. (2006) Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides. Biochemical and Biophysical Research Communications 339:2, pages 506-513.
Crossref
Ritchie L. Longoria, Michael C. Cox & William D. Figg. (2005) Antiangiogenesis: A Possible Treatment Option for Prostate Cancer?. Clinical Genitourinary Cancer 4:3, pages 197-202.
Crossref
Marcin Okrój, Wojciech Kamysz, Ewa M. Slominska, Andrzej Mysliwski & Jacek Bigda. (2005) A novel mechanism of action of the fumagillin analog, TNP-470, in the B16F10 murine melanoma cell line. Anti-Cancer Drugs 16:8, pages 817-823.
Crossref
Lara S. Kallander, Qing Lu, Wenfang Chen, Thaddeus Tomaszek, Guang Yang, David Tew, Thomas D. Meek, Glenn A. Hofmann, Christina K. Schulz-Pritchard, Ward W. Smith, Cheryl A. Janson, M. Dominic Ryan, Gui-Feng Zhang, Kyung O. Johanson, Robert B. Kirkpatrick, Thau F. Ho, Paul W. Fisher, Michael R. Mattern, Randall K. Johnson, Michael J. Hansbury, James D. Winkler, Keith W. Ward, Daniel F. Veber & Scott K. Thompson. (2005) 4-Aryl-1,2,3-triazole:  A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo. Journal of Medicinal Chemistry 48:18, pages 5644-5647.
Crossref
Fatoumata Camara, Johana Angarita & David R. Mootoo. (2005) Oxocarbenium Ion Cyclizations for C-Branched Cyclitols:  Synthesis of a Relay Intermediate for Fumagillin Analogues. The Journal of Organic Chemistry 70:17, pages 6870-6875.
Crossref
Alicja J. Copik, Sarah Waterson, Sabina I. Swierczek, Brian Bennett & Richard C. Holz. (2005) Both Nucleophile and Substrate Bind to the Catalytic Fe(II)-Center in the Type-II Methionyl Aminopeptidase from Pyrococcus f uriosus . Inorganic Chemistry 44:5, pages 1160-1162.
Crossref
Ventris M. D’souza, Robert S. Brown, Brian Bennett & Richard C. Holz. (2004) Characterization of the active site and insight into the binding mode of the anti-angiogenesis agent fumagillin to the manganese(II)-loaded methionyl aminopeptidase from Escherichia coli. JBIC Journal of Biological Inorganic Chemistry 10:1, pages 41-50.
Crossref
David Semela & Jean-Fran?ois Dufour. (2004) Angiogenesis and hepatocellular carcinoma. Journal of Hepatology 41:5, pages 864-880.
Crossref
D. W. J. van der Schaft, R. E. B. Seftor, E. A. Seftor, A. R. Hess, L. M. Gruman, D. A. Kirschmann, Y. Yokoyama, A. W. Griffioen & M. J. C. Hendrix. (2004) Effects of Angiogenesis Inhibitors on Vascular Network Formation by Human Endothelial and Melanoma Cells. JNCI Journal of the National Cancer Institute 96:19, pages 1473-1477.
Crossref
Sunkyu Kim, Kenneth LaMontagne, Michael Sabio, Sushil Sharma, Richard W. Versace, Naeem Yusuff & Penny E. Phillips. (2004) Depletion of Methionine Aminopeptidase 2 Does Not Alter Cell Response to Fumagillin or Bengamides. Cancer Research 64:9, pages 2984-2987.
Crossref
Jing-Ya Li, Yong-Mei Cui, Ling-Ling Chen, Min Gu, Jia Li, Fa-Jun Nan & Qi-Zhuang Ye. (2004) Mutations at the S1 Sites of Methionine Aminopeptidases from Escherichia coli and Homo sapiens Reveal the Residues Critical for Substrate Specificity. Journal of Biological Chemistry 279:20, pages 21128-21134.
Crossref
Cathleen M. Brdlik & Craig M. Crews. (2004) A Single Amino Acid Residue Defines the Difference in Ovalicin Sensitivity between Type I and II Methionine Aminopeptidases*. Journal of Biological Chemistry 279:10, pages 9475-9480.
Crossref
Deukjoon Kim, Jaeki Min, Soon Kil Ahn, Hong Woo Lee, Nam Song Choi & Seung Kee Moon. (2004) 5-Demethoxyfumagillol, a Potent Angiogenesis Inhibitor Isolated from Aspergillus fumigatus. CHEMICAL & PHARMACEUTICAL BULLETIN 52:4, pages 447-450.
Crossref
William W. Li. 2004. Cancer Chemoprevention. Cancer Chemoprevention 611 633 .
Udai Banerji, Ian Judson & Paul Workman. 2004. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Handbook of Anticancer Pharmacokinetics and Pharmacodynamics 1 27 .
Joseph A. Vetro, Benjamin Dummitt & Yie-Hwa Chang. 2004. Aminopeptidases in Biology and Disease. Aminopeptidases in Biology and Disease 17 44 .
Roy S. Herbst, Amir Onn & John Mendelsohn. 2004. Signal Transduction in Cancer. Signal Transduction in Cancer 19 72 .
François Bontems, Pascal le Floch, Francis Duffieux, Corinne Biderre, Pierre Peyret & Jean-Yves Lallemand. (2003) Homology modeling and calculation of the cobalt cluster charges of the Encephazlitozoon cuniculi methionine aminopeptidase, a potential target for drug design. Biophysical Chemistry 105:1, pages 29-43.
Crossref
Sue C Heffelfinger, Robin B Gear, Joanne Schneider, Kathy LaDow, Mei Yan, Fengxian Lu, Amy L Pyle & David Warshawsky. (2003) TNP-470 Inhibits 7,12-Dimethylbenz[a]anthracene–Induced Mammary Tumor Formation When Administered Before the Formation of Carcinoma In Situ but Is Not Additive with Tamoxifen. Laboratory Investigation 83:7, pages 1001-1011.
Crossref
Liliana Guedez, Alexandra M. Rivera, Rita Salloum, Megan L. Miller, Jared J. Diegmueller, Peter M. Bungay & William G. Stetler-Stevenson. (2003) Quantitative Assessment of Angiogenic Responses by the Directed in Vivo Angiogenesis Assay. The American Journal of Pathology 162:5, pages 1431-1439.
Crossref
Zong-Hai Huang. (2003) Effects of TNP-470 on proliferation and apoptosis in human colon cancer xenografts in nude mice. World Journal of Gastroenterology 9:2, pages 281.
Crossref
Akira Hori, Yasuhiro Imaeda, Keiji Kubo & Masami Kusaka. (2002) Novel benzimidazole derivatives selectively inhibit endothelial cell growth and suppress angiogenesis in vitro and in vivo. Cancer Letters 183:1, pages 53-60.
Crossref
Maria A. Rupnick, Dipak Panigrahy, Chen-Yu Zhang, Susan M. Dallabrida, Bradford B. Lowell, Robert Langer & M. Judah Folkman. (2002) Adipose tissue mass can be regulated through the vasculature. Proceedings of the National Academy of Sciences 99:16, pages 10730-10735.
Crossref
Peng Zhang, Diarmuid E. Nicholson, Janusz M. Bujnicki, Xinzhuan Su, James J. Brendle, Michael Ferdig, Dennis E. Kyle, Wilbur K. Milhous & Peter K. Chiang. (2002) Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for Malaria and Leishmaniasis. Journal of Biomedical Science 9:1, pages 34-40.
Crossref
D. Rohde. 2002. Pharmakotherapie in der Urologie. Pharmakotherapie in der Urologie 59 96 .
Gordon R. Macpherson, Sylvia S. W. Ng, Nehal J. Lakhani, Douglas K. Price, Jurgen Venitz & William D. Figg. 2002. Prostate Cancer: New Horizons in Research and Treatment. Prostate Cancer: New Horizons in Research and Treatment 317 330 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.