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Expert Opinion on Pharmacotherapy Volume 9, 2008 - Issue 18
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Original Research

The effects of ezetimibe and orlistat, alone or in combination, on high-density lipoprotein (HDL) subclasses and HDL-associated enzyme activities in overweight and obese patients with hyperlipidaemia

ES Nakou University of Ioannina, Medical School, Department of Internal Medicine, 45 110 Ioannina, Greece +30 2651 0 97509; +30 2651 0 97016; E-mail: [email protected]
,
TD Filippatos University of Ioannina, Medical School, Department of Internal Medicine, 45 110 Ioannina, Greece +30 2651 0 97509; +30 2651 0 97016; E-mail: [email protected]
,
DN Kiortsis University of Ioannina, Medical School, Laboratory of Physiology, Ioannina, Greece
,
CS Derdemezis University of Ioannina, Medical School, Department of Internal Medicine, 45 110 Ioannina, Greece +30 2651 0 97509; +30 2651 0 97016; E-mail: [email protected]
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AD Tselepis University of Ioannina, Department of Chemistry, Laboratory of Biochemistry, Ioannina, Greece
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DP Mikhailidis University College London (UCL), Department of Clinical Biochemistry Royal Free Campus, London, UK
&
MS Elisaf University of Ioannina, Medical School, Department of Internal Medicine, 45 110 Ioannina, Greece +30 2651 0 97509; +30 2651 0 97016; E-mail: [email protected]
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Pages 3151-3158 | Published online: 28 Nov 2008

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Read on this site (8)

T. D. Filippatos, M. Florentin, M. Georgoula & M. S. Elisaf. (2017) Pharmacological management of diabetic dyslipidemia. Expert Review of Clinical Pharmacology 10:2, pages 187-200.
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Anastazia A. Kei, Theodosios D. Filippatos & Moses S. Elisaf. (2016) The safety of ezetimibe and simvastatin combination for the treatment of hypercholesterolemia. Expert Opinion on Drug Safety 15:4, pages 559-569.
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TD Filippatos, CS Derdemezis, PV Voulgari, V Tsimihodimos, MS Elisaf, AD Tselepis & AA Drosos. (2013) Effects of 12 months of treatment with disease-modifying anti-rheumatic drugs on low and high density lipoprotein subclass distribution in patients with early rheumatoid arthritis: a pilot study. Scandinavian Journal of Rheumatology 42:3, pages 169-175.
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Serena Tonstad & Jean-Pierre Després. (2011) Treatment of lipid disorders in obesity. Expert Review of Cardiovascular Therapy 9:8, pages 1069-1080.
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Theodosios D Filippatos & Moses S Elisaf. (2011) Fenofibrate plus simvastatin (fixed-dose combination) for the treatment of dyslipidaemia. Expert Opinion on Pharmacotherapy 12:12, pages 1945-1958.
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Aris P Agouridis, Theodosios D Filippatos, Vasilios Tsimihodimos & Moses S Elisaf. (2011) Combinations of ezetimibe with nonstatin drug regimens affecting lipid metabolism. Expert Review of Cardiovascular Therapy 9:3, pages 355-366.
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Katie S McClendon, Daniel M Riche & Gabriel Ikponmosa Uwaifo. (2009) Orlistat: current status in clinical therapeutics. Expert Opinion on Drug Safety 8:6, pages 727-744.
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Fabrizio Montecucco, Alessandra Quercioli & François Mach. (2009) Ezetimibe/simvastatin. Expert Opinion on Drug Safety 8:6, pages 715-725.
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Articles from other publishers (22)

Dominika Kunachowicz, Milena Ściskalska & Marta Kepinska. (2023) Modulatory Effect of Lifestyle-Related, Environmental and Genetic Factors on Paraoxonase-1 Activity: A Review. International Journal of Environmental Research and Public Health 20:4, pages 2813.
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Zaida Zakaria, Zaidatul Akmal Othman, Joseph Bagi Suleiman, Nur Asyilla Che Jalil, Wan Syaheedah Wan Ghazali & Mahaneem Mohamed. (2021) Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and Oxidative Stress in High-Fat Diet-Induced Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2 Activation. Veterinary Sciences 8:11, pages 274.
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Estefania Gastaldello Moreira, Karine Maria Boll, Dalmo Guilherme Correia, Janaina Favaro Soares, Camila Rigobello & Michael Maes. (2019) Why Should Psychiatrists and Neuroscientists Worry about Paraoxonase 1?. Current Neuropharmacology 17:11, pages 1004-1020.
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Bingli Zhao, Yujiao Cui, Xiaodan Fan, Ping Qi, Chunchen Liu, Xuesong Zhou & Xuewu Zhang. (2019) Anti-obesity effects of Spirulina platensis protein hydrolysate by modulating brain-liver axis in high-fat diet fed mice. PLOS ONE 14:6, pages e0218543.
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Shubo Dong, Hanyue Yang & Deju Ye. (2018) Development of an LC–MS Method for 4-Fluoroaniline Determination in Ezetimibe. Journal of Chromatographic Science 56:8, pages 724-730.
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Theodosios D. Filippatos, Anastazia Kei, Christos V. Rizos & Moses S. Elisaf. (2017) Effects of PCSK9 Inhibitors on Other than Low-Density Lipoprotein Cholesterol Lipid Variables. Journal of Cardiovascular Pharmacology and Therapeutics 23:1, pages 3-12.
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Amirhossein Sahebkar, Luis E. Simental-Mendía, Željko Reiner, Petri T. Kovanen, Mario Simental-Mendía, Vanessa Bianconi & Matteo Pirro. (2017) Effect of orlistat on plasma lipids and body weight: A systematic review and meta-analysis of 33 randomized controlled trials. Pharmacological Research 122, pages 53-65.
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Theodosios D. Filippatos & Moses S. Elisaf. (2015) Statin–Ezetimibe Combination Therapy In Diabetic Individuals. Angiology 67:6, pages 507-509.
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Ali A. RizviDragana NikolicHanaa S. SallamGiuseppe MontaltoManfredi RizzoNicola Abate. (2014) Adipokines and Lipoproteins: Modulation by Antihyperglycemic and Hypolipidemic Agents. Metabolic Syndrome and Related Disorders 12:1, pages 1-10.
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Federico Vozzi, Gualtiero Pelosi, Mariarita Puntoni, Federica Viglione, Silvia Rocchiccioli, Claudia Kusmic, Fabio Bernini, Paolo Marraccini, Maria Giovanna Trivella & Oberdan Parodi. (2014) HDL-Mediated Protection of Coronary Vasodilator Response to Adenosine in the Hypercholesterolemic Swine. Open Journal of Molecular and Integrative Physiology 04:04, pages 49-61.
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Theodosios D. Filippatos, Evangelos C. Rizos, Vasilios Tsimihodimos, Irene F. Gazi, Alexandros D. Tselepis & Moses S. Elisaf. (2013) Small High-Density Lipoprotein (HDL) Subclasses are Increased with Decreased Activity of HDL-Associated Phospholipase A2 in Subjects with Prediabetes. Lipids 48:6, pages 547-555.
Crossref
C.C. Leança, V.S. Nunes, E.R. Nakandakare, E.C. de Faria & E.C.R. Quintao. (2013) Does plasma HDL-C concentration interact with whole-body cholesterol metabolism?. Nutrition, Metabolism and Cardiovascular Diseases 23:4, pages 279-284.
Crossref
Dragana Nikolic, Niki Katsiki, Giuseppe Montalto, Esma Isenovic, Dimitri Mikhailidis & Manfredi Rizzo. (2013) Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches. Nutrients 5:3, pages 928-948.
Crossref
Elisavet Moutzouri, Constantinos C. Tellis, Kleopatra Rousouli, Evangelos N. Liberopoulos, Haralambos J. Milionis, Moses S. Elisaf & Alexandros D. Tselepis. (2012) Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide – Induced cytokine production in monocytes of hypercholesterolemic patients. Atherosclerosis 225:2, pages 381-387.
Crossref
Aneta Otocka-Kmiecik, Dimitri P. Mikhailidis, Stephen J. Nicholls, Michael Davidson, Jacek Rysz & Maciej Banach. (2012) Dysfunctional HDL: A novel important diagnostic and therapeutic target in cardiovascular disease?. Progress in Lipid Research 51:4, pages 314-324.
Crossref
Anastazia A. Kei, Theodosios D. Filippatos, Vasilios Tsimihodimos & Moses S. Elisaf. (2012) A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease. Metabolism 61:7, pages 906-921.
Crossref
Theodosios D Filippatos. (2011) Role of ezetimibe in non-alcoholic fatty liver disease. World Journal of Hepatology 3:10, pages 265.
Crossref
Justin D. Clifton, Edinson Lucumi, Michael C. Myers, Andrew Napper, Kotaro Hama, Steven A. Farber, Amos B. Smith, Donna M. Huryn, Scott L. Diamond & Michael Pack. (2010) Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish. PLoS ONE 5:8, pages e12386.
Crossref
Nurver Turfaner, Hafize Uzun, Huriye Balci, Meltem A. Ercan, Yesari H. Karter, Metin Caner, Fikret Sipahioglu & Habibe Genc. (2010) Ezetimibe Therapy and Its Influence on Oxidative Stress and Fibrinolytic Activity. Southern Medical Journal 103:5, pages 428-433.
Crossref
E. S. Nakou, T. D. Filippatos, A. P. Agouridis, C. Kostara, E. T. Bairaktari & M. S. Elisaf. (2010) The Effects of Ezetimibe and/or Orlistat on Triglyceride-Rich Lipoprotein Metabolism in Obese Hypercholesterolemic Patients. Lipids 45:5, pages 445-450.
Crossref
Theodosios D Filippatos. (2010) Combination drug treatment in obese diabetic patients. World Journal of Diabetes 1:1, pages 8.
Crossref
TD Filippatos, CS Derdemezis & MS Elisaf. (2009) Effects of orlistat, alone or combined with hypolipidemic drugs, on cardiovascular risk factors. Clinical Lipidology 4:3, pages 331-341.
Crossref

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