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Drug Evaluation

Fosaprepitant dimeglumine (MK-0517 or L-785,298), an intravenous neurokinin-1 antagonist for the prevention of chemotherapy induced nausea and vomiting

, MD PhD & , MD PhD
Pages 3261-3270 | Published online: 28 Nov 2008

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Janine Gross, Alfred R. Wegener, Martin Kronschläger, Carl-Ludwig Schönfeld, Frank G. Holz & Linda M. Meyer. (2021) UVR-B-induced NKR-1 Expression in Ocular Tissues is blocked by Substance P Receptor Antagonist Fosaprepitant in the Exposed as well as Unexposed Partner Eye. Ocular Immunology and Inflammation 29:5, pages 963-975.
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Timothy Tyler, Armin Schultz, Alessio Venturini, Claudio Giuliano, Alberto Bernareggi, Riccardo Spezia, Daniel Voisin & Valentino Stella. (2022) Challenges in the Development of Intravenous Neurokinin‐1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose‐Finding, Phase 1 Study of Intravenous Fosnetupitant. Clinical Pharmacology in Drug Development 11:12, pages 1405-1418.
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JALIL K. SHAIKH, MAZAHAR FAROOQUI & UMMUL KHAIR ASEMA SYED. (2020) Quality by Design Approach for Development and Validation of Stability Indicating RP-HPLC Method for Fosaprepitant Dimeglumine. Asian Journal of Chemistry 32:9, pages 2158-2164.
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Florence Van Ryckeghem. (2016) Corticosteroids, the oldest agent in the prevention of chemotherapy-induced nausea and vomiting: What about the guidelines?. Journal of Translational Internal Medicine 4:1, pages 46-51.
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John P. Micha, Mark A. Rettenmaier, John V. BrownIIIIII, Alberto Mendivil, Lisa N. Abaid, Katrina L. Lopez & Bram H. Goldstein. (2016) A Randomized Controlled Pilot Study Comparing the Impact of Aprepitant and Fosaprepitant on Chemotherapy Induced Nausea and Vomiting in Patients Treated for Gynecologic Cancer. International Journal of Gynecological Cancer 26:2, pages 389-393.
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Bernardo Leon Rapoport. 2016. Management of Chemotherapy-Induced Nausea and Vomiting. Management of Chemotherapy-Induced Nausea and Vomiting 85 105 .
Livia T. Hegerova, Alexis D. Leal, Darryl C. Grendahl, Drew K. Seisler, Kristine M. Sorgatz, Kari J. Anderson, Crystal R. Hilger & Charles L. Loprinzi. (2014) An analysis of fosaprepitant-induced venous toxicity in patients receiving highly emetogenic chemotherapy. Supportive Care in Cancer 23:1, pages 55-59.
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Christina Ruby. 2010. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 13 .
Monique P. Curran & Dean M. Robinson. (2009) Aprepitant. Drugs 69:13, pages 1853-1878.
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Shridhar Hegde & Michelle Schmidt. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 577 632 .

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