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Drug Evaluation

Lubiprostone: chronic constipation and irritable bowel syndrome with constipation

, PhD MD & , MD
Pages 143-152 | Published online: 16 Dec 2008

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Augusto Lauro, Roberto De Giorgio & Antonio Daniele Pinna. (2015) Advancement in the clinical management of intestinal pseudo-obstruction. Expert Review of Gastroenterology & Hepatology 9:2, pages 197-208.
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Yuan Li, Haitao Yu, Bing Xu, Fang Yuan, Ping Zhang, Shengqing Tu, Yumeng Zhou & Xin Li. (2023) Pharmacokinetics and Bioequivalence of the Lubiprostone Capsule in Healthy Chinese Subjects. Clinical Pharmacology in Drug Development 12:4, pages 436-446.
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Marina Fortea, Mercé Albert-Bayo, Mar Abril-Gil, John-Peter Ganda Mall, Xavier Serra-Ruiz, Alejandro Henao-Paez, Elba Expósito, Ana María González-Castro, Danila Guagnozzi, Beatriz Lobo, Carmen Alonso-Cotoner & Javier Santos. (2021) Present and Future Therapeutic Approaches to Barrier Dysfunction. Frontiers in Nutrition 8.
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Ryuichi Kawamoto, Asuka Kikuchi, Daisuke Ninomiya & Teru Kumagi. (2021) Clubbed Digits Presumably Caused by Lubiprostone. Internal Medicine 60:15, pages 2499-2502.
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Danhua Ge, Xin Wang & Xue-Qiang Chu. (2021) Difluoroalkylation/1,2-aryl migration of allylic alcohols under transition metal-free conditions. Tetrahedron Letters 70, pages 153002.
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Mohammed Hasosah. (2021) Chronic Refractory Constipation in Children: Think Beyond Stools. Global Pediatric Health 8, pages 2333794X2110487.
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Marcelo A. Catalán, Francisca Julio-Kalajzić, María Isabel Niemeyer, Luis Pablo Cid & Francisco V. Sepúlveda. (2020) Short Chain Fatty Acids Effect on Chloride Channel ClC-2 as a Possible Mechanism for Lubiprostone Intestinal Action. Cells 9:8, pages 1781.
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Takuya Yumizaki, Mika Maeda, Tomoe Fujita, Hiroyoshi Kakuyama & Yuji Kumagai. (2020) A 3‐Part Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DSP‐6952 in Healthy Japanese Subjects and Those With ≤3 Spontaneous Bowel Movements per Week. Clinical Pharmacology in Drug Development 9:3, pages 353-365.
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Lawrence R Schiller. (2019) Chronic constipation: new insights, better outcomes?. The Lancet Gastroenterology & Hepatology 4:11, pages 873-882.
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Ye Zong, Shengtao Zhu, Shutian Zhang, Gen Zheng, John W Wiley & Shuangsong Hong. (2018) Chronic stress and intestinal permeability: Lubiprostone regulates glucocorticoid receptor‐mediated changes in colon epithelial tight junction proteins, barrier function, and visceral pain in the rodent and human. Neurogastroenterology & Motility 31:2, pages e13477.
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John Cuppoletti, Kirti P. Tewari, Jayati Chakrabarti & Danuta H. Malinowska. (2017) Identification of the fatty acid activation site on human ClC-2. American Journal of Physiology-Cell Physiology 312:6, pages C707-C723.
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Hongwei Wang, Minghui Xu, Qingjie Kong, Peng Sun, Fengyun Yan, Wenying Tian & Xin Wang. (2017) Research and progress on ClC-2. Molecular Medicine Reports 16:1, pages 11-22.
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Vanessa C. Costilla & Amy E. Foxx-Orenstein. (2014) Constipation in Adults: Diagnosis and Management. Current Treatment Options in Gastroenterology 12:3, pages 310-321.
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Han-Yi JiaoDong Hyun KimJung Suk KiKwon Ho RyuSeok ChoiJae Yeoul Jun. (2014) Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon. The Korean Journal of Physiology & Pharmacology 18:4, pages 341.
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Marina A. Gonzalez-Martinez, Nayeli X. Ortiz-Olvera & Jorge Mendez-Navarro. (2014) Novel Pharmacological Therapies for Management of Chronic Constipation. Journal of Clinical Gastroenterology 48:1, pages 21-28.
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Kelly K. Everhart & Brian E. Lacy. 2014. Constipation. Constipation 67 95 .
Scott L. Gabbard & Brian E. Lacy. (2013) Chronic Intestinal Pseudo-Obstruction. Nutrition in Clinical Practice 28:3, pages 307-316.
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Brian E. Lacy, John M. Levenick & Michael Crowell. (2012) Chronic constipation: new diagnostic and treatment approaches. Therapeutic Advances in Gastroenterology 5:4, pages 233-247.
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E. M. M. Quigley. (2012) Commentary: long‐term lubiprostone for constipation predominant IBS. Alimentary Pharmacology & Therapeutics 35:8, pages 962-963.
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Juan F Gallegos-Orozco, Amy E Foxx-Orenstein, Susan M Sterler & Jean M Stoa. (2012) Chronic Constipation in the Elderly. American Journal of Gastroenterology 107:1, pages 18-25.
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Anthony J. Lembo, John F. Johanson, Henry P. Parkman, Satish S. Rao, Philip B. MinerJr.Jr. & Ryuji Ueno. (2011) Long-Term Safety and Effectiveness of Lubiprostone, a Chloride Channel (ClC-2) Activator, in Patients with Chronic Idiopathic Constipation. Digestive Diseases and Sciences 56:9.
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Joseph Y Chang & Nicholas J Talley. (2011) An update on irritable bowel syndrome: from diagnosis to emerging therapies. Current Opinion in Gastroenterology 27:1, pages 72-78.
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Joseph Y. Chang & Nicholas J. Talley. (2010) Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment. Trends in Pharmacological Sciences 31:7, pages 326-334.
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