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HIV protease inhibitors: recent clinical trials and recommendations on use

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Pages 1615-1629 | Published online: 15 Jun 2009

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Iman Fathy Abou-El-Naga, Maha Mohamed Gomaa & Samar Nabil ElAchy. (2022) Effect of HIV aspartyl protease inhibitors on experimental infection with a cystogenic Me49 strain of Toxoplasma gondii. Pathogens and Global Health 116:2, pages 107-118.
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José Vicente Fernández-Montero, Eugenia Vispo & Vicente Soriano. (2014) Emerging antiretroviral drugs. Expert Opinion on Pharmacotherapy 15:2, pages 211-219.
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Jose V Fernandez-Montero, Eugenia Eugenia, Pablo Barreiro, Pablo Labarga & Vicente Soriano. (2013) Antiretroviral drug-related toxicities – clinical spectrum, prevention, and management. Expert Opinion on Drug Safety 12:5, pages 697-707.
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C. Tremblay, B. Trottier, A. Rachlis, J.G. Baril, M. Loutfy, R. Lalonde, J.S. Sampalis & F. Boulerice. (2011) Treatment Durability, Effectiveness, and Safety with Atazanavir/Ritonavir-Based HAART Regimen in Treatment-Naïve HIV-lnfected Patients. HIV Clinical Trials 12:3, pages 151-160.
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Miguel Ángel Artacho, Pablo Barreiro & José Vicente Fernández-Montero. (2010) Long-term treatment of patients with HIV-1: the role of atazanavir. HIV/AIDS - Research and Palliative Care 2, pages 157-166.
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Articles from other publishers (28)

Sónia Soares, Mélina Bornet, Clara Grosso, Maria João Ramalhosa, Irene Gouvinhas, Juliana Garcia, Francisca Rodrigues & Cristina Delerue-Matos. (2022) Honey as an Adjuvant in the Treatment of COVID-19 Infection: A Review. Applied Sciences 12:15, pages 7800.
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Seyed Ali Hemmati & Saeid Tabein. (2022) Insect protease inhibitors; promising inhibitory compounds against SARS-CoV-2 main protease. Computers in Biology and Medicine 142, pages 105228.
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Shreyas Kaptan, Mykhailo Girych, Giray Enkavi, Waldemar Kulig, Vivek Sharma, Joni Vuorio, Tomasz Rog & Ilpo Vattulainen. (2022) Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease. Computational and Structural Biotechnology Journal 20, pages 3336-3346.
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Monica Florin-Christensen, Sarah N. Wieser, Carlos E. Suarez & Leonhard Schnittger. (2021) In Silico Survey and Characterization of Babesia microti Functional and Non-Functional Proteases. Pathogens 10:11, pages 1457.
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Essa M. Saied, Yousra A. El-Maradny, Alaa A. Osman, Amira M. G. Darwish, Hebatallah H. Abo Nahas, Gniewko Niedbała, Magdalena Piekutowska, Mohamed A. Abdel-Rahman, Bassem A. Balbool & Ahmed M. Abdel-Azeem. (2021) A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19. Pharmaceutics 13:11, pages 1759.
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Jiangnan Dong, Su Li & Guangxuan Liu. (2021) Binimetinib Is a Potent Reversible and Time-Dependent Inhibitor of Cytochrome P450 1A2. Chemical Research in Toxicology 34:4, pages 1169-1174.
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Nakarin Suwannarach, Jaturong Kumla, Kanaporn Sujarit, Thanawat Pattananandecha, Chalermpong Saenjum & Saisamorn Lumyong. (2020) Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses. Molecules 25:8, pages 1800.
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Eva Agnes Odongpiny Laker, Maria Sarah Nabaggala, Arvind Kaimal, Damalie Nalwanga, Barbara Castelnuovo, Abdu Musubire, Agnes Kiragga, Mohammed Lamorde & Rosalind Parkes- Ratanshi. (2019) An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir. BMC Infectious Diseases 19:1.
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Xiucai Guo, Wei Li, Qingmei Li, Yan Chen, Guode Zhao, Ying Peng & Jiang Zheng. (2019) Tofacitinib Is a Mechanism-Based Inactivator of Cytochrome P450 3A4. Chemical Research in Toxicology 32:9, pages 1791-1800.
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Ayodeji A. Agbowuro, Wilhelmina M. Huston, Allan B. Gamble & Joel D. A. Tyndall. (2018) Proteases and protease inhibitors in infectious diseases. Medicinal Research Reviews 38:4, pages 1295-1331.
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Iman Fathy Abou-El-Naga, Eman Dorry El Kerdany, Rasha Fadly Mady, Thanaa Ibrahim Shalaby & Enas Mohammed Zaytoun. (2017) The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis. Parasitology International 66:6, pages 735-747.
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Biswajit G Roy. (2017) Potential of small-molecule fungal metabolites in antiviral chemotherapy. Antiviral Chemistry and Chemotherapy 25:2, pages 20-52.
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Carlos Brites, Isabella Nóbrega & Eduardo Martins Netto. (2015) Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients. The Brazilian Journal of Infectious Diseases 19:5, pages 529-532.
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Brooke M. Rock, Shawna M. Hengel, Dan A. Rock, Larry C. Wienkers & Kent L. Kunze. (2014) Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4. Molecular Pharmacology 86:6, pages 665-674.
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Maren Kuhnert, Holger Steuber & Wibke E. Diederich. (2014) Structural Basis for HTLV-1 Protease Inhibition by the HIV-1 Protease Inhibitor Indinavir. Journal of Medicinal Chemistry 57:14, pages 6266-6272.
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Georgio Kourjian, Yang Xu, Ijah Mondesire-Crump, Mariko Shimada, Pauline Gourdain & Sylvie Le Gall. (2014) Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors. The Journal of Immunology 192:8, pages 3496-3506.
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Kirsten M. Stray, Christian Callebaut, Bärbel Glass, Luong Tsai, Lianhong Xu, Barbara Müller, Hans-Georg Kräusslich & Tomas Cihlar. (2013) Mutations in Multiple Domains of Gag Drive the Emergence of In Vitro Resistance to the Phosphonate-Containing HIV-1 Protease Inhibitor GS-8374 . Journal of Virology 87:1, pages 454-463.
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Olawale Ajose, Siddharth Mookerjee, Edward J. Mills, Andrew Boulle & Nathan Ford. (2012) Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings. AIDS 26:8, pages 929-938.
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Filippo Canducci, Elisa Rita Ceresola, Diego Saita, Yousef Al-Abed, Gianni Garotta, Massimo Clementi & Ferdinando Nicoletti. (2011) The new and less toxic protease inhibitor saquinavir–NO maintains anti-HIV-1 properties in vitro indistinguishable from those of the parental compound saquinavir. Antiviral Research 91:3, pages 292-295.
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Jinzi J. Wu & Joseph Musto. 2011. Antiviral Drugs. Antiviral Drugs 19 30 .
Alessandra Viganò, Valeria Manfredini, Francesca Penagini, Vania Giacomet & Gian Vincenzo Zuccotti. (2011) Antiretroviral drugs in HIV-infected children. Pharmacological Research 64:1, pages 1-3.
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Prasenjit Mukherjee, Falgun Shah, Prashant Desai & Mitchell Avery. (2011) Inhibitors of SARS-3CL pro : Virtual Screening, Biological Evaluation, and Molecular Dynamics Simulation Studies . Journal of Chemical Information and Modeling 51:6, pages 1376-1392.
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Sérgio Filipe Sousa, Bruno Tamames, Pedro Alexandrino Fernandes & Maria João Ramos. (2011) Detailed Atomistic Analysis of the HIV-1 Protease Interface. The Journal of Physical Chemistry B 115:21, pages 7045-7057.
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Vicente Soriano, Keikawus Arastéh, Horacio Migrone, Thomas Lutz, Milos Opravil, Jaime Andrade-Villanueva, Francisco Antunes, Giovanni Di Perri, Daniel Podzamczer, Steve Taylor, Pere Domingo, Holger Gellermann & Lothar de Rossi. (2010) Nevirapine versus Atazanavir/Ritonavir, Each Combined with Tenofovir Disoproxil Fumarate/Emtricitabine, in Antiretroviral-Naive HIV-1 Patients: The Arten Trial. Antiviral Therapy 16:3, pages 339-348.
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Paul W. Hruz, Qingyun Yan, Luong Tsai, Joseph Koster, Lianhong Xu, Tomas Cihlar & Christian Callebaut. (2011) GS-8374, a Novel HIV Protease Inhibitor, Does Not Alter Glucose Homeostasis in Cultured Adipocytes or in a Healthy-Rodent Model System. Antimicrobial Agents and Chemotherapy 55:4, pages 1377-1382.
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Erdembileg Anuurad, Andrew Bremer & Lars Berglund. (2010) HIV protease inhibitors and obesity. Current Opinion in Endocrinology, Diabetes and Obesity 17:5, pages 478-485.
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Judit Morello, Sonia Rodríguez-Novoa, Francisco Blanco, Eugenia Vispo, Pablo Barreiro, Gema Gonzalez-Pardo, Inmaculada Jiménez-Nácher, Juan González-Lahoz & Vincent Soriano. (2010) The Benefit of Simplification From Tipranavir/Ritonavir 500/200 bid to 500/100 bid Guided by Therapeutic Drug Monitoring. Therapeutic Drug Monitoring 32:2, pages 242-244.
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Jana Pokorná, Ladislav Machala, Pavlína Řezáčová & Jan Konvalinka. (2009) Current and Novel Inhibitors of HIV Protease. Viruses 1:3, pages 1209-1239.
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