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Drug Evaluations

Zonisamide in the treatment of epilepsy

Pages 115-126 | Published online: 10 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Lan Gao & Shuchuen Li. (2016) Emerging drugs for partial-onset epilepsy: a review of brivaracetam. Therapeutics and Clinical Risk Management 12, pages 719-734.
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Andreas Schulze-Bonhage. (2015) The safety and long-term efficacy of zonisamide as adjunctive therapy for focal epilepsy. Expert Review of Neurotherapeutics 15:8, pages 857-865.
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Maria Stella Vari & Pasquale Striano. (2014) A review of safety and efficacy of zonisamide for treatment of pediatric partial epilepsy. Pediatric Health, Medicine and Therapeutics 5, pages 155-160.
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Marco Mula. (2013) Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults. Drug Design, Development and Therapy 7, pages 397-402.
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Articles from other publishers (22)

Grace Victoria Govada & Sabbasani Rajasekhara Reddy. (2023) Synthesis and in Silico Study of Novel Benzisoxazole‐Chromene Derivatives as Potent Inhibitors of Acetylcholinesterase: Metal‐Free Site‐Selective C−N Bond Formation via Aza‐Michael Reaction . Chemistry & Biodiversity 20:8.
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Rohit Pal, Karanvir Singh, Shah Alam Khan, Pooja Chawla, Bhupinder Kumar & Md Jawaid Akhtar. (2021) Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction. European Journal of Medicinal Chemistry 226, pages 113890.
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J. C. Martínez-Ávila, A. García Bartolomé, I. García, I. Dapía, Hoi Y. Tong, L. Díaz, P. Guerra, J. Frías, A. J. Carcás Sansuan & A. M. Borobia. (2018) Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction. Metabolomics 14:5.
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Ling-Yan Shao, Zhi Xu, Cun-Ying Wang, Xiao-Pan Fu, Miao-Miao Chen, Hong-Wei Liu & Ya-Fei Ji. (2018) Palladium-catalyzed direct mono -aroylation of O -arylmethyl and aryl-substituted acetoxime ethers . Organic & Biomolecular Chemistry 16:34, pages 6284-6294.
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Ying Guo, Kun-Kun Yu, Li-Hao Xing, Hong-Wei Liu, Wei Wang & Ya-Fei Ji. (2017) Palladium-Catalyzed Divergent Regioselective Homocoupling and Hydroxylation of 3-Arylbenzo[ d ]isoxazoles . Advanced Synthesis & Catalysis 359:3, pages 410-418.
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Ying Guo, Ling-Yan Shao, Kun-Kun Yu, Ya-Hua Hu, Hong-Wei Liu, Dao-Hua Liao & Ya-Fei Ji. (2017) Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d]isoxazoles. Organic Chemistry Frontiers 4:10, pages 1962-1966.
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Dina Lourenço, Mafalda Sarraguça, Gilberto Alves, Paula Coutinho, André R. T. S. Araujo & Márcio Rodrigues. (2017) A novel HPLC method for the determination of zonisamide in human plasma using microextraction by packed sorbent optimised by experimental design. Anal. Methods 9:40, pages 5910-5919.
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Júlia Miro, Sònia Jaraba, Roser Juvany, Milagrosa Santurino, Sara Cobo & Mercè Falip. (2016) Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide?. Clinical Neuropharmacology 39:3, pages 121-124.
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Jianhang Jiao, Winnie Jensen, Kristian R. Harreby & Cristian Sevcencu. (2016) The Effect of Spinal Cord Stimulation on Epileptic Seizures. Neuromodulation: Technology at the Neural Interface 19:2, pages 154-160.
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Shang‐Yeong Kwan, Yao‐Chung Chuang, Chin‐Wei Huang, Ta‐Cheng Chen, Shuo‐Bin Jou & Amitabh Dash. (2015) Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy. CNS Neuroscience & Therapeutics 21:9, pages 683-691.
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Joanna H. Cox, Stefano Seri & Andrea E. Cavanna. (2014) Zonisamide as a Treatment for Partial Epileptic Seizures: A Systematic Review. Advances in Therapy 31:3, pages 276-288.
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Pingping Duan, Yunfang Yang, Rong Ben, Yiyong Yan, Lu Dai, Mei Hong, Yun-Dong Wu, Dongqi Wang, Xinhao Zhang & Jing Zhao. (2014) Palladium-catalyzed benzo[d]isoxazole synthesis by C–H activation/[4 + 1] annulation. Chem. Sci. 5:4, pages 1574-1578.
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B. Neubauer & A. Hahn. 2014. Dooses Epilepsien im Kindes- und Jugendalter. Dooses Epilepsien im Kindes- und Jugendalter 371 387 .
E. Trinka, L. Giorgi, A. Patten & J. Segieth. (2013) Safety and tolerability of zonisamide in elderly patients with epilepsy. Acta Neurologica Scandinavica 128:6, pages 422-428.
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Kamal M. Matar. (2013) Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits. BioMed Research International 2013, pages 1-5.
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M. J. Brodie, E. Ben-Menachem, I. Chouette & L. Giorgi. (2012) Zonisamide: its pharmacology, efficacy and safety in clinical trials. Acta Neurologica Scandinavica 126, pages 19-28.
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Michel Baulac, Martin J Brodie, Anna Patten, Joanna Segieth & Luigi Giorgi. (2012) Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial. The Lancet Neurology 11:7, pages 579-588.
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Bernd A. Neubauer & Andreas HahnBernd A. Neubauer & Andreas Hahn. 2012. Dooses Epilepsien im Kindes- und Jugendalter. Dooses Epilepsien im Kindes- und Jugendalter 347 359 .
Cheng-yi Chen, Teresa Andreani & Hongmei Li. (2011) A Divergent and Selective Synthesis of Isomeric Benzoxazoles from a Single N–Cl Imine. Organic Letters 13:23, pages 6300-6303.
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Christoph Helmstaedter, Hermann Stefan & Juri‐Alexander Witt. (2011) Quality of life in patients with partial‐onset seizures under adjunctive therapy with zonisamide: results from a prospective non‐interventional surveillance study. Epileptic Disorders 13:3, pages 263-276.
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Claudia B. Catarino, Emanuele Bartolini, Gail S. Bell, Alan W.C. Yuen, John S. Duncan & Josemir W. Sander. (2011) The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre. Epilepsy Research 96:1-2, pages 39-44.
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Władysław Lasoń, Monika Dudra-Jastrzębska, Konrad Rejdak & Stanisław J. Czuczwar. (2011) Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update. Pharmacological Reports 63:2, pages 271-292.
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